| scholarly article | Q13442814 |
| P356 | DOI | 10.1038/NCB2621 |
| P2888 | exact match | https://scigraph.springernature.com/pub.10.1038/ncb2621 |
| P698 | PubMed publication ID | 23159929 |
| P50 | author | W-K Sung | Q84808115 |
| Gaye Sağınç | Q85472526 | ||
| Arkasubhra Ghosh | Q39186591 | ||
| P2093 | author name string | Vinay Tergaonkar | |
| Jianbiao Zhou | |||
| Edison Liu | |||
| Zhizhuo Zhang | |||
| Guoliang Li | |||
| Shang Li | |||
| Shi Chi Leow | |||
| Wee Joo Chng | |||
| Ekta Khattar | |||
| Marc Wong | |||
| Ting Dong Yan | |||
| Eun Myong Shin | |||
| P2860 | cites work | A telomerase component is defective in the human disease dyskeratosis congenita | Q22010917 |
| Hallmarks of Cancer: The Next Generation | Q22252312 | ||
| Telomerase modulates Wnt signalling by association with target gene chromatin | Q24310084 | ||
| An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA | Q24336971 | ||
| DNA damage-mediated induction of a chemoresistant niche | Q24616267 | ||
| The UCSC Genome Browser database: update 2011 | Q24625811 | ||
| The human genome browser at UCSC | Q24672361 | ||
| Cancer-related inflammation | Q27860907 | ||
| THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS | Q28202269 | ||
| Integrating cell-signalling pathways with NF-kappaB and IKK function | Q28280069 | ||
| Oncogenically active MYD88 mutations in human lymphoma | Q28301648 | ||
| Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. | Q28366118 | ||
| Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection | Q28509078 | ||
| Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression | Q28587192 | ||
| Conditional telomerase induction causes proliferation of hair follicle stem cells | Q28591715 | ||
| Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence | Q42053248 | ||
| Telomerase activation in atherosclerosis and induction of telomerase reverse transcriptase expression by inflammatory stimuli in macrophages | Q42170737 | ||
| The emerging role of telomerase reverse transcriptase in mitochondrial DNA metabolism | Q42245565 | ||
| The nuclear factor-kappaB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter. | Q42479390 | ||
| hTERT overexpression alleviates intracellular ROS production, improves mitochondrial function, and inhibits ROS-mediated apoptosis in cancer cells | Q42479814 | ||
| Distinct roles of IkappaB proteins in regulating constitutive NF-kappaB activity. | Q42483415 | ||
| Mechanism of telomerase induction during T cell activation | Q44208409 | ||
| Telomere shortening and growth inhibition of human cancer cells by novel synthetic telomerase inhibitors MST-312, MST-295, and MST-1991. | Q44246932 | ||
| Tumor necrosis factor alpha mediates the lethal hepatotoxic effects of poly(I:C) in D-galactosamine-sensitized mice | Q46709188 | ||
| Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-independent mechanism. | Q51889494 | ||
| Inflaming gastrointestinal oncogenic programming. | Q53319713 | ||
| Rapid inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telomerase RNA and anti-telomerase short-interfering RNA. | Q53851296 | ||
| Nuclear NF-κB/p65 expression and response to neoadjuvant chemotherapy in breast cancer. | Q54627424 | ||
| Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis | Q56508142 | ||
| Telomerase modulates expression of growth-controlling genes and enhances cell proliferation | Q73322990 | ||
| Expression of telomerase inhibits hydroxyl radical-induced apoptosis in normal telomerase negative human lung fibroblasts | Q73408019 | ||
| Dramatic increase of telomerase activity during dendritic cell differentiation and maturation | Q73719164 | ||
| Shared principles in NF-kappaB signaling | Q29547234 | ||
| NF-kappaB functions as a tumour promoter in inflammation-associated cancer | Q29614598 | ||
| GREAT improves functional interpretation of cis-regulatory regions | Q29614846 | ||
| Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1 | Q29617043 | ||
| Crosstalk in NF-κB signaling pathways | Q29617418 | ||
| Genomic maps of long noncoding RNA occupancy reveal principles of RNA-chromatin interactions | Q29617830 | ||
