The multiple layers of ubiquitin-dependent cell cycle control.

scientific article published on April 2009

The multiple layers of ubiquitin-dependent cell cycle control. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1021/CR800414E
P932PMC publication ID3206288
P698PubMed publication ID19146381
P5875ResearchGate publication ID23790436

P50authorMichael RapeQ55163233
P2093author name stringKatherine Wickliffe
Lingyan Jin
Adam Williamson
P2860cites workJAMM: a metalloprotease-like zinc site in the proteasome and signalosomeQ21092836
A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formationQ22003817
Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradationQ24290777
APC2 Cullin Protein and APC11 RING Protein Comprise the Minimal Ubiquitin Ligase Module of the Anaphase-promoting ComplexQ24291991
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damageQ24292278
NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTENQ24292919
Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinasesQ24294546
p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2Q24294568
Regulation of cell cycle progression and gene expression by H2A deubiquitinationQ24296401
Regulation of p27 degradation and S-phase progression by Ro52 RING finger proteinQ24298491
Human USP3 is a chromatin modifier required for S phase progression and genome stabilityQ24299488
UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulationQ24300065
Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitorQ24300354
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteinsQ24300411
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assemblyQ24300428
Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repairQ24300495
The Mad2 conformational dimer: structure and implications for the spindle assembly checkpointQ24300755
Mitotic regulation of the human anaphase-promoting complex by phosphorylationQ24301075
A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1Q24301361
Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topologyQ24301551
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activitiesQ24303505
A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathwayQ24303605
Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphaseQ24304123
The tumor suppressor CYLD regulates entry into mitosisQ24305326
Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage responseQ24306765
RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sitesQ24306789
Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage responseQ24306807
A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cellsQ24307672
Final stages of cytokinesis and midbody ring formation are controlled by BRUCEQ24308799
Mechanism of ubiquitin-chain formation by the human anaphase-promoting complexQ24313604
CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transitionQ24316218
Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphaseQ24317284
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53Q24317677
BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppressionQ24321439
Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/CQ24322917
Cell-intrinsic regulation of axonal morphogenesis by the Cdh1-APC target SnoNQ24324676
M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCPQ24329203
UBPY: a growth-regulated human ubiquitin isopeptidase.Q24336064
Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligaseQ24337721
Vps22/EAP30 in ESCRT-II mediates endosomal sorting of growth factor and chemokine receptors destined for lysosomal degradationQ24338164
Recognition of the polyubiquitin proteolytic signalQ24530006
Systematic analysis and nomenclature of mammalian F-box proteinsQ24561715
Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpointQ24563156
Kinetic Proofreading: A New Mechanism for Reducing Errors in Biosynthetic Processes Requiring High SpecificityQ24563898
The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiationQ24601346
CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcriptionQ24603619
Human CtIP promotes DNA end resectionQ24646062
Linking kinetochore-microtubule binding to the spindle checkpointQ24646166
Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancerQ24648025
SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradationQ24653723
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligaseQ24653776
The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosisQ24656114
VCIP135 acts as a deubiquitinating enzyme during p97-p47-mediated reassembly of mitotic Golgi fragmentsQ24677725
Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3Q24683139
Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repairQ24685928
The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20Q27637433
Basis for a ubiquitin-like protein thioester switch toggling E1–E2 affinityQ27641129
Crystal structure and solution NMR studies of Lys48-linked tetraubiquitin at neutral pHQ27643602
Proteasome subunit Rpn13 is a novel ubiquitin receptorQ27650664
Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interactionQ27650666
Wnt/beta-catenin signaling in development and diseaseQ27860784
Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperoneQ27930650
Identification of subunits of the anaphase-promoting complex of Saccharomyces cerevisiaeQ27932699
The Doc1 subunit is a processivity factor for the anaphase-promoting complex.Q27935255
