| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/S1097-2765(00)00134-9 |
| P8608 | Fatcat ID | release_kvico6374neg3i4d7fk36kgotm |
| P3181 | OpenCitations bibliographic resource ID | 948886 |
| P698 | PubMed publication ID | 11163210 |
| P5875 | ResearchGate publication ID | 12167092 |
| P2093 | author name string | J L Wrana | |
| C G Causing | |||
| G H Thomsen | |||
| H Zhu | |||
| P Kavsak | |||
| R K Rasmussen | |||
| S Bonni | |||
| P2860 | cites work | A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation | Q22003817 |
| SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor | Q22008583 | ||
| Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein | Q22010706 | ||
| MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling | Q24310282 | ||
| Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor | Q24321977 | ||
| The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules | Q24323939 | ||
| Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination | Q24532806 | ||
| The ubiquitin system | Q27860803 | ||
| Nitrogen-regulated ubiquitination of the Gap1 permease of Saccharomyces cerevisiae | Q27939736 | ||
| The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase | Q28145635 | ||
| Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7 | Q28146026 | ||
| The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling | Q28243202 | ||
| Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling | Q28251743 | ||
| Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members | Q28280195 | ||
| Transforming growth factor beta1 induces nuclear export of inhibitory Smad7 | Q28286474 | ||
| Smads: transcriptional activators of TGF-beta responses | Q28292325 | ||
| SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor beta signaling | Q28608960 | ||
| Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1 | Q29617290 | ||
| Gettin' down with ubiquitin: turning off cell-surface receptors, transporters and channels | Q33592643 | ||
| Regulation of Smad activity | Q33830190 | ||
| The types II and III transforming growth factor-beta receptors form homo-oligomers | Q36234419 | ||
| Rapid flux in transforming growth factor-beta receptors on bone cells | Q38354386 | ||
| SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53. | Q40868752 | ||
| Ubiquitin-dependent degradation of TGF-beta-activated smad2. | Q40913405 | ||
| Down-regulation of transforming growth factor-beta receptors: cooperativity between the types I, II, and III receptors and modulation at the cell surface | Q40922209 | ||
| Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway. | Q40968846 | ||
| Processing of the transforming growth factor beta type I and II receptors. Biosynthesis and ligand-induced regulation | Q41121166 | ||
| Smad6 inhibits signalling by the TGF-beta superfamily | Q48044158 | ||
| NPl1, an essential yeast gene involved in induced degradation of Gap1 and Fur4 permeases, encodes the Rsp5 ubiquitin-protein ligase | Q48070002 | ||
| Biosynthesis of the type I and type II TGF-beta receptors. Implications for complex formation | Q73248337 | ||
| Endocytosis and degradation of the growth hormone receptor are proteasome-dependent | Q73357536 | ||
| Differential requirement for type I and type II transforming growth factor beta receptor kinase activity in ligand-mediated receptor endocytosis | Q77172105 | ||
| Ubiquitin and the control of protein fate in the secretory and endocytic pathways | Q77803382 | ||
| P433 | issue | 6 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | SMAD specific E3 ubiquitin protein ligase 2 | Q21112471 |
| P304 | page(s) | 1365-75 | |
| P577 | publication date | 2000-12-01 | |
| P1433 | published in | Molecular Cell | Q3319468 |
| P1476 | title | Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation | |
| P478 | volume | 6 |
| Q36990620 | 'Yin-Yang' functions of transforming growth factor-beta and T regulatory cells in immune regulation |
| Q40459020 | 2-Methoxyestradiol-induced apoptosis in prostate cancer cells requires Smad7. |
| Q41502368 | A C-terminal sequence in the guanine nucleotide exchange factor Sec7 mediates Golgi association and interaction with the Rsp5 ubiquitin ligase |
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| Q38046131 | A Smurf1 tale: function and regulation of an ubiquitin ligase in multiple cellular networks |
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| Q35691568 | A central role for the ring finger protein RNF11 in ubiquitin-mediated proteolysis via interactions with E2s and E3s. |
| Q46818479 | A new Smurf in the village |
| Q77371133 | A new partner for inhibitory Smads |
| Q27313099 | A novel TGFβ modulator that uncouples R-Smad/I-Smad-mediated negative feedback from R-Smad/ligand-driven positive feedback |
| Q21284180 | A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs). |
| Q24291656 | A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC |
| Q33685408 | A positive role of microRNA-15b on regulation of osteoblast differentiation |
| Q42989591 | A rate equation approach to elucidate the kinetics and robustness of the TGF-beta pathway |
| Q35742838 | A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20. |
| Q40411584 | AIP4 restricts transforming growth factor-beta signaling through a ubiquitination-independent mechanism |
| Q21144278 | AIP4/Itch regulates Notch receptor degradation in the absence of ligand |
| Q24295158 | Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3 |
| Q51739062 | Acetylshikonin from Zicao ameliorates renal dysfunction and fibrosis in diabetic mice by inhibiting TGF-β1/Smad pathway. |
| Q39883888 | Activation of the ROCK1 branch of the transforming growth factor-beta pathway contributes to RAGE-dependent acceleration of atherosclerosis in diabetic ApoE-null mice |
| Q27346829 | Activation of the TGFβ pathway impairs endothelial to haematopoietic transition |
| Q28610139 | Activin signaling and its role in regulation of cell proliferation, apoptosis, and carcinogenesis |
| Q24307781 | Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium |
| Q47936492 | Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies |
| Q73947582 | Alpha-helix 2 in the amino-terminal mad homology 1 domain is responsible for specific DNA binding of Smad3 |
| Q24306826 | An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein |
| Q38678156 | An Unbiased Linkage Approach Reveals That the p53 Pathway Is Coupled to NK Cell Maturation. |
| Q28236707 | An expanded WW domain recognition motif revealed by the interaction between Smad7 and the E3 ubiquitin ligase Smurf2 |
| Q54981313 | Andrographolide Ameliorates Liver Fibrosis in Mice: Involvement of TLR4/NF-κB and TGF-β1/Smad2 Signaling Pathways. |
| Q79074390 | Antagonistic Effects of TNF-α on TGF-β Signaling Through Down-Regulation of TGF-β Receptor Type II in Human Dermal Fibroblasts |
| Q28513597 | Antagonistic effects of Smad2 versus Smad7 are sensitive to their expression level during tooth development |
| Q58698696 | Anti-fibrotic impact of Carvedilol in a CCl-4 model of liver fibrosis via serum microRNA-200a/SMAD7 enhancement to bridle TGF-β1/EMT track |
| Q42478274 | Antifibrotic properties of c-Ski and its regulation of cardiac myofibroblast phenotype and contractility. |
| Q24675569 | Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation |
| Q24634424 | Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7 |
| Q24306193 | Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling |
| Q34170852 | Asiatic acid inhibits liver fibrosis by blocking TGF-beta/Smad signaling in vivo and in vitro |
| Q28155799 | Assembly of Cell Regulatory Systems Through Protein Interaction Domains |
| Q87215138 | Association of down-regulation of CD109 expression with up-expression of Smad7 in pathogenesis of psoriasis |
| Q38989903 | Astragaloside IV inhibits renal tubulointerstitial fibrosis by blocking TGF-β/Smad signaling pathway in vivo and in vitro |
| Q28253459 | Atrophin-1-interacting protein 4/human Itch is a ubiquitin E3 ligase for human enhancer of filamentation 1 in transforming growth factor-beta signaling pathways |
| Q43848397 | Attenuated TGF-β1 responsiveness of dendritic cells and their precursors in atopic dermatitis |
| Q39224377 | Atypical protein kinase C phosphorylates Par6 and facilitates transforming growth factor β-induced epithelial-to-mesenchymal transition |
| Q24338345 | Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain |
| Q24315751 | Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia |
| Q33707622 | BAMBI Is Expressed in Endothelial Cells and Is Regulated by Lysosomal/Autolysosomal Degradation |
| Q36393176 | Beclin 1 regulates neuronal transforming growth factor-β signaling by mediating recycling of the type I receptor ALK5. |
| Q99241256 | Bis-indole derived nuclear receptor 4A1 (NR4A1) antagonists inhibit TGFβ-induced invasion of embryonal rhabdomyosarcoma cells |
| Q26746964 | Bone Morphogenetic Protein 4 Signalling in Neural Stem and Progenitor Cells during Development and after Injury |