| Suppression of TNF-alpha-induced apoptosis by NF-kappaB | Q29618717 | ||
| Inflammation meets cancer, with NF-κB as the matchmaker | Q29620242 | ||
| A signal-noise model for significance analysis of ChIP-seq with negative control | Q33550016 | ||
| Control of apoptosis by Rel/NF-kappaB transcription factors | Q33797163 | ||
| The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. | Q33852211 | ||
| Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IkappaBalpha. | Q33863064 | ||
| Constitutive telomerase expression promotes mammary carcinomas in aging mice | Q34031827 | ||
| Telomerase extracurricular activities | Q34188137 | ||
| Telomerase contributes to tumorigenesis by a telomere length-independent mechanism | Q34188701 | ||
| Connection between telomerase activity in PBMC and markers of inflammation and endothelial dysfunction in patients with metabolic syndrome | Q34256706 | ||
| ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress | Q34620780 | ||
| Recognition and elongation of telomeres by telomerase | Q34676361 | ||
| Ulcerative typhlocolitis associated with Helicobacter mastomyrinus in telomerase-deficient mice | Q34836569 | ||
| CENTDIST: discovery of co-associated factors by motif distribution | Q35075636 | ||
| The human TTAGGG repeat factors 1 and 2 bind to a subset of interstitial telomeric sequences and satellite repeats | Q35348831 | ||
| Separation of telomerase functions by reverse genetics | Q35647835 | ||
| Senescence and immortalization: role of telomeres and telomerase | Q35912152 | ||
| Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals | Q36368282 | ||
| Degradation of promoter-bound p65/RelA is essential for the prompt termination of the nuclear factor kappaB response | Q36403968 | ||
| Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization | Q36754020 | ||
| Replication and protection of telomeres | Q36854279 | ||
| Telomerase and cancer therapeutics | Q37078833 | ||
| Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins | Q37846533 | ||
| The diverse and complex roles of NF-κB subunits in cancer | Q37976939 | ||
| NF-kappa B regulates transcription of the mouse telomerase catalytic subunit | Q38308646 | ||
| Nuclear factor-kappaB is an important modulator of the altered gene expression profile and malignant phenotype in squamous cell carcinoma. | Q38336511 | ||
| The telomerase inhibitor imetelstat depletes cancer stem cells in breast and pancreatic cancer cell lines | Q39633952 | ||
| Requirement of the NF-kappaB subunit p65/RelA for K-Ras-induced lung tumorigenesis | Q39712653 | ||
| WIP1 phosphatase is a negative regulator of NF-kappaB signalling | Q39859211 | ||
| Cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated depletion of telomerase RNA. | Q40435095 | ||
| Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling | Q40851705 | ||
| Mechanisms regulating telomerase activity in murine T cells. | Q41134584 | ||
| P433 | issue | 12 | |
| P921 | main subject | NF-κB | Q411114 |
| P304 | page(s) | 1270-1281 | |
| P577 | publication date | 2012-11-18 | |
| P1433 | published in | Nature Cell Biology | Q1574111 |
| P1476 | title | Telomerase directly regulates NF-κB-dependent transcription | |
| P478 | volume | 14 |
| Q91956367 | A transcriptional regulatory atlas of coronavirus infection of human cells |
| Q26995561 | Aberrant nuclear factor-kappa B activity in acute myeloid leukemia: from molecular pathogenesis to therapeutic target |
| Q37546085 | An investigation of the effects of the core protein telomerase reverse transcriptase on Wnt signaling in breast cancer cells |
| Q38458724 | Analysis of the intricate relationship between chronic inflammation and cancer. |
| Q35753087 | Association between TERT promoter polymorphisms and acute myeloid leukemia risk and prognosis. |
| Q35644577 | Association of TERT Polymorphisms with Clinical Outcome of Non-Small Cell Lung Cancer Patients |
| Q36221232 | Association of telomerase reverse transcriptase promoter mutations with clinicopathological features and prognosis of thyroid cancer: a meta-analysis |
