Good cop, bad cop: the different faces of NF-kappaB

scientific article

Good cop, bad cop: the different faces of NF-kappaB is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1038/SJ.CDD.4401838
P3181OpenCitations bibliographic resource ID786823
P698PubMed publication ID16410803
P5875ResearchGate publication ID7361037

P2093author name stringT D Gilmore
N D Perkins
P2860cites workNucleosome sliding via TBP DNA binding in vivoQ74558133
A role for NF-kappa B subunits p50 and p65 in the inhibition of lipopolysaccharide-induced shockQ80884570
Hostile takeovers: viral appropriation of the NF-kB pathwayQ22241900
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylaseQ24293656
Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stressQ24300945
MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14Q24303450
The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesisQ24317603
IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3aQ24336832
Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimersQ24562579
Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alphaQ71513462
Pervanadate-induced nuclear factor-kappaB activation requires tyrosine phosphorylation and degradation of IkappaBalpha. Comparison with tumor necrosis factor-alphaQ73561082
Mutations within a conserved protein kinase A recognition sequence confer temperature-sensitive and partially defective activities onto mouse c-RelQ73633196
NF-kappaB RelA phosphorylation regulates RelA acetylationQ28115098
Nucleolar sequestration of RelA (p65) regulates NF-kappaB-driven transcription and apoptosisQ28182225
To be, or not to be: NF-kappaB is the answer--role of Rel/NF-kappaB in the regulation of apoptosisQ28190313
EnhanceosomesQ28204862
Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatasesQ28239642
Oscillations in NF-kappaB signaling control the dynamics of gene expressionQ28289121
Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammationQ28302681
IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland developmentQ28508430
A dual role for Ikk alpha in tooth developmentQ28592979
Signaling to NF-kappaBQ29547844
Activators and target genes of Rel/NF-kappaB transcription factorsQ29547882
The two NF-kappaB activation pathways and their role in innate and adaptive immunityQ29614355
IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancerQ29614599
Shaping the nuclear action of NF-kappaBQ29614600
The IkappaB-NF-kappaB signaling module: temporal control and selective gene activationQ29617813
PTEN blocks tumor necrosis factor-induced NF-kappa B-dependent transcription by inhibiting the transactivation potential of the p65 subunitQ30308560
SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survivalQ30434865
IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapyQ34048503
A novel protein overexpressed in hepatoma accelerates export of NF-kappa B from the nucleus and inhibits p53-dependent apoptosisQ34156179
Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.Q34285636
Suppression of MEK/ERK signaling pathway enhances cisplatin-induced NF-kappaB activation by protein phosphatase 4-mediated NF-kappaB p65 Thr dephosphorylationQ34312155
p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1.Q34312166
Inverse correlation between p16INK4A expression and NF-kappaB activation in melanoma progressionQ34339263
Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexesQ34411407
The IkappaB kinase complex and NF-kappaB act as master regulators of lipopolysaccharide-induced gene expression and control subordinate activation of AP-1.Q35126481
p53 represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone deacetylase 1.Q35150453
The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repressionQ35200339
The IKK NF-kappa B system: a treasure trove for drug developmentQ35621375
NF-kappaB: tumor promoter or suppressor?Q35753163
Nuclear factor-kappaB: its role in health and diseaseQ35791198
NF-kappaB and JNK: an intricate affairQ35990196
NF-kappaB in human disease: current inhibitors and prospects for de novo structure based design of inhibitorsQ36050646
Interactions of NF-kappaB with chromatin: the art of being at the right place at the right timeQ36103478
CDK4 regulation by TNFR1 and JNK is required for NF-kappaB-mediated epidermal growth controlQ36321393
