Cytokines as genetic modifiers in K5-/- mice and in human epidermolysis bullosa simplex

scientific article published on May 2009

Cytokines as genetic modifiers in K5-/- mice and in human epidermolysis bullosa simplex is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/HUMU.20981
P698PubMed publication ID19267394

P50authorLeena Bruckner-TudermanQ1812122
P2093author name stringThomas M Magin
Claudia Wohlenberg
Ursula Reuter
Wera Roth
P2860cites workLoss-of-function mutations in the keratin 5 gene lead to Dowling-Degos diseaseQ24540828
p120-catenin mediates inflammatory responses in the skinQ24647606
Macrophage inflammatory protein 3alpha is involved in the constitutive trafficking of epidermal langerhans cellsQ24671761
The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migrationQ28201887
CCL27-CCR10 interactions regulate T cell-mediated skin inflammationQ28217086
Thymus and activation regulated chemokine (TARC)/CCL17 and skin diseasesQ28253402
Good cop, bad cop: the different faces of NF-kappaBQ28291669
Acquisition of immune function during the development of the Langerhans cell network in neonatal miceQ28366015
Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent fashionQ28585367
A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growthQ28592102
The Human Intermediate Filament Database: comprehensive information on a gene family involved in many human diseases.Q30366056
Regulation of dendritic cell recruitment by chemokinesQ34505316
Keratins: a structural scaffold with emerging functions.Q35076346
Keratins and skin disordersQ35923500
The basal keratin network of stratified squamous epithelia: defining K15 function in the absence of K14.Q36235624
Current insights into the formation and breakdown of hemidesmosomes.Q36498608
Langerhans cells renew in the skin throughout life under steady-state conditionsQ36505129
Catenins: keeping cells from getting their signals crossedQ36644519
Structural and regulatory functions of keratins.Q36791981
Diseases of epidermal keratins and their linker proteinsQ36832566
Loss of p120 catenin and links to mitotic alterations, inflammation, and skin cancerQ36899976
Complete cytolysis and neonatal lethality in keratin 5 knockout mice reveal its fundamental role in skin integrity and in epidermolysis bullosa simplexQ38762092
p120 Catenin is required for growth factor-dependent cell motility and scattering in epithelial cellsQ39788653
KRT14 haploinsufficiency results in increased susceptibility of keratinocytes to TNF-alpha-induced apoptosis and causes Naegeli-Franceschetti-Jadassohn syndromeQ40042316
Constitutive expression and regulated release of the transmembrane chemokine CXCL16 in human and murine skinQ40158221
An autocrine/paracrine loop linking keratin 14 aggregates to tumor necrosis factor alpha-mediated cytotoxicity in a keratinocyte model of epidermolysis bullosa simplexQ40609811
A usual frameshift and delayed termination codon mutation in keratin 5 causes a novel type of epidermolysis bullosa simplex with migratory circinate erythema.Q42446267
Targeted deletion of the integrin beta4 signaling domain suppresses laminin-5-dependent nuclear entry of mitogen-activated protein kinases and NF-kappaB, causing defects in epidermal growth and migrationQ42480617
New insights into the molecular basis of desmoplakin- and desmin-related cardiomyopathies.Q50708085
TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2Q57198247
Induction of Inflammatory Cytokines by a Keratin Mutation and their Repression by a Small Molecule in a Mouse Model for EBSQ59591354
A frequent functional SNP in theMMP1promoter is associated with higher disease severity in recessive dystrophic epidermolysis bullosaQ61843807
P433issue5
P921main subjectepidermolysis bullosaQ923020
P304page(s)832-841
P577publication date2009-05-01
P1433published inHuman MutationQ5937269
P1476titleCytokines as genetic modifiers in K5-/- mice and in human epidermolysis bullosa simplex
P478volume30

Reverse relations

cites work (P2860)
Q27320939A Drosophila Model of Epidermolysis Bullosa Simplex.
Q84210782Animal models of epidermolysis bullosa: update 2010
Q36631641Animal models of skin disease for drug discovery.
Q35759101Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis
Q26852211Defining keratin protein function in skin epithelia: epidermolysis bullosa simplex and its aftermath
Q33888515Directed expression of a chimeric type II keratin partially rescues keratin 5-null mice
Q52615636Expression signature of epidermolysis bullosa simplex.
Q46103260Induction of phenotype modifying cytokines by FERMT1 mutations.
Q38768002Keratin 8-deletion induced colitis predisposes to murine colorectal cancer enforced by the inflammasome and IL-22 pathway
Q35125858Keratin gene mutations in disorders of human skin and its appendages
Q36580507Keratin intermediate filament proteins - novel regulators of inflammation and immunity in skin
Q38332150Keratins and skin disease.
Q28591014Keratins regulate protein biosynthesis through localization of GLUT1 and -3 upstream of AMP kinase and Raptor
Q33713926Mechanisms of fibroblast cell therapy for dystrophic epidermolysis bullosa: high stability of collagen VII favors long-term skin integrity
Q50875254Pro-Inflammatory Chemokines and Cytokines Dominate the Blister Fluid Molecular Signature in Patients with Epidermolysis Bullosa and Affect Leukocyte and Stem Cell Migration.
Q28393706Progress towards genetic and pharmacological therapies for keratin genodermatoses: current perspective and future promise
Q34319779The expanding significance of keratin intermediate filaments in normal and diseased epithelia
Q39740388The ubiquitin ligase CHIP/STUB1 targets mutant keratins for degradation.
Q64248984Unraveling the ECM-Immune Cell Crosstalk in Skin Diseases
Q52625823Verrucous carcinoma in epidermolysis bullosa simplex is possibly associated with a novel mutation in the keratin 5 gene.

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