Understanding cullin-RING E3 biology through proteomics-based substrate identification

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Understanding cullin-RING E3 biology through proteomics-based substrate identification is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/MCP.R112.021154
P8608Fatcat IDrelease_vmnjojt7zvegxos2q4sbol22fe
P932PMC publication ID3518111
P698PubMed publication ID22962057

P50authorJeffrey W. HarperQ57326226
P2093author name stringMeng-Kwang Marcus Tan
P2860cites workSCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint responseQ24298620
An OBSL1-Cul7Fbxw8 Ubiquitin Ligase Signaling Mechanism Regulates Golgi Morphology and Dendrite PatterningQ24302459
SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteinsQ24304073
Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphaseQ24304123
Ubiquitin-dependent regulation of COPII coat size and functionQ24305964
Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligaseQ24306203
Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugationQ24314520
Defining the human deubiquitinating enzyme interaction landscapeQ24315885
Control of iron homeostasis by an iron-regulated ubiquitin ligaseQ24317234
An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasisQ24317309
Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repairQ24336569
SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradationQ24337147
Systematic analysis and nomenclature of mammalian F-box proteinsQ24561715
The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitroQ24608829
Systematic and quantitative assessment of the ubiquitin-modified proteomeQ24634631
Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancerQ24648025
SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradationQ24653723
RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesisQ26853207
Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligasesQ27644446
RING domain E3 ubiquitin ligasesQ27860546
The ubiquitin systemQ27860803
F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase ComplexQ27934075
SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-boxQ27936367
SCF ubiquitin protein ligases and phosphorylation-dependent proteolysisQ27937519
Comprehensive identification of substrates for F-box proteins by differential proteomics analysisQ83959951
Use of Proteome Arrays to Globally Identify Substrates for E3 Ubiquitin LigasesQ84815219
A Complex of Cdc4p, Skp1p, and Cdc53p/Cullin Catalyzes Ubiquitination of the Phosphorylated CDK Inhibitor Sic1pQ27939049
Function and regulation of cullin-RING ubiquitin ligasesQ28131707
Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replicationQ28209282
A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory rolesQ28247080
mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTORQ28251026
mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTORQ28251047
Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stressQ28255529
S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growthQ28269583
Control of chromosome stability by the beta-TrCP-REST-Mad2 axisQ28273354
The SCF ubiquitin ligase: insights into a molecular machineQ28279993
Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arraysQ28566104
Regulation of postsynaptic RapGAP SPAR by Polo-like kinase 2 and the SCFbeta-TRCP ubiquitin ligase in hippocampal neuronsQ28577634
A proteomics approach to understanding protein ubiquitinationQ29547312
FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiationQ29616127
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancerQ29616732
Physiological functions of the HECT family of ubiquitin ligasesQ29617293
Whose end is destruction: cell division and the anaphase-promoting complexQ29618257
Building ubiquitin chains: E2 enzymes at workQ29619578
How the cyclin became a cyclin: regulated proteolysis in the cell cycleQ33641413
The anaphase-promoting complex: it's not just for mitosis any more.Q34147374
Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profilingQ34159143
Constructing and decoding unconventional ubiquitin chains.Q34182233
Identification of mutations in CUL7 in 3-M syndromeQ34448386
The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradationQ34835596
Identification of SCF ubiquitin ligase substrates by global protein stability profilingQ34874145
SCF ubiquitin ligases in the maintenance of genome stabilityQ35754115
PINK1- and Parkin-mediated mitophagy at a glanceQ36851332
Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugationQ37101488
The multiple layers of ubiquitin-dependent cell cycle control.Q37369189
Degradation of ubiquitin: the fate of the cellular reaperQ37682565
The cullin protein familyQ37873586
SCF(FBXO22) regulates histone H3 lysine 9 and 36 methylation levels by targeting histone demethylase KDM4A for ubiquitin-mediated proteasomal degradation.Q38285971
Quantitative proteomic analysis of cellular protein modulation upon inhibition of the NEDD8-activating enzyme by MLN4924.Q39451819
Global identification of modular cullin-RING ligase substratesQ39462405
Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymesQ41141041
The cyclin box fold: protein recognition in cell-cycle and transcription controlQ41684087
The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligaseQ46603785
P433issue12
P304page(s)1541-1550
P577publication date2012-09-07
P1433published inMolecular & Cellular ProteomicsQ6895932
P1476titleUnderstanding cullin-RING E3 biology through proteomics-based substrate identification
P478volume11

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cites work (P2860)
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Q50968214The Histone Variant MacroH2A1 Is a BRCA1 Ubiquitin Ligase Substrate
Q38888153The NEDD8 inhibitor MLN4924 increases the size of the nucleolus and activates p53 through the ribosomal-Mdm2 pathway.
Q28115944Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation
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Q26770849Ubiquitylation as a Rheostat for TCR Signaling: From Targeted Approaches Toward Global Profiling
Q42101565pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase

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