| scholarly article | Q13442814 |
| P50 | author | Hirohito Yamaguchi | Q125291436 |
| Mien-Chie Hung | Q1532952 | ||
| P2093 | author name string | Jennifer L Hsu | |
| P2860 | cites work | FOXO3a mediates the androgen-dependent regulation of FLIP and contributes to TRAIL-induced apoptosis of LNCaP cells | Q39994736 |
| AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in precl | Q40093939 | ||
| Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1. | Q40206763 | ||
| IKKalpha stabilizes cytosolic beta-catenin by inhibiting both canonical and non-canonical degradation pathways | Q40292285 | ||
| Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activation | Q40439343 | ||
| Ubiquitin, proteasomes, and the regulation of intracellular protein degradation | Q40445002 | ||
| MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol | Q40537978 | ||
| Inhibition of Akt kinase signalling and activation of Forkhead are indispensable for upregulation of FasL expression in apoptosis of glioma cells. | Q40623335 | ||
| Akt activation promotes degradation of tuberin and FOXO3a via the proteasome | Q40679017 | ||
| PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest | Q40702262 | ||
| HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation | Q40767550 | ||
| Increased expression of Mcl-1 is responsible for the blockage of TRAIL-induced apoptosis mediated by EGF/ErbB1 signaling pathway | Q42798518 | ||
| Lipopolysaccharide activates Akt in human alveolar macrophages resulting in nuclear accumulation and transcriptional activity of beta-catenin | Q43545365 | ||
| Granulocyte macrophage colony-stimulating factor signaling and proteasome inhibition delay neutrophil apoptosis by increasing the stability of Mcl-1. | Q44840279 | ||
| Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. | Q46615053 | ||
| Epithelial-Mesenchymal Transitions in development and disease: old views and new perspectives. | Q51795587 | ||
| Wnt-beta-catenin signaling. | Q51947351 | ||
| Snail silencing effectively suppresses tumour growth and invasiveness. | Q54576035 | ||
| UV irradiation induces Snail expression by AP-1 dependent mechanism in human skin keratinocytes | Q54649125 | ||
| Ultraviolet radiation stimulates expression of Snail family transcription factors in keratinocytes | Q58394174 | ||
| Mdm2 induces mono-ubiquitination of FOXO4 | Q21092186 | ||
| Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor | Q22009126 | ||
| Emerging roles for the non-canonical IKKs in cancer | Q24305225 | ||
| Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition | Q24305416 | ||
| Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis | Q24306444 | ||
| p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma | Q24306453 | ||
| Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1 | Q24308005 | ||
| Identification of c- MYC as a Target of the APC Pathway | Q24310637 | ||
| Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion | Q24321517 | ||
| The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation | Q24324551 | ||
| IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a | Q24336832 | ||
| IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway | Q24337225 | ||
| Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls | Q24570128 | ||
| Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma | Q24597152 | ||
| Skp2: A novel potential therapeutic target for prostate cancer | Q24625558 | ||
| MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib | Q24646295 | ||
| Targeting the PI3K signaling pathway in cancer | Q24647554 | ||
| The basics of epithelial-mesenchymal transition | Q24652992 | ||
| RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis | Q26853207 | ||
| Mcl-1 ubiquitination and destruction | Q37879077 | ||
| FoxO transcription factors; Regulation by AKT and 14-3-3 proteins | Q37894891 | ||
| Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7. | Q39582682 | ||
| Overexpression of c-myc induces epithelial mesenchymal transition in mammary epithelial cells | Q39741671 | ||
| p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug | Q39850223 | ||
| MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation. | Q39868313 | ||
| Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation | Q39895438 | ||
| RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth | Q27659493 | ||
| Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery | Q27860586 | ||
| Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B | Q27860731 | ||
| Mutations of the BRAF gene in human cancer | Q27860760 | ||
| The ubiquitin system | Q27860803 | ||
| Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation | Q28117650 | ||
| AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation | Q28139447 | ||
| FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines | Q28207468 | ||
| Regulation of beta-catenin function by the IkappaB kinases | Q28214709 | ||
| Raf kinases in cancer-roles and therapeutic opportunities | Q28237793 | ||
| Regulation and function of IKK and IKK-related kinases | Q28268930 | ||
| The FoxO code | Q28275268 | ||
| Integrating cell-signalling pathways with NF-kappaB and IKK function | Q28280069 | ||
| FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis | Q28285131 | ||
| DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein | Q28577209 | ||
| Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway | Q28646919 | ||
| A brief introduction to FOXOlogy | Q29392646 | ||
| The BCL-2 protein family: opposing activities that mediate cell death | Q29547380 | ||
| Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? | Q29547559 | ||
| PI3K pathway alterations in cancer: variations on a theme | Q29615530 | ||
| FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress | Q29615562 | ||
| Mitogen-activated protein kinase pathways | Q29618431 | ||
| Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress | Q29619436 | ||
| ERBB receptors and cancer: the complexity of targeted inhibitors | Q29619520 | ||
| Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells | Q32084034 | ||
| Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1). | Q33606105 | ||
| Inhibition of FOXO3 tumor suppressor function by betaTrCP1 through ubiquitin-mediated degradation in a tumor mouse model | Q33631113 | ||
| The IKK complex, a central regulator of NF-kappaB activation | Q33693802 | ||
| Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation | Q33755125 | ||
| A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy | Q33833506 | ||
| Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer | Q33956177 | ||
| The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB | Q33959407 | ||
| Snail: More than EMT | Q33977450 | ||
| IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapy | Q34048503 | ||
| Snail family regulation and epithelial mesenchymal transitions in breast cancer progression | Q34095480 | ||
| Series introduction: the transcription factor NF-kappaB and human disease | Q34116362 | ||
| IKKalpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf. | Q34177562 | ||
| Development of anticancer drugs targeting the MAP kinase pathway | Q34293560 | ||
| Blocking oncogenic Ras signaling for cancer therapy | Q34311585 | ||
| EGFR and cancer prognosis | Q34399312 | ||
| SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction | Q34788849 | ||
| Beta-catenin hits chromatin: regulation of Wnt target gene activation | Q34967116 | ||
| Awakening guardian angels: drugging the p53 pathway | Q35014385 | ||
| The many forks in FOXO's road | Q35079447 | ||
| Epidermal growth factor regulates Mcl-1 expression through the MAPK-Elk-1 signalling pathway contributing to cell survival in breast cancer | Q35134513 | ||
| FOXO3a-Dependent Mechanism of E1A-Induced Chemosensitization | Q35622770 | ||
| Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression | Q35679187 | ||
| Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health | Q35679353 | ||
| Rapid turnover of mcl-1 couples translation to cell survival and apoptosis | Q35695499 | ||
| IKKα activation of NOTCH links tumorigenesis via FOXA2 suppression | Q35713747 | ||
| Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity | Q35748395 | ||
| Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization | Q35857019 | ||
| Perturbations of the AKT signaling pathway in human cancer | Q36313181 | ||
| FoxO tumor suppressors and BCR-ABL-induced leukemia: a matter of evasion of apoptosis | Q36334327 | ||
| Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB | Q36559932 | ||
| ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation | Q36647913 | ||
| Regulation of catalytic activities of HECT ubiquitin ligases | Q36714155 | ||
| The ubiquitous nature of cancer: the role of the SCF(Fbw7) complex in development and transformation | Q36836053 | ||
| Advances in targeting IKK and IKK-related kinases for cancer therapy | Q37036746 | ||
| FOXO animal models reveal a variety of diverse roles for FOXO transcription factors | Q37129810 | ||
| Down-regulation of myeloid cell leukemia-1 through inhibiting Erk/Pin 1 pathway by sorafenib facilitates chemosensitization in breast cancer | Q37177949 | ||
| Drug discovery approaches targeting the PI3K/Akt pathway in cancer | Q37270455 | ||
| Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer | Q37274280 | ||
| Adhesive and signaling functions of cadherins and catenins in vertebrate development. | Q37412685 | ||
| The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells | Q37452295 | ||
| Mdm2-mediated ubiquitylation: p53 and beyond. | Q37508606 | ||
| Proteomic analysis identifies that 14-3-3zeta interacts with beta-catenin and facilitates its activation by Akt. | Q37593591 | ||
| The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression | Q37614211 | ||
| Exploiting the balance between life and death: targeted cancer therapy and "oncogenic shock". | Q37704646 | ||
| EGFR tyrosine kinases inhibitors in cancer treatment: in vitro and in vivo evidence. | Q37825245 | ||
| P921 | main subject | protein ubiquitination | Q3547638 |
| P304 | page(s) | 15 | |
| P577 | publication date | 2012-02-20 | |
| P1433 | published in | Frontiers in Oncology | Q26839986 |
| P1476 | title | Regulation of ubiquitination-mediated protein degradation by survival kinases in cancer | |
| P478 | volume | 2 |
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| Q37457788 | Activin B promotes endometrial cancer cell migration by down-regulating E-cadherin via SMAD-independent MEK-ERK1/2-SNAIL signaling. |
| Q37180745 | Acute Ethanol Inhibition of γ Oscillations Is Mediated by Akt and GSK3β |
| Q58573362 | Biglycan Regulates MG63 Osteosarcoma Cell Growth Through a LPR6/β-Catenin/IGFR-IR Signaling Axis |
| Q57257740 | Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance |
| Q43527311 | Cullin 4B is a novel prognostic marker that correlates with colon cancer progression and pathogenesis |
| Q54978473 | Cypripedin diminishes an epithelial-to-mesenchymal transition in non-small cell lung cancer cells through suppression of Akt/GSK-3β signalling. |
| Q36041696 | Downregulation of ubiquitin-associated protein 2-like with a short hairpin RNA inhibits human glioma cell growth in vitro |
| Q50459269 | Erythropoietin reduces acute lung injury and multiple organ failure/dysfunction associated to a scald-burn inflammatory injury in the rat. |
| Q37237202 | Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity. |
| Q33598835 | Lentivirus-mediated RNA interference of tripartite motif 68 inhibits the proliferation of colorectal cancer cell lines SW1116 and HCT116 in vitro |
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| Q52685727 | NEDD4 promotes cell growth and motility in hepatocellular carcinoma |
| Q46491430 | Niclosamide Prevents Systemic Sclerosis in a Reactive Oxygen Species-Induced Mouse Model. |
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| Q39090006 | Up-regulation of tripartite motif-containing 29 promotes cancer cell proliferation and predicts poor survival in colorectal cancer |
| Q35781570 | miR-93 promotes cell proliferation in gliomas through activation of PI3K/Akt signaling pathway |
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