| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1049531372 |
| P356 | DOI | 10.1038/35050509 |
| P8608 | Fatcat ID | release_s3ievjr5pzghjc77qyv3ht2vwm |
| P3181 | OpenCitations bibliographic resource ID | 611397 |
| P698 | PubMed publication ID | 11146634 |
| P5875 | ResearchGate publication ID | 12181992 |
| P2093 | author name string | Zhang W | |
| Patterson C | |||
| Cyr DM | |||
| Meacham GC | |||
| Younger JM | |||
| P2860 | cites work | Apoprotein B100, an inefficiently translocated secretory protein, is bound to the cytosolic chaperone, heat shock protein 70 | Q71743468 |
| Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions | Q22010047 | ||
| The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins | Q24290709 | ||
| BAG-1 modulates the chaperone activity of Hsp70/Hsc70. | Q24313113 | ||
| Identification, expression, and chromosomal localization of ubiquitin conjugating enzyme 7 (UBE2G2), a human homologue of the Saccharomyces cerevisiae ubc7 gene | Q24321463 | ||
| Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome | Q24533430 | ||
| The Hdj-2/Hsc70 chaperone pair facilitates early steps in CFTR biogenesis | Q24533965 | ||
| GrpE-like regulation of the hsc70 chaperone by the anti-apoptotic protein BAG-1 | Q24536019 | ||
| ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway | Q27932376 | ||
| A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly. | Q27935265 | ||
| A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum | Q27936443 | ||
| Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA | Q28119124 | ||
| Hop modulates Hsp70/Hsp90 interactions in protein folding | Q28260829 | ||
| Aggresomes: a cellular response to misfolded proteins | Q28292275 | ||
| Identification of rabbit reticulocyte E217K as a UBC7 homologue and functional characterization of its core domain loop | Q28569543 | ||
| Hip, a novel cochaperone involved in the eukaryotic hsc70/hsp40 reaction cycle | Q28569622 | ||
| Degradation of CFTR by the ubiquitin-proteasome pathway | Q29616142 | ||
| Posttranslational quality control: folding, refolding, and degrading proteins. | Q30323825 | ||
| DeltaF508 CFTR protein expression in tissues from patients with cystic fibrosis | Q33854446 | ||
| Identification of two regions in apolipoprotein B100 that are exposed on the cytosolic side of the endoplasmic reticulum membrane | Q36255357 | ||
| The pathway of US11-dependent degradation of MHC class I heavy chains involves a ubiquitin-conjugated intermediate | Q36310746 | ||
| Dynamic association of proteasomal machinery with the centrosome | Q36342153 | ||
| Sorting signals in the MHC class II invariant chain cytoplasmic tail and transmembrane region determine trafficking to an endocytic processing compartment | Q36382892 | ||
| Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis | Q40488178 | ||
| Conformational maturation of CFTR but not its mutant counterpart (delta F508) occurs in the endoplasmic reticulum and requires ATP | Q40794305 | ||
| A novel component involved in ubiquitination is required for development of Dictyostelium discoideum | Q41010998 | ||
| Membrane trafficking of the cystic fibrosis gene product, cystic fibrosis transmembrane conductance regulator, tagged with green fluorescent protein in madin-darby canine kidney cells | Q41016178 | ||
| Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis | Q41714520 | ||
| Characterization and dynamics of aggresome formation by a cytosolic GFP-chimera | Q42870983 | ||
| Multiple proteolytic systems, including the proteasome, contribute to CFTR processing. | Q50337154 | ||
| The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70 | Q56971940 | ||
| The U box is a modified RING finger — a common domain in ubiquitination | Q57263070 | ||
| Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells | Q59073603 | ||
| Mislocalization of ΔF508 CFTR in cystic fibrosis sweat gland | Q67468902 | ||
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | molecular chaperones | Q422496 |
| P304 | page(s) | 100-5 | |
| P577 | publication date | 2001-01-01 | |
| P1433 | published in | Nature Cell Biology | Q1574111 |
| P1476 | title | The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation | |
| P478 | volume | 3 |
| Q35639867 | 4-Phenylbutyrate stimulates Hsp70 expression through the Elp2 component of elongator and STAT-3 in cystic fibrosis epithelial cells |
| Q28078724 | A Decade of Boon or Burden: What Has the CHIP Ever Done for Cellular Protein Quality Control Mechanism Implicated in Neurodegeneration and Aging? |
| Q56552003 | A New Gun in Town: The U Box Is a Ubiquitin Ligase Domain |
| Q98945635 | A Novel Treatment for Arrhythmias via the Control of the Degradation of Ion Channel Proteins |
| Q27671664 | A Structural Model of the Sgt2 Protein and Its Interactions with Chaperones and the Get4/Get5 Complex |
| Q28539323 | A chaperone-assisted degradation pathway targets kinetochore proteins to ensure genome stability |
| Q37038867 | A counterintuitive approach to treat enzyme deficiencies: use of enzyme inhibitors for restoring mutant enzyme activity |
| Q30485241 | A critical role for CHIP in the aggresome pathway |
| Q36322876 | A foldable CFTR{Delta}F508 biogenic intermediate accumulates upon inhibition of the Hsc70-CHIP E3 ubiquitin ligase |
| Q42808557 | A misassembled transmembrane domain of a polytopic protein associates with signal peptide peptidase |
| Q36078874 | A network of ubiquitin ligases is important for the dynamics of misfolded protein aggregates in yeast |
| Q36181399 | A new frontier in pharmacology: the endoplasmic reticulum as a regulated export pathway in health and disease |
| Q28216296 | A new gun in town: the U box is a ubiquitin ligase domain |
| Q38313516 | A novel route for F-box protein-mediated ubiquitination links CHIP to glycoprotein quality control |
| Q42688247 | A soluble sulfogalactosyl ceramide mimic promotes Delta F508 CFTR escape from endoplasmic reticulum associated degradation |