Activation of nuclear factor kappaB and Bcl-x survival gene expression by nerve growth factor requires tyrosine phosphorylation of IkappaBalpha.Q36375798
Degradation of promoter-bound p65/RelA is essential for the prompt termination of the nuclear factor kappaB responseQ36403968
Regulation of NF-kappaB function.Q36454315
Tumor necrosis factor receptor 1-mediated signaling is required for skin cancer development induced by NF-kappaB inhibitionQ37415678
Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105.Q37574047
IkappaB kinase beta phosphorylates Dok1 serines in response to TNF, IL-1, or gamma radiationQ37713955
Inhibition of transcription factor NF-kappaB signaling proteins IKKbeta and p65 through specific cysteine residues by epoxyquinone A monomer: correlation with its anti-cancer cell growth activity.Q38317613
Activity of hypoxia-inducible factor 2alpha is regulated by association with the NF-kappaB essential modulatorQ38331952
Tumor necrosis factor-alpha activation of nuclear transcription factor-kappaB in marrow macrophages is mediated by c-Src tyrosine phosphorylation of Ikappa Balpha.Q38331977
beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancerQ38361640
Genetic analysis of NF- B/Rel transcription factors defines functional specificitiesQ39962410
NF-kappaB mediates inhibition of mesenchymal cell differentiation through a posttranscriptional gene silencing mechanism.Q39977637
IkappaB kinase-independent IkappaBalpha degradation pathway: functional NF-kappaB activity and implications for cancer therapyQ40172372
Immortalized fibroblasts from NF-kappaB RelA knockout mice show phenotypic heterogeneity and maintain increased sensitivity to tumor necrosis factor alpha after transformation by v-RasQ40396069
Activated AKT regulates NF-kappaB activation, p53 inhibition and cell survival in HTLV-1-transformed cellsQ40399507
Impaired inhibition of NF-kappaB activity by melanoma-associated p16INK4a mutationsQ40418070
Nuclear factor-kappaB induced by doxorubicin is deficient in phosphorylation and acetylation and represses nuclear factor-kappaB-dependent transcription in cancer cellsQ40421120
NF-kappaB RelA opposes epidermal proliferation driven by TNFR1 and JNK.Q40431585
Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activationQ40439343
Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressorQ40445496
Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B.Q40571746
Crossregulation of NF-kappaB by the APC/GSK-3beta/beta-catenin pathwayQ40584185
IKK beta and phosphatidylinositol 3-kinase/Akt participate in non-pathogenic Gram-negative enteric bacteria-induced RelA phosphorylation and NF-kappa B activation in both primary and intestinal epithelial cell linesQ40715411
p53 stabilization is decreased upon NFkappaB activation: a role for NFkappaB in acquisition of resistance to chemotherapyQ40717571
Immortalized embryonic mouse fibroblasts lacking the RelA subunit of transcription factor NF-kappaB have a malignantly transformed phenotypeQ40736254
Crucial role of the amino-terminal tyrosine residue 42 and the carboxyl-terminal PEST domain of I kappa B alpha in NF-kappa B activation by an oxidative stressQ40831600
p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor.Q41062073
Achieving transcriptional specificity with NF-kappa B.Q41756452
Convergent actions of I kappa B kinase beta and protein kinase C delta modulate mRNA stability through phosphorylation of 14-3-3 beta complexed with tristetraprolinQ41890618
Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injuryQ41982755
IKKalpha controls formation of the epidermis independently of NF-kappaB.Q42502421
Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38.Q42830960
Possible new role for NF-kappaB in the resolution of inflammation.Q43811439
p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitmentQ43822750
Phase I dose escalation trial of feverfew with standardized doses of parthenolide in patients with cancer.Q44879834
Transient and selective NF-kappa B p65 serine 536 phosphorylation induced by T cell costimulation is mediated by I kappa B kinase beta and controls the kinetics of p65 nuclear importQ44885075
NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia.Q45982548
One nucleotide in a kappaB site can determine cofactor specificity for NF-kappaB dimersQ46128002
IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesisQ46576855