| Q34994089 | Attenuation of lysyl oxidase and collagen gene expression in keratoconus patient corneal epithelium corresponds to disease severity |
| Q92756102 | Back to the future: The intimate and evolving connection between telomere-related factors and genotoxic stress |
| Q35820032 | Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation |
| Q36545969 | Bortezomib-mediated down-regulation of telomerase and disruption of telomere homeostasis contributes to apoptosis of malignant cells |
| Q43060096 | Catalytically inactive telomerase in oncogenesis |
| Q60053690 | Cell cycle-dependent and -independent telomere shortening accompanies murine brain aging |
| Q38896922 | Cellular lifespan and senescence: a complex balance between multiple cellular pathways |
| Q41471328 | Chronic Inflammation in Immune Aging: Role of Pattern Recognition Receptor Crosstalk with the Telomere Complex? |
| Q33877362 | Chronic inflammation induces telomere dysfunction and accelerates ageing in mice. |
| Q36346985 | Cross talk between EBV and telomerase: the role of TERT and NOTCH2 in the switch of latent/lytic cycle of the virus |
| Q37741228 | Current Insights to Regulation and Role of Telomerase in Human Diseases. |
| Q41983972 | Cytotoxic effects of caffeic acid undecyl ester are involved in the inhibition of telomerase activity in NALM-6 human B-cell leukemia cells |
| Q34117601 | DEAD-box helicase DP103 defines metastatic potential of human breast cancers |
| Q47121817 | DNA hypermethyation and silencing of PITX1 correlated with advanced stage and poor postoperative prognosis of esophageal squamous cell carcinoma. |
| Q42278533 | Decoding telomere protein Rap1: Its telomeric and nontelomeric functions and potential implications in diabetic cardiomyopathy |
| Q37700566 | Different cellular localization of NF-κB p65 expression as an indicator of different prognoses of stage I-III gastric cancer patients |
| Q33580398 | Efficient DNA binding of NF-κB requires the chaperone-like function of NPM1. |
| Q92092817 | Enhanced cardiac repair by telomerase reverse transcriptase over-expression in human cardiac mesenchymal stromal cells |
| Q91967497 | Eukaryotic initiation factor 3, subunit C silencing inhibits cell proliferation and promotes apoptosis in human ovarian cancer cells |
| Q37418806 | Extracting extra-telomeric phenotypes from telomerase mouse models |
| Q35741628 | Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers. |
| Q36395933 | Gastrointestinal cancer cells treatment with bevacizumab activates a VEGF autoregulatory mechanism involving telomerase catalytic subunit hTERT via PI3K-AKT, HIF-1α and VEGF receptors |
| Q58612842 | Genomic Medicine and Implications for Hepatocellular Carcinoma Prevention and Therapy |
| Q36144711 | Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition. |
| Q31115332 | HPV16 E7 protein and hTERT proteins defective for telomere maintenance cooperate to immortalize human keratinocytes |
| Q54983938 | Hexokinase 2 is a molecular bridge linking telomerase and autophagy. |
| Q36998258 | Human telomerase reverse transcriptase (hTERT) promotes gastric cancer invasion through cooperating with c-Myc to upregulate heparanase expression |
| Q38864853 | Human telomerase reverse transcriptase regulates vascular endothelial growth factor expression via human papillomavirus oncogene E7 in HPV-18-positive cervical cancer cells |
| Q52620813 | Implications of TERT promoter mutations and telomerase activity in urothelial carcinogenesis. |
| Q26825812 | Implications of telomere-independent activities of telomerase reverse transcriptase in human cancer |
| Q89478652 | Interleukin 8 is a biomarker of telomerase inhibition in cancer cells |
| Q54257233 | Is there a connection between inflammation, telomerase activity and the transcriptional status of telomerase reverse transcriptase in renal failure? |
| Q39433499 | Loss of telomere protection: consequences and opportunities. |
| Q38869842 | MST-312 induces G2/M cell cycle arrest and apoptosis in APL cells through inhibition of telomerase activity and suppression of NF-κB pathway |
