p300-mediated acetylation of COMMD1 regulates its stability, and the ubiquitylation and nucleolar translocation of the RelA NF-κB subunit

scientific article published on 29 July 2014

p300-mediated acetylation of COMMD1 regulates its stability, and the ubiquitylation and nucleolar translocation of the RelA NF-κB subunit is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1242/JCS.149328
P932PMC publication ID4150058
P698PubMed publication ID25074812
P5875ResearchGate publication ID264392453

P50authorAnn C WilliamsQ61109139
P2093author name stringAndrew O'Hara
Pierre Morin
Carolyn J Loveridge
Lesley A Stark
James Simpson
Sonia M Novo
P2860cites workXIAP: cell death regulation meets copper homeostasisQ24300814
A novel role for XIAP in copper homeostasis through regulation of MURR1Q24302274
Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53Q24310030
Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunitQ24317508
COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligaseQ24337774
Nucleolar sequestration of RelA (p65) regulates NF-kappaB-driven transcription and apoptosisQ28182225
p38-mediated inactivation of cyclin D1/cyclin-dependent kinase 4 stimulates nucleolar translocation of RelA and apoptosis in colorectal cancer cellsQ28219173
Good cop, bad cop: the different faces of NF-kappaBQ28291669
Regulation of NF-κB activity by competition between RelA acetylation and ubiquitinationQ28511500
Shaping the nuclear action of NF-kappaBQ29614600
GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kappaB/RelAQ30438310
The puzzle posed by COMMD1, a newly discovered protein binding Cu(II).Q33350537
The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activationQ33733316
Copper metabolism domain-containing 1 represses genes that promote inflammation and protects mice from colitis and colitis-associated cancerQ33861612
Phosphorylation of NF-kappaB p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal eliminationQ34959023
Degradation of promoter-bound p65/RelA is essential for the prompt termination of the nuclear factor kappaB responseQ36403968
Deubiquitination of NF-κB by Ubiquitin-Specific Protease-7 promotes transcriptionQ36535326
Posttranslational modifications of NF-kappaB: another layer of regulation for NF-kappaB signaling pathwayQ37723806
Effect of aspirin and NSAIDs on risk and survival from colorectal cancerQ37789123
Tuning NF-κB activity: a touch of COMMD proteinsQ38147699
Nucleolar NF-κB/RelA mediates apoptosis by causing cytoplasmic relocalization of nucleophosminQ39067763
COMMD1 disrupts HIF-1alpha/beta dimerization and inhibits human tumor cell invasionQ39705482
Functional interplay between acetylation and methylation of the RelA subunit of NF-kappaB.Q39738771
Nucleolar targeting of RelA(p65) is regulated by COMMD1-dependent ubiquitinationQ39756182
The proapoptotic effects of sulindac, sulindac sulfone and indomethacin are mediated by nucleolar translocation of the RelA(p65) subunit of NF-kappaB.Q40039714
Gene expression profiling of liver cells after copper overload in vivo and in vitro reveals new copper-regulated genesQ40185193
Neoplastic transformation of a human colonic epithelial cell line: in vitro evidence for the adenoma to carcinoma sequence.Q41725839
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P433issuePt 17
P407language of work or nameEnglishQ1860
P921main subjectNF-κBQ411114
ubiquitinationQ33059483
P304page(s)3659-3665
P577publication date2014-07-29
P1433published inJournal of Cell ScienceQ1524177
P1476titlep300-mediated acetylation of COMMD1 regulates its stability, and the ubiquitylation and nucleolar translocation of the RelA NF-κB subunit
P478volume127

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cites work (P2860)
Q50949247A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-κB degradation and cell growth suppression in neuroblastoma.
Q42709414Beclin 1 acetylation impairs the anticancer effect of aspirin in colorectal cancer cells
Q35076655COMMD1/Murr1 reinforces HIV-1 latent infection through IκB-α stabilization
Q46360947COMMD1: A Multifunctional Regulatory Protein.
Q57297294Crosstalk between NF-κB and Nucleoli in the Regulation of Cellular Homeostasis
Q41697013Ex vivo treatment of patient biopsies as a novel method to assess colorectal tumour response to the MEK1/2 inhibitor, Selumetinib
Q99411662Investigating potential molecular mechanisms of serum exosomal miRNAs in colorectal cancer based on bioinformatics analysis
Q48181924MDM2 Degrades Deacetylated Nucleolin Through Ubiquitination to Promote Glioma Stem-Like Cell Enrichment for Chemotherapeutic Resistance.
Q96950415Overcoming cancer therapeutic bottleneck by drug repurposing
Q36115749SUMOylation-disrupting WAS mutation converts WASp from a transcriptional activator to a repressor of NF-κB response genes in T cells

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