CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation

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CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M412275200
P8608Fatcat IDrelease_s4pahcrvdjgdtoywzvpzt32i64
P698PubMed publication ID15781469

P50authorHongxiu NingQ124328193
P2093author name stringHong Xin
Linyu Li
Xialian Xu
Xin-Yuan Fu
Yinyin Wang
Yu Rong
Yu Shang
Zhijie Chang
P2860cites workDirect interaction between Smad3, APC10, CDH1 and HEF1 in proteasomal degradation of HEF1Q21284174
A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs).Q21284180
A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formationQ22003817
TGF-beta signal transductionQ22003891
Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functionsQ22010047
Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signalingQ24290353
Overexpression of the cochaperone CHIP enhances Hsp70-dependent folding activity in mammalian cells.Q39777855
Ubiquitin-dependent degradation of TGF-beta-activated smad2.Q40913405
Smad7 differentially regulates transforming growth factor beta-mediated signaling pathwaysQ40920197
Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway.Q40968846
Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.Q41157114
CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded proteinQ41776375
Protein turnover: a CHIP programmed for proteolysis.Q43854002
Protein quality control: U-box-containing E3 ubiquitin ligases join the foldQ44061660
Nomenclature: vertebrate mediators of TGFbeta family signalsQ48058869
Physical and functional interaction of SMADs and p300/CBPQ64381971
Induction of the AP-1 members c-Jun and JunB by TGF-beta/Smad suppresses early Smad-driven gene activationQ74010133
The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteinsQ24290709
Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligaseQ24290743
Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradationQ24290777
Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradationQ24291000
CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activityQ24302505
Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcriptionQ24311810
TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4Q24314661
CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcriptionQ24603619
Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteinsQ24633428
Smads bind directly to the Jun family of AP-1 transcription factorsQ24685193
Mechanisms of TGF-beta signaling from cell membrane to the nucleusQ27860785
A Smad transcriptional corepressorQ28141283
TGFbeta signaling in growth control, cancer, and heritable disordersQ28142605
TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradationQ28199064
C-terminal Hsp-interacting protein slows androgen receptor synthesis and reduces its rate of degradationQ28206370
ErbB2 degradation mediated by the co-chaperone protein CHIPQ28208008
Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signallingQ28251743
The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3Q28276517
SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signallingQ28506547
Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor betaQ28608955
The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradationQ29616141
A DNA vector-based RNAi technology to suppress gene expression in mammalian cellsQ29616551
Transcriptional control by the TGF-beta/Smad signaling systemQ29618985
How cells read TGF-beta signalsQ29619993
Regulation of Smad activityQ33830190
SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genesQ33867572
Ski/Sno and TGF-beta signaling.Q34225107
The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activationQ35205960
The 26S proteasome system in the signaling pathways of TGF-beta superfamilyQ35212814
Regulation of the TGFbeta signalling pathway by ubiquitin-mediated degradationQ35691559
Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding proteinQ36573904
TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding proteinQ36926151
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectSMAD bindingQ14902697
STIP1 homology and U-box containing protein 1Q21116753
P304page(s)20842-50
P577publication date2005-05-27
P1433published inJournal of Biological ChemistryQ867727
P1476titleCHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation
P478volume280