| Q37948028 | Abiotic stress tolerance mediated by protein ubiquitination |
| Q44546807 | Activation of CFTR by genistein in human airway epithelial cell lines |
| Q38003982 | Aggrephagy: selective disposal of protein aggregates by macroautophagy. |
| Q35224117 | An RNA aptamer specific to Hsp70-ATP conformation inhibits its ATPase activity independent of Hsp40. |
| Q28258333 | An androgen receptor NH2-terminal conserved motif interacts with the COOH terminus of the Hsp70-interacting protein (CHIP) |
| Q46705910 | An energy-dependent maturation step is required for release of the cystic fibrosis transmembrane conductance regulator from early endoplasmic reticulum biosynthetic machinery |
| Q41934077 | Analysis of CFTR folding and degradation in transiently transfected cells |
| Q40489614 | Analysis of estrogen receptor alpha signaling complex at the plasma membrane |
| Q36673300 | Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions |
| Q34076025 | Applications of proteomic technologies for understanding the premature proteolysis of CFTR. |
| Q36580076 | Aptamer-Enabled Manipulation of the Hsp70 Chaperone System Suggests a Novel Strategy for Targeted Ubiquitination |
| Q81358747 | Arrest of CFTRDeltaF508 folding |
| Q46325087 | Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control |
| Q36954146 | Assembly and misassembly of cystic fibrosis transmembrane conductance regulator: folding defects caused by deletion of F508 occur before and after the calnexin-dependent association of membrane spanning domain (MSD) 1 and MSD2 |
| Q51599660 | AtCHIP, a U-box-containing E3 ubiquitin ligase, plays a critical role in temperature stress tolerance in Arabidopsis. |
| Q30418755 | Ataxia and hypogonadism caused by the loss of ubiquitin ligase activity of the U box protein CHIP |
| Q30277961 | Augmentation of CFTR maturation by S-nitrosoglutathione reductase |
| Q35675549 | BAG-1--a nucleotide exchange factor of Hsc70 with multiple cellular functions |
| Q24534836 | BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP. |
| Q28505838 | BAG-6 is essential for selective elimination of defective proteasomal substrates |
| Q34685246 | BAG3 expression in glioblastoma cells promotes accumulation of ubiquitinated clients in an Hsp70-dependent manner |
| Q24321768 | BAP31 interacts with Sec61 translocons and promotes retrotranslocation of CFTRDeltaF508 via the derlin-1 complex |
| Q48132331 | Bag1 Co-chaperone Promotes TRC8 E3 Ligase-dependent Degradation of Misfolded Human Ether a Go-Go-related Gene (hERG) Potassium Channels. |
| Q35121021 | Balance between folding and degradation for Hsp90-dependent client proteins: a key role for CHIP. |
| Q41917827 | Biosynthesis and secretion of parathyroid hormone are sensitive to proteasome inhibitors in dispersed bovine parathyroid cells |
| Q47988257 | Blocking protein quality control to counter hereditary cancers |
| Q34427541 | Brain distribution of carboxy terminus of Hsc70-interacting protein (CHIP) and its nuclear translocation in cultured cortical neurons following heat stress or oxygen-glucose deprivation. |
| Q37339007 | C terminus of Hsc70-interacting protein promotes smooth muscle cell proliferation and survival through ubiquitin-mediated degradation of FoxO1. |
| Q28206370 | C-terminal Hsp-interacting protein slows androgen receptor synthesis and reduces its rate of degradation |
| Q33899695 | C-terminus of heat shock protein 70-interacting protein facilitates degradation of apoptosis signal-regulating kinase 1 and inhibits apoptosis signal-regulating kinase 1-dependent apoptosis |
| Q50288960 | CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation |
| Q28073996 | CFTR Modulators: Shedding Light on Precision Medicine for Cystic Fibrosis |
| Q35764311 | CFTR and chaperones: processing and degradation. |
| Q36814102 | CFTR: folding, misfolding and correcting the ΔF508 conformational defect. |
| Q42133537 | CHIP Is an Essential Determinant of Neuronal Mitochondrial Stress Signaling |
| Q39642191 | CHIP Promotes Human Telomerase Reverse Transcriptase Degradation and Negatively Regulates Telomerase Activity |
| Q36266926 | CHIP activates HSF1 and confers protection against apoptosis and cellular stress |
| Q45780754 | CHIP as a membrane-shuttling proteostasis sensor. |
| Q51578869 | CHIP chaperones wild type p53 tumor suppressor protein. |
| Q24298589 | CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation |
| Q36710789 | CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control |
| Q28292712 | CHIP has a protective role against oxidative stress-induced cell death through specific regulation of endonuclease G |
| Q24295301 | CHIP interacts with heat shock factor 1 during heat stress |
| Q41776375 | CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein |
| Q24302505 | CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity |
| Q24603619 | CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription |
| Q51580141 | CHIP overexpression reduces mutant androgen receptor protein and ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model. |
| Q24338386 | CHIP participates in protein triage decisions by preferentially ubiquitinating Hsp70-bound substrates |
| Q37052961 | CHIP protects against cardiac pressure overload through regulation of AMPK. |
| Q37115256 | CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity |
| Q35935156 | CHIP stabilizes amyloid precursor protein via proteasomal degradation and p53-mediated trans-repression of β-secretase |
| Q45298680 | CHIP suppresses polyglutamine aggregation and toxicity in vitro and in vivo. |
| Q28183470 | CHIP-Hsc70 Complex Ubiquitinates Phosphorylated Tau and Enhances Cell Survival |
| Q24336920 | CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response |
| Q51476524 | CHIP-mediated degradation of transglutaminase 2 negatively regulates tumor growth and angiogenesis in renal cancer. |
