Nucleolar sequestration of RelA (p65) regulates NF-kappaB-driven transcription and apoptosis

scientific article (publication date: July 2005)

Nucleolar sequestration of RelA (p65) regulates NF-kappaB-driven transcription and apoptosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.25.14.5985-6004.2005
P3181OpenCitations bibliographic resource ID1678037
P932PMC publication ID1168799
P698PubMed publication ID15988014

P50authorMalcolm G. DunlopQ37371270
P2093author name stringLesley A Stark
P2860cites workIdentification of a novel protein from glial cells based on its ability to interact with NF‐κB subunitsrQ24299995
Identification of nucleophosmin as an NF-kappaB co-activator for the induction of the human SOD2 geneQ24337067
In vivo analysis of NHPX reveals a novel nucleolar localization pathway involving a transient accumulation in splicing specklesQ24671777
Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB.Q28118359
Sulindac inhibits activation of the NF-kappaB pathwayQ28162606
Increased NF-κB DNA binding but not transcriptional activity during apoptosis induced by the COX-2-selective inhibitor NS-398 in colorectal carcinoma cellsQ28165527
Evidence for colorectal cancer cell specificity of aspirin effects on NF kappa B signalling and apoptosisQ28168893
Aspirin-induced activation of the NF-kappaB signaling pathway: a novel mechanism for aspirin-mediated apoptosis in colon cancer cellsQ28183225
Nucleolar localization and mobility analysis of the NF-kappaB repressing factor NRFQ28269469
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κBQ28508403
UV stimulation of nucleophosmin/B23 expression is an immediate-early gene response induced by damaged DNAQ28588776
Activators and target genes of Rel/NF-kappaB transcription factorsQ29547882
Shaping the nuclear action of NF-kappaBQ29614600
NF-kappaB in cancer: from innocent bystander to major culpritQ29614603
Inhibition of NF-kappa B by sodium salicylate and aspirinQ29614708
The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-betaQ29617188
Does the ribosome translate cancer?Q29618775
NF-kappa B: a lesson in family valuesQ29620228
Pro-inflammatory signaling: last pieces in the NF-kappaB puzzle?Q33368441
How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complexQ33797139
Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.Q34285636
Nuclear trafficking of La protein depends on a newly identified nucleolar localization signal and the ability to bind RNA.Q34310515
The contribution of nuclear compartmentalization to gene regulationQ34574321
Dynamics of chromatin, proteins, and bodies within the cell nucleusQ35145827
p19ARF targets certain E2F species for degradation.Q35260543
NF-kappaB: tumor promoter or suppressor?Q35753163
Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanismsQ36634373
Regulation of RelA subcellular localization by a putative nuclear export signal and p50.Q39448268
Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.Q39451903
Cytosolic, nuclear and nucleolar localization signals determine subcellular distribution and activity of the NF-kappaB inducing kinase NIK.Q40536131
Myc-ARF (alternate reading frame) interaction inhibits the functions of Myc.Q40544963
Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B.Q40571746
p53 stabilization is decreased upon NFkappaB activation: a role for NFkappaB in acquisition of resistance to chemotherapyQ40717571
Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosisQ41189266
Identification of lysine residues required for signal-induced ubiquitination and degradation of I kappa B-alpha in vivoQ41192799
Protein kinase CK2 promotes aberrant activation of nuclear factor-kappaB, transformed phenotype, and survival of breast cancer cells.Q42527969
Dual roles for NF-kappaB activation in osteoblastic cells by serum deprivation: osteoblastic apoptosis and cell-cycle arrestQ42827095
Accumulation of soluble and nucleolar-associated p53 proteins following cellular stress.Q43592681
Celecoxib loses its anti-inflammatory efficacy at high doses through activation of NF-kappaB.Q43654472
Human p14(Arf): an exquisite sensor of morphological changes and of short-lived perturbations in cell cycle and in nucleolar functionQ44165071
Temporal pattern of NFkappaB activation influences apoptotic cell fate in a stimuli-dependent fashionQ44216722
NF-kappaB kinetics predetermine TNF-alpha sensitivity of colorectal cancer cellsQ45871895
The p14ARF tumor suppressor protein facilitates nucleolar sequestration of hypoxia-inducible factor-1alpha (HIF-1alpha ) and inhibits HIF-1-mediated transcriptionQ46504176
CK2 Is a C-Terminal IκB Kinase Responsible for NF-κB Activation during the UV ResponseQ46589615
Role of IkappaBalpha ubiquitination in signal-induced activation of NFkappaB in vivoQ47070611
Role of NF-κB in p53-mediated programmed cell deathQ57248006
p53- and Mdm2-Independent Repression of NF-κB Transactivation by the ARF Tumor SuppressorQ58287158
Nuclear Retention of IκBα Protects It from Signal-induced Degradation and Inhibits Nuclear Factor κB Transcriptional ActivationQ60304974
NF-kappaB, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polypsQ63916236
Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaBQ64381570
Activation of nuclear factor kappaB in single living cells. Dependence of nuclear translocation and anti-apoptotic function on EGFPRELA concentrationQ73297580
Non-activated p53 co-localizes with sites of transcription within both the nucleoplasm and the nucleolusQ73379071
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
NF-κBQ411114
apoptotic processQ14599311
P304page(s)5985-6004
P577publication date2005-07-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleNucleolar sequestration of RelA (p65) regulates NF-kappaB-driven transcription and apoptosis
P478volume25