| Q38872877 | Bone Morphogenetic Proteins in Vascular Homeostasis and Disease |
| Q45972509 | Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7. |
| Q39478295 | CD109-mediated degradation of TGF-β receptors and inhibition of TGF-β responses involve regulation of SMAD7 and Smurf2 localization and function. |
| Q35866186 | CD8 co-receptor promotes susceptibility of CD8+ T cells to transforming growth factor-β (TGF-β)-mediated suppression |
| Q24298589 | CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation |
| Q24603619 | CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription |
| Q28508530 | CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis |
| Q30418766 | Cadherin-6B stimulates an epithelial mesenchymal transition and the delamination of cells from the neural ectoderm via LIMK/cofilin mediated non-canonical BMP receptor signaling |
| Q83396397 | Cancer-fighting Smurf |
| Q38096319 | Caveolin and TGF-β entanglements |
| Q50958644 | Cbl-b mediates TGFβ sensitivity by downregulating inhibitory SMAD7 in primary T cells. |
| Q42738100 | Cdh1-anaphase-promoting complex targets Skp2 for destruction in transforming growth factor beta-induced growth inhibition |
| Q35124896 | Chaihuang-Yishen granule inhibits diabetic kidney disease in rats through blocking TGF-β/Smad3 signaling. |
| Q35080458 | Characterization of negative feedback network motifs in the TGF-β signaling pathway |
| Q64057171 | Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3 |
| Q28202338 | Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7 |
| Q36028155 | Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling |
| Q37595180 | Cleavages within the prodomain direct intracellular trafficking and degradation of mature bone morphogenetic protein-4. |
| Q52117034 | Cloning and developmental expression of Baf57 in Xenopus laevis. |
| Q28975773 | Comprehensive functional characterization of cancer-testis antigens defines obligate participation in multiple hallmarks of cancer |
| Q42147850 | Computational modelling of Smad-mediated negative feedback and crosstalk in the TGF-β superfamily network |
| Q38332721 | Conditional BMP inhibition in Xenopus reveals stage-specific roles for BMPs in neural and neural crest induction |
| Q24292829 | Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase |
| Q35541207 | Connective tissue disorders and cardiovascular complications: the indomitable role of transforming growth factor-beta signaling |
| Q33300339 | Constraint-based modeling and kinetic analysis of the Smad dependent TGF-beta signaling pathway |
| Q28212409 | Control of Smad7 stability by competition between acetylation and ubiquitination |
| Q24645749 | Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins |
| Q37137542 | Controlling hair follicle signaling pathways through polyubiquitination |
| Q39044519 | Controlling long-term signaling: receptor dynamics determine attenuation and refractory behavior of the TGF-β pathway. |
| Q39791091 | Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads |
| Q35779701 | Coordinate regulation of cell growth and differentiation by TGF-beta superfamily and Runx proteins |
| Q40281114 | Cotylenin A-induced differentiation is independent of the transforming growth factor-beta signaling system in human myeloid leukemia HL-60 cells |
| Q27664978 | Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity |
| Q24644592 | Critical regulation of TGFbeta signaling by Hsp90 |
| Q54318129 | Crocodile oil enhances cutaneous burn wound healing and reduces scar formation in rats. |
| Q36241249 | Crosstalk mechanisms between the mitogen-activated protein kinase pathways and Smad signaling downstream of TGF-beta: implications for carcinogenesis. |
| Q37851398 | Crosstalk of TGF-β and estrogen receptor signaling in breast cancer |
| Q26745695 | Cutting the brakes on hematopoietic regeneration by blocking TGFβ to limit chemotherapy-induced myelosuppression |
| Q37244989 | Decoding the quantitative nature of TGF-beta/Smad signaling. |
| Q34875675 | Deficiency of Smad7 enhances cardiac remodeling induced by angiotensin II infusion in a mouse model of hypertension |
| Q34328384 | Deficiency of thioredoxin binding protein-2 (TBP-2) enhances TGF-β signaling and promotes epithelial to mesenchymal transition |
| Q34021184 | Deficient Smad7 expression: a putative molecular defect in scleroderma |
| Q40317939 | Degradation of RhoA by Smurf1 ubiquitin ligase |
| Q50298179 | Degradation of TGF-beta receptor complex |
| Q40437388 | Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases |
| Q34579319 | Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways. |
| Q36241231 | Deregulated TGF-beta signaling in leukemogenesis |
| Q55453582 | Deregulation of Negative Controls on TGF-β1 Signaling in Tumor Progression. |
| Q58837454 | Developing Small-Molecule Inhibitors of HECT-Type Ubiquitin Ligases for Therapeutic Applications: Challenges and Opportunities |
| Q38687425 | Diabetic cardiomyopathy: role of the E3 ubiquitin ligase |
| Q38356850 | Differential expression, regulation, and induction of Smads, transforming growth factor-beta signal transduction pathway in leiomyoma, and myometrial smooth muscle cells and alteration by gonadotropin-releasing hormone analog |
| Q38471403 | Differential gene expression profiles of peripheral blood mononuclear cells in childhood asthma |
| Q34395698 | Differential regulation of Smad3 and of the type II transforming growth factor-β receptor in mitosis: implications for signaling |
| Q40641509 | Differential ubiquitination defines the functional status of the tumor suppressor Smad4. |
| Q34542559 | Disruption of Smad7 promotes ANG II-mediated renal inflammation and fibrosis via Sp1-TGF-β/Smad3-NF.κB-dependent mechanisms in mice. |
| Q44419411 | Distinct endocytic pathways regulate TGF-β receptor signalling and turnover |
| Q37424165 | Distinct ubiquitin ligases act sequentially for RNA polymerase II polyubiquitylation |
| Q37934555 | Diverse roles of TGF-β/Smads in renal fibrosis and inflammation |
| Q24339424 | Dlg5 interacts with the TGF-β receptor and promotes its degradation |
| Q34514594 | Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice |
| Q36866940 | Downregulation of MMP-2 and -9 by proteasome inhibition: a possible mechanism to decrease LEC migration and prevent posterior capsular opacification |
| Q24305745 | Downregulation of Ski and SnoN co-repressors by anisomycin |
| Q88534281 | Downregulation of Smurf2 ubiquitin ligase in pancreatic cancer cells reversed TGF-β-induced tumor formation |
| Q37569328 | Downregulation of Smurf2, a tumor-suppressive ubiquitin ligase, in triple-negative breast cancers: involvement of the RB-microRNA axis |
| Q45318133 | Downregulation of TGF-beta receptor signaling |
| Q39698194 | Downregulation of ZEB1 and overexpression of Smad7 contribute to resistance to TGF-beta1-mediated growth suppression in adult T-cell leukemia/lymphoma |
| Q35800653 | Dual-mode modulation of Smad signaling by Smad-interacting protein Sip1 is required for myelination in the central nervous system |
| Q34767980 | Dubble or nothing? Is HAUSP deubiquitylating enzyme the final arbiter of p53 levels? |
| Q34022613 | Dynamics of TGF-β/Smad signaling |
| Q42742537 | Dynamics of Transforming Growth Factor Beta Signaling in Wound Healing and Scarring |
| Q35849217 | Dysregulation of IL-15-mediated T-cell homeostasis in TGF-beta dominant-negative receptor transgenic mice |
| Q36519010 | Dysregulation of growth factor signaling in human hepatocellular carcinoma. |
| Q28547141 | E3 Ubiquitin Ligase NEDD4 Promotes Influenza Virus Infection by Decreasing Levels of the Antiviral Protein IFITM3 |
| Q64109835 | E3 ubiquitin ligase Smurf2: a prognostic factor in microsatellite stable colorectal cancer |
| Q48265392 | ERK5 plays an essential role in gestational beta-cell proliferation |
| Q38725540 | Effect of Exogenous Fetuin-A on TGF-β/Smad Signaling in Hepatic Stellate Cells. |
| Q35604418 | Effect of SMAD7 gene overexpression on TGF-β1-induced profibrotic responses in fibroblasts derived from Peyronie's plaque |
| Q41116388 | Effect of isopsoralen on Smad7 in osteoblastic MC3T3-E1 cells |
| Q39117256 | Effect of the protease inhibitor MG132 on the transforming growth factor-β/Smad signaling pathway in HSC-T6 cells |
| Q43102100 | Effects of Arkadia on airway remodeling through enhancing TGF-beta signaling in allergic rats |
| Q51374794 | Effects of Panax notoginoside on the expression of TGF-β1 and Smad-7 in renal tissues of diabetic rats. |
| Q39188710 | Effects of SARA on oxygen-glucose deprivation in PC12 cell line |
| Q36594142 | Efficient and specific rescue of human immunodeficiency virus type 1 budding defects by a Nedd4-like ubiquitin ligase |
| Q92813939 | Emerging roles of HECT-type E3 ubiquitin ligases in autophagy regulation |
| Q47303784 | Emodin ameliorates renal fibrosis in rats via TGF-β1/Smad signaling pathway and function study of Smurf 2. |