| Q28303344 | CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70 |
| Q38285306 | CHIP: a co-chaperone for degradation by the proteasome |
| Q35759085 | CHIP: a link between the chaperone and proteasome systems |
| Q35097617 | CHIP: a quality-control E3 ligase collaborating with molecular chaperones |
| Q51809505 | Calreticulin negatively regulates the cell surface expression of cystic fibrosis transmembrane conductance regulator. |
| Q35561105 | Carboxyl terminus of HSC70-interacting protein (CHIP) down-regulates NF-κB-inducing kinase (NIK) and suppresses NIK-induced liver injury |
| Q39601937 | Carboxyl terminus of Hsp70-interacting protein (CHIP) contributes to human glioma oncogenesis |
| Q36857823 | Carboxyl terminus of hsc70-interacting protein (CHIP) can remodel mature aryl hydrocarbon receptor (AhR) complexes and mediate ubiquitination of both the AhR and the 90 kDa heat-shock protein (hsp90) in vitro |
| Q36362409 | Cellular response to endoplasmic reticulum stress: a matter of life or death |
| Q41153852 | Cellular responses to misfolded proteins and protein aggregates |
| Q42160937 | Cellular toxicity of mutant SOD1 protein is linked to an easily soluble, non-aggregated form in vitro |
| Q30362083 | Chaperone functions of the E3 ubiquitin ligase CHIP. |
| Q36194355 | Chaperone networks: tipping the balance in protein folding diseases |
| Q41623081 | Chaperone-Based Therapies for Disease Modification in Parkinson's Disease. |
| Q64986365 | Chaperone-Independent Peripheral Quality Control of CFTR by RFFL E3 Ligase. |
| Q28248976 | Chaperone-dependent E3 ligase CHIP ubiquitinates and mediates proteasomal degradation of soluble guanylyl cyclase |
| Q34190181 | Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu |
| Q44595338 | Chaperone-dependent regulation of endothelial nitric-oxide synthase intracellular trafficking by the co-chaperone/ubiquitin ligase CHIP. |
| Q35210968 | Chaperone-mediated hierarchical control in targeting misfolded proteins to aggresomes |
| Q24296990 | Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex |
| Q47260941 | Chaperones and the Proteasome System: Regulating the Construction and Demolition of Striated Muscle |
| Q36413186 | Chaperones in autophagy |
| Q38230957 | Chaperoning proteins for destruction: diverse roles of Hsp70 chaperones and their co-chaperones in targeting misfolded proteins to the proteasome |
| Q36658914 | Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR. |
| Q37196094 | Chemical and biological folding contribute to temperature-sensitive DeltaF508 CFTR trafficking |
| Q36713641 | Chemical rescue of deltaF508-CFTR mimics genetic repair in cystic fibrosis bronchial epithelial cells. |
| Q28237362 | Cleaning up in the endoplasmic reticulum: ubiquitin in charge |
| Q28115341 | Co-chaperone HSJ1a dually regulates the proteasomal degradation of ataxin-3 |
| Q33763709 | Complement yourself: Transcomplementation rescues partially folded mutant proteins |
| Q26824750 | Control of cystic fibrosis transmembrane conductance regulator membrane trafficking: not just from the endoplasmic reticulum to the Golgi |
| Q33334739 | Control of translocation through the Sec61 translocon by nascent polypeptide structure within the ribosome |
| Q28202126 | Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling |
| Q37146655 | Cooperative assembly and misfolding of CFTR domains in vivo. |
| Q42321930 | Correction of both NBD1 energetics and domain interface is required to restore ΔF508 CFTR folding and function |
| Q51415859 | Counterregulation of cAMP-directed kinase activities controls ciliogenesis. |
| Q37958101 | Cross-functional E3 ligases Parkin and C-terminus Hsp70-interacting protein in neurodegenerative disorders. |
| Q36019211 | Crystallization and preliminary X-ray crystallographic analysis of the Bag2 amino-terminal domain from Mus musculus |
| Q34131032 | Cysteine string protein interacts with and modulates the maturation of the cystic fibrosis transmembrane conductance regulator |
| Q34493239 | Cysteine string protein monitors late steps in cystic fibrosis transmembrane conductance regulator biogenesis |
| Q37094222 | Cysteine string protein promotes proteasomal degradation of the cystic fibrosis transmembrane conductance regulator (CFTR) by increasing its interaction with the C terminus of Hsp70-interacting protein and promoting CFTR ubiquitylation. |
| Q40153875 | Cystic fibrosis transmembrane conductance regulator (CFTR) functionality is dependent on coatomer protein I (COPI). |
| Q39968686 | Cystic fibrosis transmembrane conductance regulator degradation depends on the lectins Htm1p/EDEM and the Cdc48 protein complex in yeast |
| Q34140759 | Cystic fibrosis transmembrane conductance regulator degradation: cross-talk between the ubiquitylation and SUMOylation pathways |
| Q24643310 | Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum |
| Q26801509 | DNAJs: more than substrate delivery to HSPA |
| Q24293214 | Dab2 is a key regulator of endocytosis and post-endocytic trafficking of the cystic fibrosis transmembrane conductance regulator |
| Q28184153 | Defining the role for XAP2 in stabilization of the dioxin receptor |
| Q39938826 | Degradation of the bile salt export pump at endoplasmic reticulum in progressive familial intrahepatic cholestasis type II |
| Q24312937 | Deletion of Phe508 in the first nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator increases its affinity for the heat shock cognate 70 chaperone |
| Q35797496 | Delta F508 CFTR pool in the endoplasmic reticulum is increased by calnexin overexpression. |
| Q36322083 | Dendritic cell aggresome-like induced structures are dedicated areas for ubiquitination and storage of newly synthesized defective proteins |
| Q36266479 | Dendritic cells, DRiPs, and DALIS in the control of antigen processing. |
| Q40297593 | Destabilizing missense mutations in the tumour suppressor protein p53 enhance its ubiquitination in vitro and in vivo |
