Integrating cell-signalling pathways with NF-kappaB and IKK function

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Integrating cell-signalling pathways with NF-kappaB and IKK function is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1041332849
P356DOI10.1038/NRM2083
P3181OpenCitations bibliographic resource ID846568
P698PubMed publication ID17183360
P5875ResearchGate publication ID6617757

P2093author name stringNeil D Perkins
P2860cites workA physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathwayQ21735927
Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105Q22008770
Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinaseQ24295084
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signallingQ24299573
Oncogenes, tumor suppressors and p52 NF-κBQ79204181
An NF-kappaB-specific inhibitor, IkappaBalpha, binds to and inhibits cyclin-dependent kinase 4Q79300288
NF-kappaB is required for UV-induced JNK activation via induction of PKCdeltaQ82579230
Chemical approaches to angiogenesisQ95805186
Stabilization of p53 is a novel mechanism for proapoptotic function of NF-kappaB.Q40563919
Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B.Q40571746
Identification of a ZU5 and death domain-containing inhibitor of NF-kappaB.Q40591236
Transfection of a dominant-negative mutant NF-kB inhibitor (IkBm) represses p53-dependent apoptosis in acute lymphoblastic leukemia cells: interaction of IkBm and p53Q40619108
Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-kappa.Q40626543
Casper/c-FLIP is physically and functionally associated with NF-kappaB1 p105.Q40633937
Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.Q40701074
IKK beta and phosphatidylinositol 3-kinase/Akt participate in non-pathogenic Gram-negative enteric bacteria-induced RelA phosphorylation and NF-kappa B activation in both primary and intestinal epithelial cell linesQ40715411
p53 stabilization is decreased upon NFkappaB activation: a role for NFkappaB in acquisition of resistance to chemotherapyQ40717571
Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesisQ41283113
Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoidsQ41283123
Achieving transcriptional specificity with NF-kappa B.Q41756452
Convergent actions of I kappa B kinase beta and protein kinase C delta modulate mRNA stability through phosphorylation of 14-3-3 beta complexed with tristetraprolinQ41890618
Molecular determinants of crosstalk between nuclear receptors and toll-like receptors.Q42135532
IKKalpha controls formation of the epidermis independently of NF-kappaB.Q42502421
Tumor necrosis factor alpha-mediated reduction of KLF2 is due to inhibition of MEF2 by NF-kappaB and histone deacetylasesQ42590508
The 20S proteasome processes NF-kappaB1 p105 into p50 in a translation-independent mannerQ42703666
Interleukin-1alpha inhibits insulin signaling with phosphorylating insulin receptor substrate-1 on serine residues in 3T3-L1 adipocytes.Q42810369
Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38.Q42830960
p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitmentQ43822750
Recruitment of CBP/p300 by the IFN beta enhanceosome is required for synergistic activation of transcriptionQ44445912
A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expressionQ44467329
Nuclear factor-(kappa)B modulates the p53 response in neurons exposed to DNA damage.Q44814700
Transient and selective NF-kappa B p65 serine 536 phosphorylation induced by T cell costimulation is mediated by I kappa B kinase beta and controls the kinetics of p65 nuclear importQ44885075
Cotranslational biogenesis of NF-kappaB p50 by the 26S proteasomeQ46501220
The kinases MSK1 and MSK2 are required for epidermal growth factor-induced, but not tumor necrosis factor-induced, histone H3 Ser10 phosphorylationQ46975926
Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation.Q52931988
Differential effects of NF-kappaB on apoptosis induced by DNA-damaging agents: the type of DNA damage determines the final outcome.Q53346181
The nuclear factor kappaB subunits RelA/p65 and c-Rel potentiate but are not required for Ras-induced cellular transformation.Q53364037
Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signalingQ56897808
Role of NF-κB in p53-mediated programmed cell deathQ57248006
p53- and Mdm2-Independent Repression of NF-κB Transactivation by the ARF Tumor SuppressorQ58287158
IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammationQ59054264
Update on glucocorticoid action and resistanceQ61712455
Reversal of intrinsic DNA bends in the IFN beta gene enhancer by transcription factors and the architectural protein HMG I(Y)Q70866496
Expression of the Bcl-3 proto-oncogene suppresses p53 activationQ24300022
MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14Q24303450
IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3aQ24336832
Recruitment of IkappaBalpha to the hes1 promoter is associated with transcriptional repressionQ24559651
The putative oncoprotein Bcl-3 induces cyclin D1 to stimulate G(1) transitionQ24746253
Modulation of p53 activity by IkappaBalpha: evidence suggesting a common phylogeny between NF-kappaB and p53 transcription factorsQ24811971
To be, or not to be: NF-kappaB is the answer--role of Rel/NF-kappaB in the regulation of apoptosisQ28190313
CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family membersQ28201693
Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaBQ28201706
The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitinationQ28201717
EnhanceosomesQ28204862
Regulation of beta-catenin function by the IkappaB kinasesQ28214709
Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatasesQ28239642
Nuclear receptors versus inflammation: mechanisms of transrepressionQ28260953
IkappaB kinase alpha regulates subcellular distribution and turnover of cyclin D1 by phosphorylationQ28267530
NF-kappaB is essential for induction of CYLD, the negative regulator of NF-kappaB: evidence for a novel inducible autoregulatory feedback pathwayQ28269436
IKK mediates ischemia-induced neuronal deathQ28281709
TLR signalingQ28291637
Signals from within: the DNA-damage-induced NF-kappaB responseQ28291658
Good cop, bad cop: the different faces of NF-kappaBQ28291669
NF-kappaB and IKK as therapeutic targets in cancerQ28297985
IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9Q28507728
The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppressionQ28585698
Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signalingQ28588278
A dual role for Ikk alpha in tooth developmentQ28592979
Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300Q28619230
Live or let die: the cell's response to p53Q29547663
Signaling to NF-kappaBQ29547844
Activators and target genes of Rel/NF-kappaB transcription factorsQ29547882
The two NF-kappaB activation pathways and their role in innate and adaptive immunityQ29614355
Shaping the nuclear action of NF-kappaBQ29614600
Ubiquitin signalling in the NF-kappaB pathwayQ29616322
Virus induction of human IFN beta gene expression requires the assembly of an enhanceosomeQ29616850
SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survivalQ30434865
IkappaB kinase alpha-mediated derepression of SMRT potentiates acetylation of RelA/p65 by p300.Q30439073
IkappaB kinase is an essential component of the Tpl2 signaling pathwayQ36732464
Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105.Q37574047
IkappaB kinase beta phosphorylates Dok1 serines in response to TNF, IL-1, or gamma radiationQ37713955
Inhibition of the RelA(p65) NF-kappaB subunit by Egr-1.Q38315535
Acetylation of Stat1 modulates NF-kappaB activityQ38315771
Achieving stability of lipopolysaccharide-induced NF-kappaB activationQ38320977
Activity of hypoxia-inducible factor 2alpha is regulated by association with the NF-kappaB essential modulatorQ38331952
Nuclear integration of glucocorticoid receptor and nuclear factor-kappaB signaling by CREB-binding protein and steroid receptor coactivator-1.Q38331993
beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancerQ38361640
Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunitQ38774316
Transcriptional cross talk between NF-kappaB and p53.Q39445554
Mechanism of rapid transcriptional induction of tumor necrosis factor alpha-responsive genes by NF-kappaB.Q39681517
Myosin motor Myo1c and its receptor NEMO/IKK-gamma promote TNF-alpha-induced serine307 phosphorylation of IRS-1.Q39729795
Genetic analysis of NF- B/Rel transcription factors defines functional specificitiesQ39962410
IKKalpha stabilizes cytosolic beta-catenin by inhibiting both canonical and non-canonical degradation pathwaysQ40292285
IKKbeta/2 induces TWEAK and apoptosis in mammary epithelial cellsQ40300890
Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuliQ40312088
Cisplatin mimics ARF tumor suppressor regulation of RelA (p65) nuclear factor-kappaB transactivationQ40327525
IKK alpha regulates estrogen-induced cell cycle progression by modulating E2F1 expressionQ40331218
Stimulus specificity of gene expression programs determined by temporal control of IKK activityQ40372675
Activated AKT regulates NF-kappaB activation, p53 inhibition and cell survival in HTLV-1-transformed cellsQ40399507
Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activationQ40439343
Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressorQ40445496
Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expressionQ33289443
The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression.Q33780734
Genetic approaches in mice to understand Rel/NF-kappaB and IkappaB function: transgenics and knockoutsQ33797150
Transcription factor NF-kappaB differentially regulates death receptor 5 expression involving histone deacetylase 1.Q33862991
Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12.Q33915125
IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapyQ34048503
Dorsal gradient networks in the Drosophila embryoQ34129901
IKKalpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf.Q34177562
p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1.Q34312166
cis-acting, element-specific transcriptional activity of differentially phosphorylated nuclear factor-kappa B.Q34363403
A hyper-dynamic equilibrium between promoter-bound and nucleoplasmic dimers controls NF-kappaB-dependent gene activityQ34410995
Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexesQ34411407
Molecular targets of dietary agents for prevention and therapy of cancerQ34505253
Nuclear role of I kappa B Kinase-gamma/NF-kappa B essential modulator (IKK gamma/NEMO) in NF-kappa B-dependent gene expressionQ34543054
Stat3 activation of NF-{kappa}B p100 processing involves CBP/p300-mediated acetylationQ34624443
Molecular diagnosis of lymphoid malignancies by gene expression profilingQ34664632
p14ARF activates a Tip60-dependent and p53-independent ATM/ATR/CHK pathway in response to genotoxic stressQ34717991
The IkappaB kinase complex and NF-kappaB act as master regulators of lipopolysaccharide-induced gene expression and control subordinate activation of AP-1.Q35126481
p53 represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone deacetylase 1.Q35150453
The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repressionQ35200339
The IKK NF-kappa B system: a treasure trove for drug developmentQ35621375
The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancerQ35687935
Nuclear factor-kappaB: its role in health and diseaseQ35791198
Distinct domains of IkappaB-alpha inhibit human immunodeficiency virus type 1 replication through NF-kappaB and Rev.Q35881335
Putting the rap on Akt.Q35917901
Inflammatory diseases: is ubiquitinated NEMO at the hub?Q35994296
A pervasive role of ubiquitin conjugation in activation and termination of IkappaB kinase pathwaysQ36089051
Interactions of NF-kappaB with chromatin: the art of being at the right place at the right timeQ36103478
CDK4 regulation by TNFR1 and JNK is required for NF-kappaB-mediated epidermal growth controlQ36321393
Reactive oxygen species mediate crosstalk between NF-kappaB and JNK.Q36337991
The NF-kappaB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and diseaseQ36386035
Dissection of the NF-kappaB signalling cascade in transgenic and knockout mice.Q36392829
Shaping alternative NF-kappaB-dependent gene expression programs: new clues to specificity.Q36399444
Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathwayQ36637883
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectNF-κBQ411114
P304page(s)49-62
P577publication date2007-01-01
P1433published inNature Reviews Molecular Cell BiologyQ1573120
P1476titleIntegrating cell-signalling pathways with NF-kappaB and IKK function
P478volume8

Reverse relations

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Q37825936Can muscle regeneration fail in chronic inflammation: a weakness in inflammatory myopathies?
Q36076963Can we predict the effects of NF-kappaB inhibition in sepsis? Studies with parthenolide and ethyl pyruvate
Q39011484Cancerous cell targeting and destruction using pH stabilized amperometric bioconjugated gold nanoparticles from marine macroalgae, Padina gymnospora
Q92422872Cannabidiol Regulates the Expression of Keratinocyte Proteins Involved in the Inflammation Process through Transcriptional Regulation
Q40211722Carbon dioxide-dependent regulation of NF-κB family members RelB and p100 gives molecular insight into CO2-dependent immune regulation.
Q41477958Carnosic acid prevents dextran sulfate sodium-induced acute colitis associated with the regulation of the Keap1/Nrf2 pathway
Q28118134Caspase-3 cleaved p65 fragment dampens NF-κB-mediated anti-apoptotic transcription by interfering with the p65/RPS3 interaction
Q36263521Catabolic cytokines disrupt the circadian clock and the expression of clock-controlled genes in cartilage via an NFкB-dependent pathway.
Q92770872Cathelicidin attenuates hyperoxia-induced intestinal injury through inhibition of NF-κB activity in newborn rats
Q27692076Caught in the cross fire: p53 in inflammation.
