review article | Q7318358 |
scholarly article | Q13442814 |
P2093 | author name string | Stanley Lipkowitz | |
Allan M. Weissman | |||
P2860 | cites work | Mapping the functional domains of BRCA1. Interaction of the ring finger domains of BRCA1 and BARD1 | Q22008789 |
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis | Q22009936 | ||
RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination | Q22010577 | ||
Hallmarks of Cancer: The Next Generation | Q22252312 | ||
Identification of a cryptic nucleolar-localization signal in MDM2 | Q22253304 | ||
Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53 | Q22253350 | ||
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing | Q24291102 | ||
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation | Q24291783 | ||
Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex | Q24292279 | ||
The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways | Q24294805 | ||
E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1) | Q24296663 | ||
Cbl and human myeloid neoplasms: the Cbl oncogene comes of age. | Q33925815 | ||
Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development | Q33946999 | ||
The p53 orchestra: Mdm2 and Mdmx set the tone | Q34020353 | ||
The genetic basis of kidney cancer: a metabolic disease | Q34087148 | ||
Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells | Q34136434 | ||
Deregulated degradation of the cdk inhibitor p27 and malignant transformation. | Q34167777 | ||
Parc: a cytoplasmic anchor for p53. | Q34170344 | ||
BRCA1 and BRCA2 and the genetics of breast and ovarian cancer | Q34189009 | ||
Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu | Q34190181 | ||
Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma. | Q34277639 | ||
Structural model of the UbcH5B/CNOT4 complex revealed by combining NMR, mutagenesis, and docking approaches. | Q34310787 | ||
Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations | Q34317446 | ||
Tumor suppression and normal aging in mice with constitutively high p53 activity | Q34324057 | ||
Expression of Pirh2, a newly identified ubiquitin protein ligase, in lung cancer. | Q34368432 | ||
Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitors | Q34379259 | ||
Activation of estrogen signaling pathways collaborates with loss of Brca1 to promote development of ERalpha-negative and ERalpha-positive mammary preneoplasia and cancer | Q34609774 | ||
Role of FLT3 in leukemia | Q34664542 | ||
CUL7 is a novel antiapoptotic oncogene | Q34702306 | ||
Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice. | Q34761024 | ||
BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP | Q34863348 | ||
Alterations of anaphase-promoting complex genes in human colon cancer cells | Q24297514 | ||
Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL | Q24299061 | ||
UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation | Q24300065 | ||
WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase | Q24316117 | ||
Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase | Q24316238 | ||
The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8 | Q24320007 | ||
Mdm2 promotes the rapid degradation of p53 | Q24322597 | ||
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53 | Q24328775 | ||
An essential function of the extreme C-terminus of MDM2 can be provided by MDMX | Q24328822 | ||
CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex | Q24336508 | ||
Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C | Q24336712 | ||
Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2 | Q24337575 | ||
Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents | Q24337605 | ||
A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair | Q24337655 | ||
Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3 | Q24538330 | ||
The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins | Q24564802 | ||
Role of the F-box protein Skp2 in lymphomagenesis | Q24603883 | ||
v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas | Q24624849 | ||
Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands | Q24631957 | ||
How the fanconi anemia pathway guards the genome | Q24634556 | ||
Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl: implications for Cbl's function and oncogenicity | Q24645473 | ||
Control of cell growth by the SCF and APC/C ubiquitin ligases | Q24647543 | ||
Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer | Q24648025 | ||
SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation | Q24653723 | ||
Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex | Q24654714 | ||
Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth | Q24800550 | ||
Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases | Q27626747 | ||
Structure of a BRCA1-BARD1 heterodimeric RING-RING complex | Q27635007 | ||
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2 | Q27642888 | ||
Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans | Q27649717 | ||
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers | Q27851474 | ||
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy | Q27860519 | ||
Regulation of p53 stability by Mdm2 | Q27860744 | ||
Wnt/beta-catenin signaling in development and disease | Q27860784 | ||
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation | Q27860876 | ||
Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli | Q28116145 | ||
Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain | Q28119149 | ||
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase | Q28131711 | ||
The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7 | Q28138892 | ||
Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase | Q28139082 | ||
MDM2 interacts with MDMX through their RING finger domains | Q28142437 | ||
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase | Q28145635 | ||
Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7 | Q28146026 | ||
Oncogenic kinase signalling | Q28189493 | ||
Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex | Q28199187 | ||
Role of direct interaction in BRCA1 inhibition of estrogen receptor activity | Q28204456 | ||
The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation | Q28207617 | ||
ErbB2 degradation mediated by the co-chaperone protein CHIP | Q28208008 | ||
Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein | Q28214794 | ||
Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells | Q28253606 | ||
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53 | Q28266637 | ||
Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia | Q28267951 | ||
E2 conjugating enzymes must disengage from their E1 enzymes before E3-dependent ubiquitin and ubiquitin-like transfer | Q28270616 | ||
Amplification of a gene encoding a p53-associated protein in human sarcomas | Q28270924 | ||
Control of chromosome stability by the beta-TrCP-REST-Mad2 axis | Q28273354 | ||
Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5 | Q28276949 | ||
The Cbl interactome and its functions | Q28277251 | ||
Association of BRCA1 with Rad51 in mitotic and meiotic cells | Q28302118 | ||
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase | Q28506124 | ||
Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation | Q28609772 | ||
Negative regulation of prolactin receptor stability and signaling mediated by SCF(beta-TrCP) E3 ubiquitin ligase | Q28617041 | ||
Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway | Q28910446 | ||
Blinded by the Light: The Growing Complexity of p53 | Q29547590 | ||
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53 | Q29614430 | ||
Brca1 controls homology-directed DNA repair | Q29614844 | ||
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein | Q29615928 | ||
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability | Q29615945 | ||
FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation | Q29616127 | ||
Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1 | Q29617290 | ||
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53 | Q29617850 | ||
Ubiquitin ligases: cell-cycle control and cancer | Q29617992 | ||
The anaphase promoting complex/cyclosome: a machine designed to destroy | Q29618398 | ||
Identification of the von Hippel-Lindau disease tumor suppressor gene | Q29618644 | ||
c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor | Q29618661 | ||
Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage | Q29619360 | ||