CK2 Is a C-Terminal IκB Kinase Responsible for NF-κB Activation during the UV ResponseQ46589615
Phosphorylation of RelA/p65 on serine 536 defines an I{kappa}B{alpha}-independent NF-{kappa}B pathwayQ46654957
Loss of nuclear factor-kappaB is tumor promoting but does not substitute for loss of p53.Q47255105
The nuclear factor kappaB subunits RelA/p65 and c-Rel potentiate but are not required for Ras-induced cellular transformation.Q53364037
Modulation of NF-kappaB activity by exchange of dimers.Q53860042
NF-κB and IκBα Are Found in the MitochondriaQ54976830
TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2Q57198247
Role of NF-κB in p53-mediated programmed cell deathQ57248006
p53- and Mdm2-Independent Repression of NF-κB Transactivation by the ARF Tumor SuppressorQ58287158
IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammationQ59054264
Divergent gene regulation and growth effects by NF-κB in epithelial and mesenchymal cells of human skinQ60726281
Post-translational modification of RelA(p65) NF-kappaBQ61863694
Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaBQ64381570
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectNF-κBQ411114
P304page(s)759-72
P577publication date2006-05-01
P1433published inCell Death & DifferentiationQ2943974
P1476titleGood cop, bad cop: the different faces of NF-kappaB
P478volume13

Reverse relations

cites work (P2860)
Q42014943A distinctive physiological role for IkappaBbeta in the propagation of mitochondrial respiratory stress signaling
Q28393278A multi-targeted approach to suppress tumor-promoting inflammation
Q35099514A novel pathway links oxidative stress to loss of insulin growth factor-2 (IGF2) imprinting through NF-κB activation
Q24316467A20-binding inhibitor of nuclear factor-kappaB (NF-kappaB)-2 (ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase alpha (IKKalpha)-mediated NF-kappaB transcriptional activity
Q34620780ATM- and NEMO-Dependent ELKS Ubiquitination Coordinates TAK1-Mediated IKK Activation in Response to Genotoxic Stress
Q37016599Actin-binding protein alpha-actinin 4 (ACTN4) is a transcriptional co-activator of RelA/p65 sub-unit of NF-kB.
Q47942760Activation of TWIST1 by COL11A1 promotes chemoresistance and inhibits apoptosis in ovarian cancer cells by modulating NF-κB-mediated IKKβ expression.
Q34249164Adenomatous polyposis coli and hypoxia-inducible factor-1{alpha} have an antagonistic connection
Q28074665Adenosine A2B Receptor: From Cell Biology to Human Diseases
Q39561145An RNAi screen identifies USP2 as a factor required for TNF-α-induced NF-κB signaling
Q42781272Antagonistic crosstalk between APC and HIF-1α.
Q38209789Anti-galectin-3 therapy: a new chance for multiple myeloma and ovarian cancer?
Q47730321Anti-inflammatory effect of Euphorbia supina extract in dextran sulfate sodium-induced colitis mice
Q27004250Anti-tumor activity of non-steroidal anti-inflammatory drugs: cyclooxygenase-independent targets
Q83059738Antioxidative effects of the spice cardamom against non-melanoma skin cancer by modulating nuclear factor erythroid-2-related factor 2 and NF-κB signalling pathways
Q56562349Arginine inhibits the malignant transformation induced by interferon-gamma through the NF-κB-GCN2/eIF2α signaling pathway in mammary epithelial cells in vitro and in vivo
Q89260017Arsenic-induced apoptosis in the p53-proficient and p53-deficient cells through differential modulation of NFkB pathway
Q47605422Association of growth factors, HIF-1 and NF-κB expression with proteasomes in endometrial cancer.
Q37341585Aurora kinase A promotes inflammation and tumorigenesis in mice and human gastric neoplasia
Q24611183Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment
Q34158284Benzyl isothiocyanate-mediated inhibition of histone deacetylase leads to NF-kappaB turnoff in human pancreatic carcinoma cells
Q39037261Bex2 controls proliferation of human glioblastoma cells through NF-κB signaling pathway
Q38531952Biliverdin reductase: a target for cancer therapy?
Q34046542Black tea extract prevents lipopolysaccharide-induced NF-κB signaling and attenuates dextran sulfate sodium-induced experimental colitis
Q54624599Black tea polyphenol theaflavin suppresses LPS-induced ICAM-1 and VCAM-1 expression via blockage of NF-κB and JNK activation in intestinal epithelial cells.