Q47360113Celastrol attenuates impairments associated with lipopolysaccharide-induced acute respiratory distress syndrome (ARDS) in rats
Q28487695Celastrol suppresses tumor cell growth through targeting an AR-ERG-NF-κB pathway in TMPRSS2/ERG fusion gene expressing prostate cancer
Q36791575Cell autonomous expression of inflammatory genes in biologically aged fibroblasts associated with elevated NF-kappaB activity
Q37471658Cell survival and apoptosis-related molecules in cancer cells in effusions: a comprehensive review
Q37536673Cellular stress response pathway system as a sentinel ensemble in toxicological screening
Q38075860Cellular-signaling pathways unveil the carcinogenic potential of chemicals
Q60918131Changes of the Fatty Acid Profile in Erythrocyte Membranes of Patients following 6-Month Dietary Intervention Aimed at the Regression of Nonalcoholic Fatty Liver Disease (NAFLD)
Q42095873Characterization of Virulence Factors of Staphylococcus aureus: Novel Function of Known Virulence Factors That Are Implicated in Activation of Airway Epithelial Proinflammatory Response
Q21134745Charting the NF-κB pathway interactome map
Q38401947Chemistry and Biology of Resveratrol-Derived Natural Products
Q37097045Chemopreventive potential of natural compounds in head and neck cancer
Q42590248Chronic NF-kappaB activation delays RasV12-induced premature senescence of human fibroblasts by suppressing the DNA damage checkpoint response.
Q46013208Chronic etanercept treatment prevents the development of hypertension in fructose-fed rats.
Q34079481Chronic inflammation and cancer: potential chemoprevention through nuclear factor kappa B and p53 mutual antagonism
Q28397740Cigarette smoke extract profoundly suppresses TNFα-mediated proinflammatory gene expression through upregulation of ATF3 in human coronary artery endothelial cells
Q37360552Cigarette smoke, inflammation, and lung injury: a mechanistic perspective
Q33784498Circadian disruption accelerates tumor growth and angio/stromagenesis through a Wnt signaling pathway
Q64075105Clinical and Immunological Phenotype of Patients With Primary Immunodeficiency Due to Damaging Mutations in
Q28391594Co-regulation of NF-kappaB and inflammasome-mediated inflammatory responses by myxoma virus pyrin domain-containing protein M013
Q34325386Cobalt chloride attenuates oxidative stress and inflammation through NF-κB inhibition in human renal proximal tubular epithelial cells
Q37417304Coexpression network based on natural variation in human gene expression reveals gene interactions and functions
Q45918170Combination treatment with ethyl pyruvate and aspirin enhances neuroprotection in the postischemic brain.
Q34109197Communicating oscillatory networks: frequency domain analysis.
Q33606893Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence
Q89884716Comparison of cytokine and gene activities in tissue and blood samples of patients with celiac disease
Q36803645Complement Factor B Production in Renal Tubular Cells and Its Role in Sodium Transporter Expression During Polymicrobial Sepsis
Q90364865Comprehensive Transcriptional Profiling of the Gastrointestinal Tract of Ruminants from Birth to Adulthood Reveals Strong Developmental Stage Specific Gene Expression
Q33517638Comprehensive analysis of inflammatory immune mediators in vitreoretinal diseases
Q33968131Conditional ablation of Ikkb inhibits melanoma tumor development in mice
Q38835068Conditional deletion of epithelial IKKβ impairs alveolar formation through apoptosis and decreased VEGF expression during early mouse lung morphogenesis
Q35694011Consequences of alteration in leucine zipper sequence of melittin in its neutralization of lipopolysaccharide-induced proinflammatory response in macrophage cells and interaction with lipopolysaccharide
Q64068068Construction and Analysis of Protein-Protein Interaction Network of Heroin Use Disorder
Q36961298Consumption of hydrolyzable tannins-rich pomegranate extract suppresses inflammation and joint damage in rheumatoid arthritis.
Q21285160Context-Dependent Regulation of Autophagy by IKK-NF-κB Signaling: Impact on the Aging Process
Q30443697Convergent findings for abnormalities of the NF-κB signaling pathway in schizophrenia
Q35961300Corneal Wound Healing Requires IKB kinase β Signaling in Keratocytes
Q50526646Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase.
Q28354065Coxiella burnetii Employs the Dot/Icm Type IV Secretion System to Modulate Host NF-κB/RelA Activation
Q36972324Creating a pro-survival and anti-inflammatory phenotype by modulation of acetylation in models of hemorrhagic and septic shock
Q60149868Critical role of FOXO3a in carcinogenesis
Q36621573Cross talk between cytokine and hyperthermia-induced pathways: identification of different subsets of NF-κB-dependent genes regulated by TNFα and heat shock.
Q39734014Cross talk between stimulated NF-kappaB and the tumor suppressor p53.
Q26777119Crossing the Vascular Wall: Common and Unique Mechanisms Exploited by Different Leukocyte Subsets during Extravasation
Q38084036Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process
Q39816600Crosstalk between the NF-kappaB activating IKK-complex and the CSN signalosome
Q29617418Crosstalk in NF-κB signaling pathways
Q35082703Cryptosporidium parvum induces SIRT1 expression in host epithelial cells through downregulating let-7i
Q40136654Ctenopharyngodon idella IKKβ interacts with PKR and IκBα.
Q54250937Curcumenol isolated from Curcuma zedoaria suppresses Akt-mediated NF-κB activation and p38 MAPK signaling pathway in LPS-stimulated BV-2 microglial cells.
Q39264604Curcumin inhibits prostate cancer metastasis in vivo by targeting the inflammatory cytokines CXCL1 and -2.
Q34163076Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma.
Q37012964Cutting edge: K63-linked polyubiquitination of NEMO modulates TLR signaling and inflammation in vivo
Q39458500Cytokine receptor signaling activates an IKK-dependent phosphorylation of PUMA to prevent cell death
Q37061012Cytoplasmic TRADD confers a worse prognosis in glioblastoma
Q38926413Cytoprotective pathways in the vascular endothelium. Do they represent a viable therapeutic target?
Q41680911Cytotoxic effects exerted by pentachlorophenol by targeting nodal pro-survival signaling pathways in human pancreatic cancer cells
Q48677731DAPT protects brain against cerebral ischemia by down-regulating the expression of Notch 1 and nuclear factor κB in rats.
Q34117601DEAD-box helicase DP103 defines metastatic potential of human breast cancers
Q37995692DNA damage-dependent NF-κB activation: NEMO turns nuclear signaling inside out.
Q24644085DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes
Q42426515Defective osteoclastogenesis by IKKbeta-null precursors is a result of receptor activator of NF-kappaB ligand (RANKL)-induced JNK-dependent apoptosis and impaired differentiation
Q33936499Defective regulation of CXCR2 facilitates neutrophil release from bone marrow causing spontaneous inflammation in severely NF-kappa B-deficient mice
Q104795158Deletion of IKK2 in haematopoietic cells of adult mice leads to elevated interleukin-6, neutrophilia and fatal gastrointestinal inflammation
Q50187886Deletion of IκB-Kinase β in Smooth Muscle Cells Induces Vascular Calcification Through β-Catenin-Runt-Related Transcription Factor 2 Signaling.
Q94547470Deubiquitinase Inhibitor b-AP15 Attenuated LPS-Induced Inflammation via Inhibiting ERK1/2, JNK, and NF-Kappa B
Q54976552Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation.
Q28075814Dietary Phytochemicals in Neuroimmunoaging: A New Therapeutic Possibility for Humans?
Q33616780Dietary Sources and Bioactivities of Melatonin
Q48024166Dietary selenium protects adiponectin knockout mice against chronic inflammation induced colon cancer
Q28075214Differential Protein Distribution between the Nucleus and Mitochondria: Implications in Aging
Q90643299Differential impact of classical and non-canonical NF-κB pathway-related gene expression on the survival of breast cancer patients
Q41965715Differential requirements for IKKalpha and IKKbeta in the differentiation of primary human osteoarthritic chondrocytes.
Q92066922Dimethyl Fumarate Targets MSK1, RSK1, 2 and IKKα/β Kinases and Regulates NF-κB /p65 Activation in Psoriasis: A Demonstration of the Effect on Peripheral Blood Mononuclear Cells, Drawn from Two Patients with Severe Psoriasis Before and After Treatmen
Q27343134Discovery of Novel Orally Active Tetrahydro-Naphthyl-N-Acylhydrazones with In Vivo Anti-TNF-α Effect and Remarkable Anti-Inflammatory Properties
Q38112122Dissecting Major Signaling Pathways throughout the Development of Prostate Cancer
Q28541751Disulfiram suppresses growth of the malignant pleural mesothelioma cells in part by inducing apoptosis
Q35875721Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action
Q37337951Double-edged swords as cancer therapeutics: simultaneously targeting p53 and NF-kappaB pathways.
Q47377421Downregulation of miR-199b promotes the acute spinal cord injury through IKKβ-NF-κB signaling pathway activating microglial cells
Q44093032Doxorubicin-induced activation of NF-κB in melanoma cells is abrogated by inhibition of IKKβ, but not by a novel IKKα inhibitor
Q33954474Dynamic chromatin localization of Sirt6 shapes stress- and aging-related transcriptional networks.
Q35219857Earliest innate immune responses require macrophage RelA during pneumococcal pneumonia
Q38986531Early Trypanosoma cruzi infection reprograms human epithelial cells.
Q97569198Early modulation of macrophage ROS-PPARγ-NF-κB signalling by sonodynamic therapy attenuates neointimal hyperplasia in rabbits
Q46256119Ecological disturbance influences adaptive divergence despite high gene flow in golden perch (Macquaria ambigua): implications for management and resilience to climate change
Q38099576Ectodysplasin/NF-κB signaling in embryonic mammary gland development
Q39254750Effect of Ni(II) on inflammatory gene expression in THP1 monocytic cells
Q46363812Effect of long-term maternal smoking on the offspring's lung health
Q37997735Effector functions of NLRs in the intestine: innate sensing, cell death, and disease
Q36584442Effects of (5Z)-7-oxozeaenol on MDA-MB-231 breast cancer cells.
Q36584470Effects of (5Z)-7-oxozeaenol on the oxidative pathway of cancer cells.
Q34151380Effects of 5,14-HEDGE, a 20-HETE mimetic, on lipopolysaccharide-induced changes in MyD88/TAK1/IKKβ/IκB-α/NF-κB pathway and circulating miR-150, miR-223, and miR-297 levels in a rat model of septic shock.
Q33787082Effects of Electroacupuncture on Facial Nerve Function and HSV-1 DNA Quantity in HSV-1 Induced Facial Nerve Palsy Mice
Q47138934Effects of HuR downregulation on anaplastic thyroid cancer cells
Q39413673Effects of Resveratrol and Other Polyphenols on Sirt1: Relevance to Brain Function During Aging
Q36953281Effects of a GSK-3β inhibitor on the renal expression levels of RANK, RANKL and NF-κB in a rat model of diabetic nephropathy
Q34247293Effects of ghrelin on protein expression of antioxidative enzymes and iNOS in the rat liver.
Q36930450Effects of low-dose aspirin and fish oil on platelet function and NF-kappaB in adults with diabetes mellitus
Q54396188Effects of protein-energy malnutrition on NF-kappaB signalling in murine peritoneal macrophages.
Q49738181Efficacy of thermosensitive chitosan/β-glycerophosphate hydrogel loaded with β-cyclodextrin-curcumin for the treatment of cutaneous wound infection in rats.
Q34551711Elements of transcriptional machinery are compatible among plants and mammals
Q33919428Elevated CO2 selectively inhibits interleukin-6 and tumor necrosis factor expression and decreases phagocytosis in the macrophage
Q33564601Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophages
Q33515424Elucidation of functional consequences of signalling pathway interactions.
Q51758259Emerging Players at the Intersection of Chondrocyte Loss of Maturational Arrest, Oxidative Stress, Senescence and Low-Grade Inflammation in Osteoarthritis.
Q24305225Emerging roles for the non-canonical IKKs in cancer
Q37384227Endothelial microRNAs and atherosclerosis
Q34177961Enteropathogenic and enterohaemorrhagic Escherichia coli: even more subversive elements
Q38103460Environmental factors and unhealthy lifestyle influence oxidative stress in humans--an overview
Q28485910Epidermal growth factor protects squamous cell carcinoma against cisplatin-induced cytotoxicity through increased interleukin-1β expression
Q90311523Epigenetic Regulation of Inflammatory Cytokine-Induced Epithelial-To-Mesenchymal Cell Transition and Cancer Stem Cell Generation
Q34082965Epigenetic coordination of embryonic heart transcription by dynamically regulated long noncoding RNAs
Q34202778Epithelial proinflammatory response and curcumin-mediated protection from staphylococcal toxic shock syndrome toxin-1
Q39903905Epithelial-to-mesenchymal transition of peritoneal mesothelial cells is regulated by an ERK/NF-kappaB/Snail1 pathway.
Q36363901Epstein-Barr virus BGLF4 kinase downregulates NF-κB transactivation through phosphorylation of coactivator UXT.