| Q35522530 | Endocytic deficiency induced by ITSN-1s knockdown alters the Smad2/3-Erk1/2 signaling balance downstream of Alk5 |
| Q34892916 | Endocytic regulation of TGF-beta signaling |
| Q64897697 | Epigenetic Reprogramming of TGF-β Signaling in Breast Cancer. |
| Q50965106 | Eplerenone Prevents Atrial Fibrosis via the TGF-β Signaling Pathway |
| Q46391933 | Establishment of mesodermal gene expression patterns in early Xenopus embryos: the role of repression |
| Q33825125 | Estrogen inhibits transforming growth factor beta signaling by promoting Smad2/3 degradation |
| Q40008192 | Etoposide-induced Smad6 expression is required for the G1 to S phase transition of the cell cycle in CMT-93 mouse intestinal epithelial cells |
| Q73282252 | Evidence for a role of Smad3 and Smad2 in stabilization of the tumor-derived mutant Smad2.Q407R |
| Q35865201 | Evidence for an Important Role of Smad-7 in Intervertebral Disc Degeneration |
| Q58699470 | Exosomal miR-21-5p derived from gastric cancer promotes peritoneal metastasis via mesothelial-to-mesenchymal transition |
| Q57044361 | Exploring major signaling cascades in melanomagenesis: a rationale route for targetted skin cancer therapy |
| Q42607432 | Expression of Smad ubiquitin regulatory factor 2 (Smurf2) in rhesus monkey endometrium and placenta during early pregnancy |
| Q52945736 | Expression of Smad7 and Smad ubiquitin regulatory factor 2 in a rat model of chronic pancreatitis. |
| Q33951282 | FGFR3 induces degradation of BMP type I receptor to regulate skeletal development |
| Q54312563 | FK506 inhibits the enhancing effects of transforming growth factor (TGF)-β1 on collagen expression and TGF-β/Smad signalling in keloid fibroblasts: implication for new therapeutic approach. |
| Q42440126 | Fibroblast-specific Expression of a Kinase-deficient Type II Transforming Growth Factor β (TGFβ) Receptor Leads to Paradoxical Activation of TGFβ Signaling Pathways with Fibrosis in Transgenic Mice |
| Q35169066 | Fibrosis in scleroderma |
| Q57802152 | Fine-tuning the ubiquitin-proteasome system to treat pulmonary fibrosis |
| Q39218826 | Fucoidan induces changes in the epithelial to mesenchymal transition and decreases metastasis by enhancing ubiquitin-dependent TGFβ receptor degradation in breast cancer. |
| Q34365917 | Fucoidan inhibition of lung cancer in vivo and in vitro : role of the Smurf2-dependent ubiquitin proteasome pathway in TGFβ receptor degradation |
| Q37405583 | Fucose-containing fraction of Ling-Zhi enhances lipid rafts-dependent ubiquitination of TGFβ receptor degradation and attenuates breast cancer tumorigenesis |
| Q24298398 | Functional proteomics mapping of a human signaling pathway |
| Q91658846 | Functional role of WW domain-containing proteins in tumor biology and diseases: Insight into the role in ubiquitin-proteasome system |
| Q24676599 | GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor |
| Q24682784 | GATA- and Smad1-dependent enhancers in the Smad7 gene differentially interpret bone morphogenetic protein concentrations |
| Q24804612 | Gene expression profiling reveals novel TGFbeta targets in adult lung fibroblasts |
| Q42582538 | Generation of Smad7(-Cre) recombinase mice: A useful tool for the study of epithelial-mesenchymal transformation within the embryonic heart |
| Q55021581 | Generation of Smurf2 Conditional Knockout Mice. |
| Q54462280 | Genetic variations in the TGFβ signaling pathway, smoking and risk of colorectal cancer in a Chinese population. |
| Q46790834 | Glomerular expression of thrombospondin-1, transforming growth factor beta and connective tissue growth factor at different stages of diabetic nephropathy and their interdependent roles in mesangial response to diabetic stimuli |
| Q91830086 | Gut microbe-derived metabolite trimethylamine N-oxide accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis |
| Q30444132 | HECT E3s and human disease |
| Q24338460 | HECT ubiquitin ligase Smurf1 targets the tumor suppressor ING2 for ubiquitination and degradation |
| Q28204233 | HER2/Neu- and TAK1-mediated up-regulation of the transforming growth factor beta inhibitor Smad7 via the ETS protein ER81 |
| Q34359348 | HILI inhibits TGF-β signaling by interacting with Hsp90 and promoting TβR degradation |
| Q39281800 | Heat shock protein 90 inhibitor attenuates renal fibrosis through degradation of transforming growth factor-β type II receptor. |
| Q42444492 | Hepatocyte growth factor inhibits epithelial to myofibroblast transition in lung cells via Smad7. |
| Q37627437 | Hepatocyte-specific Smad7 deletion accelerates DEN-induced HCC via activation of STAT3 signaling in mice |
| Q37935680 | How ubiquitination regulates the TGF-β signalling pathway: new insights and new players: new isoforms of ubiquitin-activating enzymes in the E1-E3 families join the game |
| Q40618164 | Hrs mediates downregulation of multiple signalling receptors in Drosophila |
| Q37431653 | Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling. |
| Q92376668 | Human ucMSCs seeded in a decellularized kidney scaffold attenuate renal fibrosis by reducing epithelial-mesenchymal transition via the TGF-β/Smad signaling pathway |
| Q30422218 | IQGAP1 suppresses TβRII-mediated myofibroblastic activation and metastatic growth in liver |
| Q41713745 | Identification of a lysosomal pathway regulating degradation of the bone morphogenetic protein receptor type II. |
| Q37285105 | Identification of a novel negative regulator of activin/nodal signaling in mesendodermal formation of Xenopus embryos |
| Q36328809 | Immunity by ubiquitylation: a reversible process of modification |
| Q24626938 | Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts |
| Q35125625 | In or out? The dynamics of Smad nucleocytoplasmic shuttling |
| Q46610850 | In vivo investigations on anti-fibrotic potential of proteasome inhibition in lung and skin fibrosis. |
| Q36948026 | Increased proteasome-dependent degradation of estrogen receptor-alpha by TGF-beta1 in breast cancer cell lines |
| Q24794867 | Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro |
| Q33884789 | Induction of Ski Protein Expression upon Luteinization in Rat Granulosa Cells |
| Q37085644 | Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice. |
| Q40435167 | Induction of ectopic olfactory structures and bone morphogenetic protein inhibition by Rossy, a group XII secreted phospholipase A2. |
| Q37397518 | Informatics approaches to understanding TGFbeta pathway regulation. |
| Q46382135 | Inhibition of the transforming growth factor-β/SMAD cascade mitigates the anti-neurogenic effects of the carbamate pesticide carbofuran |
| Q24671742 | Inhibition of transforming growth factor-beta1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARA |
| Q35105653 | Inhibitory SMADs: potential regulators of ovarian function |
| Q41559221 | Inhibitory Smads differentially regulate cell fate specification and axon dynamics in the dorsal spinal cord |
| Q37923302 | Integrating developmental signals: a Hippo in the (path)way |
| Q34929949 | Integration of the TGF-beta pathway into the cellular signalling network |
| Q53208281 | Interaction between Smad1 and p97/VCP in rat testis and epididymis during the postnatal development. |
| Q24556984 | Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis |
| Q38348547 | Interferon-γ suppresses transforming growth factor-β-induced invasion of gastric carcinoma cells through cross-talk of Smad pathway in a three-dimensional culture model |
| Q89133954 | Intervertebral Disc Aging, Degeneration, and Associated Potential Molecular Mechanisms |
| Q38423864 | Intracellular signaling of cardiac fibroblasts |
| Q47397700 | Intracellular trafficking of transforming growth factor β receptors |
| Q24304249 | Involvement of the constitutive complex formation of c-Ski/SnoN with Smads in the impaired negative feedback regulation of transforming growth factor beta signaling in scleroderma fibroblasts |
| Q88947003 | Isoform-specific effects of transforming growth factor β on endothelial-to-mesenchymal transition |
| Q35039000 | Itch E3 ubiquitin ligase positively regulates TGF-β signaling to EMT via Smad7 ubiquitination |
| Q24522552 | Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation |
| Q24313377 | Jab1/CSN5, a component of the COP9 signalosome, regulates transforming growth factor beta signaling by binding to Smad7 and promoting its degradation |
| Q38760746 | JunD Is Required for Proliferation of Prostate Cancer Cells and Plays a Role in Transforming Growth Factor-β (TGF-β)-induced Inhibition of Cell Proliferation |
| Q37689595 | KRAS protein stability is regulated through SMURF2: UBCH5 complex-mediated β-TrCP1 degradation |
| Q89766137 | Kelch-like protein 42 is a profibrotic ubiquitin E3 ligase involved in systemic sclerosis |
| Q39790068 | Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progression |
| Q26824916 | Key role for ubiquitin protein modification in TGFβ signal transduction |