Yeast Chfr homologs retard cell cycle at G1 and G2/M via Ubc4 and Ubc13/Mms2-dependent ubiquitinationQ27936398
Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complexQ29617624
The anaphase promoting complex/cyclosome: a machine designed to destroyQ29618398
p53 ubiquitination: Mdm2 and beyondQ29619502
Mms2-Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formationQ29619698
A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin BQ29620071
Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machineryQ30159944
Elevating the level of Cdc34/Ubc3 ubiquitin-conjugating enzyme in mitosis inhibits association of CENP-E with kinetochores and blocks the metaphase alignment of chromosomes.Q30307758
The reversibility of mitotic exit in vertebrate cellsQ30445825
Dose-dependent effects of stable cyclin B1 on progression through mitosis in human cellsQ30477570
The schedule of destruction of three mitotic cyclins can dictate the timing of events during exit from mitosisQ30494671
The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4.Q33292338
Patented small molecule inhibitors in the ubiquitin proteasome systemQ33307875
Beta-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatasesQ33756957
Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27.Q33837015
Clathrin-independent endocytosis of ubiquitinated cargosQ33864329
Delivery of ubiquitinated substrates to protein-unfolding machinesQ33989072
Mad2-Independent Inhibition of APCCdc20 by the Mitotic Checkpoint Protein BubR1Q34101240
The multiple nuclear functions of BRCA1: transcription, ubiquitination and DNA repairQ34203060
Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligasesQ34230579
Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.Q34283106
The making and breaking of sister chromatid cohesionQ34340521
Ubiquitination on nonlysine residues by a viral E3 ubiquitin ligaseQ34430908
Molecular determinants of polyubiquitin linkage selection by an HECT ubiquitin ligaseQ34547388
KEN-box-dependent degradation of the Bub1 spindle checkpoint kinase by the anaphase-promoting complex/cyclosome.Q34589481
Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages.Q34617875
Cdc20: a WD40 activator for a cell cycle degradation machineQ34646331
Substrate modification with lysine 63-linked ubiquitin chains through the UBC13-UEV1A ubiquitin-conjugating enzymeQ34665108
The role of cyclin synthesis and degradation in the control of maturation promoting factor activityQ34667889
Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytesQ34701605
TGFbeta-SMAD signal transduction: molecular specificity and functional flexibilityQ34713446
The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapyQ34763495
The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradationQ34835596
BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIPQ34863348
Cyclin is a component of maturation-promoting factor from XenopusQ34997301
Distinct monoubiquitin signals in receptor endocytosisQ35579542
Skp2-mediated degradation of p27 regulates progression into mitosisQ47640200
The Mad2 spindle checkpoint protein has two distinct natively folded statesQ47943415
Cdh1-APC controls axonal growth and patterning in the mammalian brainQ48096732
Autoregulation of an E2 enzyme by ubiquitin-chain assembly on its catalytic residueQ50696442
REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesisQ52049234
Centrosomes have a role in regulating the destruction of cyclin B in early Drosophila embryosQ52584129
The END network couples spindle pole assembly to inhibition of the anaphase-promoting complex/cyclosome in early mitosisQ53543164
Inactivation of the ubiquitin conjugating enzyme UBE2Q2 causes a prophase arrest and enhanced apoptosis in response to microtubule inhibiting agentsQ53556295
Identification of the active amino acid residue of the polypeptide of ATP-dependent protein breakdownQ53878176
"Covalent affinity" purification of ubiquitin-activating enzymeQ55062459
The U box is a modified RING finger — a common domain in ubiquitinationQ57263070
Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topologyQ58215681
Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85Q70212185
Regulation of the cell cycle during early Xenopus developmentQ70367519
Metabolism of ubiquitinated histonesQ72895063
PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2)Q73617626
Anaphase inactivation of the spindle checkpointQ79851805
Structural mechanisms underlying posttranslational modification by ubiquitin-like proteinsQ80262122
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.Q27937465
Rad6-Rad18 mediates a eukaryotic SOS response by ubiquitinating the 9-1-1 checkpoint clamp.Q27938900
Regulation of monoubiquitinated PCNA by DUB autocleavageQ28115531
Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domainQ28119149
Cyclin is degraded by the ubiquitin pathwayQ28131704
Function and regulation of cullin-RING ubiquitin ligasesQ28131707
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27Q28137860
RING finger proteins: mediators of ubiquitin ligase activityQ28139717
Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chainQ28142613
Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damageQ28182301
Mass spectrometric and mutational analyses reveal Lys-6-linked polyubiquitin chains catalyzed by BRCA1-BARD1 ubiquitin ligaseQ28187365
Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell linesQ28188140
Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaBQ28201706
Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligaseQ28215069
SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphataseQ28234989
Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligaseQ28244312
A genetic screen for candidate tumor suppressors identifies RESTQ28257011
Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage divisionQ28261164
Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domainQ28265018
An oncogenic fusion product of the phosphatidylinositol 3-kinase p85β subunit and HUMORF8, a putative deubiquitinating enzymeQ28270394
The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assemblyQ28271991
Control of chromosome stability by the beta-TrCP-REST-Mad2 axisQ28273354
A molecular view of anti-ErbB monoclonal antibody therapyQ28275404
The Cbl interactome and its functionsQ28277251
A genomic and functional inventory of deubiquitinating enzymesQ28284911
Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme chargingQ28307753
Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85Q28591666
MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cellsQ28593914
Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpointQ28631721
A proteomics approach to understanding protein ubiquitinationQ29547312
FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiationQ29616127
Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1Q29617290
Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpointQ35677350
Inhibitory factors associated with anaphase-promoting complex/cylosome in mitotic checkpointQ35690967
N-terminal ubiquitination: more protein substrates join in.Q35727083
Endocytosis and cancer.Q35804803
Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivityQ35865833
The anaphase promoting complex/cyclosome is recruited to centromeres by the spindle assembly checkpoint.Q35868075
Mitosis persists in the absence of Cdk1 activity when proteolysis or protein phosphatase activity is suppressedQ36149275
ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradationQ36359536
Precise destruction: an emerging picture of the APC.Q36657557
Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced ErbB4 isoforms.Q36670188
Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damageQ36696336
Regulation of catalytic activities of HECT ubiquitin ligasesQ36714155
Ubiquitin-mediated activation of TAK1 and IKK.Q36819396
CDC25 phosphatases in cancer cells: key players? Good targets?Q36849329
Cell cycle regulation of DNA replication.Q36881426
Finishing mitosis, one step at a time.Q36958864
ESCRTing proteins in the endocytic pathwayQ36995735
Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box proteinQ37073031
Reverse the curse--the role of deubiquitination in cell cycle controlQ37112275
Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A.Q39983420
CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage responseQ40104298
Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivoQ40142306
C-terminal modifications regulate MDM2 dissociation and nuclear export of p53.Q40157263
Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth.Q40261081
Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligasesQ40437388
Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry.Q40488999
Smad4 protein stability is regulated by ubiquitin ligase SCF beta-TrCP1.Q40584931
The Anaphase-Promoting Complex Mediates TGF-β Signaling by Targeting SnoN for DestructionQ40763954
Destruction of Xenopus cyclins A and B2, but not B1, requires binding to p34cdc2.Q40790755
Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27.Q40872982
APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphaseQ41127007
Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivationQ41792415
Solution conformation of Lys63-linked di-ubiquitin chain provides clues to functional diversity of polyubiquitin signalingQ42614287
Nuclear localization of the ubiquitin-activating enzyme, E1, is cell-cycle-dependentQ42835094
The roles of Fzy/Cdc20 and Fzr/Cdh1 in regulating the destruction of cyclin B in space and timeQ42917794
Securin regulates entry into M-phase by modulating the stability of cyclin B.Q44229519
Distinct endocytic pathways regulate TGF-β receptor signalling and turnoverQ44419411
Independent regulation of synaptic size and activity by the anaphase-promoting complexQ45154532
The anaphase-promoting complex regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C. elegansQ45158404
The processivity of multiubiquitination by the APC determines the order of substrate degradation.Q45345067
Regulation of MPF activity in vitroQ46123825
Cyclin activation of p34cdc2.Q46130213
Sequential E2s drive polyubiquitin chain assembly on APC targetsQ46225392
Mechanism of lysine 48-linked ubiquitin-chain synthesis by the cullin-RING ubiquitin-ligase complex SCF-Cdc34.Q46711534
The E2-C vihar is required for the correct spatiotemporal proteolysis of cyclin B and itself undergoes cyclical degradation.Q47071672
P433issue4
P304page(s)1537-1548
P577publication date2009-04-01
P13046publication type of scholarly workreview articleQ7318358
P1433published inChemical ReviewsQ900502
P1476titleThe multiple layers of ubiquitin-dependent cell cycle control
P478volume109

Reverse relations

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