Q24648180Epstein-Barr virus-induced miR-155 attenuates NF-kappaB signaling and stabilizes latent virus persistence
Q24321689Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4)
Q64243483Essential Roles for the Non-Canonical IκB Kinases in Linking Inflammation to Cancer, Obesity, and Diabetes
Q39414094Euscaphic acid isolated from roots of Rosa rugosa inhibits LPS-induced inflammatory responses via TLR4-mediated NF-κB inactivation in RAW 264.7 macrophages
Q90638896Evidence for the Involvement of the Master Transcription Factor NF-κB in Cancer Initiation and Progression
Q27487552Ex vivo promoter analysis of antiviral heat shock cognate 70B gene in Anopheles gambiae
Q95306567Exemplifying complexity of immune suppression by a 'canonical' speech: A glimpse into TNFRSF-activated signaling pathways in Treg cells
Q33654192Exon-level transcriptome profiling in murine breast cancer reveals splicing changes specific to tumors with different metastatic abilities
Q43070544Expanding NFκB and SUMO ties
Q90496223Expression Of Intracellular Components of the NF-κB Alternative Pathway (NF-κB2, RelB, NIK and Bcl3) is Associated With Clinical Outcome of NSCLC Patients
Q28505064Expression and function of NIK- and IKK2-binding protein (NIBP) in mouse enteric nervous system
Q37225644Expression of TCTP antisense in CD25(high) regulatory T cells aggravates cuff-injured vascular inflammation
Q45975058Expressions of IL-6, TNF-α and NF-кB in the skin of Chinese brown frog (Rana dybowskii).
Q26738276Extracellular Release and Signaling by Heat Shock Protein 27: Role in Modifying Vascular Inflammation
Q36446515FOXP3 Controls an miR-146/NF-κB Negative Feedback Loop That Inhibits Apoptosis in Breast Cancer Cells
Q36204796FOXP3-miR-146-NF-κB Axis and Therapy for Precancerous Lesions in Prostate
Q37642866Fatty acids and immune function: relevance to inflammatory bowel diseases.
Q42232704Fatty acids increase hepatitis B virus X protein stabilization and HBx-induced inflammatory gene expression
Q34610542Fatty acids regulate CREBh via transcriptional mechanisms that are dependent on proteasome activity and insulin
Q34190365Fermentation by Lactobacillus enhances anti-inflammatory effect of Oyaksungisan on LPS-stimulated RAW 264.7 mouse macrophage cells
Q39312481Fermentation improves anti-inflammatory effect of sipjeondaebotang on LPS-stimulated RAW 264.7 cells
Q90602545Ferulic Acid Rescues LPS-Induced Neurotoxicity via Modulation of the TLR4 Receptor in the Mouse Hippocampus
Q39635235Fisetin, a dietary flavonoid, induces cell cycle arrest and apoptosis through activation of p53 and inhibition of NF-kappa B pathways in bladder cancer cells
Q34990519Fish oil has beneficial effects on allergen-induced airway inflammation and hyperreactivity in mice
Q39985969Focal adhesion kinase mediates the interferon-gamma-inducible GTPase-induced phosphatidylinositol 3-kinase/Akt survival pathway and further initiates a positive feedback loop of NF-kappaB activation
Q42183550Forkhead transcription factor FOXO3a protein activates nuclear factor κB through B-cell lymphoma/leukemia 10 (BCL10) protein and promotes tumor cell survival in serum deprivation
Q36920802From cell signaling to cancer therapy
Q39738771Functional interplay between acetylation and methylation of the RelA subunit of NF-kappaB.
Q37293340G protein-coupled receptor connectivity to NF-kappaB in inflammation and cancer
Q38350764Gene regulation of alpha4beta2 nicotinic receptors: microarray analysis of nicotine-induced receptor up-regulation and anti-inflammatory effects
Q33412610Gene set-based module discovery in the breast cancer transcriptome
Q30679678Genes-environment interactions in obesity- and diabetes-associated pancreatic cancer: a GWAS data analysis.
Q36995669Genetic Diagnosis Using Whole Exome Sequencing in Common Variable Immunodeficiency
Q36031774Genomic analysis of Ugandan and Rwandan chicken ecotypes using a 600 k genotyping array.
Q46032244Ginsenoside Rg1 attenuates concanavalin A-induced hepatitis in mice through inhibition of cytokine secretion and lymphocyte infiltration.
Q34190186Glucocorticoids suppress selected components of the senescence-associated secretory phenotype
Q34085544Glutaredoxin 1 regulates cigarette smoke-mediated lung inflammation through differential modulation of I{kappa}B kinases in mice: impact on histone acetylation
Q39179612Gold nanoparticles induce transcriptional activity of NF-κB in a B-lymphocyte cell line
Q56501517Gomisin N enhances TNF-α-induced apoptosis via inhibition of the NF-κB and EGFR survival pathways
Q36719282Gonadotropin-regulated testicular helicase (DDX25), an essential regulator of spermatogenesis, prevents testicular germ cell apoptosis.
Q64127716Grape seed proanthocyanidin extract alleviates arsenic-induced lung damage through NF-κB signaling
Q100632942HOPS/Tmub1 involvement in the NF-kB-mediated inflammatory response through the modulation of TRAF6
Q37228895HOXA1 binds RBCK1/HOIL-1 and TRAF2 and modulates the TNF/NF-κB pathway in a transcription-independent manner
Q33720245HSCARG downregulates NF-κB signaling by interacting with USP7 and inhibiting NEMO ubiquitination
Q36045102Haploinsufficiency of the NF-κB1 Subunit p50 in Common Variable Immunodeficiency.
Q35909254Health implications of high dietary omega-6 polyunsaturated Fatty acids.
Q40023974Helicobacter pylori-induced H,K-ATPase alpha-subunit gene repression is mediated by NF-kappaB p50 homodimer promoter binding
Q92295568Hepatitis C Virus Infection Induces Hepatic Expression of NF-κB-Inducing Kinase and Lipogenesis by Downregulating miR-122
Q36913366Hepatitis C virus infection activates an innate pathway involving IKK-α in lipogenesis and viral assembly
Q44519577Hesperidin alleviates oxidative stress and downregulates the expressions of proliferative and inflammatory markers in azoxymethane-induced experimental colon carcinogenesis in mice
Q34658850High natural gene expression variation in the reef-building coral Acropora millepora: potential for acclimative and adaptive plasticity
Q85042745High-mobility group box 1 exacerbates concanavalin A-induced hepatic injury in mice
Q33614697Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling
Q28570860Histone deacetylase-1 is enriched at the platelet-derived growth factor-D promoter in response to interleukin-1beta and forms a cytokine-inducible gene-silencing complex with NF-kappab p65 and interferon regulatory factor-1
Q34538026Hit identification of IKKβ natural product inhibitor
Q37285549Homeostatic regulation of blood neutrophil counts
Q38008211How Helicobacter pylori infection controls gastric acid secretion
Q36057809How do cytokines trigger genomic instability?
Q37948116How do pleiotropic kinase hubs mediate specific signaling by TNFR superfamily members?
Q38911746How host regulation of Helicobacter pylori-induced gastritis protects against peptic ulcer disease and gastric cancer.
Q35261245Human T Lymphotropic Virus Type 1 (HTLV-1): Molecular Biology and Oncogenesis
Q37711402Human airway smooth muscle cells from asthmatic individuals have CXCL8 hypersecretion due to increased NF-kappa B p65, C/EBP beta, and RNA polymerase II binding to the CXCL8 promoter
Q38312038Human coronavirus OC43 nucleocapsid protein binds microRNA 9 and potentiates NF-κB activation
Q34998223Human cytomegalovirus gene UL76 induces IL-8 expression through activation of the DNA damage response.
Q30619213Human rabies: neuropathogenesis, diagnosis, and management
Q55402006Huperzine A attenuates nonalcoholic fatty liver disease by regulating hepatocyte senescence and apoptosis: an in vitro study.
Q91924929Hyperbilirubinemia in Gunn Rats is Associated with Decreased Inflammatory Response in LPS-Mediated Systemic Inflammation
Q38396688Hypothalamic innate immune reaction in obesity
Q26752556Hypoxia Induced NF-κB
Q38978198Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster
Q24292870IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer
Q98945486IKBKB rs2272736 is Associated with Gastric Cancer Survival
Q41472551IKBKE regulates cell proliferation and epithelial-mesenchymal transition of human malignant glioma via the Hippo pathway
Q34148484IKK and NF-kappaB-mediated regulation of Claspin impacts on ATR checkpoint function
Q36990765IKK epsilon kinase is crucial for viral G protein-coupled receptor tumorigenesis
Q40035390IKK gamma (NEMO) is involved in the coordination of the AP-1 and NF-kappa B pathways
Q33776852IKK is a therapeutic target in KRAS-Induced lung cancer with disrupted p53 activity
Q37697852IKK-dependent activation of NF-κB contributes to myeloid and lymphoid leukemogenesis by BCR-ABL1.
Q36560442IKK-β mediates hydrogen peroxide induced cell death through p85 S6K1
Q37349789IKK/NF-kappaB signaling in intestinal epithelial cells controls immune homeostasis in the gut.
Q36775432IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver
Q47944116IKK2/NF-κB signaling protects neurons after traumatic brain injury
Q30436327IKKbeta mediates cell shape-induced aromatase expression and estrogen biosynthesis in adipose stromal cells
Q35888836IKKα contributes to UVB-induced VEGF expression by regulating AP-1 transactivation
Q92309583IKKβ Inhibitor IMD-0354 Attenuates Radiation Damage in Whole-body X-Irradiated Mice
Q59329152IKKβ activates p53 to promote cancer cell adaptation to glutamine deprivation
Q34562654IKKβ in myeloid cells controls the host response to lethal and sublethal Francisella tularensis LVS infection
Q33872159IKKβ regulates the repair of DNA double-strand breaks induced by ionizing radiation in MCF-7 breast cancer cells
Q39186578IKKε-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.
Q37466068IL-21 modulates release of proinflammatory cytokines in LPS-stimulated macrophages through distinct signaling pathways
Q35859525IPO3-mediated Nonclassical Nuclear Import of NF-κB Essential Modulator (NEMO) Drives DNA Damage-dependent NF-κB Activation
Q89286707Identification and expression of alternatively spliced novel isoforms of cancer associated MYD88 lacking death domain in mouse
Q24313202Identification and functional characterization of FMN2, a regulator of the cyclin-dependent kinase inhibitor p21
Q33306274Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation
Q96134610Identification of TUBB2A by quantitative proteomic analysis as a novel biomarker for the prediction of distant metastatic breast cancer
Q38923475Identification of a ligand-induced transient refractory period in nuclear factor-kappaB signaling.
Q36466792Identification of an N-terminal truncation of the NF-κB p65 subunit that specifically modulates ribosomal protein S3-dependent NF-κB gene expression.
Q34490064Identification of genes that elicit disuse muscle atrophy via the transcription factors p50 and Bcl-3.
Q92738411Identification of key miRNA‑mRNA pairs in septic mice by bioinformatics analysis
Q36890591Identification of novel pretranslational regulatory mechanisms for NF-κB activation.
Q34391237Identification of plumericin as a potent new inhibitor of the NF-κB pathway with anti-inflammatory activity in vitro and in vivo
Q38937811Identification of therapeutic target genes with DNA microarray in multiple myeloma cell line treated by IKKβ/NF-κB inhibitor
Q39098951Identifying post-translational modifications of NEMO by tandem mass spectrometry after high affinity purification
Q33749325IkappaB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappaB in the central nervous system
Q33294682IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway
Q38315020Immune mechanisms linked to depression via oxidative stress and neuroprogression
Q37373811Immune-Enhancing Effects of a High Molecular Weight Fraction of Cynanchum wilfordii Hemsley in Macrophages and Immunosuppressed Mice.
Q34666924Immunoglobulin light chains activate nuclear factor-κB in renal epithelial cells through a Src-dependent mechanism
Q33690029Impact of gene dosage on gene expression, biological processes and survival in cervical cancer: a genome-wide follow-up study
Q90730968Improvement of insulin signalling rescues inflammatory cardiac dysfunction
Q43064732In CD28-costimulated human naïve CD4+ T cells, I-κB kinase controls the expression of cell cycle regulatory proteins via interleukin-2-independent mechanisms.
Q37729946In Vitro and In Vivo Effects of Gracilaria verrucosa Extracts on Osteoclast Differentiation
Q39999981In vitro evaluation of antitumoral efficacy of catalase in combination with traditional chemotherapeutic drugs against human lung adenocarcinoma cells.
Q54563722Increased expression of stomatin-like protein 2 (STOML2) predicts decreased survival in gastric adenocarcinoma: a retrospective study.
Q30460471Increased expression of the homologue of enhancer-of-split 1 protects neurons from beta amyloid neurotoxicity and hints at an alternative role for transforming growth factor beta1 as a neuroprotector
Q37041562Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways
Q54439014Induction in gastric mucosal prostaglandin and nitric oxide by Helicobacter pylori is dependent on MAPK/ERK-mediated activation of IKK-β and cPLA2: modulatory effect of ghrelin.
Q24336239Induction of a pro-apoptotic ATM-NF-kappaB pathway and its repression by ATR in response to replication stress
Q43298098Induction of hepatic cyclooxygenase-2 by hyperhomocysteinemia via nuclear factor-kappaB activation
Q38284139Infection of polarized airway epithelial cells by normal and small-colony variant strains of Staphylococcus aureus is increased in cells with abnormal cystic fibrosis transmembrane conductance regulator function and is influenced by NF-κB.