| Q24311975 | Deubiquitinases sharpen substrate discrimination during membrane protein degradation from the ER |
| Q30421217 | Development of CFTR Structure |
| Q58599202 | Different SUMO paralogs determine the fate of WT and mutant CFTRs: biogenesis vs. degradation |
| Q47070627 | Dimerization of the human E3 ligase CHIP via a coiled-coil domain is essential for its activity. |
| Q34922254 | Dimerization, ubiquitylation and endocytosis go together in growth hormone receptor function |
| Q27934755 | Distinct roles for the Hsp40 and Hsp90 molecular chaperones during cystic fibrosis transmembrane conductance regulator degradation in yeast |
| Q38173991 | Diverse roles of C-terminal Hsp70-interacting protein (CHIP) in tumorigenesis |
| Q24642979 | Diversity of degradation signals in the ubiquitin-proteasome system |
| Q36571903 | Down-regulation of cellular FLICE-inhibitory protein (Long Form) contributes to apoptosis induced by Hsp90 inhibition in human lung cancer cells |
| Q51584140 | Down-regulation of the mixed-lineage dual leucine zipper-bearing kinase by heat shock protein 70 and its co-chaperone CHIP. |
| Q36525810 | Drug discovery in the ubiquitin-proteasome system. |
| Q37916635 | Drug targets from genetics: α-synuclein |
| Q51486128 | E3 ligase CHIP and Hsc70 regulate Kv1.5 protein expression and function in mammalian cells. |
| Q41817177 | E3 ligase STUB1/CHIP regulates NAD(P)H:quinone oxidoreductase 1 (NQO1) accumulation in aged brain, a process impaired in certain Alzheimer disease patients |
| Q38011658 | E3 ubiquitin ligases in protein quality control mechanism. |
| Q30488209 | ER-associated complexes (ERACs) containing aggregated cystic fibrosis transmembrane conductance regulator (CFTR) are degraded by autophagy. |
| Q34970862 | ER-associated degradation in protein quality control and cellular regulation |
| Q28264823 | ERAD: the long road to destruction |
| Q41396117 | Efficient delivery of RNA interference oligonucleotides to polarized airway epithelia in vitro |
| Q34576386 | Emergent properties of proteostasis in managing cystic fibrosis |
| Q38000121 | Emerging roles of the ubiquitin-proteasome system in the steroid receptor signaling |
| Q24320293 | Endoplasmic reticulum protein quality control is determined by cooperative interactions between Hsp/c70 protein and the CHIP E3 ligase |
| Q35595660 | Endoplasmic reticulum stress decreases intracellular thyroid hormone activation via an eIF2a-mediated decrease in type 2 deiodinase synthesis. |
| Q38702487 | Endoplasmic reticulum stress-induced degradation of DNAJB12 stimulates BOK accumulation and primes cancer cells for apoptosis |
| Q33888627 | Endoplasmic reticulum-associated degradation of Niemann-Pick C1: evidence for the role of heat shock proteins and identification of lysine residues that accept ubiquitin |
| Q60526595 | Endoplasmic reticulum-associated protein degradation |
| Q36286010 | Enhancement of ubiquitin conjugation activity reduces intracellular aggregation of V76D mutant γD-crystallin |
| Q47948643 | Epigenetic regulation by the menin pathway |
| Q42529026 | Epithelial sodium channel (ENaC) is multi-ubiquitinated at the cell surface |
| Q28208008 | ErbB2 degradation mediated by the co-chaperone protein CHIP |
| Q28588247 | Essential role of synoviolin in embryogenesis |
| Q90152596 | Evaluation of the Role of Human DNAJAs in the Response to Cytotoxic Chemotherapeutic Agents in a Yeast Model System |
| Q41822888 | Expression of K6W-ubiquitin in lens epithelial cells leads to upregulation of a broad spectrum of molecular chaperones. |
| Q35671992 | Expression of three topologically distinct membrane proteins elicits unique stress response pathways in the yeast Saccharomyces cerevisiae |
| Q90736025 | Extracellular Vesicle-Mediated siRNA Delivery, Protein Delivery, and CFTR Complementation in Well-Differentiated Human Airway Epithelial Cells |
| Q34610210 | FBXO15 regulates P-glycoprotein/ABCB1 expression through the ubiquitin--proteasome pathway in cancer cells. |
| Q35604648 | FKBP38 peptidylprolyl isomerase promotes the folding of cystic fibrosis transmembrane conductance regulator in the endoplasmic reticulum |
| Q28590989 | Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains |
| Q64997269 | Feedback inhibition of cAMP effector signaling by a chaperone-assisted ubiquitin system. |
| Q64964435 | Folding Status Is Determinant over Traffic-Competence in Defining CFTR Interactors in the Endoplasmic Reticulum. |
| Q64244254 | Folding and Misfolding of Human Membrane Proteins in Health and Disease: From Single Molecules to Cellular Proteostasis |
| Q60907329 | Folding-function relationship of the most common cystic fibrosis-causing CFTR conductance mutants |
| Q34400939 | From the cradle to the grave: molecular chaperones that may choose between folding and degradation |
| Q38971505 | From the endoplasmic reticulum to the plasma membrane: mechanisms of CFTR folding and trafficking |
| Q38051325 | Functional Rescue of F508del-CFTR Using Small Molecule Correctors |
| Q47644235 | Functional genomic responses to cystic fibrosis transmembrane conductance regulator (CFTR) and CFTR(delta508) in the lung |
| Q28593080 | Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis |
| Q30583575 | GSK3β controls epithelial-mesenchymal transition and tumor metastasis by CHIP-mediated degradation of Slug |
| Q39714472 | Geldanamycin-induced PCNA degradation in isolated Hsp90 complex from cancer cells |
| Q35693982 | Genetic Inhibition Of The Ubiquitin Ligase Rnf5 Attenuates Phenotypes Associated To F508del Cystic Fibrosis Mutation. |
| Q60919623 | Genome-Wide Identification and Analysis of U-Box E3 Ubiquitin⁻Protein Ligase Gene Family in Banana |
| Q39575086 | Genome-Wide Identification of Soybean U-Box E3 Ubiquitin Ligases and Roles of GmPUB8 in Negative Regulation of Drought Stress Response in Arabidopsis |