Q90568296CCL20 triggered by chemotherapy hinders the therapeutic efficacy of breast cancer
Q89397415CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-κB/RelA in maintaining the homeostasis of human vascular cells
Q38646671CRISPR/Cas9-mediated knockout of c-REL in HeLa cells results in profound defects of the cell cycle.
Q38239860Caveolin-1 in oral squamous cell carcinoma microenvironment: an overview
Q38853856Cecropin B Represses CYP3A29 Expression through Activation of the TLR2/4-NF-κB/PXR Signaling Pathway
Q37471658Cell survival and apoptosis-related molecules in cancer cells in effusions: a comprehensive review
Q33674213Cellular stress responses: cell survival and cell death
Q37578158Characterization of genes and pathways that respond to heat stress in Holstein calves through transcriptome analysis.
Q33761615Chikusetsu saponin IVa ameliorates high fat diet-induced inflammation in adipose tissue of mice through inhibition of NLRP3 inflammasome activation and NF-κB signaling
Q36106570Chronic activation of the kinase IKKβ impairs T cell function and survival
Q35347850Crosstalk of reactive oxygen species and NF-κB signaling
Q36637900Current insights into the regulation of programmed cell death by NF-kappaB.
Q42450498Cytokines as genetic modifiers in K5-/- mice and in human epidermolysis bullosa simplex
Q36578949DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation
Q88337377DNA damage-induced nuclear factor-kappa B activation and its roles in cancer progression
Q42182499DW2007 Ameliorates Colitis and Rheumatoid Arthritis in Mice by Correcting Th17/Treg Imbalance and Inhibiting NF-κB Activation
Q36585524Daxx represses RelB target promoters via DNA methyltransferase recruitment and DNA hypermethylation
Q21090037Degraded carrageenan causing colitis in rats induces TNF secretion and ICAM-1 upregulation in monocytes through NF-kappaB activation
Q45874459Demethylation of IGFBP5 by Histone Demethylase KDM6B Promotes Mesenchymal Stem Cell-Mediated Periodontal Tissue Regeneration by Enhancing Osteogenic Differentiation and Anti-Inflammation Potentials.
Q27015288Deregulation of innate immune and inflammatory signaling in myelodysplastic syndromes
Q35828767Development of a murine model for blastoid variant mantle-cell lymphoma
Q42950439Discovery of imidazo[1,2-b]pyridazine derivatives as IKKβ inhibitors. Part 1: Hit-to-lead study and structure–activity relationship
Q37144548Distinct Differentiation Programs Triggered by IL-6 and LPS in Teleost IgM(+) B Cells in The Absence of Germinal Centers.
Q39761702Dynamic NF-κB and E2F interactions control the priority and timing of inflammatory signalling and cell proliferation.
Q34060669EGF receptor uses SOS1 to drive constitutive activation of NFκB in cancer cells
Q42541546Effects of Exercise on Gene Expression of Inflammatory Markers in Human Peripheral Blood Cells: A Systematic Review
Q41574344Effects of Fullerenols on Mouse Brain Microvascular Endothelial Cells
Q39217797Effects of peroxisome proliferator-activated receptor-γ activation on apoptosis in rats with acute pancreatitis
Q35931200Epigallocatechin-3-gallate Inhibits LPS-Induced NF-κB and MAPK Signaling Pathways in Bone Marrow-Derived Macrophages
Q41788901Evasion of apoptosis as a cellular stress response in cancer
Q90638896Evidence for the Involvement of the Master Transcription Factor NF-κB in Cancer Initiation and Progression
Q33813506Evolutionary conserved regulation of HIF-1β by NF-κB.
Q39985969Focal adhesion kinase mediates the interferon-gamma-inducible GTPase-induced phosphatidylinositol 3-kinase/Akt survival pathway and further initiates a positive feedback loop of NF-kappaB activation
Q38138557Friend or foe: emerging role of nuclear factor kappa-light-chain-enhancer of activated B cells in cell senescence
Q39591089Further insights into the mechanism of hypoxia-induced NFκB. [corrected].