Q35103171Inflammation and p53: A Tale of Two Stresses
Q42344455Inflammation in the spotlight-clinical relevance of genetic variants affecting nuclear factor κB and tumor necrosis factor receptor 1.
Q38790379Inflammatory Response in the CNS: Friend or Foe?
Q38222905Inflammatory mediators in mastitis and lactation insufficiency
Q35202147Inflammatory pathways in children with insufficient or disordered sleep
Q51376079Influence of the nuclear membrane, active transport, and cell shape on the Hes1 and p53-Mdm2 pathways: insights from spatio-temporal modelling.
Q41824496Inhibiting NF-κB in the developing lung disrupts angiogenesis and alveolarization
Q37379354Inhibition of IKKβ Reduces Ethanol Consumption in C57BL/6J Mice
Q38727093Inhibition of IKKβ by celastrol and its analogues - an in silico and in vitro approach
Q24312867Inhibition of IkappaB kinase by vaccinia virus virulence factor B14
Q33718757Inhibition of NF-κB transcriptional activation in HepG2 cells by diterpenoids from the soft coral Sinularia maxima
Q64074622Inhibition of PAK1 alleviates cerulein-induced acute pancreatitis via p38 and NF-κB pathways
Q39420735Inhibition of matrine against gastric cancer cell line MNK45 growth and its anti-tumor mechanism
Q82792234Inhibition of nuclear factor kappa B activation reduces Coxsackievirus B3 replication in lymphoid cells
Q34599727Inhibition of nuclear factor-κB activation in pancreatic β-cells has a protective effect on allogeneic pancreatic islet graft survival
Q35841795Inhibition of nuclear transcription factor-κB and activation of peroxisome proliferator-activated receptors in HepG2 cells by cucurbitane-type triterpene glycosides from Momordica charantia
Q28748917Inhibition of the nuclear factor-κB pathway prevents beta cell failure and diet induced diabetes in Psammomys obesus
Q34043446Inhibitor of NF-kappa B kinases alpha and beta are both essential for high mobility group box 1-mediated chemotaxis [corrected]
Q35804937Inhibitor of apoptosis proteins as intracellular signaling intermediates
Q37673277Inhibitor κB kinase 2 is a myosin light chain kinase in vascular smooth muscle
Q37727209Inhibitors of NF-kappaB reverse cellular invasion and target gene upregulation in an experimental model of aggressive oral squamous cell carcinoma
Q64121563Inhibitory Effects of Menadione on Growth and -Induced Inflammation via NF-κB Inhibition
Q39139791Inhibitory effects and molecular mechanisms of garlic organosulfur compounds on the production of inflammatory mediators
Q57807665Inhibitory-κB Kinase (IKK) α and Nuclear Factor-κB (NFκB)-Inducing Kinase (NIK) as Anti-Cancer Drug Targets
Q34979016Insulin-like growth factor-binding protein-3 (IGFBP-3) blocks the effects of asthma by negatively regulating NF-κB signaling through IGFBP-3R-mediated activation of caspases
Q30541124Interaction and antagonistic roles of NF-κB and Hes6 in the regulation of cortical neurogenesis
Q33698109Interaction of the TNFR-receptor associated factor TRAF1 with I-kappa B kinase-2 and TRAF2 indicates a regulatory function for NF-kappa B signaling
Q33811270Interactions among oscillatory pathways in NF-kappa B signaling
Q54403182Interferon regulatory factor 3 constrains IKKβ/NF-κB signaling to alleviate hepatic steatosis and insulin resistance.
Q36225776Interrogation of inhibitor of nuclear factor κB α/nuclear factor κB (IκBα/NF-κB) negative feedback loop dynamics: from single cells to live animals in vivo
Q35017127Intervention of transforming pulmonary fibrosis with NF-κB p65 antisense oligonucleotide
Q34100135Intracellular iron transport and storage: from molecular mechanisms to health implications
Q88554417Intrauterine growth restriction decreases NF-κB signaling in fetal pulmonary artery endothelial cells of fetal sheep
Q40562004Intravenous Glutamine Administration Modulates TNF-α/IL-10 Ratio and Attenuates NFkB Phosphorylation in a Protein Malnutrition Model
Q38287647Introduction of 2,6-Diaminopurines into Serinol Nucleic Acid Improves Anti-miRNA Performance.
Q38910228Involvement of mitogen-activated protein kinase and NF-κB signaling pathways in perfluorooctane sulfonic acid-induced inflammatory reaction in BV2 microglial cells
Q43756486Involvement of p38 MAPK-dependent activator protein (AP-1) activation in modulation of gastric mucosal inflammatory responses to Helicobacter pylori by ghrelin
Q28388335Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases
Q46445823Irradiation with UV-C inhibits TNF-α-dependent activation of the NF-κB pathway in a mechanism potentially mediated by reactive oxygen species
Q35558873Isotretinoin and FoxO1: A scientific hypothesis
Q42799107IκB kinase β (IKKβ) does not mediate feedback inhibition of the insulin signalling cascade.
Q36397332IκB kinase ε phosphorylates TRAF2 to promote mammary epithelial cell transformation
Q24302544IκB kinases increase Myc protein stability and enhance progression of breast cancer cells
Q46160734IκB-kinase-ε in the tumor microenvironment is essential for the progression of gastric cancer.
Q37596166IκBβ-mediated NF-κB activation confers protection against hyperoxic lung injury
Q37406535KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta
Q53317062KPNβ1 promotes palmitate-induced insulin resistance via NF-κB signaling in hepatocytes.
Q38097975Ketamine and peripheral inflammation.
Q39652400Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and casein kinase II inhibition as a potential treatment option.
Q39465501Knockdown of stomatin-like protein 2 (STOML2) reduces the invasive ability of glioma cells through inhibition of the NF-κB/MMP-9 pathway.
Q90330785Kobophenol A Isolated from Roots of Caragana sinica (Buc'hoz) Rehder Exhibits Anti-inflammatory Activity by Regulating NF-κB Nuclear Translocation in J774A.1 Cells
Q64107286L-Cysteine-Derived HS Promotes Microglia M2 Polarization via Activation of the AMPK Pathway in Hypoxia-Ischemic Neonatal Mice
Q35782878LBH-589 (panobinostat) potentiates fludarabine anti-leukemic activity through a JNK- and XIAP-dependent mechanism
Q37317234LGR5 expression is controled by IKKα in basal cell carcinoma through activating STAT3 signaling pathway
Q37414197LMP1-augmented kappa intron enhancer activity contributes to upregulation expression of Ig kappa light chain via NF-kappaB and AP-1 pathways in nasopharyngeal carcinoma cells
Q24318791LUBAC regulates NF-κB activation upon genotoxic stress by promoting linear ubiquitination of NEMO
Q28585382Lack of Cyp1b1 promotes the proliferative and migratory phenotype of perivascular supporting cells
Q40699389Leukemia-Associated Nup214 Fusion Proteins Disturb the XPO1-Mediated Nuclear-Cytoplasmic Transport Pathway and Thereby the NF-κB Signaling Pathway.
Q36849582Leukocyte Calpain Deficiency Reduces Angiotensin II-Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice
Q92260940Lgr5 in cancer biology: functional identification of Lgr5 in cancer progression and potential opportunities for novel therapy
Q37446868Lipid peroxidation and apoptotic response in rat brain areas induced by long-term administration of nandrolone: the mutual crosstalk between ROS and NF-kB
Q36097312Lipopolysaccharide from Salmonella enterica activates NF-kappaB through both classical and alternative pathways in primary B Lymphocytes
Q36210917Liposome encapsulated curcumin-difluorinated (CDF) inhibits the growth of cisplatin resistant head and neck cancer stem cells
Q83522390Long-chain fatty acids and inflammation
Q49335222Loperamide, an antidiarrheal agent, induces apoptosis and DNA damage in leukemia cells.
Q36858825Loss of IκB kinase β promotes myofibroblast transformation and senescence through activation of the ROS-TGFβ autocrine loop
Q41082340Loss of miR-514a-3p regulation of PEG3 activates the NF-kappa B pathway in human testicular germ cell tumors.
Q35743688Low-dose arsenic induces chemotherapy protection via p53/NF-κB-mediated metabolic regulation
Q92865160Luciferase Reporter Mice for In Vivo Monitoring and Ex Vivo Assessment of Hypothalamic Signaling of Socs3 Expression
Q35154856MALT1-ubiquitination triggers non-genomic NF-κB/IKK signaling upon platelet activation
Q64077351MET overexpression and activation favors invasiveness in a model of anaplastic thyroid cancer
Q53786044Malvidin attenuates pain and inflammation in rats with osteoarthritis by suppressing NF-κB signaling pathway.
Q36868559Many faces of NF-kappaB signaling induced by genotoxic stress
Q21146681Maternal undernutrition and cardiometabolic disease: a Latin American perspective
Q42803133Matrix Metalloproteinase-9 gene induction by a truncated oncogenic NF-kappaB2 protein involves the recruitment of MLL1 and MLL2 H3K4 histone methyltransferase complexes
Q39673666Maximal adamantyl-substituted retinoid-related molecule-induced apoptosis requires NF-κB noncanonical and canonical pathway activation
Q30426266Mechanical phenotype is important for stromal aromatase expression
Q90048237Mechanism of Anti-Cancer Activity of Curcumin on Androgen-Dependent and Androgen-Independent Prostate Cancer
Q28394732Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease
Q33916362Mechanisms of neuroblastoma cell growth inhibition by CARP-1 functional mimetics
Q28085043Mechanisms of neuroimmune gene induction in alcoholism
Q39029101Mechanisms of p53 Functional De-Regulation: Role of the IκB-α/p53 Complex
Q64089054Mechanistic Target of Rapamycin Complex 1 Signaling Modulates Vascular Endothelial Function Through Reactive Oxygen Species
Q92882183Mechanistic basis of neonatal heart regeneration revealed by transcriptome and histone modification profiling
Q39698795Mechanistic insights into the events that lead to synergistic induction of interleukin 6 transcription upon activation of the aryl hydrocarbon receptor and inflammatory signaling.
Q38219604Melatonin and ubiquitin: what's the connection?
Q42219273Metabolic adaptation and neuroprotection differ in the retina and choroid in a piglet model of acute postnatal hypoxia
Q50912773Metformin activation of AMPK suppresses AGE-induced inflammatory response in hNSCs.
Q34148357Metformin inhibits P-glycoprotein expression via the NF-κB pathway and CRE transcriptional activity through AMPK activation
Q51366721Metformin restores the correlation between serum-oxidized LDL and leptin levels in type 2 diabetic patients.
Q33929794Methyl salicylate lactoside inhibits inflammatory response of fibroblast-like synoviocytes and joint destruction in collagen-induced arthritis in mice
Q36633464MiR-1180 promotes apoptotic resistance to human hepatocellular carcinoma via activation of NF-κB signaling pathway
Q34221882MiR-143 acts as a tumor suppressor by targeting N-RAS and enhances temozolomide-induced apoptosis in glioma
Q33828286MicroRNA-146a promotes gastric cancer cell apoptosis by targeting transforming growth factor β-activated kinase 1
Q36005391MicroRNA-181b regulates NF-κB-mediated vascular inflammation
Q35640588MicroRNA-30e* promotes human glioma cell invasiveness in an orthotopic xenotransplantation model by disrupting the NF-κB/IκBα negative feedback loop
Q47986520MicroRNA-375 Is Induced in Cisplatin Nephrotoxicity to Repress Hepatocyte Nuclear Factor 1-β.
Q42121996MicroRNAs in Vascular Biology
Q64262231MicroRNA‑199a‑5p functions as a tumor suppressor in oral squamous cell carcinoma via targeting the IKKβ/NF‑κB signaling pathway
Q49196241Microenvironmental stromal cells abrogate NF-κB inhibitor-induced apoptosis in chronic lymphocytic leukemia.
Q37599639Mitochondria in neurodegenerative disorders: regulation of the redox state and death signaling leading to neuronal death and survival
Q90382152Mitogen-Activated Protein Kinases (MAPKs) and Cholangiocarcinoma: The Missing Link
Q39365749Modulating Both Tumor Cell Death and Innate Immunity Is Essential for Improving Radiation Therapy Effectiveness
Q34635234Modulation of acetylation: creating a pro-survival and anti-inflammatory phenotype in lethal hemorrhagic and septic shock
Q39153756Modulation of airway epithelial cell functions by Pidotimod: NF-kB cytoplasmatic expression and its nuclear translocation are associated with an increased TLR-2 expression
Q37968314Modulation of mammalian apoptotic pathways by intracellular protozoan parasites.
Q42560744Modulation of pineal melatonin synthesis by glutamate involves paracrine interactions between pinealocytes and astrocytes through NF-κB activation
Q89538271Molecular Mechanisms of Anticancer Activities of Puerarin
Q53309303Molecular bases of neuroserpin function and pathology.
Q26796229Molecular basis of hypohidrotic ectodermal dysplasia: an update
Q38125279Molecular biology of atherosclerosis
Q34440170Molecular cloning and characterization of an IKK homologue from amphioxus (Branchiostoma belcheri).