| Q34400942 | Glucocorticoid-induced Leucine Zipper 1 Stimulates the Epithelial Sodium Channel by Regulating Serum- and Glucocorticoid-induced Kinase 1 Stability and Subcellular Localization |
| Q28508835 | Glycoprotein-specific ubiquitin ligases recognize N-glycans in unfolded substrates |
| Q40021104 | Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRDeltaF508. |
| Q90424090 | Guiding tail-anchored membrane proteins to the endoplasmic reticulum in a chaperone cascade |
| Q24304451 | HSJ1 is a neuronal shuttling factor for the sorting of chaperone clients to the proteasome |
| Q24679412 | HSP27 is a ubiquitin-binding protein involved in I-kappaBalpha proteasomal degradation |
| Q89978558 | HSP70 Multi-Functionality in Cancer |
| Q30354473 | HSPA8/HSC70 chaperone protein: structure, function, and chemical targeting. |
| Q34195771 | Heat shock protein 70 binds caspase-activated DNase and enhances its activity in TCR-stimulated T cells |
| Q28565453 | Heat shock protein 70 interacts with aquaporin-2 and regulates its trafficking |
| Q42144029 | Heat shock protein 90 functions to stabilize and activate the testis-specific serine/threonine kinases, a family of kinases essential for male fertility |
| Q37529532 | Heat shock proteins in antigen trafficking--implications on antigen presentation to T cells. |
| Q35120739 | Heat shock proteins, cellular chaperones that modulate mitochondrial cell death pathways |
| Q24671304 | Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation |
| Q89995993 | How to Avoid a No-Deal ER Exit |
| Q33317262 | Hsc70 focus formation at the periphery of HSV-1 transcription sites requires ICP27. |
| Q37234555 | Hsc70 negatively regulates epithelial sodium channel trafficking at multiple sites in epithelial cells |
| Q28585533 | Hsc70 regulates accumulation of cyclin D1 and cyclin D1-dependent protein kinase |
| Q40007443 | Hsc70 regulates cell surface ASIC2 expression and vascular smooth muscle cell migration |
| Q33661427 | Hsp40 chaperones promote degradation of the HERG potassium channel |
| Q39428376 | Hsp70 - a master regulator in protein degradation |
| Q92593512 | Hsp70 and DNAJA2 limit CFTR levels through degradation |
| Q36812500 | Hsp70 and Hsp90 multichaperone complexes sequentially regulate thiazide-sensitive cotransporter endoplasmic reticulum-associated degradation and biogenesis |
| Q34170760 | Hsp70 and its molecular role in nervous system diseases |
| Q36674471 | Hsp70 chaperone as a survival factor in cell pathology |
| Q34545594 | Hsp70 chaperone machines. |
| Q24644472 | Hsp70 chaperones: cellular functions and molecular mechanism |
| Q37353065 | Hsp70 structure, function, regulation and influence on yeast prions |
| Q24316177 | Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis |
| Q34583912 | Hsp90 inhibitors as novel cancer chemotherapeutic agents |
| Q36041929 | Hsp90 regulates O-linked β-N-acetylglucosamine transferase: a novel mechanism of modulation of protein O-linked β-N-acetylglucosamine modification in endothelial cells |
| Q44019897 | Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway |
| Q36739599 | Hsp90 regulates the phosphorylation and activity of serum- and glucocorticoid-regulated kinase-1. |
| Q24291482 | Hsp90: a specialized but essential protein-folding tool |
| Q40050938 | HspB8 chaperone activity toward poly(Q)-containing proteins depends on its association with Bag3, a stimulator of macroautophagy. |
| Q24298901 | Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum |
| Q36003713 | Human heat shock protein 105/110 kDa (Hsp105/110) regulates biogenesis and quality control of misfolded cystic fibrosis transmembrane conductance regulator at multiple levels |
| Q43979780 | Human sulfotransferase SULT2A1 pharmacogenetics: genotype-to-phenotype studies |
| Q40791919 | Identification and pharmacological correction of a membrane trafficking defect associated with a mutation in the sulfonylurea receptor causing familial hyperinsulinism |
| Q35995064 | Identification of C-terminal Hsp70-interacting protein as a mediator of tumour necrosis factor action in osteoblast differentiation by targeting osterix for degradation |
| Q48257092 | Identifying the substrate proteins of U-box E3s E4B and CHIP by orthogonal ubiquitin transfer. |
| Q35311042 | Importin beta interacts with the endoplasmic reticulum-associated degradation machinery and promotes ubiquitination and degradation of mutant alpha1-antitrypsin |
| Q35964106 | In vitro assembly of semi-artificial molecular machine and its use for detection of DNA damage |
| Q37142961 | In vivo suppression of polyglutamine neurotoxicity by C-terminus of Hsp70-interacting protein (CHIP) supports an aggregation model of pathogenesis. |
| Q28554668 | Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics |
| Q28212970 | Inhibition of MDM2 by hsp90 contributes to mutant p53 stabilization |
| Q28187990 | Inositol 1,4,5-trisphosphate receptor ubiquitination is mediated by mammalian Ubc7, a component of the endoplasmic reticulum-associated degradation pathway, and is inhibited by chelation of intracellular Zn2+ |
| Q74472513 | Interaction between the N-terminal and middle regions is essential for the in vivo function of HSP90 molecular chaperone |
| Q28214346 | Interaction of Hsp90 with 20S proteasome: thermodynamic and kinetic characterization |
| Q24297095 | Interaction of Hsp90 with ribosomal proteins protects from ubiquitination and proteasome-dependent degradation |
| Q44930825 | Interaction of U-box-type ubiquitin-protein ligases (E3s) with molecular chaperones |
| Q39000578 | Interference with ubiquitination in CFTR modifies stability of core glycosylated and cell surface pools. |
| Q35903227 | Intracellular heat shock protein-70 negatively regulates TLR4 signaling in the newborn intestinal epithelium. |
| Q57167862 | Intrinsic proteotoxic stress levels vary and act as a predictive marker for sensitivity of cancer cells to Hsp90 inhibition |
| Q42011536 | Just a trim, please: refining ER degradation through deubiquitination |
