Millepachine, a potential topoisomerase II inhibitor induces apoptosis via activation of NF-κB pathway in ovarian cancer

scientific article published on 20 July 2016

Millepachine, a potential topoisomerase II inhibitor induces apoptosis via activation of NF-κB pathway in ovarian cancer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.10739
P932PMC publication ID5239551
P698PubMed publication ID27447570

P2093author name stringXiaoyan Wang
Lijuan Chen
Yuquan Wei
Haoyu Ye
Buyun Ma
Jingqiang Zhu
Jianhong Yang
Wenshuang Wu
Taijin Wang
P2860cites workThe DNA-damage response in human biology and diseaseQ24606586
Structural basis of type II topoisomerase inhibition by the anticancer drug etoposideQ27670929
The DNA Damage Response: Making It Safe to Play with KnivesQ27861055
ATM and ATR: networking cellular responses to DNA damageQ28143424
The DNA damage response: ten years afterQ28261230
Good cop, bad cop: the different faces of NF-kappaBQ28291669
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaksQ29614215
Cancer. p53, guardian of the genomeQ29615610
The NF-κB inhibitor SC75741 efficiently blocks influenza virus propagation and confers a high barrier for development of viral resistanceQ30425939
NF-kappaB activation by double-strand breaksQ33343137
Phosphatases in the cellular response to DNA damage.Q34198570
Cytometric assessment of DNA damage in relation to cell cycle phase and apoptosisQ34334647
PIDD mediates NF-kappaB activation in response to DNA damageQ34477303
Circumventing tumor resistance to chemotherapy by nanotechnologyQ34618357
Activation and regulation of ATM kinase activity in response to DNA double-strand breaksQ34722727
EBV-driven LMP1 and IFN-γ up-regulate PD-L1 in nasopharyngeal carcinoma: Implications for oncotargeted therapyQ35067875
Repair of endogenous DNA damageQ35132488
Catalytic topoisomerase II inhibitors in cancer therapy.Q35187762
Characteristics of gamma-H2AX foci at DNA double-strand breaks sitesQ35191534
DNA damage tumor suppressor genes and genomic instabilityQ35755997
Identification of a novel pro-apopotic function of NF-kappaB in the DNA damage responseQ35832054
Chromosomal aberrations and genomic instability induced by topoisomerase-targeted antitumour drugsQ35849665
Rethinking ovarian cancer: recommendations for improving outcomesQ36050883
REV7 counteracts DNA double-strand break resection and affects PARP inhibitionQ36351056
IkappaB kinase complexes: gateways to NF-kappaB activation and transcriptionQ36637874
DNA repair pathways and their implication in cancer treatmentQ37785855
Regulation of NF-κB signaling by caspases and MALT1 paracaspaseQ37814066
DNA topoisomerases as anticancer drug targetsQ37901390
Various modes of cell death induced by DNA damageQ38064783
ATM and ATR as therapeutic targets in cancerQ38289832
PARP inhibitors: A new era of targeted therapyQ38364532
DNA polymerase η modulates replication fork progression and DNA damage responses in platinum-treated human cellsQ39061225
The comet assay: a comprehensive reviewQ40604761
Inflammatory signaling regulates hematopoietic stem and progenitor cell emergence in vertebratesQ41582148
Resistance of human ovarian cancer cells to tumor necrosis factor alpha is a consequence of nuclear factor kappaB-mediated induction of Fas-associated death domain-like interleukin-1beta-converting enzyme-like inhibitory proteinQ44285373
Different DNA lesions trigger distinct cell death responses in HCT116 colon carcinoma cellsQ44894534
The ATM protein is required for sustained activation of NF-kappaB following DNA damageQ48211878
Azatoxin is a mechanistic hybrid of the topoisomerase II-targeted anticancer drugs etoposide and ellipticine.Q52559484
Millepachine, a novel chalcone, induces G2/M arrest by inhibiting CDK1 activity and causing apoptosis via ROS-mitochondrial apoptotic pathway in human hepatocarcinoma cells in vitro and in vivo.Q54445373
A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell linesQ71805034
P433issue32
P407language of work or nameEnglishQ1860
P921main subjectovarian cancerQ172341
NF-κBQ411114
P304page(s)52281-52293
P577publication date2016-07-20
P1433published inOncotargetQ1573155
P1476titleMillepachine, a potential topoisomerase II inhibitor induces apoptosis via activation of NF-κB pathway in ovarian cancer
P478volume7

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cites work (P2860)
Q48707750Effects of metformin on endometrial cancer: Systematic review and meta-analysis
Q88701285Inhibitor of apoptosis proteins (IAPs) mediate collagen type XI alpha 1-driven cisplatin resistance in ovarian cancer