Q47225750Molecular docking of selected phytoconstituents with signaling molecules of Ultraviolet-B induced oxidative damage
Q36197335Molecular mechanisms of ursodeoxycholic acid toxicity & side effects: ursodeoxycholic acid freezes regeneration & induces hibernation mode.
Q47130932Molecular signaling mechanisms behind polyphenol-induced bone anabolism
Q41573009Mollugin Has an Anti-Cancer Therapeutic Effect by Inhibiting TNF-α-Induced NF-κB Activation
Q26830597Mucins and toll-like receptors: kith and kin in infection and cancer
Q35539750Multiple transcription factor families regulate axon growth and regeneration
Q33648473Muscle precursor cells isolated from aged rats exhibit an increased tumor necrosis factor- alpha response
Q92714639N,N'-diacetylcystine ameliorates inflammation in experimental non-alcoholic steatohepatitis by regulating nuclear transcription factor kappa B activation
Q88780395N-(2-hydroxyphenyl)acetamide and its gold nanoparticle conjugation prevent glycerol-induced acute kidney injury by attenuating inflammation and oxidative injury in mice
Q35190356NBD delivery improves the disease phenotype of the golden retriever model of Duchenne muscular dystrophy
Q35739680NEMO-binding domain peptide inhibits constitutive NF-κB activity and reduces tumor burden in a canine model of relapsed, refractory diffuse large B-cell lymphoma
Q52723706NF-kB2 Genetic Variations are Significantly Associated with Non-Small Cell Lung Cancer Risk and Overall Survival.
Q37690750NF-kappaB as a therapeutic target in chronic lymphocytic leukemia
Q34033879NF-kappaB balances vascular regression and angiogenesis via chromatin remodeling and NFAT displacement
Q39770370NF-kappaB inhibition through proteasome inhibition or IKKbeta blockade increases the susceptibility of melanoma cells to cytostatic treatment through distinct pathways
Q54546261NF-kappaB is a critical regulator of the survival of rodent and human hepatic myofibroblasts.
Q80078418NF-kappaB links oestrogen receptor signalling and EMT
Q37157187NF-kappaB serves as a cellular sensor of Kaposi's sarcoma-associated herpesvirus latency and negatively regulates K-Rta by antagonizing the RBP-Jkappa coactivator.
Q37075935NF-kappaB signaling in skeletal muscle: prospects for intervention in muscle diseases
Q47598860NF-kappaB signaling in the aging process
Q37701897NF-kappaB signaling: multiple angles to target OA.
Q38721544NF-κB Signaling Activation Induced by Chloroquine Requires Autophagosome, p62 Protein, and c-Jun N-terminal Kinase (JNK) Signaling and Promotes Tumor Cell Resistance.
Q52091959NF-κB Signalling in Glioblastoma.
Q39244926NF-κB activation by equine arteritis virus is MyD88 dependent and promotes viral replication.
Q39071650NF-κB activation coordinated by IKKβ and IKKε enables latent infection of Kaposi's sarcoma-associated herpesvirus
Q39066761NF-κB activation was involved in reactive oxygen species-mediated apoptosis and autophagy in 1-oxoeudesm-11(13)-eno-12,8α-lactone-treated human lung cancer cells
Q26777974NF-κB and HIF crosstalk in immune responses
Q35232248NF-κB and cancer: a paradigm of Yin-Yang.
Q38180760NF-κB and the cell cycle
Q37995696NF-κB and the link between inflammation and cancer
Q37981941NF-κB as a potential therapeutic target in microbial diseases
Q38172394NF-κB control of T cell development
Q38359190NF-κB in cancer therapy.
Q27007045NF-κB in cellular senescence and cancer treatment
Q38392308NF-κB induction of the SUMO protease SENP2: A negative feedback loop to attenuate cell survival response to genotoxic stress.
Q39189601NF-κB is a critical mediator of BRCA1-induced chemoresistance
Q39112160NF-κB non-cell-autonomously regulates cancer stem cell populations in the basal-like breast cancer subtype
Q33637267NF-κB p65 Subunit Mediates Lipopolysaccharide-Induced Na+/I−Symporter Gene Expression by Involving Functional Interaction with the Paired Domain Transcription Factor Pax8
Q58099029NF-κB p65 directs sex-specific neuroprotection in human neurons
Q90615352NF-κB p65 represses microRNA-124 transcription in diffuse large B-cell lymphoma
Q36795773NF-κB pathway in colitis-associated cancers
Q52351759NF-κB pathways in the development and progression of colorectal cancer.
Q34015940NF-κB regulates DNA double-strand break repair in conjunction with BRCA1-CtIP complexes
Q35763310NF-κB regulates MICA gene transcription in endothelial cell through a genetically inhibitable control site.
Q37449635NF-κB signaling and bone resorption
Q38227386NF-κB signaling at the crossroads of inflammation and atherogenesis: searching for new therapeutic links
Q39444289NF-κB signaling pathway is inhibited by heat shock independently of active transcription factor HSF1 and increased levels of inducible heat shock proteins
Q38025541NF-κB signaling pathways: role in nervous system physiology and pathology
Q24292906NF-κB signalling is attenuated by the E7 protein from cutaneous human papillomaviruses
Q42717979NF-κB subunits are differentially distributed in cells of lumbar dorsal root ganglia in naïve and diabetic rats
Q38478625NF-κB, a hot topic in biochemical and medical studies in China
Q55024984NF-κB-Mediated Inflammation in the Pathogenesis of Intracranial Aneurysm and Subarachnoid Hemorrhage. Does Autophagy Play a Role?
Q34877184NF-κB/Rel proteins and the humoral immune responses of Drosophila melanogaster
Q37995678NF-κB: where did it come from and why?
Q47094741NF-κβ: A Potential Target in the Management of Vascular Complications of Diabetes.
Q58758440NFKB1 and Cancer: Friend or Foe?
Q38668336NFKB1: a suppressor of inflammation, ageing and cancer
Q42411008NFX1 plays a role in human papillomavirus type 16 E6 activation of NFkappaB activity
Q37420178NFkB disrupts tissue polarity in 3D by preventing integration of microenvironmental signals
Q64099905NFkappaB is a Key Player in the Crosstalk between Inflammation and Cardiovascular Diseases
Q33748565NFkappaB promotes inflammation, coagulation, and fibrosis in the aging glomerulus
Q39105565NFκB regulates expression of Polo-like kinase 4.
Q37373888NFκB signaling regulates embryonic and adult neurogenesis
Q91387247NLRP3 inflammasome pathway is involved in olfactory bulb pathological alteration induced by MPTP
Q37665418NOD2 up-regulates TLR2-mediated IL-23p19 expression via NF-κB subunit c-Rel in Paneth cell-like cells
Q38965814NQO1 suppresses NF-κB-p300 interaction to regulate inflammatory mediators associated with prostate tumorigenesis.
Q64988211NSCLC and the alternative pathway of NF-κB: uncovering an unknown relation.
Q48540772Nanog maintains pluripotency of mouse embryonic stem cells by inhibiting NFkappaB and cooperating with Stat3.
Q42592139Nanoparticle-mediated drug delivery and pulmonary hypertension
Q38965226Natural Withanolides in the Treatment of Chronic Diseases
Q64110798Natural gypenosides: targeting cancer through different molecular pathways
Q34147534Negative regulation of NF-κB activity by brain-specific TRIpartite Motif protein 9.
Q38486593Neurological disease in human and canine leishmaniasis--clinical features and immunopathogenesis.
Q36156573Neuronal RING finger protein 11 (RNF11) regulates canonical NF-κB signaling
Q60921453Neuroprotection by Paeoniflorin against Nuclear Factor Kappa B-Induced Neuroinflammation on Spinal Cord Injury
Q58773068Neuroprotective Activity of Sitagliptin via Reduction of Neuroinflammation beyond the Incretin Effect: Focus on Alzheimer's Disease
Q48290344Neuroprotective effects of vildagliptin in rat rotenone Parkinson's disease model: role of RAGE-NFκB and Nrf2-antioxidant signaling pathways.
Q37258527Neuroserpin polymers activate NF-kappaB by a calcium signaling pathway that is independent of the unfolded protein response.
Q34197830Neutral antibodies to the TSH receptor are present in Graves' disease and regulate selective signaling cascades
Q36628651New acyclic bis phenylpropanoid and neolignans, from Myristica fragrans Houtt., exhibiting PARP-1 and NF-κB inhibitory effects
Q47097632New insights into NF-kappaB regulation and function
Q39603652New ligation-independent cloning vectors compatible with a high-throughput platform for parallel construct expression evaluation using baculovirus-infected insect cells
Q40018572Ni(II) alters the NFκB signaling pathway in monocytic cells
Q39127420Nickel ion inhibits nuclear factor-kappa B activity in human oral squamous cell carcinoma
Q54976950Nobiletin alleviates endometriosis via downregulating NF-κB activity in endometriosis mouse model.
Q35874918Non-apoptotic functions of apoptosis-regulatory proteins
Q50521157Non-apoptotic role of BID in inflammation and innate immunity.
Q38486433Non-hormonal targets underlying endometriosis: A focus on molecular mechanisms
Q37158058Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells.
Q39971503Notch-1 associates with IKKalpha and regulates IKK activity in cervical cancer cells.
Q34061821Novel mechanisms of sildenafil in pulmonary hypertension involving cytokines/chemokines, MAP kinases and Akt.
Q40105947Novel nonsense gain-of-function NFKB2 mutations associated with a combined immunodeficiency phenotype
Q36676121Nuclear Factor Kappa B Activation and Peroxisome Proliferator-activated Receptor Transactivational Effects of Chemical Components of the Roots of Polygonum multiflorum.
Q39662942Nuclear IKKβ Is an Adaptor Protein for IκBα Ubiquitination and Degradation in UV-Induced NF-κB Activation
Q35036364Nuclear export of the NF-κB inhibitor IκBα is required for proper B cell and secondary lymphoid tissue formation.
Q37082762Nuclear factor kappa B and hepatitis viruses
Q39612398Nuclear factor kappa B and tumor necrosis factor-alpha modulation of transcription of the mouse testis- and pre-implantation development-specific Rnf33/Trim60 gene
Q41887851Nuclear factor kappa B signaling either stimulates or inhibits neurite growth depending on the phosphorylation status of p65/RelA
Q37455687Nuclear factor kappaB, airway epithelium, and asthma: avenues for redox control
Q33744690Nuclear factor kappaB- and specificity protein 1-dependent p53-mediated bi-directional regulation of the human manganese superoxide dismutase gene
Q50695828Nuclear factor-kappa B is constitutively activated in peritoneal endometriosis.
Q38196790Nuclear factor-kappa-B signaling in lung development and disease: one pathway, numerous functions
Q33648301Nuclear factor-kappaB (NF-kappaB) is a novel positive transcriptional regulator of the oncogenic Wip1 phosphatase
Q36895504Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis
Q35838902Nuclear factor-κB (NF-κB) inhibitory protein IκBβ determines apoptotic cell death following exposure to oxidative stress
Q44162099Nuclear factor-κB activation in primary lymphoma of bone
Q35111621Nuclear factor-κB contributes to neuron-dependent induction of glutamate transporter-1 expression in astrocytes
Q38624686Nuclear factor-κB in glioblastoma: insights into regulators and targeted therapy
Q85484234Nuclear factor-κB in pancreatitis: Jack-of-all-trades, but which one is more important?
Q38030905Nuclear factor-κB signalling and transcriptional regulation in skeletal muscle atrophy
Q37904904Nuclear factor-κB: a key regulator in health and disease of lungs
Q35347865Nuclear initiated NF-κB signaling: NEMO and ATM take center stage
Q39270104Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response
Q36311268Nucleocytoplasmic transport blockage by SV40 peptide-modified gold nanoparticles induces cellular autophagy
Q80146628Off the beaten pathway: the complex cross talk between Notch and NF-kappaB
Q37728176Oligomannurarate sulfate blocks tumor growth by inhibiting NF-kappaB activation
Q39579099Oligomannurarate sulfate sensitizes cancer cells to doxorubicin by inhibiting atypical activation of NF-κB via targeting of Mre11.
Q97092461Omega-3 (n-3) polyunsaturated fatty acids and inflammation: From membrane to nucleus and from bench to bedside
Q35670928Omega-3 fatty acids and inflammatory processes
Q35730432Omega-3 fatty acids in critical illness
Q36620178Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?
Q35765830On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases: the central roles of LPS and LPS-induced cell death
Q36413217Opposed expression of IKKα: loss in keratinizing carcinomas and gain in non-keratinizing carcinomas
Q48832407Opposing roles of Nfkb2 gene products p100 and p52 in the regulation of breast cancer stem cells.
