Insights into the behaviour of systems biology models from dynamic sensitivity and identifiability analysis: a case study of an NF-kappaB signalling pathway.

scientific article published on 23 October 2006

Insights into the behaviour of systems biology models from dynamic sensitivity and identifiability analysis: a case study of an NF-kappaB signalling pathway. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1039/B609442B
P8608Fatcat IDrelease_pd27v6q6arffbjehdtwhrvzqcy
P698PubMed publication ID17216045
P5875ResearchGate publication ID6585553

P50authorDouglas KellQ5301676
Hong YueQ57058288
P2093author name stringDavid S Broomhead
Hong Wang
Martin Brown
Joshua Knowles
P2860cites workOscillations in NF-kappaB signaling control the dynamics of gene expressionQ28289121
Good cop, bad cop: the different faces of NF-kappaBQ28291669
The IkappaB-NF-kappaB signaling module: temporal control and selective gene activationQ29617813
Metabolomics, machine learning and modelling: towards an understanding of the language of cells.Q30350782
Synergistic control of oscillations in the NF-kappaB signalling pathwayQ33999638
The IKK NF-kappa B system: a treasure trove for drug developmentQ35621375
Identification of direct genomic targets downstream of the nuclear factor-kappaB transcription factor mediating tumor necrosis factor signaling.Q38330353
Importance of input perturbations and stochastic gene expression in the reverse engineering of genetic regulatory networks: insights from an identifiability analysis of an in silico networkQ40830283
Sensitivity analysis of stoichiometric networks: an extension of metabolic control analysis to non-steady state trajectories.Q46024499
Automated sensitivity analysis of stiff biochemical systems using a fourth-order adaptive step size Rosenbrock integration methodQ47320936
Mathematical model of NF-kappaB regulatory moduleQ47743296
A hybrid approach for efficient and robust parameter estimation in biochemical pathways.Q51334187
Computation and analysis of time-dependent sensitivities in Generalized Mass Action systems.Q51633466
Metabolic control theory: its role in microbiology and biotechnologyQ57393977
P433issue12
P921main subjectNF-κBQ411114
systems biologyQ815297
P304page(s)640-649
P577publication date2006-10-23
P1433published inMolecular BioSystemsQ3319467
P1476titleInsights into the behaviour of systems biology models from dynamic sensitivity and identifiability analysis: a case study of an NF-kappaB signalling pathway.
P478volume2

Reverse relations

cites work (P2860)
Q44861355A delay differential equation model of follicle waves in women
Q41863869A model of redox kinetics implicates the thiol proteome in cellular hydrogen peroxide responses
Q41782218A practical approach to parameter estimation applied to model predicting heart rate regulation
Q42157491A systematic survey of the response of a model NF-κB signalling pathway to TNFα stimulation.
Q35127856BioPreDyn-bench: a suite of benchmark problems for dynamic modelling in systems biology
Q41834754Bone balance within a cortical BMU: local controls of bone resorption and formation.
Q52336859Calculated cell-specific intracellular hydrogen peroxide concentration: Relevance in cancer cell susceptibility during ascorbate therapy.
Q92134153Coupled feedback regulation of nuclear factor of activated T-cells (NFAT) modulates activation-induced cell death of T cells
Q33510476Developing optimal input design strategies in cancer systems biology with applications to microfluidic device engineering
Q34060651Inference of complex biological networks: distinguishability issues and optimization-based solutions
Q38526804Information-theoretic sensitivity analysis: a general method for credit assignment in complex networks
Q57261267Integration of sensitivity and bifurcation analysis to detect critical processes in a model combining signalling and cell population dynamics
Q28388335Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases
Q43100347Mapping global sensitivity of cellular network dynamics: sensitivity heat maps and a global summation law.
Q36100503Model-based global sensitivity analysis as applied to identification of anti-cancer drug targets and biomarkers of drug resistance in the ErbB2/3 network
Q64963498Monte Carlo Simulations for the Analysis of Non-linear Parameter Confidence Intervals in Optimal Experimental Design.
Q35910074Mutation-induced protein interaction kinetics changes affect apoptotic network dynamic properties and facilitate oncogenesis
Q34505131Non Linear Programming (NLP) formulation for quantitative modeling of protein signal transduction pathways
Q35117793ON IDENTIFIABILITY OF NONLINEAR ODE MODELS AND APPLICATIONS IN VIRAL DYNAMICS.
Q36762550Oscillations in the immune system
Q33800036Parameter estimation in systems biology models using spline approximation.
Q42716597Propagation of kinetic uncertainties through a canonical topology of the TLR4 signaling network in different regions of biochemical reaction space
Q51898580Proximate parameter tuning for biochemical networks with uncertain kinetic parameters.
Q33951081Quantitative characterization and analysis of the dynamic NF-κB response in microglia
Q27340050Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states
Q34999703Simultaneous parameters identifiability and estimation of an E. coli metabolic network model
Q36419726Sloppy models, parameter uncertainty, and the role of experimental design
Q34614983Structural correlation method for model reduction and practical estimation of patient specific parameters illustrated on heart rate regulation
Q46444670Structured model and parameter estimation in plant cell cultures of Thevetia peruviana
Q33441988Systematic identifiability testing for unambiguous mechanistic modeling--application to JAK-STAT, MAP kinase, and NF-kappaB signaling pathway models
Q33891519Systems engineering medicine: engineering the inflammation response to infectious and traumatic challenges
Q24289511Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples
Q33846654Understanding dynamics using sensitivity analysis: caveat and solution
Q39391481Unscented Kalman filter with parameter identifiability analysis for the estimation of multiple parameters in kinetic models