| Q38768592 | Lanosterol Suppresses the Aggregation and Cytotoxicity of Misfolded Proteins Linked with Neurodegenerative Diseases. |
| Q30823415 | Ligand discrimination by TPR domains. Relevance and selectivity of EEVD-recognition in Hsp70 x Hop x Hsp90 complexes |
| Q40493369 | Ligand-dependent switching of ubiquitin-proteasome pathways for estrogen receptor |
| Q37583253 | Lipid disequilibrium disrupts ER proteostasis by impairing ERAD substrate glycan trimming and dislocation |
| Q34285339 | Liver cytochrome P450 3A ubiquitination in vivo by gp78/autocrine motility factor receptor and C terminus of Hsp70-interacting protein (CHIP) E3 ubiquitin ligases: physiological and pharmacological relevance |
| Q34587222 | Loss of Hsp70 in Drosophila is pleiotropic, with effects on thermotolerance, recovery from heat shock and neurodegeneration |
| Q36489119 | MKKS is a centrosome-shuttling protein degraded by disease-causing mutations via CHIP-mediated ubiquitination. |
| Q28588393 | Mammalian E4 is required for cardiac development and maintenance of the nervous system |
| Q26830475 | Mechanisms for quality control of misfolded transmembrane proteins |
| Q37346010 | Mechanisms for rescue of correctable folding defects in CFTRDelta F508. |
| Q21129277 | Mechanisms of CFTR Folding at the Endoplasmic Reticulum |
| Q27003095 | Mechanisms of protein-folding diseases at a glance |
| Q38981333 | Membrane Protein Quantity Control at the Endoplasmic Reticulum |
| Q35663471 | Menin missense mutants associated with multiple endocrine neoplasia type 1 are rapidly degraded via the ubiquitin-proteasome pathway |
| Q37799850 | Molecular Chaperones as Rational Drug Targets for Parkinsons Disease Therapeutics |
| Q21129282 | Molecular Chaperones as Targets to Circumvent the CFTR Defect in Cystic Fibrosis |
| Q47627794 | Molecular and functional analysis of Caenorhabditis elegans CHIP, a homologue of Mammalian CHIP. |
| Q35739990 | Molecular and functional characterization of the only known hemiascomycete ortholog of the carboxyl terminus of Hsc70-interacting protein CHIP in the yeast Yarrowia lipolytica |
| Q35749944 | Molecular basis for the chloride channel activity of cystic fibrosis transmembrane conductance regulator and the consequences of disease-causing mutations |
| Q51546346 | Molecular chaperone complexes with antagonizing activities regulate stability and activity of the tumor suppressor LKB1. |
| Q26828834 | Molecular chaperones and co-chaperones in Parkinson disease |
| Q36496399 | Molecular chaperones and selection against mutations |
| Q73435261 | Molecular chaperones and the art of recognizing a lost cause |
| Q35688796 | Molecular chaperones in Parkinson's disease--present and future |
| Q26828990 | Molecular chaperones in targeting misfolded proteins for ubiquitin-dependent degradation |
| Q90043813 | Molecular identification of HSPA8 as an accessory protein of a hyperpolarization-activated chloride channel from rat pulmonary vein cardiomyocytes |
| Q42155234 | Molecular mechanism of 17-allylamino-17-demethoxygeldanamycin (17-AAG)-induced AXL receptor tyrosine kinase degradation |
| Q36804170 | Molecular pathogenesis of alpha-1-antitrypsin deficiency-associated liver disease: a meeting review |
| Q33836913 | Most F508del-CFTR is targeted to degradation at an early folding checkpoint and independently of calnexin |
| Q47215834 | Most mutations that cause spinocerebellar ataxia autosomal recessive type 16 (SCAR16) destabilize the protein quality-control E3 ligase CHIP. |
| Q37234365 | N-glycans are direct determinants of CFTR folding and stability in secretory and endocytic membrane traffic |
| Q92731864 | Nitration-induced ubiquitination and degradation control quality of ERK1 |
| Q36489351 | Non-native Conformers of Cystic Fibrosis Transmembrane Conductance Regulator NBD1 Are Recognized by Hsp27 and Conjugated to SUMO-2 for Degradation |
| Q37527405 | Notch-induced E2A degradation requires CHIP and Hsc70 as novel facilitators of ubiquitination |
| Q24658302 | One step at a time: endoplasmic reticulum-associated degradation |
| Q39777855 | Overexpression of the cochaperone CHIP enhances Hsp70-dependent folding activity in mammalian cells. |
| Q40658225 | Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function. |
| Q48363496 | Parkinson's disease-associated receptor GPR37 is an ER chaperone for LRP6. |
| Q29618887 | Pathways of chaperone-mediated protein folding in the cytosol |
| Q57490973 | Peripheral Protein Quality Control as a Novel Drug Target for CFTR Stabilizer |
| Q41111670 | Peripheral protein quality control removes unfolded CFTR from the plasma membrane |
| Q37622461 | Pharmacological targeting of the Hsp70 chaperone |
| Q50014672 | Pharmacoperones as Novel Therapeutics for Diverse Protein Conformational Diseases |
| Q33609884 | Polyglutamine-rich suppressors of huntingtin toxicity act upstream of Hsp70 and Sti1 in spatial quality control of amyloid-like proteins |
| Q34218064 | Potassium channels: the importance of transport signals. |
| Q60305725 | Predicting protein targets for drug-like compounds using transcriptomics |
| Q51807037 | Presenilin 1 forms aggresomal deposits in response to heat shock. |
| Q34380963 | Prognostic implications of carboxyl-terminus of Hsc70 interacting protein and lysyl-oxidase expression in human breast cancer |
| Q28393706 | Progress towards genetic and pharmacological therapies for keratin genodermatoses: current perspective and future promise |
| Q37024066 | Protection against doxorubicin-induced myocardial dysfunction in mice by cardiac-specific expression of carboxyl terminus of hsp70-interacting protein |
| Q57036995 | Protein Quality Control in the Endoplasmic Reticulum and Cancer |
| Q35145866 | Protein aggregation and the ubiquitin proteasome pathway: gaining the UPPer hand on neurodegeneration |
| Q34413909 | Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition |
| Q29618400 | Protein degradation and protection against misfolded or damaged proteins |
| Q37875533 | Protein quality control at the plasma membrane |
| Q27023202 | Protein quality control in the nucleus |
| Q44061660 | Protein quality control: U-box-containing E3 ubiquitin ligases join the fold |
| Q40400832 | Protein quality control: chaperones culling corrupt conformations |
| Q43854002 | Protein turnover: a CHIP programmed for proteolysis. |
| Q59136620 | Proteostasis by STUB1/HSP70 complex controls sensitivity to androgen receptor targeted therapy in advanced prostate cancer |
| Q35469778 | Proteostasis regulation at the endoplasmic reticulum: a new perturbation site for targeted cancer therapy |
| Q48703959 | Purification and assay of the chaperone-dependent ubiquitin ligase of the carboxyl terminus of Hsc70-interacting protein |
| Q90628328 | Putting CHIP(s) on the Table: Introducing Nitrosothiols into the Arena of CFTR Modulation |
| Q39997139 | Putting the brakes on vascular smooth muscle cell migration |
| Q26853052 | Quality control and fate determination of Hsp90 client proteins |
| Q33803716 | Quality control autophagy degrades soluble ERAD-resistant conformers of the misfolded membrane protein GnRHR |
| Q34412404 | Quality control for unfolded proteins at the plasma membrane |
| Q24305127 | RING finger protein RNF207, a novel regulator of cardiac excitation |
| Q35036565 | RING finger ubiquitin protein ligases: implications for tumorigenesis, metastasis and for molecular targets in cancer |
| Q35590787 | RNA Interference Screen to Identify Kinases That Suppress Rescue of ΔF508-CFTR. |
| Q24323658 | RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR) |
| Q42222018 | Reconstitution of CHIP E3 ubiquitin ligase activity |
| Q24336904 | Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane |
| Q36481817 | Reduced PDZ interactions of rescued ΔF508CFTR increases its cell surface mobility. |
| Q92637479 | Regulation of CFTR Biogenesis by the Proteostatic Network and Pharmacological Modulators |
| Q37223507 | Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β. |
| Q37572504 | Regulation of IL-4 receptor signaling by STUB1 in lung inflammation |
| Q35092829 | Regulation of PIDD auto-proteolysis and activity by the molecular chaperone Hsp90 |
| Q35676153 | Regulation of proto-oncogenic dbl by chaperone-controlled, ubiquitin-mediated degradation |
| Q42816327 | Regulation of the Dbl proto-oncogene by heat shock cognate protein 70 (Hsc70). |
| Q28272894 | Regulation of the cytoplasmic quality control protein degradation pathway by BAG2 |
| Q59072649 | Regulations of P-Glycoprotein/ABCB1/MDR1 in Human Cancer Cells |
| Q39430414 | Repair or destruction-an intimate liaison between ubiquitin ligases and molecular chaperones in proteostasis |
| Q37375772 | Rescue of DeltaF508-CFTR by the SGK1/Nedd4-2 signaling pathway |
| Q46136957 | Rescuing proteins of low kinetic stability by chaperones and natural ligands phenylketonuria, a case study |
| Q38758711 | Restoration of R117H CFTR folding and function in human airway cells through combination treatment with VX-809 and VX-770 |
| Q35215090 | Revertant mutants G550E and 4RK rescue cystic fibrosis mutants in the first nucleotide-binding domain of CFTR by different mechanisms |
| Q35160700 | Role of Hsc70 binding cycle in CFTR folding and endoplasmic reticulum-associated degradation |
| Q28296575 | Role of the ubiquitin system in regulating ion transport |
| Q36931758 | Role of ubiquitin protein ligases in the pathogenesis of polyglutamine diseases. |
| Q27012739 | Roles for the ubiquitin-proteasome pathway in protein quality control and signaling in the retina: implications in the pathogenesis of age-related macular degeneration |
| Q36355930 | Roles of p97-associated deubiquitinases in protein quality control at the endoplasmic reticulum |
| Q90609204 | S-Nitrosylation of CHIP Enhances F508Del-CFTR Maturation |
| Q24322717 | SLP-2 negatively modulates mitochondrial sodium-calcium exchange |
| Q48015222 | STUB1 regulates TFEB-induced autophagy-lysosome pathway |
| Q28568829 | STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy |
| Q46353737 | SYVN1, NEDD8, and FBXO2 Proteins Regulate ΔF508 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Ubiquitin-mediated Proteasomal Degradation |
| Q34208996 | Salicylic acid signaling controls the maturation and localization of the arabidopsis defense protein ACCELERATED CELL DEATH6 |
| Q36090973 | Search and destroy: ER quality control and ER-associated protein degradation |
| Q90118044 | Selective Binding of HSC70 and its Co-Chaperones to Structural Hotspots on CFTR |
| Q35652691 | Semi-artificial Fluorescent Molecular Machine for DNA Damage Detection |
| Q24299501 | Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator |
| Q35119479 | Sidechain biology and the immunogenicity of PDC-E2, the major autoantigen of primary biliary cirrhosis |
| Q24563260 | Small glutamine-rich protein/viral protein U-binding protein is a novel cochaperone that affects heat shock protein 70 activity |
| Q36523614 | Small heat shock proteins target mutant cystic fibrosis transmembrane conductance regulator for degradation via a small ubiquitin-like modifier-dependent pathway |
| Q35650734 | Small heat-shock proteins select deltaF508-CFTR for endoplasmic reticulum-associated degradation |
| Q28552929 | Specific Hsp100 Chaperones Determine the Fate of the First Enzyme of the Plastidial Isoprenoid Pathway for Either Refolding or Degradation by the Stromal Clp Protease in Arabidopsis |
| Q34543848 | Stability of the Peutz-Jeghers syndrome kinase LKB1 requires its binding to the molecular chaperones Hsp90/Cdc37. |
| Q42650380 | Strategies for the etiological therapy of cystic fibrosis |
| Q27652982 | Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2 |
| Q27640661 | Structural insights into the U-box, a domain associated with multi-ubiquitination |
| Q101476598 | Targeted deubiquitination rescues distinct trafficking-deficient ion channelopathies |