Q36995066Oregano Essential Oil Improves Intestinal Morphology and Expression of Tight Junction Proteins Associated with Modulation of Selected Intestinal Bacteria and Immune Status in a Pig Model
Q34742048Orf virus ORFV121 encodes a novel inhibitor of NF-kappaB that contributes to virus virulence
Q42097322Origin and pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma as revealed by global gene expression analysis
Q41472493Oroxylin A inhibits the generation of Tregs in non-small cell lung cancer
Q37626090Osteoclasts have multiple roles in bone in addition to bone resorption
Q34926779Osteopetrosis in TAK1-deficient mice owing to defective NF-κB and NOTCH signaling
Q64986259Overexpression of PIMREG promotes breast cancer aggressiveness via constitutive activation of NF-κB signaling.
Q38422325Overexpression of astrocyte elevated gene-1 (AEG-1) is associated with esophageal squamous cell carcinoma (ESCC) progression and pathogenesis.
Q38069883Oxidative stress and antioxidant defense
Q33926105Oxidative stress increases phosphorylation of IkappaB kinase-alpha by enhancing NF-kappaB-inducing kinase after transient focal cerebral ischemia
Q27490449Oxidized Hemoglobin Is an Endogenous Proinflammatory Agonist That Targets Vascular Endothelial Cells
Q41517623PACS-2 mediates the ATM and NF-κB-dependent induction of anti-apoptotic Bcl-xL in response to DNA damage
Q37198834PAFR activation of NF-κB p65 or p105 precursor dictates pro- and anti-inflammatory responses during TLR activation in murine macrophages
Q37361876PEITC induces G1 cell cycle arrest on HT-29 cells through the activation of p38 MAPK signaling pathway
Q64108981PKC regulates the production of fibroblast growth factor 23 (FGF23)
Q34011446PMC, a potent hydrophilic α-tocopherol derivative, inhibits NF-κB activation via PP2A but not IκBα-dependent signals in vascular smooth muscle cells.
Q91272135POTEE drives colorectal cancer development via regulating SPHK1/p65 signaling
Q36822439PPE38 of Mycobacterium marinum triggers the cross-talk of multiple pathways involved in the host response, as revealed by subcellular quantitative proteomics
Q43027152PPM1D gene amplification and overexpression in breast cancer: a qRT-PCR and chromogenic in situ hybridization study
Q37103890PRMT5 dimethylates R30 of the p65 subunit to activate NF-κB.
Q33857705PUMA is directly activated by NF-kappaB and contributes to TNF-alpha-induced apoptosis
Q36842418Paricalcitol inhibits renal inflammation by promoting vitamin D receptor-mediated sequestration of NF-kappaB signaling
Q101409821Parp3 promotes astrocytic differentiation through a tight regulation of Nox4-induced ROS and mTorc2 activation
Q33651139Pathogenesis of ovarian cancer: clues from selected overexpressed genes
Q37678929Pathogenic Bacterial Proteins and their Anti-Inflammatory Effects in the Eukaryotic Host
Q26777901Pathophysiology of osteoarthritis: canonical NF-κB/IKKβ-dependent and kinase-independent effects of IKKα in cartilage degradation and chondrocyte differentiation
Q35016939Peptide-based inhibition of NF-κB rescues diaphragm muscle contractile dysfunction in a murine model of Duchenne muscular dystrophy.
Q38124377Periodontal disease: modulation of the inflammatory cascade by dietary n-3 polyunsaturated fatty acids
Q58826193Phenolic Plant Extracts Induce Sirt1 Activity and Increase Antioxidant Levels in the Rabbit's Heart and Liver
Q34055456Phorbol ester-induced human cytomegalovirus major immediate-early (MIE) enhancer activation through PKC-delta, CREB, and NF-kappaB desilences MIE gene expression in quiescently infected human pluripotent NTera2 cells
Q33316851Phosphatidylinositol 3-kinase signaling in proliferating cells maintains an anti-apoptotic transcriptional program mediated by inhibition of FOXO and non-canonical activation of NFkappaB transcription factors
Q28116780Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation
Q34310237Phosphorylation of p65(RelA) on Ser(547) by ATM represses NF-κB-dependent transcription of specific genes after genotoxic stress
Q33456429Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation
Q39886675Phosphorylation on Thr-106 and NO-modification of glyoxalase I suppress the TNF-induced transcriptional activity of NF-kappaB.
Q39687493Piceatannol, a catechol-type polyphenol, inhibits phorbol ester-induced NF-{kappa}B activation and cyclooxygenase-2 expression in human breast epithelial cells: cysteine 179 of IKK{beta} as a potential target.
Q39289461Pistacia chinensis inhibits NO production and upregulates HO-1 induction via PI-3K/Akt pathway in LPS stimulated macrophage cells.
Q26766128Placental origins of adverse pregnancy outcomes: potential molecular targets: an Executive Workshop Summary of the Eunice Kennedy Shriver National Institute of Child Health and Human Development
Q42003365Plant polyphenols as inhibitors of NF-κB induced cytokine production-a potential anti-inflammatory treatment for Alzheimer's disease?
Q28548326Platelet Activation in Human Immunodeficiency Virus Type-1 Patients Is Not Altered with Cocaine Abuse
Q40206118Polydatin reduces Staphylococcus aureus lipoteichoic acid-induced injury by attenuating reactive oxygen species generation and TLR2-NFκB signalling
Q98778912Polygonatum sibiricum polysaccharides prevent LPS-induced acute lung injury by inhibiting inflammation via the TLR4/Myd88/NF-κB pathway
Q35112128Polymorphisms in NFKB1 and TLR4 and interaction with dietary and life style factors in relation to colorectal cancer in a Danish prospective case-cohort study
Q42206807Porcine reproductive and respiratory syndrome virus nonstructural protein 4 antagonizes beta interferon expression by targeting the NF-κB essential modulator
Q36102059Possible Anticancer Mechanisms of Some Costus speciosus Active Ingredients Concerning Drug Discovery.
Q42738476Possible role of NFkappaB in the embryonic vascular remodeling and the endothelial mesenchymal transition process
Q43793566Potential role of Hedgehog signaling and microRNA-29 in liver fibrosis of IKKβ-deficient mouse
Q41361567Prediction of anticancer property of bowsellic acid derivatives by quantitative structure activity relationship analysis and molecular docking study
Q52641505Presenting a New Standard Drug Model for Turmeric and Its Prized Extract, Curcumin.
Q51722230Prodrugs Bioactivated to Quinones Target NF-κB and Multiple Protein Networks: Identification of the Quinonome.
Q35085082Proepithelin stimulates growth plate chondrogenesis via nuclear factor-kappaB-p65-dependent mechanisms
Q54981868Prognostic significance of preoperative IKBKE expression in esophageal squamous cell carcinoma.
Q101038363Progress in the mechanism and targeted drug therapy for COPD
Q35097960Promise of resveratrol for easing status epilepticus and epilepsy
Q44408604Prophylactic treatment with Hypoxis hemerocallidea corm (African potato) methanolic extract ameliorates Brachyspira hyodysenteriae-induced murine typhlocolitis.
Q37357720Proteasome regulation of ULBP1 transcription
Q53539447Protective effect of proteins derived from Calotropis procera latex against acute inflammation in rat.
Q39787675Protective effect of resveratrol on acute lung injury induced by lipopolysaccharide in mice
Q35763347Protective role of oleic acid against cardiovascular insulin resistance and in the early and late cellular atherosclerotic process
Q47101584Protective role of tenuigenin on sepsis-induced acute kidney injury in mice
Q34514350Protective role of the cholinergic anti-inflammatory pathway in a mouse model of viral myocarditis
Q37147836Protein kinase CK2, an important regulator of the inflammatory response?
Q38416078Protein-protein interaction analysis of distinct molecular pathways in two subtypes of colorectal carcinoma
Q34975036Pulsatile stimulation determines timing and specificity of NF-kappaB-dependent transcription
Q48096114Quantitative Assessment of the Effects of Trypsin Digestion Methods on Affinity Purification-Mass Spectrometry-based Protein-Protein Interaction Analysis
Q55080415Quantitative analysis reveals crosstalk mechanisms of heat shock-induced attenuation of NF-κB signaling at the single cell level.
Q40058893R-Roscovitine simultaneously targets both the p53 and NF-kappaB pathways and causes potentiation of apoptosis: implications in cancer therapy.
Q39123617RAGE-TLR Crosstalk Sustains Chronic Inflammation in Neurodegeneration
Q91105578RBBP6, a RING finger-domain E3 ubiquitin ligase, induces epithelial-mesenchymal transition and promotes metastasis of colorectal cancer
Q52673265RGC32 Promotes Bleomycin-Induced Systemic Sclerosis in a Murine Disease Model by Modulating Classically Activated Macrophage Function.
Q26859628Raf kinase inhibitory protein (RKIP): functional pleiotropy in the mammalian brain
Q35890327Rapamycin Inhibits Oxidized Low Density Lipoprotein Uptake in Human Umbilical Vein Endothelial Cells via mTOR/NF-κB/LOX-1 Pathway
Q37032282Redox control of inflammation in macrophages
Q41852311Redox homeostasis: The Golden Mean of healthy living
Q99565745Redox signaling and Alzheimer's disease: from pathomechanism insights to biomarker discovery and therapy strategy
Q51347935Reduced risk of apoptosis: mechanisms of stress responses.
Q37165144Regulation by reversible S-glutathionylation: molecular targets implicated in inflammatory diseases
Q36184999Regulation of CLU gene expression by oncogenes and epigenetic factors implications for tumorigenesis.
Q36647410Regulation of GTP-binding protein (Gαs) expression in human myometrial cells: a role for tumor necrosis factor in modulating Gαs promoter acetylation by transcriptional complexes.
Q38613277Regulation of Innate Immune Responses by Bovine Herpesvirus 1 and Infected Cell Protein 0 (bICP0).
Q39627012Regulation of IκB kinase by GβL through recruitment of the protein phosphatases
Q35094641Regulation of Mcl-1 by constitutive activation of NF-κB contributes to cell viability in human esophageal squamous cell carcinoma cells
Q38642386Regulation of Survival Motor Neuron Protein by the Nuclear Factor-Kappa B Pathway in Mouse Spinal Cord Motoneurons.
Q39623770Regulation of activity and function of the p52 NF-κB subunit following DNA damage
Q35080815Regulation of c-Fos gene expression by NF-κB: a p65 homodimer binding site in mouse embryonic fibroblasts but not human HEK293 cells
Q36426283Regulation of caveolin-1 expression, nitric oxide production and tissue injury by tumor necrosis factor-alpha following ozone inhalation
Q37995693Regulation of cell death and autophagy by IKK and NF-κB: critical mechanisms in immune function and cancer
Q37666992Regulation of high-density lipoprotein by inflammatory cytokines: establishing links between immune dysfunction and cardiovascular disease
Q37860703Regulation of neural process growth, elaboration and structural plasticity by NF-κB.
Q36702425Regulation of neurite growth by tumour necrosis superfamily member RANKL.
Q34364436Regulation of nuclear factor κB (NF-κB) transcriptional activity via p65 acetylation by the chaperonin containing TCP1 (CCT)
Q41726404Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence.
Q90289973Regulation of the Larval Transcriptome of Diatraea saccharalis (Lepidoptera: Crambidae) by Maternal and Other Factors of the Parasitoid Cotesia flavipes (Hymenoptera: Braconidae)
Q35971560Regulation of ubiquitination-mediated protein degradation by survival kinases in cancer
Q88780401Regulatory roles of miR-155 and let-7b on the expression of inflammation-related genes in THP-1 cells: effects of fatty acids
Q36638965RelA/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice
Q39317401RelB inhibits cell proliferation and tumor growth through p53 transcriptional activation.
Q47408910Resveratrol-based cinnamic ester hybrids: synthesis, characterization, and anti-inflammatory activity
Q58106758Retracted: The role of NF-κB and miRNA in oral cancer and cancer stem cells with or without HPV16 infection
Q58608081Reversal of proliferation deficits caused by chromosome 16p13.11 microduplication through targeting NFκB signaling: an integrated study of patient-derived neuronal precursor cells, cerebral organoids and in vivo brain imaging
Q33802112Rho protein GTPases and their interactions with NFκB: crossroads of inflammation and matrix biology
Q39314241Role of LPS-elicited signaling in triggering gastric mucosal inflammatory responses to H. pylori: modulatory effect of ghrelin
Q92421585Role of MYC-miR-29-B7-H3 in Medulloblastoma Growth and Angiogenesis
Q37679979Role of Notch signaling pathway in pancreatic cancer
Q89589416Role of Nuclear factor kappa B (NF-κB) Signalling in Neurodegenerative Diseases: An Mechanistic Approach
Q80814292Role of PKCs and NF-kappaB activation in myocardial inflammation: enemy or ally?
Q39767528Role of PPAR-delta in the development of zymosan-induced multiple organ failure: an experiment mice study
Q40638253Role of WW Domain-containing Oxidoreductase WWOX in Driving T Cell Acute Lymphoblastic Leukemia Maturation.
Q90168827Role of heat shock protein 22 in the protective effect of geranylgeranylacetone in response to oxidized-LDL
Q35216722Role of inhibitory κB kinase and c-Jun NH2-terminal kinase in the development of hepatic insulin resistance in critical illness diabetes
Q37720780Role of nuclear factor kappaB in liver health and disease.
