Modified vaccinia virus Ankara can activate NF-kappaB transcription factors through a double-stranded RNA-activated protein kinase (PKR)-dependent pathway during the early phase of virus replication

scientific article published on September 2009

Modified vaccinia virus Ankara can activate NF-kappaB transcription factors through a double-stranded RNA-activated protein kinase (PKR)-dependent pathway during the early phase of virus replication is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.VIROL.2009.06.012
P932PMC publication ID2765328
P698PubMed publication ID19596385
P5875ResearchGate publication ID26665097

P50authorBryan WilliamsQ27840138
Anthony J SadlerQ62748460
Justin PollaraQ114519514
David J PickupQ120587566
P2093author name stringCaroline A Ray
Ian T D Petty
Heather E Lynch
Katrina L Oie
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Microarray analysis reveals characteristic changes of host cell gene expression in response to attenuated modified vaccinia virus Ankara infection of human HeLa cells.Q38341228
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The block in assembly of modified vaccinia virus Ankara in HeLa cells reveals new insights into vaccinia virus morphogenesisQ39753058
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Cowpox virus and other members of the orthopoxvirus genus interfere with the regulation of NF-kappaB activationQ40781958
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Vaccinia virus host range genesQ41716592
Cowpox virus contains two copies of an early gene encoding a soluble secreted form of the type II TNF receptorQ42601211
IRF-1 induced cell growth inhibition and interferon induction requires the activity of the protein kinase PKR.Q42825330
Double-stranded RNA-binding protein E3 controls translation of viral intermediate RNA, marking an essential step in the life cycle of modified vaccinia virus AnkaraQ43894392
The cowpox virus host range gene, CP77, affects phosphorylation of eIF2 alpha and vaccinia viral translation in apoptotic HeLa cellsQ45090422
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Vaccinia virus-encoded elF-2α homolog abrogates the antiviral effect of interferonQ45859752
NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signalingQ46820406
Tumor necrosis factor receptor p75 mediates cell-specific activation of nuclear factor kappa B and induction of human cytomegalovirus enhancerQ72287816
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The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2Q33930433
Cowpox virus encodes a fifth member of the tumor necrosis factor receptor family: a soluble, secreted CD30 homologueQ34032643
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Immunology 101 at poxvirus U: immune evasion genesQ34209968
The complete genomic sequence of the modified vaccinia Ankara strain: comparison with other orthopoxvirusesQ34469355
Circuitry of nuclear factor kappaB signalingQ34514908
Poxviral regulation of the host NF-kappaB response: the vaccinia virus M2L protein inhibits induction of NF-kappaB activation via an ERK2 pathway in virus-infected human embryonic kidney cells.Q35024097
Vaccinia virus infection attenuates innate immune responses and antigen presentation by epidermal dendritic cellsQ35101495
Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.Q35566028
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Double-stranded RNA is a trigger for apoptosis in vaccinia virus-infected cells.Q35878092
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Induction of protein kinase PKR-dependent activation of interferon regulatory factor 3 by vaccinia virus occurs through adapter IPS-1 signalingQ37000233
The vaccinia virus K1L gene product inhibits host NF-kappaB activation by preventing IkappaBalpha degradationQ37010771
Nonreplicating vaccinia vector efficiently expresses recombinant genesQ37299518
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P433issue2
P407language of work or nameEnglishQ1860
P921main subjectNF-κBQ411114
Vaccinia virusQ1986297
P304page(s)177-186
P577publication date2009-09-01
P1433published inVirologyQ7934867
P1476titleModified vaccinia virus Ankara can activate NF-kappaB transcription factors through a double-stranded RNA-activated protein kinase (PKR)-dependent pathway during the early phase of virus replication
P478volume391

Reverse relations

cites work (P2860)
Q38780546CCL2 expression is mediated by type I IFN receptor and recruits NK and T cells to the lung during MVA infection
Q35539329Cowpox virus induces interleukin-10 both in vitro and in vivo
Q36961137Cowpox virus inhibits human dendritic cell immune function by nonlethal, nonproductive infection.
Q37944321Innate immune recognition of poxviral vaccine vectors
Q38092466Modified Vaccinia virus Ankara: innate immune activation and induction of cellular signalling
Q35151746Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway
Q35962511Production of prostaglandin E₂ in response to infection with modified vaccinia Ankara virus
Q34262138Rapid expansion of CD8+ T cells in wild-type and type I interferon receptor-deficient mice correlates with protection after low-dose emergency immunization with modified vaccinia virus Ankara
Q34594898Recombinant modified vaccinia virus Ankara generating excess early double-stranded RNA transiently activates protein kinase R and triggers enhanced innate immune responses.
Q35800430Selection of recombinant MVA by rescue of the essential D4R gene
Q34780607Smallpox vaccines: targets of protective immunity
Q39323853The C11R gene, which encodes the vaccinia virus growth factor, is partially responsible for MVA-induced NF-κB and ERK2 activation.
Q36675284The modulation of hepatitis C virus 1a replication by PKR is dependent on NF-kB mediated interferon beta response in Huh7.5.1 cells
Q38620980Use of functional genomics to understand replication deficient poxvirus-host interactions
Q24609947Viral double-stranded RNAs from vaccinia virus early or intermediate gene transcripts possess PKR activating function, resulting in NF-kappaB activation, when the K1 protein is absent or mutated

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