Genetic approaches in mice to understand Rel/NF-kappaB and IkappaB function: transgenics and knockouts

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Genetic approaches in mice to understand Rel/NF-kappaB and IkappaB function: transgenics and knockouts is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P6179Dimensions Publication ID1047772247
P356DOI10.1038/SJ.ONC.1203236
P698PubMed publication ID10602464
P5875ResearchGate publication ID245595318

P2093author name stringY Nakamura
S Gerondakis
T Pohl
M Grossmann
R Grumont
P2860cites workMutations in TWIST, a basic helix-loop-helix transcription factor, in Saethre-Chotzen syndromeQ24311679
IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survivalQ24323200
The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosisQ24608044
A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcriptionQ24644412
Aberrant rel/nfkb genes and activity in human cancerQ28140722
The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-kappa B-mediated inhibitionQ28155838
The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimersQ28267241
NF-kappa B RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responsesQ28505819
Immunological defects in mice with a targeted disruption in Bcl-3Q28506495
Expression of relB is required for the development of thymic medulla and dendritic cellsQ28594949
An essential role for NF-kappaB in preventing TNF-alpha-induced cell deathQ29614707
NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activationQ29618715
Multiple signals converging on NF-kappaB.Q33597403
Control of development and immunity by rel transcription factors in DrosophilaQ33797143
Control of apoptosis by Rel/NF-kappaB transcription factorsQ33797163
Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-RelQ33797168
Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel familyQ34317095
Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethalityQ35064315
Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosisQ35189463
Requirement for NF-kappaB in osteoclast and B-cell developmentQ35199657
An essential role for nuclear factor kappaB in promoting double positive thymocyte apoptosisQ35834615
Alterations in NF-kappaB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-kappaB.Q35913517
The Rel subunit of NF-kappaB-like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populationsQ35917603
Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-kappaB.Q36377290
Mice deficient in nuclear factor (NF)-kappa B/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitectureQ36400143
Nuclear factor (NF)-kappa B2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responsesQ36400158
B lymphocytes differentially use the Rel and nuclear factor kappaB1 (NF-kappaB1) transcription factors to regulate cell cycle progression and apoptosis in quiescent and mitogen-activated cellsQ36400425
Functional redundancy of the nuclear factor kappa B inhibitors I kappa B alpha and I kappa B betaQ36401827
IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in miceQ36559410
Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factorQ37654865
Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient miceQ38289217
Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-kappaB2.Q38342766
Expression of constitutively active IkappaB beta in T cells of transgenic mice: persistent NF-kappaB activity is required for T-cell immune responsesQ39631389
Overexpression of RelA in transgenic mouse thymocytes: specific increase in levels of the inhibitor protein I kappa B alphaQ40016532
Constitutive expression of Bc1-3 in thymocytes increases the DNA binding of NF-kappaB1 (p50) homodimers in vivoQ40018450
Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient miceQ40956523
Severe liver degeneration in mice lacking the IkappaB kinase 2 geneQ40962152
Multiple hemopoietic defects and lymphoid hyperplasia in mice lacking the transcriptional activation domain of the c-Rel proteinQ41043956
Genetic approaches to study Rel/NF-kappa B/I kappa B function in miceQ41595434
Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinaseQ41644582
IkappaBalpha overexpression delays tumor formation in v-rel transgenic mice.Q41855462
p50-NF-kappaB complexes partially compensate for the absence of RelB: severely increased pathology in p50(-/-)relB(-/-) double-knockout miceQ41954424
Limb and skin abnormalities in mice lacking IKKalphaQ42470314
Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responsesQ42488424
Chronic inflammation and susceptibility to bacterial infections in mice lacking the polypeptide (p)105 precursor (NF-kappaB1) but expressing p50.Q42971521
I kappa B gamma, a 70 kd protein identical to the C-terminal half of p110 NF-kappa B: a new member of the I kappa B familyQ46153930
Role of Rel/NF-kappaB transcription factors during the outgrowth of the vertebrate limb.Q46700056
The regulation and roles of Rel/NF-kappa B transcription factors during lymphocyte activationQ47933661
Inhibition of NF-kappaB activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis.Q52188586
Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2.Q52192178
Mice lacking the transcription factor subunit Rel can clear an influenza infection and have functional anti-viral cytotoxic T cells but do not develop an optimal antibody responseQ57607842
Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expressionQ62817899
Failure of lymphopoiesis after adoptive transfer of NF-kappaB-deficient fetal liver cellsQ73479969
RelB is essential for the development of myeloid-related CD8alpha- dendritic cells but not of lymphoid-related CD8alpha+ dendritic cellsQ77769122
P433issue49
P407language of work or nameEnglishQ1860
P921main subjectNF-κBQ411114
P304page(s)6888-6895
P577publication date1999-11-01
P1433published inOncogeneQ1568657
P1476titleGenetic approaches in mice to understand Rel/NF-kappaB and IkappaB function: transgenics and knockouts
P478volume18

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cites work (P2860)
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