Reverse relations

cites work (P2860)
Q34974010A randomized placebo-controlled prevention trial of aspirin and/or resistant starch in young people with familial adenomatous polyposis
Q55439392Aspirin Prevention of Colorectal Cancer: Focus on NF-κB Signalling and the Nucleolus.
Q39675144Characterization and prediction of protein nucleolar localization sequences.
Q57297294Crosstalk between NF-κB and Nucleoli in the Regulation of Cellular Homeostasis
Q36637900Current insights into the regulation of programmed cell death by NF-kappaB.
Q34936210Dynamic localisation of mature microRNAs in Human nucleoli is influenced by exogenous genetic materials.
Q41697013Ex vivo treatment of patient biopsies as a novel method to assess colorectal tumour response to the MEK1/2 inhibitor, Selumetinib
Q39291225Formononetin attenuates IL-1β-induced apoptosis and NF-κB activation in INS-1 cells.
Q28388105Gadd45 proteins as critical signal transducers linking NF-kappaB to MAPK cascades
Q35860667Gene network inference and visualization tools for biologists: application to new human transcriptome datasets.
Q34441487Genome-wide analysis of androgen receptor targets reveals COUP-TF1 as a novel player in human prostate cancer
Q46863397Glutamate induces oxidative stress and apoptosis in cerebral vascular endothelial cells: contributions of HO-1 and HO-2 to cytoprotection
Q28291669Good cop, bad cop: the different faces of NF-kappaB
Q48478299HO-2 provides endogenous protection against oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells
Q34808205Ibuprofen inhibits activation of nuclear {beta}-catenin in human colon adenomas and induces the phosphorylation of GSK-3{beta}.
Q64996434Identification of a novel TIF-IA-NF-κB nucleolar stress response pathway.
Q35898212Induction of p53-independent apoptosis by ectopic expression of HOXA5 in human liposarcomas
Q28082431Insights into the regulation of neuronal viability by nucleophosmin/B23
Q36868559Many faces of NF-kappaB signaling induced by genotoxic stress
Q34013972NF-kappaB activation enhances cell death by antimitotic drugs in human prostate cancer cells
Q28297985NF-kappaB and IKK as therapeutic targets in cancer
Q81768343NF-kappaB in carcinoma therapy and prevention
Q52351759NF-κB pathways in the development and progression of colorectal cancer.
Q27865187Nuclear and nucleolar targeting of influenza A virus NS1 protein: striking differences between different virus subtypes
Q36637905Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression
Q34662321Nuclear factor-kappaB sensitizes to benzyl isothiocyanate-induced antiproliferation in p53-deficient colorectal cancer cells
Q39067763Nucleolar NF-κB/RelA mediates apoptosis by causing cytoplasmic relocalization of nucleophosmin
Q91869139Nucleolar Sequestration: Remodeling Nucleoli Into Amyloid Bodies
Q28506343Nucleolar release of Hand1 acts as a molecular switch to determine cell fate
Q36781105Nucleolar repression facilitates initiation and maintenance of senescence
Q58577976Nucleoli in embryos: a central structural platform for embryonic chromatin remodeling?
Q37514072Nucleophosmin Mutations Induce Chemosensitivity in THP-1 Leukemia Cells by Suppressing NF-κB Activity and Regulating Bax/Bcl-2 Expression
Q43213955Old and new faces of the nucleolus. Workshop on the Nucleolus and Disease
Q41439912Opposite Effects of SET7/9 on Apoptosis of Human Acute Myeloid Leukemia Cells and Lung Cancer Cells
Q30651049Prostaglandins regulate nuclear localization of Fascin and its function in nucleolar architecture
Q28569360RNA polymerase 1-driven transcription as a mediator of BDNF-induced neurite outgrowth
Q39182053Reducing Peripheral Inflammation with Infliximab Reduces Neuroinflammation and Improves Cognition in Rats with Hepatic Encephalopathy
Q21134929Revisiting G3BP1 as a RasGAP binding protein: sensitization of tumor cells to chemotherapy by the RasGAP 317-326 sequence does not involve G3BP1
Q37497981Sulindac activates NF-κB signaling in colon cancer cells
Q26748938The Ubiquitination of NF-κB Subunits in the Control of Transcription
Q35154638The biphasic role of NF-kappaB in progression and chemoresistance of ovarian cancer
Q37484539The cell's nucleolus: an emerging target for chemotherapeutic intervention
Q24609491The nucleolar detention pathway: A cellular strategy for regulating molecular networks
Q40039714The proapoptotic effects of sulindac, sulindac sulfone and indomethacin are mediated by nucleolar translocation of the RelA(p65) subunit of NF-kappaB.
Q27009508Transcriptional regulation by the Set7 lysine methyltransferase
Q30540340UV-C irradiation delays mitotic progression by recruiting Mps1 to kinetochores
Q92646341Various Nucleolar Stress Inducers Result in Highly Distinct Changes in Water, Dry Mass and Elemental Content in Cancerous Cell Compartments: Investigation Using a Nano-Analytical Approach
Q97692796Yolk sac-derived Pdcd11-positive cells modulate zebrafish microglia differentiation through the NF-κB-Tgfβ1 pathway
Q42852637p300-mediated acetylation of COMMD1 regulates its stability, and the ubiquitylation and nucleolar translocation of the RelA NF-κB subunit

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