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial | Q29619615 | ||
Nucleolar Arf sequesters Mdm2 and activates p53 | Q29620244 | ||
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial | Q30080035 | ||
The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme | Q30156839 | ||
Novel roles of hakai in cell proliferation and oncogenesis | Q30489228 | ||
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors. | Q33209208 | ||
CBL is frequently altered in lung cancers: its relationship to mutations in MET and EGFR tyrosine kinases | Q33528991 | ||
BRCA1 regulates acetylation and ubiquitination of estrogen receptor-alpha | Q33576505 | ||
The breast cancer susceptibility gene BRCA1 regulates progesterone receptor signaling in mammary epithelial cells | Q33652431 | ||
c-Cbl promotes T cell receptor-induced thymocyte apoptosis by activating the phosphatidylinositol 3-kinase/Akt pathway | Q33796333 | ||
Oncogenic activation of NF-kappaB. | Q33849388 | ||
Proteasome inhibitors in cancer therapy | Q34939959 | ||
Escape from Cbl-mediated downregulation: a recurrent theme for oncogenic deregulation of receptor tyrosine kinases | Q35169572 | ||
The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity | Q35201819 | ||
Signaling to p53: ribosomal proteins find their way. | Q35206381 | ||
The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity | Q35610627 | ||
Ablation of Cbl-b provides protection against transplanted and spontaneous tumors | Q35664087 | ||
Estrogen receptor alpha is a putative substrate for the BRCA1 ubiquitin ligase | Q35749504 | ||
Skp2 is oncogenic and overexpressed in human cancers | Q35862209 | ||
Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity | Q35865833 | ||
Anaphase-promoting complex-dependent proteolysis of cell cycle regulators and genomic instability of cancer cells | Q36002265 | ||
Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma. | Q36155317 | ||
Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells | Q36229277 | ||
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors | Q36229551 | ||
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53. | Q36347917 | ||
Regulating the regulator: negative regulation of Cbl ubiquitin ligases | Q36365848 | ||
Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity | Q36732343 | ||
Therapeutic targets in the ARF tumor suppressor pathway. | Q36879301 | ||
Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2. | Q36986557 | ||
IAPs as a target for anticancer therapy. | Q37065372 | ||
Mechanism of BRCA1-mediated inhibition of progesterone receptor transcriptional activity | Q37283603 | ||
Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene | Q37285776 | ||
Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein | Q37286026 | ||
The tumor suppressor gene TRC8/RNF139 is disrupted by a constitutional balanced translocation t(8;22)(q24.13;q11.21) in a young girl with dysgerminoma | Q37306830 | ||
Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma | Q37314736 | ||
Ubiquitin in trafficking: the network at work | Q37325110 | ||
BRCA1 and its toolbox for the maintenance of genome integrity | Q37507563 | ||
Mdm2-mediated ubiquitylation: p53 and beyond. | Q37508606 | ||
The multiple levels of regulation by p53 ubiquitination | Q37526379 | ||
Siah proteins: novel drug targets in the Ras and hypoxia pathways | Q37634198 | ||
COP1 is a tumour suppressor that causes degradation of ETS transcription factors | Q39542337 | ||
MDM2 antagonists boost antitumor effect of androgen withdrawal: implications for therapy of prostate cancer | Q39548990 | ||
Effect of MDM2 and vascular endothelial growth factor inhibition on tumor angiogenesis and metastasis in neuroblastoma | Q39560187 | ||
BIM(EL), an intrinsically disordered protein, is degraded by 20S proteasomes in the absence of poly-ubiquitylation. | Q39580598 | ||
Essential role of E3 ubiquitin ligase activity in Cbl-b-regulated T cell functions | Q39605573 | ||
The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress. | Q39762239 | ||
CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/myelodysplastic syndrome subtypes. | Q39874787 | ||