| Q45875016 | Kidney-targeting Smad7 gene transfer inhibits renal TGF-β/MAD homologue (SMAD) and nuclear factor κB (NF-κB) signalling pathways, and improves diabetic nephropathy in mice |
| Q35766401 | Latent transforming growth factor binding protein 4 regulates transforming growth factor beta receptor stability. |
| Q39361954 | Lead induces an osteoarthritis-like phenotype in articular chondrocytes through disruption of TGF-β signaling |
| Q36137526 | Leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction induces a novel genetic signature resulting in T-cells refractory to transforming growth factor-β signaling |
| Q37497085 | Ligand-dependent and -independent transforming growth factor-beta receptor recycling regulated by clathrin-mediated endocytosis and Rab11. |
| Q51129815 | Lipopolysaccharide Activates Toll-Like Receptor 4 and Prevents Cardiac Fibroblast-to-Myofibroblast Differentiation |
| Q93173473 | Long non‑coding RNA LINC00858 promotes TP53‑wild‑type colorectal cancer progression by regulating the microRNA‑25‑3p/SMAD7 axis |
| Q57184107 | Loss of angiotensin-converting enzyme 2 enhances TGF-β/Smad-mediated renal fibrosis and NF-κB-driven renal inflammation in a mouse model of obstructive nephropathy |
| Q42159260 | Mammary branch initiation and extension are inhibited by separate pathways downstream of TGFβ in culture |
| Q36346393 | Mathematical model of TGF-βsignalling: feedback coupling is consistent with signal switching. |
| Q36638792 | Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system |
| Q54299380 | Mechanisms navigating the TGF-β pathway in prostate cancer. |
| Q27860785 | Mechanisms of TGF-beta signaling from cell membrane to the nucleus |
| Q33804105 | Mechanisms of the epithelial-mesenchymal transition by TGF-beta |
| Q43859650 | Meeting report: signaling schemes for TGF-beta |
| Q47359039 | Membrane targeting of inhibitory Smads through palmitoylation controls TGF-β/BMP signaling |
| Q28510844 | Methylation of Smad6 by protein arginine N-methyltransferase 1 |
| Q37204786 | MiR-10a improves hepatic fibrosis by regulating the TGFβl/Smads signal transduction pathway |
| Q90459247 | MiR-195 and miR-497 suppress tumorigenesis in lung cancer by inhibiting SMURF2-induced TGF-β receptor I ubiquitination |
| Q89622272 | MiR-216a accelerates proliferation and fibrogenesis via targeting PTEN and SMAD7 in human cardiac fibroblasts |
| Q36807057 | Mice overexpressing latent TGF-beta1 are protected against renal fibrosis in obstructive kidney disease |
| Q37533326 | MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells |
| Q36947118 | MicroRNA-195a-5p inhibits mouse medullary thymic epithelial cells proliferation by directly targeting Smad7 |
| Q52978300 | MicroRNA-590-5p Stabilizes Runx2 by Targeting Smad7 During Osteoblast Differentiation. |
| Q28540805 | Model-based analysis for qualitative data: an application in Drosophila germline stem cell regulation |
| Q38325122 | Modulation of the TGFbeta/Smad signaling pathway in mesangial cells by CTGF/CCN2. |
| Q34134107 | Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven in absentia homologue |
| Q27667356 | Molecular Mechanism of the Negative Regulation of Smad1/5 Protein by Carboxyl Terminus of Hsc70-interacting Protein (CHIP) |
| Q38749008 | Molecular mechanisms of atrial fibrosis: implications for the clinic |
| Q50066731 | Molecular regulation of Nodal signaling during mesendoderm formation |
| Q36724904 | Molecular requirements for induction of CTGF expression by TGF-beta1 in primary osteoblasts |
| Q38062404 | Molecular targets for treatment of kidney fibrosis |
| Q38315883 | Multifaceted role of the ubiquitin ligase Itch in immune regulation |
| Q46658856 | Myostatin auto-regulates its expression by feedback loop through Smad7 dependent mechanism |
| Q40501781 | NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor |
| Q41353750 | NEDD4-family E3 ligase dysfunction due to PKHD1/Pkhd1 defects suggests a mechanistic model for ARPKD pathobiology. |
| Q35916282 | Nanosized titanium dioxide resulted in the activation of TGF-β/Smads/p38MAPK pathway in renal inflammation and fibration of mice |
| Q24291789 | Nedd4 regulates ubiquitination and stability of the guanine-nucleotide exchange factor CNrasGEF |
| Q40607119 | Negative regulation of SCFSkp2 ubiquitin ligase by TGF-beta signaling. |
| Q35996296 | Negative regulation of TGF-beta signaling in development |
| Q28268852 | Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1) |
| Q34609912 | Neural induction, the default model and embryonic stem cells |
| Q52127609 | New developments for TGFbeta. |
| Q38245806 | New tricks for an old fox: impact of TGFβ on the DNA damage response and genomic stability |
| Q38058562 | Non-26S proteasome proteolytic role of ubiquitin in plant endocytosis and endosomal trafficking(F). |
| Q39013667 | Non-Smad Signaling Pathways of the TGF-β Family |
| Q35800181 | Non-degradative ubiquitination in Smad-dependent TGF-β signaling |
| Q60948824 | Non-proteolytic ubiquitin modification of PPARγ by Smurf1 protects the liver from steatosis |
| Q37044600 | Noncanonical TGF-β signaling during mammary tumorigenesis |
| Q27015094 | Normal morphogenesis of epithelial tissues and progression of epithelial tumors |
| Q37725064 | Notch prevents transforming growth factor-beta-assisted epithelial-mesenchymal transition in cultured limbal progenitor cells through the induction of Smad7. |
| Q59132121 | Notoginsenoside R1 Protects Against Diabetic Cardiomyopathy Through Activating Estrogen Receptor α and Its Downstream Signaling |
| Q24300517 | Novel RING E3 ubiquitin ligases in breast cancer |
| Q42175822 | Nuclear Smad7 Overexpressed in Mesenchymal Cells Acts as a Transcriptional Corepressor by Interacting with HDAC-1 and E2F to Regulate Cell Cycle |
| Q57269883 | Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-β signalling |
| Q38780491 | Nuclear receptor TLX inhibits TGF-β signaling in glioblastoma |
| Q37359956 | Nucleocytoplasmic shuttling of Smad proteins |
| Q42811215 | Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity |
| Q99710964 | OTUD4 enhances TGFβ signalling through regulation of the TGFβ receptor complex |
| Q33889211 | OVOL2 antagonizes TGF-β signaling to regulate epithelial to mesenchymal transition during mammary tumor metastasis. |
| Q64108169 | Opposing roles and potential antagonistic mechanism between TGF-β and BMP pathways: Implications for cancer progression |
| Q23920947 | Osteoactivin acts as downstream mediator of BMP-2 effects on osteoblast function |
| Q99708310 | Over-expression of Smad7 in hypothalamic POMC neurons disrupts glucose balance by attenuating central insulin signaling |
| Q26864900 | Overactive bone morphogenetic protein signaling in heterotopic ossification and Duchenne muscular dystrophy |
| Q39342955 | Overexpression of Smad ubiquitin regulatory factor 2 suppresses transforming growth factor-β mediated liver fibrosis |
| Q39647327 | Overexpression of Smad7 results in severe pathological alterations in multiple epithelial tissues |
| Q43186409 | Overexpression of Smurf2 stimulates endochondral ossification through upregulation of beta-catenin |
| Q41704237 | Overexpression of the FoxO1 Ameliorates Mesangial Cell Dysfunction in Male Diabetic Rats |
| Q36015282 | Overexpression of the TGF-beta antagonist Smad7 in endometrial cancer |
| Q33848601 | Oxidative exposure impairs TGF-β pathway via reduction of type II receptor and SMAD3 in human skin fibroblasts |
| Q36294546 | PICK1 promotes caveolin-dependent degradation of TGF-β type I receptor |
| Q42005326 | Paeoniflorin suppresses TGF-β mediated epithelial-mesenchymal transition in pulmonary fibrosis through a Smad-dependent pathway |
| Q29617293 | Physiological functions of the HECT family of ubiquitin ligases |
| Q24313316 | Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins |
| Q34947708 | Pivotal role of the C2 domain of the Smurf1 ubiquitin ligase in substrate selection |
| Q34066256 | Plasticity of TGF-β signaling |
| Q38012228 | Post-translational regulation of TGF-β receptor and Smad signaling. |
| Q39026435 | Posttranslational Regulation of Smads |
| Q26825421 | Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins |
| Q24291512 | Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads |
| Q44130958 | Proteasomal activity modulates TGF-ss signaling in a gene-specific manner |
| Q43746980 | Proteasomal degradation of Smad1 induced by bone morphogenetic proteins |
| Q37693531 | Proteasomal regulation of pulmonary fibrosis |
| Q38970493 | Proteasome dysfunction in cardiomyopathies. |
| Q28574398 | Protein kinase Czeta and glycogen synthase kinase-3beta control neuronal polarity in developing rodent enteric neurons, whereas SMAD specific E3 ubiquitin protein ligase 1 promotes neurite growth but does not influence polarity |
| Q44811143 | Protein related to DAN and cerberus is a bone morphogenetic protein antagonist that participates in ovarian paracrine regulation |