| Q38987554 | Means to the ends: The role of telomeres and telomere processing machinery in metastasis |
| Q64955692 | Mechanism of Apoptosis Induced by Curcumin in Colorectal Cancer. |
| Q55119833 | NF-κB promotes the stem-like properties of leukemia cells by activation of LIN28B. |
| Q49594691 | NF-κB, inflammation, immunity and cancer: coming of age. |
| Q38373920 | NUCKS: a potential biomarker in cancer and metabolic disease |
| Q34283730 | Negative regulation of signal transducer and activator of transcription-3 signalling cascade by lupeol inhibits growth and induces apoptosis in hepatocellular carcinoma cells. |
| Q38875386 | New prospects for targeting telomerase beyond the telomere. |
| Q36635311 | Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation. |
| Q92482185 | Non-canonical Roles of Telomerase: Unraveling the Imbroglio |
| Q92209336 | Overexpression of cellular telomerase RNA enhances virus-induced cancer formation |
| Q64055055 | PES1 is a critical component of telomerase assembly and regulates cellular senescence |
| Q92564137 | PITX1 protein interacts with ZCCHC10 to regulate hTERT mRNA transcription |
| Q64945759 | Pan-cancer analysis identifies telomerase-associated signatures and cancer subtypes. |
| Q38902476 | Quantitative assessment of telomerase components in cancer cell lines |
| Q89484239 | RAGE and Its Ligands: Molecular Interplay Between Glycation, Inflammation, and Hallmarks of Cancer-a Review |
| Q36781142 | Rap1 induces cytokine production in pro-inflammatory macrophages through NFκB signaling and is highly expressed in human atherosclerotic lesions |
| Q35120785 | Re-expression of HPV16 E2 in SiHa (human cervical cancer) cells potentiates NF-κB activation induced by TNF-α concurrently increasing senescence and survival |
| Q26769014 | Reactivation of telomerase in cancer |
| Q35176004 | Reciprocal activation between IL-6/STAT3 and NOX4/Akt signalings promotes proliferation and survival of non-small cell lung cancer cells |
| Q33802112 | Rho protein GTPases and their interactions with NFκB: crossroads of inflammation and matrix biology |
| Q92671574 | Role of lncRNAs in aging and age-related diseases |
| Q26744271 | Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies |
| Q49217039 | Snail1 transcription factor controls telomere transcription and integrity. |
| Q92802731 | Stem cells, immortality, and the evolution of metastatic properties in breast cancer: telomere maintenance mechanisms and metastatic evolution |
| Q93176410 | Stress and immunosenescence: The role of telomerase |
| Q54115289 | Subunit-Specific Role of NF-κB in Cancer. |
| Q28390726 | TERT promoter mutations and polymorphisms as prognostic factors in primary glioblastoma |
| Q35068013 | TERT promoter mutations are associated with distant metastases in upper tract urothelial carcinomas and serve as urinary biomarkers detected by a sensitive castPCR |
| Q26770808 | TERT promoter mutations in thyroid cancer |
| Q87090405 | TERT rs2736100T/G polymorphism upregulates interleukin 6 expression in non-small cell lung cancer especially in adenocarcinoma |
| Q89526241 | Targeted Covalent Inhibition of Telomerase |
| Q90211132 | Telomerase Biology Associations offer Keys to Cancer and Aging Therapeutics |
| Q52883665 | Telomerase activates transcription of cyclin D1 gene through an interaction with NOL1. |
| Q90735507 | Telomerase promotes formation of a telomere protective complex in cancer cells |
| Q36857933 | Telomerase reactivation in cancers: Mechanisms that govern transcriptional activation of the wild-type vs. mutant TERT promoters |
| Q35720003 | Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity |
| Q36423119 | Telomerase reverse transcriptase acts in a feedback loop with NF-κB pathway to regulate macrophage polarization in alcoholic liver disease |
| Q89120729 | Telomerase reverse transcriptase coordinates with the epithelial-to-mesenchymal transition through a feedback loop to define properties of breast cancer stem cells |