Regulated degradation of FANCM in the Fanconi anemia pathway during mitosis | Q39875666 | ||
The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation | Q40044913 | ||
The ubiquitin ligase SCF(betaTrCP) regulates the degradation of the growth hormone receptor | Q40133210 | ||
A role of estrogen/ERalpha signaling in BRCA1-associated tissue-specific tumor formation | Q40133909 | ||
Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist | Q40202330 | ||
Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells | Q40410781 | ||
Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors. | Q40585447 | ||
Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms | Q40773986 | ||
Cbl-b regulates the CD28 dependence of T-cell activation. | Q40904107 | ||
Tumour suppression by the human von Hippel-Lindau gene product | Q41320477 | ||
The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair | Q41914934 | ||
BARD1 homozygous deletion, a possible alternative to BRCA1 mutation in basal breast cancer | Q42477044 | ||
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms | Q42795736 | ||
Mutations of the VHL tumour suppressor gene in renal carcinoma | Q42806703 | ||
Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. A critical role for Cbl tyrosine kinase-binding domain | Q42815138 | ||
MDM4 (MDMX) is overexpressed in chronic lymphocytic leukaemia (CLL) and marks a subset of p53wild-type CLL with a poor cytotoxic response to Nutlin-3. | Q43052729 | ||
Mutation of the RAD51C gene in a Fanconi anemia-like disorder | Q43094703 | ||
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein | Q44043145 | ||
The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma | Q44043146 | ||
Endocytosis of Receptor Tyrosine Kinases Is Driven by Monoubiquitylation, Not Polyubiquitylation | Q44420471 | ||
Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. | Q44896717 | ||
Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction. | Q45179048 | ||
Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms | Q47960630 | ||
PARC and CUL7 form atypical cullin RING ligase complexes. | Q50336204 | ||
BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a brca1 transgene. | Q52537650 | ||
Breast cancer risk following bilateral oophorectomy in BRCA1 and BRCA2 mutation carriers: an international case-control study. | Q53265333 | ||
Genomic stability and tumour suppression by the APC/C cofactor Cdh1. | Q53471624 | ||
Myeloid Leukemia Development in c-Cbl RING Finger Mutant Mice Is Dependent on FLT3 Signaling | Q54642331 | ||
Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation. | Q54680719 | ||
Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification. | Q55476278 | ||
SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype | Q55671559 | ||
Flt3-dependent transformation by inactivating c-Cbl mutations in AML | Q57269958 | ||
Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b | Q59058408 | ||
Cancer predisposing BARD1 mutations in breast-ovarian cancer families | Q64386906 | ||
cbl-b inhibits EGF-receptor-induced apoptosis by enhancing ubiquitination and degradation of activated receptors | Q73133553 | ||
BRCA1 ubiquitylation of CtIP: Just the tIP of the iceberg? | Q79207429 | ||
Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide | Q79733375 | ||
Cancer predisposing missense and protein truncating BARD1 mutations in non-BRCA1 or BRCA2 breast cancer families | Q82528631 | ||
P433 | issue | 9 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 629-43 | |
P577 | publication date | 2011-08-24 | |
P1433 | published in | Nature Reviews Cancer | Q641657 |
P1476 | title | RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis | |
P478 | volume | 11 |
Q39181769 | A Comprehensive Guide to the MAGE Family of Ubiquitin Ligases |
Q37072912 | A fast workflow for identification and quantification of proteomes. |
Q38727581 | A hypoxia-responsive TRAF6-ATM-H2AX signalling axis promotes HIF1α activation, tumorigenesis and metastasis |
Q93197932 | A patent review of the ubiquitin ligase system: 2015-2018 |
Q38084210 | A portrayal of E3 ubiquitin ligases and deubiquitylases in cancer |
Q57666020 | A systems-wide screen identifies substrates of the SCF TrCP ubiquitin ligase |