| Q61982458 | PyCoTools: a Python toolbox for COPASI |
| Q38386260 | Quantitative Proteomics of the SMAD (Suppressor of Mothers against Decapentaplegic) Transcription Factor Family Identifies Importin 5 as a Bone Morphogenic Protein Receptor SMAD-specific Importin |
| Q35088882 | Quantitative analysis of transient and sustained transforming growth factor-β signaling dynamics. |
| Q47347285 | Quantitative single-molecule study of TGF-β/Smad signaling |
| Q38420659 | RB1CC1 protein positively regulates transforming growth factor-beta signaling through the modulation of Arkadia E3 ubiquitin ligase activity |
| Q40358313 | RING finger-dependent ubiquitination by PRAJA is dependent on TGF-beta and potentially defines the functional status of the tumor suppressor ELF. |
| Q38908304 | RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor β signaling |
| Q45021930 | Receptor-regulated and inhibitory Smads are critical in regulating transforming growth factor beta-mediated Meckel's cartilage development |
| Q42270113 | Recognition mechanism of p63 by the E3 ligase Itch: novel strategy in the study and inhibition of this interaction |
| Q92286519 | Recombinant human PRG4 (rhPRG4) suppresses breast cancer cell invasion by inhibiting TGFβ-Hyaluronan-CD44 signalling pathway |
| Q53302797 | Reduction of transforming growth factor-beta type II receptor is caused by the enhanced ubiquitin-dependent degradation in human renal cell carcinoma. |
| Q44008456 | Regionally different immunoreactivity for Smurf2 and pSmad2/3 in TDP-43-positive inclusions of amyotrophic lateral sclerosis |
| Q37333694 | Regulating the stability of TGFbeta receptors and Smads |
| Q34696270 | Regulation of CCN2/connective tissue growth factor expression in the nucleus pulposus of the intervertebral disc: role of Smad and activator protein 1 signaling |
| Q52657648 | Regulation of CNKSR2 protein stability by the HECT E3 ubiquitin ligase Smurf2, and its role in breast cancer progression. |
| Q39507845 | Regulation of EGFR protein stability by the HECT-type ubiquitin ligase SMURF2. |
| Q34606049 | Regulation of Krüppel-like factor 4 by the anaphase promoting complex pathway is involved in TGF-beta signaling |
| Q29619145 | Regulation of Membrane Protein Transport by Ubiquitin and Ubiquitin-Binding Proteins |
| Q35652597 | Regulation of Smad activities |
| Q37276098 | Regulation of TGF-beta family signaling by E3 ubiquitin ligases |
| Q37779572 | Regulation of TGF-beta signalling by protein phosphatases |
| Q39029996 | Regulation of TGF-β Family Signaling by Inhibitory Smads. |
| Q26996826 | Regulation of TGF-β Signal Transduction |
| Q26830449 | Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination |
| Q35905598 | Regulation of TGF-β receptor activity |
| Q26827667 | Regulation of TGF-β signal transduction by mono- and deubiquitylation of Smads |
| Q33624967 | Regulation of Ubiquitin Enzymes in the TGF-β Pathway. |
| Q58047195 | Regulation of collagen synthesis by inhibitory Smad7 in cardiac myofibroblasts |
| Q41979197 | Regulation of early xenopus embryogenesis by Smad ubiquitination regulatory factor 2. |
| Q41883428 | Regulation of embryonic endochondral ossification by Smurf2. |
| Q37450141 | Regulation of endothelial barrier function by TGF-β type I receptor ALK5: potential role of contractile mechanisms and heat shock protein 90. |
| Q34979698 | Regulation of myofibroblast differentiation by miR-424 during epithelial-to-mesenchymal transition. |
| Q35691559 | Regulation of the TGFbeta signalling pathway by ubiquitin-mediated degradation |
| Q38020840 | Regulation of the transforming growth factor β pathway by reversible ubiquitylation |
| Q28180197 | Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3 |
| Q92384293 | Regulatory cytokine function in the respiratory tract |
| Q41528846 | Relationship between Sloan-Kettering virus expression and mammalian follicular development |
| Q58691532 | Reovirus infection induces stabilization and up-regulation of cellular transcripts that encode regulators of TGF-β signaling |
| Q28510682 | Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor |
| Q33840778 | Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception |
| Q37001195 | Retinoids regulate TGFbeta signaling at the level of Smad2 phosphorylation and nuclear accumulation. |
| Q90408538 | Rhein, a novel Histone Deacetylase (HDAC) inhibitor with antifibrotic potency in human myocardial fibrosis |
| Q46434881 | Role of Different Natural Antioxidants in the Modulation of mRNA-expression of Apoptotic Molecules in the Livers of Carbon Tetrachloride-Intoxicated Rats |
| Q34249350 | Role of Dlg5/lp-dlg, a membrane-associated guanylate kinase family protein, in epithelial-mesenchymal transition in LLc-PK1 renal epithelial cells |
| Q26774309 | Role of Noncoding RNAs as Biomarker and Therapeutic Targets for Liver Fibrosis |
| Q37885217 | Role of Smads in TGFβ signaling |
| Q36636365 | Role of TGF beta-mediated inflammation in cutaneous wound healing. |
| Q28081170 | Role of TGFβ in regulation of the tumor microenvironment and drug delivery (review) |
| Q36655274 | Role of Transforming Growth Factor-β1 and Smads Signaling Pathway in Intrauterine Adhesion |
| Q26821836 | Role of endoglin in fibrosis and scleroderma |
| Q28278757 | Role of the TGF-β/BMP-7/Smad pathways in renal diseases |
| Q36677493 | Role of transforming growth factor-beta in cancer progression |
| Q36399296 | Role of transforming growth factor-beta in hematologic malignancies |
| Q40419434 | Roles for lysine residues of the MH2 domain of Smad3 in transforming growth factor-beta signaling |
| Q28262241 | Roles for the MH2 domain of Smad7 in the specific inhibition of transforming growth factor-beta superfamily signaling |
| Q33781079 | Roles of E3 ubiquitin ligases in cell adhesion and migration |
| Q39192272 | SCUBE3 regulation of early lung cancer angiogenesis and metastatic progression |
| Q37037723 | SET9-Mediated Regulation of TGF-β Signaling Links Protein Methylation to Pulmonary Fibrosis |
| Q28589415 | SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation |
| Q90697987 | SMAD3 promotes ELK3 expression following transforming growth factor β-mediated stimulation of MDA-MB231 cells |
| Q50298168 | SMAD7 binds to SMURF2 |
| Q57821193 | SMAD7 is a novel independent predictor of survival in patients with cutaneous melanoma |
| Q39978119 | SMAD7, an antagonist of TGF-beta signaling, is a candidate of prenatal skeletal muscle development and weaning weight in pigs |
| Q38220764 | SMAD7: a timer of tumor progression targeting TGF-β signaling |
| Q50298177 | SMAD7:SMURF complex binds to phosphorylated TGFBR1 |
| Q50298169 | SMAD7:SMURF2 complex translocates to the cytosol |
| Q102141757 | SMURF1, a promoter of tumor cell progression? |
| Q89900964 | SMURF2 prevents detrimental changes to chromatin, protecting human dermal fibroblasts from chromosomal instability and tumorigenesis |
| Q37660607 | SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts |
| Q50298178 | SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 |
| Q24338384 | SNX25 regulates TGF-β signaling by enhancing the receptor degradation |
| Q38868773 | SPSB1, a Novel Negative Regulator of the Transforming Growth Factor-β Signaling Pathway Targeting the Type II Receptor. |
| Q81388843 | SUMO amplifies TGF-beta signalling |
| Q40920052 | Screening of SMAD7 in Malay patients with ventricular septal defect. |
| Q41612152 | Selective compounds enhance osteoblastic activity by targeting HECT domain of ubiquitin ligase Smurf1. |
| Q24338165 | Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT |
| Q40652029 | Signal-dependent N-CoR Requirement for Repression by the Ski Oncoprotein |
| Q38915720 | Signaling Receptors for TGF-β Family Members |
| Q93377974 | Single Nucleotide Polymorphism in SMAD7 and CHI3L1 and Colorectal Cancer Risk |
| Q35905611 | Skeletal Characterization of Smurf2-Deficient Mice and In Vitro Analysis of Smurf2-Deficient Chondrocytes |
| Q41816907 | Ski inhibits TGF-β/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes |
| Q35118772 | Sliding doors: clathrin-coated pits or caveolae? |
| Q40363154 | Smad proteins are targets of transforming growth factor beta1 in immortalised gonadotrophin-releasing hormone releasing neurones |
| Q33674328 | Smad signaling in skeletal development and regeneration |
| Q36620519 | Smad ubiquitination regulatory factor 2 expression is enhanced in hypertrophic scar fibroblasts from burned children |
| Q37091520 | Smad ubiquitination regulatory factor 2 promotes metastasis of breast cancer cells by enhancing migration and invasiveness |
| Q39343131 | Smad ubiquitination regulatory factor-2 controls gap junction intercellular communication by modulating endocytosis and degradation of connexin43. |
| Q55053400 | Smad ubiquitination regulatory factor-2 in progressive supranuclear palsy |
| Q37244477 | Smad ubiquitination regulatory factor-2 in the fibrotic kidney: regulation, target specificity, and functional implication |