Q28731826Genetic diversity of EBV-encoded LMP1 in the Swiss HIV Cohort Study and implication for NF-Κb activation
Q38861733Ginsenoside Rg3 suppresses FUT4 expression through inhibiting NF-κB/p65 signaling pathway to promote melanoma cell death.
Q40783620Glycyrrhetic Acid Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Vivo.
Q35041362HIF-1α restricts NF-κB-dependent gene expression to control innate immunity signals
Q64121653HSV-1\EGFP stimulates miR-146a expression in a NF-κB-dependent manner in monocytic THP-1 cells
Q38886096HTLV-1 tax-induced NF-kappaB activation is synergistically enhanced by 12-O-tetradecanoylphorbol-13-acetate: mechanism and implications for Tax oncogenicity
Q38724755High IKKα expression is associated with reduced time to recurrence and cancer specific survival in oestrogen receptor (ER)-positive breast cancer.
Q39641751High glucose promotes nascent nephron apoptosis via NF-kappaB and p53 pathways
Q38746127Histone Deacetylase Inhibitor RGFP109 Overcomes Temozolomide Resistance by Blocking NF-κB-Dependent Transcription in Glioblastoma Cell Lines
Q37711402Human airway smooth muscle cells from asthmatic individuals have CXCL8 hypersecretion due to increased NF-kappa B p65, C/EBP beta, and RNA polymerase II binding to the CXCL8 promoter
Q26752556Hypoxia Induced NF-κB
Q24306394IEX-1 directly interferes with RelA/p65 dependent transactivation and regulation of apoptosis
Q34148484IKK and NF-kappaB-mediated regulation of Claspin impacts on ATR checkpoint function
Q35587163IKKβ and NF-κB transcription govern lymphoma cell survival through AKT-induced plasma membrane trafficking of GLUT1.
Q35832054Identification of a novel pro-apopotic function of NF-kappaB in the DNA damage response
Q35841971Identification of a nuclear localization sequence in β-arrestin-1 and its functional implications
Q38376729IkappaB, NF-kappaB regulation model: simulation analysis of small number of molecules
Q42260200Impact of intravascular hemolysis in malaria on liver dysfunction: involvement of hepatic free heme overload, NF-κB activation, and neutrophil infiltration
Q36967517Increased oxidative stress and apoptosis in the hypothalamus of diabetic male mice in the insulin receptor substrate-2 knockout model.
Q38919904Indole-3-carbinol suppresses NF-κB activity and stimulates the p53 pathway in pre-B acute lymphoblastic leukemia cells.
Q24336239Induction of a pro-apoptotic ATM-NF-kappaB pathway and its repression by ATR in response to replication stress
Q33257134Induction of cell cycle changes and modulation of apoptogenic/anti-apoptotic and extracellular signaling regulatory protein expression by water extracts of I'm-Yunity (PSP)
Q38933527Infection of human amniotic and endothelial cells by Japanese encephalitis virus: Increased expression of HLA-F.
Q42936280Inflammation, Cancer and Oxidative Lipoxygenase Activity are Intimately Linked
Q33926884Inflammatory gene regulatory networks in amnion cells following cytokine stimulation: translational systems approach to modeling human parturition
Q54473491Inhibition of Leydig tumor growth by farnesoid X receptor activation: the in vitro and in vivo basis for a novel therapeutic strategy.
Q33872837Inhibition of nuclear factor kappa-B signaling reduces growth in medulloblastoma in vivo
Q37907354Inhibitory kappa B Kinases as targets for pharmacological regulation
Q51084869Insights into the behaviour of systems biology models from dynamic sensitivity and identifiability analysis: a case study of an NF-kappaB signalling pathway.
Q28280069Integrating cell-signalling pathways with NF-kappaB and IKK function
Q37331339Interleukin-10 provides direct trophic support to neurons.