Q58780400 | Abnormal regulation of BCR signalling by c-Cbl in chronic lymphocytic leukaemia |
Q50296653 | AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex |
Q39450797 | Advances of small molecule targeting of kinases. |
Q38052310 | Ambra1 at the crossroad between autophagy and cell death |
Q41628007 | Arsenite Binds to the RING Finger Domain of FANCL E3 Ubiquitin Ligase and Inhibits DNA Interstrand Crosslink Repair. |
Q52586912 | Arsenite Targets the RING Finger Domain of Rbx1 E3 Ubiquitin Ligase to Inhibit Proteasome-Mediated Degradation of Nrf2. |
Q34282520 | Arsenite binds to the RING finger domains of RNF20-RNF40 histone E3 ubiquitin ligase and inhibits DNA double-strand break repair |
Q46325087 | Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control |
Q35792362 | BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5. |
Q28592344 | BMP signaling controls muscle mass |
Q24622900 | Biological influence of Hakai in cancer: a 10-year review |
Q50296648 | CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus |
Q50296644 | CAND1 binds cytosolic CRL E3 ubiquitin ligases |
Q30414178 | CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration |
Q41060304 | CRL3IBTK Regulates the Tumor Suppressor Pdcd4 through Ubiquitylation Coupled to Proteasomal Degradation |
Q83388672 | Cbl exposes its RING finger |
Q64950200 | Cbl interacts with multiple E2s in vitro and in cells. |
Q38038873 | Cbl proteins in platelet activation |
Q34474505 | Cbl-c ubiquitin ligase activity is increased via the interaction of its RING finger domain with a LIM domain of the paxillin homolog, Hic 5. |
Q38112644 | Cbl-family proteins as regulators of cytoskeleton-dependent phenomena |
Q38935044 | Cbl-family ubiquitin ligases and their recruitment of CIN85 are largely dispensable for epidermal growth factor receptor endocytosis. |
Q33953067 | Cellular senescence and protein degradation: breaking down cancer |
Q34691368 | Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner. |
Q34981666 | Characterization of the Arabidopsis thaliana E3 ubiquitin-ligase AtSINAL7 and identification of the ubiquitination sites. |
Q35867102 | Chk1 Activation Protects Rad9A from Degradation as Part of a Positive Feedback Loop during Checkpoint Signalling. |
Q30422626 | Comparison of splenic transcriptome activity of two rainbow trout strains differing in robustness under regional aquaculture conditions. |
Q36358111 | Control of developmentally primed erythroid genes by combinatorial co-repressor actions |
Q39031194 | Cool-1-mediated inhibition of c-Cbl modulates multiple critical properties of glioblastomas, including the ability to generate tumors in vivo |
Q90567849 | Cul5-type Ubiquitin Ligase KLHDC1 Contributes to the Elimination of Truncated SELENOS Produced by Failed UGA/Sec Decoding |
Q38059746 | Cullin-RING Ligases as attractive anti-cancer targets |
Q36841120 | DCAF4L2 promotes colorectal cancer invasion and metastasis via mediating degradation of NFκb negative regulator PPM1B |
Q37416699 | De novo PHIP-predicted deleterious variants are associated with developmental delay, intellectual disability, obesity, and dysmorphic features |
Q91791317 | Degradation of CCNB1 mediated by APC11 through UBA52 ubiquitination promotes cell cycle progression and proliferation of non-small cell lung cancer cells |
Q33924237 | Degradation of the transcription factor Twist, an oncoprotein that promotes cancer metastasis. |
Q30278581 | Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis |
Q64118188 | Deubiquitinase ubiquitin-specific protease 9X regulates the stability and function of E3 ubiquitin ligase ring finger protein 115 in breast cancer cells |
Q34343401 | Domain organization of XAF1 and the identification and characterization of XIAP(RING) -binding domain of XAF1. |
Q90057475 | E3 ligase MDM2 mediates urea transporter-A1 ubiquitination under either constitutive or stimulatory conditions |
Q33953086 | E3 ubiquitin ligase Cbl-b in innate and adaptive immunity |
Q38074797 | E3 ubiquitin ligase-mediated regulation of bone formation and tumorigenesis |
Q36955086 | ETS2 and Twist1 promote invasiveness of Helicobacter pylori-infected gastric cancer cells by inducing Siah2 |