| Q28208250 | Smad-dependent and Smad-independent pathways in TGF-beta family signalling |
| Q28066288 | Smad-dependent mechanisms of inflammatory bone destruction |
| Q42507600 | Smad3 controls β-1,3-glucuronosyltransferase 1 expression in rat nucleus pulposus cells: implications of dysregulated expression in disc disease |
| Q52620425 | Smad3 mediates ANG II-induced hypertensive kidney disease in mice. |
| Q24600452 | Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN |
| Q43492573 | Smad6 inhibits non-canonical TGF-β1 signalling by recruiting the deubiquitinase A20 to TRAF6. |
| Q24296392 | Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation |
| Q34563317 | Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1. |
| Q39478664 | Smad6-specific recruitment of Smurf E3 ligases mediates TGF-β1-induced degradation of MyD88 in TLR4 signalling |
| Q36322115 | Smad6/Smurf1 overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopenia |
| Q40438629 | Smad7 abrogates transforming growth factor-beta1-mediated growth inhibition in COLO-357 cells through functional inactivation of the retinoblastoma protein |
| Q91742165 | Smad7 and Colorectal Carcinogenesis: A Double-Edged Sword |
| Q33237935 | Smad7 and protein phosphatase 1alpha are critical determinants in the duration of TGF-beta/ALK1 signaling in endothelial cells. |
| Q24302554 | Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation |
| Q47713497 | Smad7 enables STAT3 activation and promotes pluripotency independent of TGF-β signaling |
| Q40351576 | Smad7 induces G0/G1 cell cycle arrest in mesenchymal cells by inhibiting the expression of G1 cyclins |
| Q34645458 | Smad7 inhibits autocrine expression of TGF-β2 in intestinal epithelial cells in baboon necrotizing enterocolitis |
| Q41839528 | Smad7 inhibits transforming growth factor-beta family type i receptors through two distinct modes of interaction. |
| Q24309482 | Smad7 is inactivated through a direct physical interaction with the LIM protein Hic-5/ARA55 |
| Q38342615 | Smad7 is required for TGF-beta-induced activation of the small GTPase Cdc42. |
| Q38409230 | Smad7 promotes and enhances skeletal muscle differentiation |
| Q35828473 | Smad7 protects against chronic aristolochic acid nephropathy in mice |
| Q33579825 | Smad7 regulates the adult neural stem/progenitor cell pool in a transforming growth factor beta- and bone morphogenetic protein-independent manner |
| Q37832528 | Smad7: not only a regulator, but also a cross-talk mediator of TGF-β signalling. |
| Q26865998 | Smads as therapeutic targets for chronic kidney disease |
| Q33553498 | Smurf-mediated differential proteolysis generates dynamic BMP signaling in germline stem cells during Drosophila testis development |
| Q35591035 | Smurf1 facilitates myogenic differentiation and antagonizes the bone morphogenetic protein-2-induced osteoblast conversion by targeting Smad5 for degradation |
| Q35155505 | Smurf1 inhibits mesenchymal stem cell proliferation and differentiation into osteoblasts through JunB degradation |
| Q37113932 | Smurf1 inhibits osteoblast differentiation and bone formation in vitro and in vivo |
| Q24291000 | Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation |
| Q45060698 | Smurf1 regulates lung cancer cell growth and migration through interaction with and ubiquitination of PIPKIγ. |
| Q24303055 | Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane |
| Q43014041 | Smurf1 ubiquitin ligase causes downregulation of BMP receptors and is induced in monocrotaline and hypoxia models of pulmonary arterial hypertension |
| Q41827585 | Smurf2 E3 ubiquitin ligase modulates proliferation and invasiveness of breast cancer cells in a CNKSR2 dependent manner |
| Q39592886 | Smurf2 alters BPV1 trafficking and decreases infection |
| Q37271332 | Smurf2 as a novel mitotic regulator: From the spindle assembly checkpoint to tumorigenesis |
| Q37288448 | Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage. |
| Q28297767 | Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells |
| Q24316887 | Smurf2 participates in human trophoblast cell invasion by inhibiting TGF-beta type I receptor |
| Q50188862 | Smurf2 regulates stability and the autophagic-lysosomal turnover of lamin A and its disease-associated form progerin |
| Q36740590 | Smurf2 regulates the senescence response and suppresses tumorigenesis in mice |
| Q37240803 | Smurf2 suppresses B-cell proliferation and lymphomagenesis by mediating ubiquitination and degradation of YY1. |
| Q24558758 | Smurf2 up-regulation activates telomere-dependent senescence |
| Q36771332 | Smurf2-mediated degradation of EZH2 enhances neuron differentiation and improves functional recovery after ischaemic stroke |
| Q35549516 | Smurf2-mediated ubiquitination and degradation of Id1 regulates p16 expression during senescence |
| Q58803474 | Smurfs in Protein Homeostasis, Signaling, and Cancer |
| Q35065290 | Sortilin associates with transforming growth factor-beta family proteins to enhance lysosome-mediated degradation |
| Q46511813 | Specificity of the inhibitory effects of Dad on TGF-beta family type I receptors, Thickveins, Saxophone, and Baboon in Drosophila. |
| Q91943837 | Specificity, versatility, and control of TGF-β family signaling |
| Q38731412 | Structural Basis for Specific Interaction of TGFβ Signaling Regulators SARA/Endofin with HD-PTP. |
| Q24628923 | Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF-β Pathways |
| Q24292106 | Structural basis of Smad1 activation by receptor kinase phosphorylation |
| Q24300948 | Structural basis of dimerization-dependent ubiquitination by the SCF(Fbx4) ubiquitin ligase |
| Q28235253 | Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling |
| Q28118751 | Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization |
| Q37340230 | TACE-mediated ectodomain shedding of the type I TGF-beta receptor downregulates TGF-beta signaling |
| Q33681686 | TGF- Biology in Mammary Development and Breast Cancer |
| Q28199064 | TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation |
| Q40247364 | TGF-beta inhibition of CTL re-stimulation requires accessory cells and induces peroxisome-proliferator-activated receptor-gamma (PPAR-gamma). |
| Q34353131 | TGF-beta signalling pathways in early Xenopus development. |
| Q34579850 | TGF-beta-mediated control of allergen-specific T-cell responses. |
| Q37103894 | TGF-beta1 attenuates mediator release and de novo Kit expression by human skin mast cells through a Smad-dependent pathway |
| Q39908378 | TGF-beta1 modulates focal adhesion kinase expression in rat intestinal epithelial IEC-6 cells via stimulatory and inhibitory Smad binding elements |
| Q40663059 | TGF-beta1-mediated alterations of renal proximal tubular epithelial cell phenotype |
| Q27025590 | TGF-β - an excellent servant but a bad master |
| Q39029986 | TGF-β Family Signaling in the Control of Cell Proliferation and Survival |
| Q92090599 | TGF-β Initiates β-Catenin-Mediated CTGF Secretory Pathway in Old Bovine Nucleus Pulposus Cells: A Potential Mechanism for Intervertebral Disc Degeneration |
| Q90631766 | TGF-β Signaling |
| Q38906099 | TGF-β Signaling from Receptors to Smads |
| Q33566661 | TGF-β activation and function in immunity |
| Q26995720 | TGF-β and BMP signaling in osteoblast differentiation and bone formation |
| Q47632031 | TGF-β and IL-6 family signalling crosstalk: an integrated model |
| Q34798852 | TGF-β and restenosis revisited: a Smad link |
| Q92883776 | TGF-β family ligands exhibit distinct signalling dynamics that are driven by receptor localisation |
| Q47608383 | TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis. |
| Q37395668 | TGF-β receptor maintains CD4 T helper cell identity during chronic viral infections |
| Q49488316 | TGF-β signaling in cancer metastasis. |
| Q36775661 | TGF-β signaling in the kidney: profibrotic and protective effects |
| Q40800185 | TGF-β signaling is activated in patients with chronic HBV infection and repressed by SMAD7 overexpression after successful antiviral treatment |
| Q57801762 | TGF-β signaling pathway mediated by deubiquitinating enzymes |
| Q36943410 | TGF-β signalling and reactive oxygen species drive fibrosis and matrix remodelling in myxomatous mitral valves |
| Q36737131 | TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis |
| Q93036211 | TGF-β/SMAD signaling regulation of mesenchymal stem cells in adipocyte commitment |
| Q26851198 | TGF-β/Smad signaling in renal fibrosis |
| Q37634488 | TGF-β: duality of function between tumor prevention and carcinogenesis. |
| Q37798252 | TGF-β: friend or foe? The role of TGF-β/SMAD signaling in epigenetic silencing of ovarian cancer and its implication in epigenetic therapy. |
| Q38724337 | TGF-β: the connecting link between nephropathy and fibrosis |
| Q34144001 | TGFbeta inducible early gene enhances TGFbeta/Smad-dependent transcriptional responses. |
| Q34713446 | TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility |
| Q40622411 | TGFbeta1 expression in colonic mucosa: modulation by dietary lipids |
| Q28083107 | TGFβ Signaling in Tumor Initiation, Epithelial-to-Mesenchymal Transition, and Metastasis |
| Q39521876 | TGFβ regulates Galectin-3 expression through canonical Smad3 signaling pathway in nucleus pulposus cells: implications in intervertebral disc degeneration |
| Q28275410 | TGFβ signalling in context |
| Q35172304 | TGFβ superfamily signaling regulators are differentially expressed in the developing and adult mouse testis |
| Q33648775 | TMPRSS2:ERG gene fusion variants induce TGF-β signaling and epithelial to mesenchymal transition in human prostate cancer cells |
| Q38253588 | TRAF4 mediates activation of TGF-β signaling and is a biomarker for oncogenesis in breast cancer |
| Q35192600 | TSC-22 promotes transforming growth factor β-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity. |
| Q61443002 | TTC3 contributes to TGF-β-induced epithelial-mesenchymal transition and myofibroblast differentiation, potentially through SMURF2 ubiquitylation and degradation |
| Q35102837 | Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma |
| Q58700082 | Targeting TGF-β Signaling in Kidney Fibrosis |
| Q104795035 | Targeting TGFβ signal transduction for cancer therapy |
| Q28287877 | Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1 |
| Q36806808 | Termination of TGF-beta superfamily signaling through SMAD dephosphorylation--a functional genomic view |
| Q39871283 | Tgf-Beta superfamily receptors-targets for antiangiogenic therapy? |
| Q54369988 | Tgfβ/Alk5 signaling is required for shear stress induced klf2 expression in embryonic endothelial cells. |
| Q64062269 | The Activin Receptor, Activin-Like Kinase 4, Mediates Activation of Hypoxia Inducible Factor-1 |
| Q33850210 | The Chinese medicine, Jianpi Huayu Decoction, inhibits the epithelial mesenchymal transition via the regulation of the Smad3/Smad7 cascade |
| Q47070374 | The DSmurf ubiquitin-protein ligase restricts BMP signaling spatially and temporally during Drosophila embryogenesis. |
| Q36985643 | The Dual Role of TGFβ in Human Cancer: From Tumor Suppression to Cancer Metastasis |
| Q59355701 | The Dynamic Roles of TGF-β Signalling in EBV-Associated Cancers |
| Q35562752 | The E3 ubiquitin ligase SMAD ubiquitination regulatory factor 2 negatively regulates Krüppel-like factor 5 protein |
| Q34016197 | The G protein-coupled receptor kinase-2 is a TGFbeta-inducible antagonist of TGFbeta signal transduction |
| Q36651563 | The Genetic Basis of Peyronie's Disease: A Review. |
| Q30484127 | The HECT E3 ligase Smurf2 is required for Mad2-dependent spindle assembly checkpoint |
| Q37206488 | The HECT family of E3 ubiquitin ligases: multiple players in cancer development |
| Q98288395 | The Influence of Adalimumab and Cyclosporine A on the Expression Profile of the Genes Related to TGFβ Signaling Pathways in Keratinocyte Cells Treated with Lipopolysaccharide A |
| Q54979151 | The Long Non-Coding RNA MIR503HG Enhances Proliferation of Human ALK-Negative Anaplastic Large-Cell Lymphoma. |
| Q34585694 | The Mub1/Ubr2 ubiquitin ligase complex regulates the conserved Dsn1 kinetochore protein |
| Q36294196 | The N domain of Smad7 is essential for specific inhibition of transforming growth factor-beta signaling |
| Q35691527 | The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture |
| Q33591420 | The PIAS3-Smurf2 sumoylation pathway suppresses breast cancer organoid invasiveness |
| Q98178433 | The Post-translational Modifications of Smurf2 in TGF-β Signaling |
| Q24651192 | The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase |
| Q58795170 | The SUMO System and TGFβ Signaling Interplay in Regulation of Epithelial-Mesenchymal Transition: Implications for Cancer Progression |
| Q24298147 | The Ski-binding protein C184M negatively regulates tumor growth factor-beta signaling by sequestering the Smad proteins in the cytoplasm |
| Q37468740 | The Smad7-Skp2 complex orchestrates Myc stability, impacting on the cytostatic effect of TGF-β |
| Q24805956 | The Smads |
| Q36708040 | The Smurf ubiquitin ligases regulate tissue separation via antagonistic interactions with ephrinB1. |
| Q34511224 | The TGF-beta--Smad network: introducing bioinformatic tools |
| Q34138871 | The WW-HECT protein Smurf2 interacts with the Docking Protein NEDD9/HEF1 for Aurora A activation. |
| Q35657960 | The adipocyte clock controls brown adipogenesis through the TGF-β and BMP signaling pathways |
| Q40763954 | The anaphase-promoting complex mediates TGF-beta signaling by targeting SnoN for destruction |
| Q40435100 | The balance between acetylation and deacetylation controls Smad7 stability. |
| Q35562497 | The deubiquitinase CYLD targets Smad7 protein to regulate transforming growth factor β (TGF-β) signaling and the development of regulatory T cells |
| Q34435000 | The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling |
| Q36118798 | The disintegrin and metalloproteinase ADAM12 contributes to TGF-beta signaling through interaction with the type II receptor |
| Q38169545 | The dual role of Smad7 in the control of cancer growth and metastasis |
| Q24338562 | The evolutionally conserved activity of Dapper2 in antagonizing TGF-beta signaling |
| Q39862772 | The extracellular domain of the TGFbeta type II receptor regulates membrane raft partitioning. |
| Q24302271 | The forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 alpha by a von Hippel-Lindau protein-independent mechanism |
| Q56741098 | The interaction of mPar3 with the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity |
| Q35633748 | The kinase activity of the Ser/Thr kinase BUB1 promotes TGF-β signaling. |
| Q47313741 | The methyltransferase SET9 regulates TGFB1 activation of renal fibroblasts via interaction with SMAD3. |
| Q35630847 | The missing link: studying the alternative TGF-β pathway provides a unifying theory for different components of diabetic nephropathy |
| Q37369189 | The multiple layers of ubiquitin-dependent cell cycle control. |
| Q24563226 | The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation |
| Q37040558 | The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cells |
| Q39781820 | The phosphatidylinositol 3-kinase/Akt pathway regulates transforming growth factor-{beta} signaling by destabilizing ski and inducing Smad7. |
| Q34527184 | The protective role of Smad7 in diabetic kidney disease: mechanism and therapeutic potential |
| Q30989535 | The protein stability of Axin, a negative regulator of Wnt signaling, is regulated by Smad ubiquitination regulatory factor 2 (Smurf2) |
| Q33857612 | The regulation of TGF-β/SMAD signaling by protein deubiquitination |
| Q34805700 | The regulatory utilization of genetic redundancy through responsive backup circuits |
| Q64929037 | The role and mechanism of transforming growth factor beta 3 in human myocardial infarction-induced myocardial fibrosis. |
| Q35143104 | The role of Smad7 in oral mucositis |
| Q39062904 | The role of TGF-β1 during skeletal muscle regeneration. |
| Q38070343 | The role of endocytic pathways in TGF-β signaling |
| Q38196802 | The role of hepatic transferrin receptor 2 in the regulation of iron homeostasis in the body |
| Q38017592 | The role of the ubiquitin-proteasome system in kidney diseases |
| Q36565602 | The role of ubiquitin-protein ligases in neurodegenerative disease |
| Q36563513 | The roles for cytokines in the generation and maintenance of regulatory T cells |
| Q33929804 | The self-limiting dynamics of TGF-β signaling in silico and in vitro, with negative feedback through PPM1A upregulation |
| Q39262611 | The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid-imidazolide alters transforming growth factor beta-dependent signaling and cell migration by affecting the cytoskeleton and the polarity complex |
| Q36370178 | The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease |
| Q34307626 | The transcriptional role of Smads and FAST (FoxH1) in TGFbeta and activin signalling |
| Q24302423 | The transforming activity of Ski and SnoN is dependent on their ability to repress the activity of Smad proteins |
| Q37112272 | The type I TGF-beta receptor is covalently modified and regulated by sumoylation |
| Q36228169 | The ubiquitin E3 ligase WWP1 decreases CXCL12-mediated MDA231 breast cancer cell migration and bone metastasis |
| Q39760437 | The ubiquitin binding region of the Smurf HECT domain facilitates polyubiquitylation and binding of ubiquitylated substrates |
| Q36799312 | The ubiquitin ligase Smurf2 suppresses TGFβ-induced epithelial-mesenchymal transition in a sumoylation-regulated manner |
| Q91624576 | The ubiquitin-proteasome system in kidney physiology and disease |
| Q35903165 | Therapeutic Effects of Tangshen Formula on Diabetic Nephropathy in Rats |
| Q39171149 | Therapeutic Potential for Bone Morphogenetic Protein 4 in Human Malignant Glioma |