Q58775945Role of nuclear factor κB in multiple sclerosis and experimental autoimmune encephalomyelitis
Q35948515Role of reactive oxygen and nitrogen species in the vascular responses to inflammation
Q37987916Role of transcription factors in peripheral nerve regeneration
Q52722878Roles of NF-κB Signaling in the Regulation of miRNAs Impacting on Inflammation in Cancer.
Q26752576Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches
Q26864035Roles of NOD1 (NLRC1) and NOD2 (NLRC2) in innate immunity and inflammatory diseases
Q35210912Roles of the kinase TAK1 in CD40-mediated effects on vascular oxidative stress and neointima formation after vascular injury
Q34413441Roles of tumor suppressors in regulating tumor-associated inflammation
Q53671825Rosmarinic Acid Attenuates Sodium Taurocholate-Induced Acute Pancreatitis in Rats by Inhibiting Nuclear Factor-κB Activation.
Q92525850Rubicon: a facilitator of viral immune evasion
Q34659163Rutin mediated targeting of signaling machinery in cancer cells.
Q47163960SYK inhibition thwarts the BAFF - B-cell receptor crosstalk and thereby antagonizes Mcl-1 in chronic lymphocytic leukemia
Q37720482Salidroside attenuates concanavalin A-induced hepatitis via modulating cytokines secretion and lymphocyte migration in mice
Q37123861Sam68/KHDRBS1 is critical for colon tumorigenesis by regulating genotoxic stress-induced NF-κB activation
Q49639892Schisandrol B and schisandrin B inhibit TGFβ1-mediated NF-κB activation via a Smad-independent mechanism.
Q34351592Schlafen 1 inhibits the proliferation and tube formation of endothelial progenitor cells
Q35140311Secretion of Antonospora (Paranosema) locustae proteins into infected cells suggests an active role of microsporidia in the control of host programs and metabolic processes
Q92966880Secretory leukocyte protease inhibitor suppresses HPV E6-expressing HNSCC progression by mediating NF-κB and Akt pathways
Q37046163Secretory versus degradative autophagy: unconventional secretion of inflammatory mediators
Q39029981Selective killing of lung cancer cells by miRNA-506 molecule through inhibiting NF-κB p65 to evoke reactive oxygen species generation and p53 activation
Q47986824Selenium Deficiency Augments the Levels of Inflammatory Factors and Heat Shock Proteins via the Redox Regulatory Pathway in the Skeletal Muscles of Mice
Q34227763Sensitization of ovarian cancer cells to cisplatin by gold nanoparticles
Q36204370Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase
Q36263746Sequencing thousands of single-cell genomes with combinatorial indexing.
Q40006395Sequestration of NF-kappaB signaling complexes in lipid rafts contributes to repression of NF-kappaB in T lymphocytes under hyperthermia stress
Q36759142Severe Hepatitis Promotes Hepatocellular Carcinoma Recurrence via NF-κB Pathway-Mediated Epithelial-Mesenchymal Transition after Resection
Q33870446Shikonin reduces oedema induced by phorbol ester by interfering with IkappaBalpha degradation thus inhibiting translocation of NF-kappaB to the nucleus
Q40087723Signal responsiveness of IkappaB kinases is determined by Cdc37-assisted transient interaction with Hsp90.
Q35452032Signaling by the tumor necrosis factor receptor superfamily in B-cell biology and disease
Q27027778Signaling cross-talk in the resistance to HER family receptor targeted therapy
Q37338836Simulated microgravity activates apoptosis and NF-kappaB in mice testis.
Q49887095Simultaneous targeting therapy for lung metastasis and breast tumor by blocking the NF-κB signaling pathway using Celastrol-loaded micelles.
Q59381633Sjögren's syndrome autoantibodies provoke changes in gene expression profiles of inflammatory cytokines triggering a pathway involving TACE/NF-κB
Q37293352Skeletal muscle diseases, inflammation, and NF-kappaB signaling: insights and opportunities for therapeutic intervention
Q36600976Small molecule therapeutics targeting F-box proteins in cancer
Q28302027Small-molecule inhibitors of IκB kinase (IKK) and IKK-related kinases
Q42388545Specific antibody deficiency and autoinflammatory disease extend the clinical and immunological spectrum of heterozygous NFKB1 loss-of-function mutations in humans
Q36820542Specific siRNA targeting receptor for advanced glycation end products (RAGE) decreases proliferation in human breast cancer cell lines
Q36973848Stepwise phosphorylation of p65 promotes NF-κB activation and NK cell responses during target cell recognition
Q41954511Stimulatory effects of insulin-like growth factor-I on growth plate chondrogenesis are mediated by nuclear factor-kappaB p65
Q55073640Stomatin-like protein 2 inhibits cisplatin-induced apoptosis through MEK/ERK signaling and the mitochondrial apoptosis pathway in cervical cancer cells.
Q98881813Structural and functional impacts of E5 genetic variants of human papillomavirus type 31
Q34553972Structural characterization of interactions between transactivation domain 1 of the p65 subunit of NF-κB and transcription regulatory factors
Q30252373Subcellular Energetics and Metabolism: A Cross-Species Framework
Q54115289Subunit-Specific Role of NF-κB in Cancer.
Q37210848Suppression of IL-12 production by tristetraprolin through blocking NF-kcyB nuclear translocation
Q24337474Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation
Q92456673Suppression of miR-143 contributes to overexpression of IL-6, HIF-1α and NF-κB p65 in Cr(VI)-induced human exposure and tumor growth
Q37002380Survival of monocytes and macrophages and their role in health and disease
Q35414780Survivin and IAP proteins in cell-death mechanisms
Q42050158Sustained NF-kappaB activation produces a short-term cell proliferation block in conjunction with repressing effectors of cell cycle progression controlled by E2F or FoxM1.
Q33764746Sustained hyperoxia-induced NF-κB activation improves survival and preserves lung development in neonatal mice
Q30557279Sustained, neuron-specific IKK/NF-κB activation generates a selective neuroinflammatory response promoting local neurodegeneration with aging
Q54976910Synergistic Inhibition of ERK1/2 and JNK, Not p38, Phosphorylation Ameliorates Neuronal Damages After Traumatic Brain Injury.
Q36738818Synergistic cytotoxic effects of bortezomib and CK2 inhibitor CX-4945 in acute lymphoblastic leukemia: turning off the prosurvival ER chaperone BIP/Grp78 and turning on the pro-apoptotic NF-κB.
Q38932350Synergistic effect of interleukin-6 and hyaluronic acid on cell migration and ERK activation in human keratinocytes.
Q57771767Synthesis and Biological Evaluation of 2-Phenylimino-5((5-phenylfuran-2-yl)methylene)thiazolidin-4-ones as IKK2 Inhibitors
Q33732848Systemic delivery of microRNA-181b inhibits nuclear factor-κB activation, vascular inflammation, and atherosclerosis in apolipoprotein E-deficient mice
Q27349064Systemic inhibition of NF-kappaB activation protects from silicosis
Q35875216Systems genetics of the nuclear factor-κB signal transduction network. I. Detection of several quantitative trait loci potentially relevant to aging
Q30439229TAB4 stimulates TAK1-TAB1 phosphorylation and binds polyubiquitin to direct signaling to NF-kappaB
Q29030353TBK-1 Promotes Autophagy-Mediated Antimicrobial Defense by Controlling Autophagosome Maturation
Q37407944TBK1 mediates critical effects of measles virus nucleocapsid protein (MVNP) on pagetic osteoclast formation.
Q36406110TIGERi: modeling and visualizing the responses to perturbation of a transcription factor network
Q39139325TLR-6 SNP P249S is associated with healthy aging in nonsmoking Eastern European Caucasians - A cohort study.
Q37113924TLR2 expression in astrocytes is induced by TNF-alpha- and NF-kappa B-dependent pathways
Q46023340TNF induces caspase-dependent inflammation in renal endothelial cells through a Rho- and myosin light chain kinase-dependent mechanism.
Q33683329TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression: implications in duchenne muscular dystrophy
Q30276641TNF-insulin crosstalk at the transcription factor GATA6 is revealed by a model that links signaling and transcriptomic data tensors
Q38689020TNF-α and sTNF-RII Are Associated with Pain Following Hip Fracture Surgery in Older Adults.
Q45758807TNFα induces expression of HIF-1α mRNA and protein but inhibits hypoxic stimulation of HIF-1 transcriptional activity in airway smooth muscle cells
Q34471711TRAF family member-associated NF-κB activator (TANK) induced by RANKL negatively regulates osteoclasts survival and function
Q38171480TWEAK/Fn14 and Non-Canonical NF-kappaB Signaling in Kidney Disease
Q42183310Taming endothelial activation with a microRNA
Q57167736Targeting IKKβ in Cancer: Challenges and Opportunities for the Therapeutic Utilisation of IKKβ Inhibitors
Q35070866Targeting inflammation to prevent bronchopulmonary dysplasia: can new insights be translated into therapies?
Q38028572Targeting kinases for the treatment of inflammatory diseases
Q37036159Targeting lymphocyte activation through the lymphotoxin and LIGHT pathways
Q38686477Targeting the Receptor for Advanced Glycation Endproducts (RAGE): A Medicinal Chemistry Perspective.
Q30353061Tax-1 and Tax-2 similarities and differences: focus on post-translational modifications and NF-κB activation.
Q39243328Telomerase directly regulates NF-κB-dependent transcription.
Q89440879Testosterone, myocardial function, and mortality
Q64971244Tetrabromobisphenol A Induces MMP-9 Expression via NADPH Oxidase and the activation of ROS, MAPK, and Akt Pathways in Human Breast Cancer MCF-7 Cells.
Q36509188TfR1 interacts with the IKK complex and is involved in IKK-NF-κB signalling
Q64946467The Biology of the Nuclear Envelope and Its Implications in Cancer Biology.
Q59360846The Crosstalk of Endoplasmic Reticulum (ER) Stress Pathways with NF-κB: Complex Mechanisms Relevant for Cancer, Inflammation and Infection
Q35635008The DNA damage response induces IFN.
Q57489043The Effect of Caffeic Acid on Spermatogonial Stem Cell-type A Cryopreservation
Q21093224The HTLV-1 Tax interactome
Q24329117The IKK complex contributes to the induction of autophagy
Q30505780The IKKα-dependent NF-κB p52/RelB noncanonical pathway is essential to sustain a CXCL12 autocrine loop in cells migrating in response to HMGB1.
Q38741062The IKKα-dependent non-canonical pathway of NF-κB activation is constitutively active and modulates progression-related functions in a subset of human melanomas
Q37072407The IkappaB kinases IKKalpha and IKKbeta are necessary and sufficient for skeletal muscle atrophy
Q58617709The Immunomodulatory and Anti-Inflammatory Role of Polyphenols
Q40252087The Inhibitory Effect of Nodakenin on Mast-Cell-Mediated Allergic Inflammation Via Downregulation of NF-κB and Caspase-1 Activation.
Q34066731The IκB kinase complex is required for plexin-B-mediated activation of RhoA
Q41662036The Marine Natural Product Pseudopterosin Blocks Cytokine Release of Triple-Negative Breast Cancer and Monocytic Leukemia Cells by Inhibiting NF-κB Signaling
Q90183180The N-Acetyl Phenylalanine Glucosamine Derivative Attenuates the Inflammatory/Catabolic Environment in a Chondrocyte-Synoviocyte Co-Culture System
Q37672294The NF-kappaB family of transcription factors and its regulation
Q41900872The NF-kappaB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes
Q39502331The NF-κB pathway mediates lysophosphatidic acid (LPA)-induced VEGF signaling and cell invasion in epithelial ovarian cancer (EOC).
Q36858771The NF-κB subunit c-Rel regulates Bach2 tumour suppressor expression in B-cell lymphoma
Q36326841The NF-κB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cells.
Q37306272The NFKB1 ATTG ins/del polymorphism and risk of coronary heart disease in three independent populations
Q37649732The Nedd8-activating enzyme inhibitor MLN4924 thwarts microenvironment-driven NF-κB activation and induces apoptosis in chronic lymphocytic leukemia B cells
Q36980637The ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-κB Signaling via TRADD and RIP1.
Q38818320The PP4R1 sub-unit of protein phosphatase PP4 is essential for inhibition of NF-κB by merkel polyomavirus small tumour antigen
Q92070068The Potassium SK Channel Activator NS309 Protects Against Experimental Traumatic Brain Injury Through Anti-Inflammatory and Immunomodulatory Mechanisms
Q36246420The RCAN1 inhibits NF-κB and suppresses lymphoma growth in mice
Q36093060The Role of the Phylogenetically Conserved Cochaperone Protein Droj2/DNAJA3 in NF-κB Signaling
Q27013358The TLR and IL-1 signalling network at a glance
Q37135363The TWEAK-Fn14 cytokine-receptor axis: discovery, biology and therapeutic targeting
Q39803714The Y-box factor ZONAB/DbpA associates with GEF-H1/Lfc and mediates Rho-stimulated transcription
Q91833312The anti-photoaging and moisturizing effects of Bouea macrophylla extract in UVB-irradiated hairless mice
Q40092549The apoptosis-inducing effect of gastrin on colorectal cancer cells relates to an increased IEX-1 expression mediating NF-kappa B inhibition
Q39897508The aryl hydrocarbon nuclear translocator alters CD30-mediated NF-kappaB-dependent transcription
Q41900857The biological functions of NF-kappaB1 (p50) and its potential as an anti-cancer target
Q36989123The c-Rel subunit of NF-κB regulates epidermal homeostasis and promotes skin fibrosis in mice.