Q64104228 | Emerging role of F-box proteins in the regulation of epithelial-mesenchymal transition and stem cells in human cancers |
Q28539113 | Enigma prevents Cbl-c-mediated ubiquitination and degradation of RETMEN2A |
Q37694816 | Epigallocatechin-3-gallate(EGCG) suppresses melanoma cell growth and metastasis by targeting TRAF6 activity. |
Q28552579 | Establishment of a Wheat Cell-Free Synthesized Protein Array Containing 250 Human and Mouse E3 Ubiquitin Ligases to Identify Novel Interaction between E3 Ligases and Substrate Proteins |
Q36347238 | F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7 |
Q90325570 | Fbxl17 is rearranged in breast cancer and loss of its activity leads to increased global O-GlcNAcylation |
Q42870285 | Fbxo45 joins the 'Par-4'ty in controlling apoptosis of cancer cells |
Q42718503 | Foiling IDOL to Help Control Cholesterol |
Q26998944 | Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis |
Q38058483 | Functional characterization of SAG/RBX2/ROC2/RNF7, an antioxidant protein and an E3 ubiquitin ligase |
Q50026061 | Functional significance and therapeutic implication of ring-type E3 ligases in colorectal cancer |
Q27027897 | Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases |
Q41985052 | Genome-wide identification and gene expression profiling of ubiquitin ligases for endoplasmic reticulum protein degradation |
Q24599672 | HECT and RING finger families of E3 ubiquitin ligases at a glance |
Q26772317 | Hepatocellular carcinoma mouse models: Hepatitis B virus-associated hepatocarcinogenesis and haploinsufficient tumor suppressor genes |
Q26825542 | Histone H2B monoubiquitination: roles to play in human malignancy |
Q41863345 | Human papillomavirus type 16 E7 oncoprotein inhibits the anaphase promoting complex/cyclosome activity by dysregulating EMI1 expression in mitosis |
Q91641819 | Identification and characterization of small molecule inhibitors of the ubiquitin ligases Siah1/2 in melanoma and prostate cancer cells |
Q35828611 | Induction of c-Cbl contributes to anti-cancer effects of HDAC inhibitor in lung cancer. |
Q36870104 | Inhibition of redox/Fyn/c-Cbl pathway function by Cdc42 controls tumour initiation capacity and tamoxifen sensitivity in basal-like breast cancer cells |
Q46741600 | Interplay of the fungal sumoylation network for control of multicellular development. |
Q37168138 | JAK2 mutants (e.g., JAK2V617F) and their importance as drug targets in myeloproliferative neoplasms |
Q34342940 | Limiting the power of p53 through the ubiquitin proteasome pathway |
Q38016717 | Mdm2 and MdmX partner to regulate p53. |
Q35774027 | Metastasis-associated protein 1 drives tumor cell migration and invasion through transcriptional repression of RING finger protein 144A |
Q49396643 | MicroRNA-300 Regulates the Ubiquitination of PTEN through the CRL4BDCAF13 E3 Ligase in Osteosarcoma Cells |
Q47423838 | Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders |
Q34541470 | Multi-analyte network markers for tumor prognosis |
Q38509939 | Mutations of c-Cbl in myeloid malignancies |
Q39300074 | Mutual regulation between SIAH2 and DYRK2 controls hypoxic and genotoxic signaling pathways. |
Q50296650 | NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex |
Q26851503 | NIRF/UHRF2 occupies a central position in the cell cycle network and allows coupling with the epigenetic landscape |
Q34351264 | Natural product MDM2 inhibitors: anticancer activity and mechanisms of action. |
Q34987403 | Neddylation and deneddylation in cardiac biology |
Q28578613 | Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors |
Q27009517 | OLA1 in centrosome biology alongside the BRCA1/BARD1 complex: looking beyond centrosomes |
Q36165185 | OTUB1 inhibits the ubiquitination and degradation of FOXM1 in breast cancer and epirubicin resistance |
Q64063638 | Overexpression of RNF38 facilitates TGF-β signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma |
Q38092800 | PML Degradation: Multiple Ways to Eliminate PML. |
Q37002164 | Parallel Regulation of von Hippel-Lindau Disease by pVHL-Mediated Degradation of B-Myb and Hypoxia-Inducible Factor α. |