| Q37021754 | Thyroid hormones inhibit TGF-β signaling and attenuate fibrotic responses. |
| Q28243485 | Tif1γ regulates the TGF-β1 receptor and promotes physiological aging of hematopoietic stem cells |
| Q33632005 | Tiul1 and TGIF are Involved in Downregulation of TGFbeta1-induced IgA Isotype Expression |
| Q37128066 | To (TGF)beta or not to (TGF)beta: fine-tuning of Smad signaling via post-translational modifications |
| Q28208130 | Tob proteins enhance inhibitory Smad-receptor interactions to repress BMP signaling |
| Q36408011 | Tollip, an intracellular trafficking protein, is a novel modulator of the transforming growth factor-β signaling pathway |
| Q34094330 | Toxoplasma gondii activates hypoxia-inducible factor (HIF) by stabilizing the HIF-1alpha subunit via type I activin-like receptor kinase receptor signaling |
| Q28247702 | Transcriptional induction of Smurf2 ubiquitin ligase by TGF-beta |
| Q35921610 | Transcriptional induction of salt-inducible kinase 1 by transforming growth factor β leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase |
| Q38362711 | Transcriptional regulation of Smad2 is required for enhancement of TGFbeta/Smad signaling by TGFbeta inducible early gene. |
| Q48182968 | Transforming Growth Factor β/NR4A1-Inducible Breast Cancer Cell Migration and Epithelial-to-Mesenchymal Transition Is p38α (Mitogen-Activated Protein Kinase 14) Dependent |
| Q91714322 | Transforming Growth Factor-Beta1 in Diabetic Kidney Disease |
| Q55177521 | Transforming Growth Factor-β Signaling Plays a Pivotal Role in the Interplay Between Osteosarcoma Cells and Their Microenvironment. |
| Q55423261 | Transforming Growth Factor-β1/Smad7 in Intestinal Immunity, Inflammation, and Cancer. |
| Q35076034 | Transforming growth factor Beta family: insight into the role of growth factors in regulation of fracture healing biology and potential clinical applications. |
| Q33712568 | Transforming growth factor beta (TGF-beta) and inflammation in cancer |
| Q28576567 | Transforming growth factor beta (TGF-beta) signaling is regulated by electrical activity in skeletal muscle cells. TGF-beta type I receptor is transcriptionally regulated by myotube excitability |
| Q40729010 | Transforming growth factor beta activates Smad2 in the absence of receptor endocytosis |
| Q37156962 | Transforming growth factor beta depletion is the primary determinant of Smad signaling kinetics |
| Q39344496 | Transforming growth factor β inhibits bone morphogenetic protein-induced transcription through novel phosphorylated Smad1/5-Smad3 complexes |
| Q38192972 | Transforming growth factor-beta and its implication in the malignancy of gliomas |
| Q37098304 | Transforming growth factor-beta signaling and ubiquitinators in cancer. |
| Q37103999 | Transforming growth factor-beta signaling in thoracic aortic aneurysm development: a paradox in pathogenesis |
| Q24804340 | Transforming growth factor-beta-induced regulatory T cells referee inflammatory and autoimmune diseases |
| Q38322625 | Transforming growth factor-beta-regulated gene transcription and protein expression in human GFAP-negative lamina cribrosa cells. |
| Q24550794 | Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3 |
| Q37633528 | Transforming growth factor-beta: a target for cancer therapy |
| Q34789300 | Transforming growth factor-β and the hallmarks of cancer |
| Q58767650 | Transforming growth factor-β signaling in head and neck squamous cell carcinoma: Insights into cellular responses |
| Q49895124 | Transforming growth factor-β signaling in systemic sclerosis |
| Q99584180 | Treatment of Hypertensive Heart Disease by Targeting Smad3 Signaling in Mice |
| Q30484142 | Treatment of established peritoneal fibrosis by gene transfer of Smad7 in a rat model of peritoneal dialysis. |
| Q42757925 | Tril targets Smad7 for degradation to allow hematopoietic specification in Xenopus embryos. |
| Q41575347 | Trps1 haploinsufficiency promotes renal fibrosis by increasing Arkadia expression |
| Q37109228 | Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts. |
| Q37262166 | Tumor necrosis factor-receptor-associated factor-4 is a positive regulator of transforming growth factor-beta signaling that affects neural crest formation |
| Q96135495 | Twist1-induced miR-199a-3p promotes liver fibrosis by suppressing caveolin-2 and activating TGF-β pathway |
| Q36079255 | USP11 augments TGFβ signalling by deubiquitylating ALK5. |
| Q30666768 | USP15 regulates SMURF2 kinetics through C-lobe mediated deubiquitination. |
| Q24305427 | USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma |
| Q33625848 | USP26 regulates TGF-β signaling by deubiquitinating and stabilizing SMAD7 |
| Q90745032 | USP32 promotes tumorigenesis and chemoresistance in gastric carcinoma via upregulation of SMAD2 |
| Q84393677 | USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor |
| Q34503492 | Ubiquitin becomes ubiquitous in cancer: emerging roles of ubiquitin ligases and deubiquitinases in tumorigenesis and as therapeutic targets |
| Q37239897 | Ubiquitin carboxyl-terminal hydrolase-L5 promotes TGFβ-1 signaling by de-ubiquitinating and stabilizing Smad2/Smad3 in pulmonary fibrosis |
| Q28513591 | Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation |
| Q37345503 | Ubiquitin ligase adaptors: regulators of ubiquitylation and endocytosis of plasma membrane proteins. |
| Q84488903 | Ubiquitin removal in the TGF-β pathway |
| Q42047648 | Ubiquitin-Dependent Degradation of Smad2 Is Increased in the Glomeruli of Rats with Anti-Thymocyte Serum Nephritis |
| Q83177771 | Ubiquitin-dependent degradation of SnoN and Ski is increased in renal fibrosis induced by obstructive injury |
| Q35082727 | Ubiquitin-dependent regulation of TGFbeta signaling in cancer |
| Q39033646 | Ubiquitination and the Regulation of Membrane Proteins |
| Q58606339 | Ubiquitination in Scleroderma Fibrosis and Its Treatment |
| Q38229325 | Ubiquitination involved enzymes and cancer |
| Q39464035 | Ubiquitination of heat shock protein 27 is mediated by its interaction with Smad ubiquitination regulatory factor 2 in A549 cells |
| Q24682414 | Ubiquitination of the GTPase Rap1B by the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity |
| Q37048402 | Ubiquitination of tumor necrosis factor receptor-associated factor 4 (TRAF4) by Smad ubiquitination regulatory factor 1 (Smurf1) regulates motility of breast epithelial and cancer cells |
| Q34365210 | Ubiquitination-dependent regulation of signaling receptors in cancer |
| Q94496782 | Ubiquitination-mediated degradation of SIRT1 by SMURF2 suppresses CRC cell proliferation and tumorigenesis |
| Q30499402 | Ultrasound-microbubble-mediated gene transfer of inducible Smad7 blocks transforming growth factor-beta signaling and fibrosis in rat remnant kidney. |
| Q42471345 | Ultraviolet irradiation induces Smad7 via induction of transcription factor AP-1 in human skin fibroblasts |
| Q35808585 | Unexpected diversity in Shisa-like proteins suggests the importance of their roles as transmembrane adaptors |
| Q35744961 | Unraveling the biological functions of Smad7 with mouse models |
| Q38857210 | Urocortin attenuates TGFβ1-induced Snail1 and slug expressions: inhibitory role of Smad7 in Smad2/3 signaling in breast cancer cells |
| Q34399941 | Vasohibin-1 deficiency enhances renal fibrosis and inflammation after unilateral ureteral obstruction |
| Q91771314 | VprBP mitigates TGF-β and Activin signaling by promoting Smurf1-mediated type I receptor degradation |
| Q85521723 | WITHDRAWN: Smurf2 negatively regulates IFN-á production through mediating IRF3 ubiquitination and degradation |
| Q31132084 | WW domain sequence activity relationships identified using ligand recognition propensities of 42 WW domains |
| Q24597197 | Wnt/beta-catenin signaling and small molecule inhibitors |
| Q28214698 | Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling |
| Q41567346 | ZC4H2 stabilizes Smads to enhance BMP signalling, which is involved in neural development in Xenopus. |
| Q64051886 | ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes |
| Q90287704 | c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression |
| Q37629637 | c-Ski, Smurf2, and Arkadia as regulators of TGF-beta signaling: new targets for managing myofibroblast function and cardiac fibrosis |
| Q44445871 | dSmurf Selectively Degrades Decapentaplegic-activated MAD, and Its Overexpression Disrupts Imaginal Disc Development |
| Q24298641 | miR-21 overexpression enhances TGF-β1-induced epithelial-to-mesenchymal transition by target smad7 and aggravates renal damage in diabetic nephropathy |
| Q41702026 | miR-590 promotes the proliferation of HUMSCs and induces ECM synthesis by targeting Smad7. |
| Q37117435 | miR-877-3p targets Smad7 and is associated with myofibroblast differentiation and bleomycin-induced lung fibrosis |
| Q41808402 | microRNA are Central Players in Anti- and Profibrotic Gene Regulation during Liver Fibrosis |
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