Q42465515The c-Rel subunit of nuclear factor-kappaB regulates murine liver inflammation, wound-healing, and hepatocyte proliferation
Q36205234The canonical NF-κB pathway differentially protects normal and human tumor cells from ROS-induced DNA damage
Q50521934The canonical nuclear factor-κB pathway regulates cell survival in a developmental model of spinal cord motoneurons.
Q35298106The complex interplay between autophagy and NF-κB signaling pathways in cancer cells
Q38126565The complexity of NF-κB signaling in inflammation and cancer
Q42183099The critical role of TAK1 in accentuated epithelial to mesenchymal transition in obliterative bronchiolitis after lung transplantation
Q37115437The dark side of a tumor suppressor: anti-apoptotic p53.
Q36835317The death domain-containing kinase RIP1 regulates p27(Kip1) levels through the PI3K-Akt-forkhead pathway
Q40330257The dengue virus nonstructural protein 1 (NS1) increases NF-κB transcriptional activity in HepG2 cells
Q37976939The diverse and complex roles of NF-κB subunits in cancer
Q28253741The emerging roles of forkhead box (Fox) proteins in cancer
Q50469530The fruits of wampee inhibit H2O2-induced apoptosis in PC12 cells via the NF-κB pathway and regulation of cellular redox status.
Q41991904The hormone-bound vitamin D receptor enhances the FBW7-dependent turnover of NF-κB subunits.
Q34594875The human cytomegalovirus UL26 protein antagonizes NF-κB activation
Q41055909The human papillomavirus (HPV) E7 protein antagonises an Imiquimod-induced inflammatory pathway in primary human keratinocytes
Q36236780The immunogenetics of Psoriasis: A comprehensive review
Q24337903The intermediate filament protein, vimentin, is a regulator of NOD2 activity
Q33855085The limited contribution of Fyn and Gab2 to the high affinity IgE receptor signaling in mast cells
Q37821229The molecular biology of head and neck cancer
Q24646616The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies
Q35025935The pleckstrin homology domain in the SKAP55 adapter protein defines the ability of the adapter protein ADAP to regulate integrin function and NF-kappaB activation
Q33997351The presence of p47phox in liver parenchymal cells is a key mediator in the pathogenesis of alcoholic liver steatosis
Q60931449The promoter polymorphism of gene contributes to susceptibility of ischemic stroke in Korean population
Q39856683The receptor interacting protein 1 mediates a link between NFkappaB and PI3-kinase signaling.
Q37632467The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function
Q28539881The role of IKKβ in Venezuelan equine encephalitis virus infection
Q26825502The role of NF-κB in the pathogenesis of glioma
Q38274559The role of RelA (p65) threonine 505 phosphorylation in the regulation of cell growth, survival, and migration
Q38334119The role of hypoxia in inflammatory disease (review)
Q37816957The role of inflammation in epilepsy
Q26786826The role of reproductive hormones in epithelial ovarian carcinogenesis
Q38235888The role of the IKK complex in viral infections
Q37102767The role of the NFkappaB signalling pathway in cancer
Q38217924The role of ubiquitin-binding domains in human pathophysiology
Q33992585The scaffold protein TANK/I-TRAF inhibits NF-kappaB activation by recruiting polo-like kinase 1.
Q35658257The subcellular location of selenoproteins and the impact on their function
Q51367386The suppression of bromodomain and extra-terminal domain inhibits vascular inflammation by blocking NF-κB and MAPK activation.
Q36016557The transcription factor Zeb2 regulates signaling in mast cells
Q33582255The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65.
Q35836872The ubiquitin-proteasome system as a prospective molecular target for cancer treatment and prevention
Q46452914Therapeutic potential of carfilzomib, an irreversible proteasome inhibitor, against acetaminophen-induced hepatotoxicity in mice.
Q39301372Thr435 phosphorylation regulates RelA (p65) NF-kappaB subunit transactivation
Q35098885Thrombospondin-1: multiple paths to inflammation
Q28910436Thymosin beta4 inhibits TNF-alpha-induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK
Q34155303Tilapia hepcidin 2-3 peptide modulates lipopolysaccharide-induced cytokines and inhibits tumor necrosis factor-alpha through cyclooxygenase-2 and phosphodiesterase 4D
Q33627717Tissue-specific target analysis of disease-associated microRNAs in human signaling pathways
Q24301502To fight or die - inhibitor of apoptosis proteins at the crossroad of innate immunity and death
Q30595791Tonicity-responsive enhancer binding protein haplodeficiency attenuates seizure severity and NF-κB-mediated neuroinflammation in kainic acid-induced seizures
Q35935511Toxic Diatom Aldehydes Affect Defence Gene Networks in Sea Urchins
Q37319943TrFAST: a tool to predict signaling pathway-specific transcription factor binding sites
Q42045886Tracking early autoimmune disease by bioluminescent imaging of NF-kappaB activation reveals pathology in multiple organ systems
Q37252851Transcriptional Modulator Ifrd1 Regulates Osteoclast Differentiation through Enhancing the NF-κB/NFATc1 Pathway
Q88801150Transcriptional Regulation Involved in Fear Memory Reconsolidation
Q37696067Transcriptional control of the TNF gene
Q27026117Transcriptional regulation of human DNA repair genes following genotoxic stress: trigger mechanisms, inducible responses and genotoxic adaptation
Q23919656Transcriptional responses to oxidative stress: pathological and toxicological implications
Q31012387Transcriptomic Changes in Coral Holobionts Provide Insights into Physiological Challenges of Future Climate and Ocean Change
Q39786229Transglutaminase 2 suppresses apoptosis by modulating caspase 3 and NF-kappaB activity in hypoxic tumor cells
Q64941129Treatment with 3-Bromo-4,5-Dihydroxybenzaldehyde Improves Cardiac Function by Inhibiting Macrophage Infiltration in Mice.
Q34926660Trichothecin induces cell death in NF-κB constitutively activated human cancer cells via inhibition of IKKβ phosphorylation
Q36561559Tristetraprolin induces cell cycle arrest in breast tumor cells through targeting AP-1/c-Jun and NF-κB pathway
Q37357296Triterpenoid resinous metabolites from the genus Boswellia: pharmacological activities and potential species-identifying properties
Q88379121Tumor necrosis factor alfa and interleukin 1 alfa induced phosphorylation and degradation of inhibitory kappa B alpha are regulated by estradiol in endometrial cells
Q38957153Tumor necrosis factor reduces Plasmodium falciparum growth and activates calcium signaling in human malaria parasites.
Q36712242Tumor necrosis factor-alpha (TNF-alpha) regulates Toll-like receptor 2 (TLR2) expression in microglia
Q41672710Tumor progression locus 2-dependent oxidative burst drives phosphorylation of extracellular signal-regulated kinase during TLR3 and 9 signaling
Q28477217Tumor suppressor p53 functions as a negative regulator in IgE-mediated mast cell activation
Q40079759Tumour Necrosis Factor-alpha and Nuclear Factor-kappa B Gene Variants in Sepsis.
Q46031593Tumour necrosis factor alpha activates nuclear factor kappaB signalling to reduce N-type voltage-gated Ca2+ current in postganglionic sympathetic neurons.
Q37980442Tuning the orchestra: transcriptional pathways controlling axon regeneration
Q24309553USP10 inhibits genotoxic NF-κB activation by MCPIP1-facilitated deubiquitination of NEMO
Q38248105UVA irradiation induced heme oxygenase-1: a novel phototherapy for morphea
Q35077552Ubiquitin-specific peptidase 20 targets TRAF6 and human T cell leukemia virus type 1 tax to negatively regulate NF-kappaB signaling
Q38021448Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications
Q38212817Unconventional post-translational modifications in immunological signaling
Q33717545Uncoupling of inflammation and insulin resistance by NF-kappaB in transgenic mice through elevated energy expenditure
Q52562778Uncovering inherent cellular plasticity of multiciliated ependyma leading to ventricular wall transformation and hydrocephalus.
Q37068819Unlike esophageal squamous cells, Barrett's epithelial cells resist apoptosis by activating the nuclear factor-kappaB pathway
Q52538370Unlocking the NF-κB Conundrum: Embracing Complexity to Achieve Specificity.
Q38379582Unraveling the Link Between Ectodermal Disorders and Primary Immunodeficiencies.
Q92732217Up-regulation of FOXO1 and reduced inflammation by β-hydroxybutyric acid are essential diet restriction benefits against liver injury
Q39965718Up-regulation of cathepsin B expression and enhanced secretion in mitochondrial DNA-depleted osteosarcoma cells
Q35625506Update of cylindromatosis gene (CYLD) mutations in Brooke-Spiegler syndrome: novel insights into the role of deubiquitination in cell signaling
Q59357569Upregulation of MicroRNA 711 Mediates HIV-1 Vpr Promotion of Kaposi's Sarcoma-Associated Herpesvirus Latency and Induction of Pro-proliferation and Pro-survival Cytokines by Targeting the Notch/NF-κB-Signaling Axis
Q43254285Use of pifithrin to inhibit p53-mediated signalling of TNF in dystrophic muscles of mdx mice.
Q87962538VEGF-A promotes both pro-angiogenic and neurotrophic capacities for nerve recovery after compressive neuropathy in rats
Q35087013Vanadium pentoxide (V(2)O(5)) induced mucin production by airway epithelium
Q36735217Vanadium-induced apoptosis of HaCaT cells is mediated by c-fos and involves nuclear accumulation of clusterin.
Q46323054Variation on Composition and Bioactivity of Essential Oils of Four Common Curcuma Herbs.
Q39575952Vinpocetine inhibits oligodendroglial precursor cell differentiation
Q27302812Withaferin A disrupts ubiquitin-based NEMO reorganization induced by canonical NF-κB signaling
Q87934205Wogonoside ameliorates lipopolysaccharide-induced acute lung injury in mice
Q37546803XIAP as a ubiquitin ligase in cellular signaling
Q64949987Xanthatin inhibits STAT3 and NF-κB signalling by covalently binding to JAK and IKK kinases.
Q51891800Xrel3/XrelA attenuates β-catenin-mediated transcription during mesoderm formation in Xenopus embryos.
Q64259397Yiqi-Huoxue Granule (YQHX) Downregulates Prothrombotic Factors by Modulating KLF2 and NF-B in HUVECs following LPS Stimulation
Q39266137Zerumbone suppresses IKKα, Akt, and FOXO1 activation, resulting in apoptosis of GBM 8401 cells
Q33852159Zinc in Infection and Inflammation
Q38378086c-Rel Regulates Inscuteable Gene Expression during Mouse Embryonic Stem Cell Differentiation
Q101476490c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis
Q36906564iNOS expression requires NADPH oxidase-dependent redox signaling in microvascular endothelial cells
Q30432890miR-10a contributes to retinoid acid-induced smooth muscle cell differentiation
Q33830016miR-15b-5p resensitizes colon cancer cells to 5-fluorouracil by promoting apoptosis via the NF-κB/XIAP axis
Q39586264miR-27b*, an oxidative stress-responsive microRNA modulates nuclear factor-kB pathway in RAW 264.7 cells
Q42259363miR-30e* is overexpressed in prostate cancer and promotes NF-κB-mediated proliferation and tumor growth
Q28382788mot-2-Mediated cross talk between nuclear factor-B and p53 is involved in arsenite-induced tumorigenesis of human embryo lung fibroblast cells
Q30625279n-3 fatty acids, inflammation and immunity: new mechanisms to explain old actions
Q35007977p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype
Q33615344p52-Independent nuclear translocation of RelB promotes LPS-induced attachment
Q38934157p53 and the Carcinogenicity of Chronic Inflammation
Q37436261p53 predominantly regulates IL-6 production and suppresses synovial inflammation in fibroblast-like synoviocytes and adjuvant-induced arthritis
Q89783061p53's Extended Reach: The Mutant p53 Secretome
Q41942106p53-dependent regulation of mitochondrial energy production by the RelA subunit of NF-κB
Q39956076α-Solanine Isolated From Solanum Tuberosum L. cv Jayoung Abrogates LPS-Induced Inflammatory Responses Via NF-κB Inactivation in RAW 264.7 Macrophages and Endotoxin-Induced Shock Model in Mice
Q54104640β₂-Glycoprotein I inhibits endothelial cell migration through the nuclear factor κB signalling pathway and endothelial nitric oxide synthase activation.

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