Q35235799 | Participation of proteasome-ubiquitin protein degradation in autophagy and the activation of AMP-activated protein kinase |
Q24301920 | Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor |
Q38016718 | Pirh2 RING-finger E3 ubiquitin ligase: its role in tumorigenesis and cancer therapy |
Q37995466 | Posttranslational control of telomere maintenance and the telomere damage response. |
Q52161912 | Proteasome Activity Is Influenced by the HECT_2 Protein Ipa1 in Budding Yeast |
Q89925905 | Protein Engineering in the Ubiquitin System: Tools for Discovery and Beyond |
Q26852269 | Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases |
Q36906753 | Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth. |
Q27334695 | Proteome wide purification and identification of O-GlcNAc-modified proteins using click chemistry and mass spectrometry |
Q93050357 | Proteomic analysis of degradation ubiquitin signaling by ubiquitin occupancy changes responding to 26S proteasome inhibition |
Q37225447 | Prp19 facilitates invasion of hepatocellular carcinoma via p38 mitogen-activated protein kinase/twist1 pathway |
Q43101547 | Put a RING on it: regulation and inhibition of RNF8 and RNF168 RING finger E3 ligases at DNA damage sites |
Q39176141 | RING finger protein 10 regulates retinoic acid-induced neuronal differentiation and the cell cycle exit of P19 embryonic carcinoma cells |
Q26850008 | RING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination |
Q37213780 | RNF122 suppresses antiviral type I interferon production by targeting RIG-I CARDs to mediate RIG-I degradation |
Q92578532 | RNF144A functions as a tumor suppressor in breast cancer through ubiquitin ligase activity-dependent regulation of stability and oncogenic functions of HSPA2 |
Q93368998 | RNF6 facilitates metastasis and radioresistance in hepatocellular carcinoma through ubiquitination of FoxA1 |
Q92739729 | Rapid and deep-scale ubiquitylation profiling for biology and translational research |
Q38984879 | Really interesting new gene finger protein 121 is a novel Golgi-localized membrane protein that regulates apoptosis |
Q36394421 | Regulation of APC/C-Cdh1 and its function in neuronal survival |
Q27024334 | Regulation of ERBB3/HER3 signaling in cancer |
Q39715869 | Regulation of GATA-binding protein 2 levels via ubiquitin-dependent degradation by Fbw7: involvement of cyclin B-cyclin-dependent kinase 1-mediated phosphorylation of THR176 in GATA-binding protein 2. |
Q55239552 | Regulation of Mammalian DNA Replication via the Ubiquitin-Proteasome System. |
Q26827667 | Regulation of TGF-β signal transduction by mono- and deubiquitylation of Smads |
Q30411902 | Regulation of TGF-β signaling, exit from the cell cycle, and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2. |
Q37584319 | Regulation of XIAP Turnover Reveals a Role for USP11 in Promotion of Tumorigenesis |
Q38881445 | Regulation of cancer stem cells by RING finger ubiquitin ligases |
Q36960990 | Regulation of hematopoietic stem cell fate by the ubiquitin proteasome system |
Q36761432 | Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase |
Q36124788 | Regulation of the protein stability of EMT transcription factors |
Q35971560 | Regulation of ubiquitination-mediated protein degradation by survival kinases in cancer |
Q49647269 | Ring finger protein 145 (RNF145) is a ubiquitin ligase for sterol-induced degradation of HMG-CoA reductase. |
Q36804013 | Role of p97/VCP (Cdc48) in genome stability |
Q37252274 | Role of ubiquitin ligases and the proteasome in oncogenesis: novel targets for anticancer therapies |
Q42237216 | SAG/RBX2 is a novel substrate of NEDD4-1 E3 ubiquitin ligase and mediates NEDD4-1 induced chemosensitization |
Q24567471 | SCF(β-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway |
Q38049544 | SIAH proteins: critical roles in leukemogenesis |
Q38403001 | SILAC-Based Quantitative Proteomic Analysis Unveils Arsenite-Induced Perturbation of Multiple Pathways in Human Skin Fibroblast Cells. |
Q24600363 | STRUCTURE-FUNCTION OF THE TUMOR SUPPRESSOR BRCA1 |
Q33586638 | Scaffold protein FHL2 facilitates MDM2-mediated degradation of IER3 to regulate proliferation of cervical cancer cells |