| Q34179834 | Telomerase reverse transcriptase in the regulation of gene expression |
| Q89100375 | Telomerase reverse transcriptase induced thyroid carcinoma cell proliferation through PTEN/AKT signaling pathway |
| Q47330759 | Telomerase reverse transcriptase mediates EMT through NF-κB signaling in tongue squamous cell carcinoma |
| Q37395716 | Telomerase reverse transcriptase promotes cancer cell proliferation by augmenting tRNA expression |
| Q24313154 | Telomerase reverse transcriptase regulates microRNAs |
| Q38966600 | Telomerase stimulates ribosomal DNA transcription under hyperproliferative conditions |
| Q50045974 | Telomere Damage Response and Low-Grade Inflammation. |
| Q36132829 | Telomere Length, TERT, and miRNA Expression |
| Q26744808 | Telomere and Telomerase Therapeutics in Cancer |
| Q88957915 | Telomere attrition is associated with declines in medial temporal lobe volume and white matter microstructure in functionally independent older adults |
| Q46277287 | Telomere length and ROS levels are positively associated with a high risk of mortality and recurrence in hepatocellular carcinoma. |
| Q37252497 | Telomere length, telomere-related genes, and breast cancer risk: the breast cancer health disparities study |
| Q30248577 | Telomeres and telomerase in head and neck squamous cell carcinoma: from pathogenesis to clinical implications. |
| Q98158989 | Telomeres and telomerase in oncogenesis |
| Q35741571 | The DNA methylation inhibitor induces telomere dysfunction and apoptosis of leukemia cells that is attenuated by telomerase over-expression |
| Q55302804 | The Direct and Indirect Roles of NF-κB in Cancer: Lessons from Oncogenic Fusion Proteins and Knock-in Mice. |
| Q42339232 | The Maintenance of Telomere Length in CD28+ T Cells During T Lymphocyte Stimulation |
| Q58123198 | The Neuro-Immuno-Senescence Integrative Model (NISIM) on the Negative Association Between Parasympathetic Activity and Cellular Senescence |
| Q90596932 | The Solo Play of TERT Promoter Mutations |
| Q39095803 | The associations of TERT-CLPTM1L variants and TERT mRNA expression with the prognosis of early stage non-small cell lung cancer |
| Q50423999 | The fetal programming of telomere biology hypothesis: an update. |
| Q34667865 | The multifaceted role of curcumin in cancer prevention and treatment. |
| Q60112361 | The non-canonical functions of telomerase: to turn off or not to turn off |
| Q37194184 | The role of telomeres and telomerase reverse transcriptase isoforms in pluripotency induction and maintenance |
| Q34021399 | The use of transformed IMR90 cell model to identify the potential extra-telomeric effects of hTERT in cell migration and DNA damage response |
| Q27027457 | Therapeutic targeting of replicative immortality |
| Q26739925 | Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene |
| Q38218964 | Transcriptional outcome of telomere signalling |
| Q58753850 | Transcriptional outcomes and kinetic patterning of gene expression in response to NF-κB activation |
| Q36348877 | Trefoil factor 1 expression suppresses Helicobacter pylori-induced inflammation in gastric carcinogenesis |
| Q64979971 | Variability within the human TERT gene, telomere length and predisposition to chronic lymphocytic leukemia. |
| Q53263421 | hTERT mediates norepinephrine-induced Slug expression and ovarian cancer aggressiveness. |
| Q36681955 | hTERT promotes cell adhesion and migration independent of telomerase activity |
| Q33688891 | hTERT promotes gastric intestinal metaplasia by upregulating CDX2 via NF-κB signaling pathway |
| Q38835327 | hTERT promotes the invasion of gastric cancer cells by enhancing FOXO3a ubiquitination and subsequent ITGB1 upregulation |
| Q37336919 | hTERT promotes tumor angiogenesis by activating VEGF via interactions with the Sp1 transcription factor |
| Q38301306 | miR-19b regulates hTERT mRNA expression through targeting PITX1 mRNA in melanoma cells |
| Q36216239 | miR-346 and miR-138 competitively regulate hTERT in GRSF1- and AGO2-dependent manners, respectively |
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