Q34747904Interleukin-1beta up-regulates RGS4 through the canonical IKK2/IkappaBalpha/NF-kappaB pathway in rabbit colonic smooth muscle
Q91965142Investigation of Anti-Inflammatory Potential of N-Arylcinnamamide Derivatives
Q28388335Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases
Q36910697Ischemia-reperfusion injury in rat steatotic liver is dependent on NFκB P65 activation
Q33896931Killer proteases and little strokes--how the things that do not kill you make you stronger
Q51417792LRRC15 promotes osteogenic differentiation of mesenchymal stem cells by modulating p65 cytoplasmic/nuclear translocation.
Q36097312Lipopolysaccharide from Salmonella enterica activates NF-kappaB through both classical and alternative pathways in primary B Lymphocytes
Q47875060Long-term ethanol exposure: Temporal pattern of microRNA expression and associated mRNA gene networks in mouse brain
Q35107420Loss of the HPV-infection resistance EVER2 protein impairs NF-κB signaling pathways in keratinocytes.
Q34116925M-CSF induces monocyte survival by activating NF-κB p65 phosphorylation at Ser276 via protein kinase C.
Q36662130Maternal diabetes modulates renal morphogenesis in offspring
Q39669340Mechanism of hypoxia-induced NF-kappaB.
Q38635632Melatonin, clock genes and mitochondria in sepsis.
Q36733199Microglia-derived TNFα induces apoptosis in neural precursor cells via transcriptional activation of the Bcl-2 family member Puma
Q37588443Millepachine, a potential topoisomerase II inhibitor induces apoptosis via activation of NF-κB pathway in ovarian cancer
Q35177001Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry
Q28397259Mitochondria and reactive oxygen species: physiology and pathophysiology
Q37395304Modified vaccinia virus Ankara can activate NF-kappaB transcription factors through a double-stranded RNA-activated protein kinase (PKR)-dependent pathway during the early phase of virus replication
Q39328503Multiple signal transduction pathways are involved in G2/M growth arrest and apoptosis induced by the immunomodulator AS101 in multiple myeloma
Q36637889Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance
Q92069747NF-kB as a key player in regulation of cellular radiation responses and identification of radiation countermeasures
Q34013972NF-kappaB activation enhances cell death by antimitotic drugs in human prostate cancer cells
Q26777974NF-κB and HIF crosstalk in immune responses
Q28477156NF-κB potentiates caspase independent hydrogen peroxide induced cell death
Q42411008NFX1 plays a role in human papillomavirus type 16 E6 activation of NFkappaB activity
Q57306207NQO1 expression correlates inversely with NFκB activation in human breast cancer
Q37446811Nuclear Factor κB is Required for Tumor Growth Inhibition Mediated by Enavatuzumab (PDL192), a Humanized Monoclonal Antibody to TweakR.
Q33757740Nuclear factor kappaB inhibitors alleviate and the proteasome inhibitor PS-341 exacerbates radiation toxicity in zebrafish embryos
Q37904904Nuclear factor-κB: a key regulator in health and disease of lungs
Q39067763Nucleolar NF-κB/RelA mediates apoptosis by causing cytoplasmic relocalization of nucleophosmin
Q35493964Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations
Q34882515Overexpression of miR-146a in basal-like breast cancer cells confers enhanced tumorigenic potential in association with altered p53 status
Q33857705PUMA is directly activated by NF-kappaB and contributes to TNF-alpha-induced apoptosis
Q42937925Partners in death: a role for p73 and NF-kB in promoting apoptosis
Q41849082Phosphoprotein profiles of candidate markers for early cellular responses to low-dose γ-radiation in normal human fibroblast cells
Q26798324Phytochemicals modulate carcinogenic signaling pathways in breast and hormone-related cancers
Q35211526Platelet-rich plasma and skeletal muscle healing: a molecular analysis of the early phases of the regeneration process in an experimental animal model.