Q37614869 | Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2. |
Q38016673 | Spotlight on the role of COP1 in tumorigenesis |
Q36544098 | Structural basis for the indispensable role of a unique zinc finger motif in LNX2 ubiquitination |
Q45111324 | Synthesis and activity of proteasome inhibitors |
Q37694860 | TRIM71 suppresses tumorigenesis via modulation of Lin28B-let-7-HMGA2 signaling |
Q39396984 | Targeted Protein Degradation: from Chemical Biology to Drug Discovery |
Q90032238 | Targeted protein degradation: elements of PROTAC design |
Q35688708 | Targeting Cdc20 as a novel cancer therapeutic strategy |
Q39343202 | Targeting the E3 ubiquitin casitas B-lineage lymphoma decreases osteosarcoma cell growth and survival and reduces tumorigenesis |
Q26866185 | Targeting the ubiquitin pathway for cancer treatment |
Q37158445 | Targeting ubiquitination for cancer therapies. |
Q89867316 | Tension in tumour cells keeps metabolism high |
Q35971862 | The APC/C Ubiquitin Ligase: From Cell Biology to Tumorigenesis |
Q92651169 | The Anaphase Promoting Complex/Cyclosome (APC/C): A Versatile E3 Ubiquitin Ligase |
Q36660304 | The Colossus of ubiquitylation: decrypting a cellular code |
Q89719555 | The Impact of Cand1 in Prostate Cancer |
Q89529233 | The RNA-Binding Ubiquitin Ligase MEX3A Affects Glioblastoma Tumorigenesis by Inducing Ubiquitylation and Degradation of RIG-I |
Q35971082 | The Role of Elongin BC-Containing Ubiquitin Ligases |
Q64069006 | The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression |
Q37989143 | The Ubiquitin System and Kaposi's Sarcoma-Associated Herpesvirus |
Q90943372 | The anaphase-promoting complex: A key mitotic regulator associated with somatic mutations occurring in cancer |
Q45345755 | The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis |
Q91362500 | The deubiquitinase USP10 regulates KLF4 stability and suppresses lung tumorigenesis |
Q91564791 | The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis |
Q99241140 | The relationship between TRAF6 and tumors |
Q34460314 | The ubiquitin ligase Nedd4-1 participates in denervation-induced skeletal muscle atrophy in mice |
Q38029132 | The ubiquitin-proteasome system and signal transduction pathways regulating Epithelial Mesenchymal transition of cancer |
Q24296784 | Threshold-controlled ubiquitination of the EGFR directs receptor fate |
Q35202325 | Transforming growth factor β1 increases p27 levels via synthesis and degradation mechanisms in the hyperproliferative gastric epithelium in rats |
Q33655162 | USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses |
Q58133758 | Ubiquitin conjugation system for body axes specification in vertebrates |
Q37978888 | Ubiquitin links to cytoskeletal dynamics, cell adhesion and migration |
Q38175272 | Ubiquitin-dependent sorting in endocytosis |
Q37991651 | Ubiquitination and the Ubiquitin-Proteasome System as regulators of transcription and transcription factors in epithelial mesenchymal transition of cancer |
Q38265657 | Ubiquitination in disease pathogenesis and treatment |
Q39330282 | Ubiquitination in melanoma pathogenesis and treatment. |
Q38229325 | Ubiquitination involved enzymes and cancer |
Q27307830 | Ubiquitination-induced fluorescence complementation (UiFC) for detection of K48 ubiquitin chains in vitro and in live cells |
Q38021448 | Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications |
Q36455676 | Understanding cullin-RING E3 biology through proteomics-based substrate identification |
Q47101387 | Up-regulation of RNF187 induces hepatocellular carcinoma cell epithelial to mesenchymal transitions |
Q34774715 | Versatile roles of k63-linked ubiquitin chains in trafficking |
Q26827754 | When ubiquitin meets NF-κB: a trove for anti-cancer drug development |
Q61813359 | Writing Histone Monoubiquitination in Human Malignancy-The Role of RING Finger E3 Ubiquitin Ligases |
Q38957110 | Zinc and zinc-containing biomolecules in childhood brain tumors. |
Q47237450 | Zinc in Wound Healing Modulation |
Q38203812 | Zinc'ing sensibly: controlling zinc homeostasis at the transcriptional level. |
Q42563084 | praja2 regulates KSR1 stability and mitogenic signaling |