Q36637883Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway
Q36446689Preclinical In Vitro, In Vivo, and Pharmacokinetic Evaluations of FLLL12 for the Prevention and Treatment of Head and Neck Cancers
Q39344613Progesterone and calcitriol attenuate inflammatory cytokines CXCL1 and CXCL2 in ovarian and endometrial cancer cells
Q40017153Prolonged exposure to IL-1beta and IFNgamma induces necrosis of L929 tumor cells via a p38MAPK/NF-kappaB/NO-dependent mechanism
Q33855223Proteasome inhibitor PS-341 (bortezomib) induces calpain-dependent IkappaB(alpha) degradation
Q28118345Protein kinase A-induced phosphorylation of the p65 subunit of nuclear factor-kappaB promotes Schwann cell differentiation into a myelinating phenotype
Q54493636Protein kinase Cε activity induces anti-inflammatory and anti-apoptotic genes via an ERK1/2- and NF-κB-dependent pathway to enhance vascular protection.
Q90171107Protein tyrosine phosphatase L1 represses endothelial-mesenchymal transition by inhibiting IL-1β/NF-κB/Snail signaling
Q36662772Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo
Q42608215Proteomic Study to Survey the CIGB-552 Antitumor Effect
Q40050346RIP1 links inflammatory and growth factor signaling pathways by regulating expression of the EGFR.
Q33426864RNAi-mediated c-Rel silencing leads to apoptosis of B cell tumor cells and suppresses antigenic immune response in vivo
Q30009903Regulation of ASPP2 interaction with p53 core domain by an intramolecular autoinhibitory mechanism
Q33591456Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65.
Q37995693Regulation of cell death and autophagy by IKK and NF-κB: critical mechanisms in immune function and cancer
Q36917158Regulation of cell death during infection by the severe acute respiratory syndrome coronavirus and other coronaviruses.
Q24657260Regulation of hypoxia-inducible factor-1alpha by NF-kappaB
Q38774316Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit
Q41901021Regulation of signal transduction by glutathione transferases
Q36193382Regulatory effects of glycyrrhizae radix extract on DSS-induced ulcerative colitis
Q37416291RelA/p65 functions to maintain cellular senescence by regulating genomic stability and DNA repair
Q36495569Repression of B-cell linker (BLNK) and B-cell adaptor for phosphoinositide 3-kinase (BCAP) is important for lymphocyte transformation by rel proteins
Q39712653Requirement of the NF-kappaB subunit p65/RelA for K-Ras-induced lung tumorigenesis
Q33803649Rhein attenuates inflammation through inhibition of NF-κB and NALP3 inflammasome in vivo and in vitro
Q37150821Ribozyme-mediated targeting of IkappaBgamma inhibits melanoma invasion and metastasis
Q54195608Rice prolamin extract ameliorates acute murine colitis by inhibiting nuclear factor-kappa B and modulating intestinal apoptosis and cell proliferation.
Q34361051Role of lysine methylation of NF-κB in differential gene regulation
Q92724115Role of the COP9 Signalosome (CSN) in Cardiovascular Diseases
Q53230021Rutin Attenuates Carfilzomib-Induced Cardiotoxicity Through Inhibition of NF-κB, Hypertrophic Gene Expression and Oxidative Stress.
Q61811661SOCS2 Is Critical for the Balancing of Immune Response and Oxidate Stress Protecting Against Acetaminophen-Induced Acute Liver Injury
Q39950004Selective repression of YKL-40 by NF-kappaB in glioma cell lines involves recruitment of histone deacetylase-1 and -2.
Q39767499Short hairpin RNA targeting beta-catenin suppresses cell proliferation and induces apoptosis in human gastric carcinoma cells
Q28302027Small-molecule inhibitors of IκB kinase (IKK) and IKK-related kinases
Q54525617Somatic mutation of TRAF3 gene is rare in common human cancers and acute leukemias.
Q37208221Sustained oxidative stress inhibits NF-kappaB activation partially via inactivating the proteasome
Q92598503Synthetic lethality between VPS4A and VPS4B triggers an inflammatory response in colorectal cancer
Q89667670Targeting cancer stem cell pathways for cancer therapy
Q46313622Targeting metabolism and survival in chronic lymphocytic leukemia and Richter syndrome cells by a novel NF-κB inhibitor.
Q36509188TfR1 interacts with the IKK complex and is involved in IKK-NF-κB signalling
Q37072407The IkappaB kinases IKKalpha and IKKbeta are necessary and sufficient for skeletal muscle atrophy
Q92012185The Influence of Light on Reactive Oxygen Species and NF-кB in Disease Progression
Q41940661The RING ubiquitin E3 RNF114 interacts with A20 and modulates NF-κB activity and T-cell activation
Q41832550The Rhizome Mixture of Anemarrhena asphodeloides and Coptidis chinensis Ameliorates Acute and Chronic Colitis in Mice by Inhibiting the Binding of Lipopolysaccharide to TLR4 and IRAK1 Phosphorylation
Q43106720The TLR3 ligand polyI: C downregulates connexin 43 expression and function in astrocytes by a mechanism involving the NF-kappaB and PI3 kinase pathways
Q28476751The Trypanosoma cruzi protease cruzain mediates immune evasion
Q91658641The Unsolved Puzzle of c-Rel in B Cell Lymphoma
Q40092549The apoptosis-inducing effect of gastrin on colorectal cancer cells relates to an increased IEX-1 expression mediating NF-kappa B inhibition
Q35154638The biphasic role of NF-kappaB in progression and chemoresistance of ovarian cancer
Q35298106The complex interplay between autophagy and NF-κB signaling pathways in cancer cells
Q38126565The complexity of NF-κB signaling in inflammation and cancer
Q37976939The diverse and complex roles of NF-κB subunits in cancer
Q36135801The diverse and complex roles of radiation on cancer treatment: therapeutic target and genome maintenance
Q35931850The homeoprotein DLX4 stimulates NF-κB activation and CD44-mediated tumor-mesothelial cell interactions in ovarian cancer
Q90584188The relationship between members of the canonical NF-kB pathway, tumour microenvironment and cancer specific survival in colorectal cancer patients
Q33779333The relationship between members of the canonical NF-κB pathway, components of tumour microenvironment and survival in patients with invasive ductal breast cancer
Q38274559The role of RelA (p65) threonine 505 phosphorylation in the regulation of cell growth, survival, and migration
Q38334119The role of hypoxia in inflammatory disease (review)
Q47347524The role of αB-crystallin in skeletal and cardiac muscle tissues
Q35546228Theaflavin Inhibits LPS-Induced IL-6, MCP-1, and ICAM-1 Expression in Bone Marrow-Derived Macrophages Through the Blockade of NF-κB and MAPK Signaling Pathways
Q38950831Tinospora cordifolia Induces Differentiation and Senescence Pathways in Neuroblastoma Cells
Q28086858To be an ally or an adversary in bladder cancer: the NF-κB story has not unfolded
Q33411305Tomato lycopene extract prevents lipopolysaccharide-induced NF-kappaB signaling but worsens dextran sulfate sodium-induced colitis in NF-kappaBEGFP mice
Q39669128Toxicity and efficiency study of plant extracts-based bleaching agents.
Q33269185Transcriptional profiling of the LPS induced NF-kappaB response in macrophages
Q37720331Transcriptome remodeling in hypoxic inflammation
Q52538370Unlocking the NF-κB Conundrum: Embracing Complexity to Achieve Specificity.
Q40150799Upregulation of Twist-1 by NF-kappaB blocks cytotoxicity induced by chemotherapeutic drugs
Q32944490Upregulation of miRNA-4776 in influenza virus infected bronchial epithelial cells is associated with downregulation of NFKBIB and increased viral survival
Q57802286Use of flow cytometry in the phenotypic diagnosis of hodgkin's lymphoma
Q47107773Vitamin D derivatives potentiate the anticancer and anti-angiogenic activity of tyrosine kinase inhibitors in combination with cytostatic drugs in an A549 non-small cell lung cancer model.
Q26827754When ubiquitin meets NF-κB: a trove for anti-cancer drug development
Q101476490c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis
Q35014215miR-9 and let-7g enhance the sensitivity to ionizing radiation by suppression of NFκB1
Q42852637p300-mediated acetylation of COMMD1 regulates its stability, and the ubiquitylation and nucleolar translocation of the RelA NF-κB subunit