| Q91722667 | Targeting DNAJB9, a novel ER luminal co-chaperone, to rescue ΔF508-CFTR |
| Q38631561 | Targeting the PI3K/Akt/mTOR signalling pathway in Cystic Fibrosis |
| Q39896634 | The ART-Rsp5 ubiquitin ligase network comprises a plasma membrane quality control system that protects yeast cells from proteotoxic stress |
| Q28117679 | The Chaperone Environment at the Cytoplasmic Face of the Endoplasmic Reticulum Can Modulate Rhodopsin Processing and Inclusion Formation |
| Q92876718 | The Complex Phosphorylation Patterns that Regulate the Activity of Hsp70 and Its Cochaperones |
| Q38215523 | The E3 ligase CHIP: insights into its structure and regulation |
| Q42833100 | The E3 ubiquitin ligase CHIP and the molecular chaperone Hsc70 form a dynamic, tethered complex |
| Q50056025 | The E3 ubiquitin ligase STUB1 regulates autophagy and mitochondrial biogenesis by modulating TFEB activity |
| Q29616140 | The HSP70 chaperone machinery: J proteins as drivers of functional specificity |
| Q36845681 | The HSP70 co-chaperone DNAJC14 targets misfolded pendrin for unconventional protein secretion |
| Q93117098 | The Hsp70 chaperone network |
| Q27933148 | The Hsp70/90 cochaperone, Sti1, suppresses proteotoxicity by regulating spatial quality control of amyloid-like proteins |
| Q33692255 | The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases |
| Q24791598 | The PEST sequence does not contribute to the stability of the cystic fibrosis transmembrane conductance regulator |
| Q34558213 | The Type II Hsp40 Sis1 cooperates with Hsp70 and the E3 ligase Ubr1 to promote degradation of terminally misfolded cytosolic protein |
| Q36982944 | The activities and function of molecular chaperones in the endoplasmic reticulum |
| Q37030528 | The biological impact of mass-spectrometry-based proteomics |
| Q35939892 | The chaperone-assisted E3 ligase C terminus of Hsc70-interacting protein (CHIP) targets PTEN for proteasomal degradation |
| Q51582129 | The chloroplast protease subunit ClpP4 is a substrate of the E3 ligase AtCHIP and plays an important role in chloroplast function. |
| Q64057115 | The cochaperone CHIP marks Hsp70- and Hsp90-bound substrates for degradation through a very flexible mechanism |
| Q24562651 | The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulator |
| Q30394029 | The cystic fibrosis transmembrane conductance regulator (CFTR) and its stability |
| Q34355404 | The cystic fibrosis transmembrane conductance regulator: an intriguing protein with pleiotropic functions |
| Q27015793 | The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiology |
| Q28975744 | The endoplasmic reticulum-associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3-dependent degradation of nascent CFTRDeltaF508 |
| Q33721156 | The endoplasmic reticulum-associated degradation of the epithelial sodium channel requires a unique complement of molecular chaperones |
| Q38979904 | The evolving role of ubiquitin modification in endoplasmic reticulum-associated degradation |
| Q48002606 | The exocyst subunit Sec3 is regulated by a protein quality control pathway. |
| Q24534481 | The human DnaJ homologue (Hdj)-1/heat-shock protein (Hsp) 40 co-chaperone is required for the in vivo stabilization of the cystic fibrosis transmembrane conductance regulator by Hsp70 |
| Q89771533 | The impact of proteostasis dysfunction secondary to environmental and genetic causes on neurodegenerative diseases progression and potential therapeutic intervention |
| Q37122324 | The mammalian endoplasmic reticulum-associated degradation system |
| Q30434799 | The neuroendocrine-derived peptide parathyroid hormone-related protein promotes prostate cancer cell growth by stabilizing the androgen receptor |
| Q26766367 | The nucleotide exchange factors of Hsp70 molecular chaperones |
| Q28476393 | The primary folding defect and rescue of ΔF508 CFTR emerge during translation of the mutant domain |
| Q34545602 | The proteasome: a supramolecular assembly designed for controlled proteolysis |
| Q36830187 | The protective and destructive roles played by molecular chaperones during ERAD (endoplasmic-reticulum-associated degradation). |
| Q40274580 | The role of BiP in endoplasmic reticulum-associated degradation of major histocompatibility complex class I heavy chain induced by cytomegalovirus proteins. |
| Q33307871 | The role of the UPS in cystic fibrosis |
| Q38194443 | The role of the cytosolic HSP70 chaperone system in diseases caused by misfolding and aberrant trafficking of ion channels |
| Q38164901 | The role of ubiquitin ligases in cardiac disease. |
| Q28658805 | The silent codon change I507-ATC->ATT contributes to the severity of the ΔF508 CFTR channel dysfunction |
| Q34181891 | The stress of protein misfolding: from single cells to multicellular organisms |
| Q40839196 | The triage of damaged proteins: degradation by the ubiquitin-proteasome pathway or repair by molecular chaperones. |
| Q24291942 | The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum |
| Q51568474 | The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways. |
| Q39094871 | The ubiquitin ligase CHIP prevents SirT6 degradation through noncanonical ubiquitination |
| Q39356833 | The ubiquitin ligase CHIP regulates c-Myc stability and transcriptional activity. |
| Q37155452 | The ubiquitin ligase E6-AP is induced and recruited to aggresomes in response to proteasome inhibition and may be involved in the ubiquitination of Hsp70-bound misfolded proteins |
| Q24292709 | The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction |
| Q33892755 | The ubiquitin-proteasome system as a drug target in cerebrovascular disease: therapeutic potential of proteasome inhibitors |
| Q27939384 | The yeast ubr1 ubiquitin ligase participates in a prominent pathway that targets cytosolic thermosensitive mutants for degradation |
| Q31099925 | The ΔF508-CFTR mutation inhibits wild-type CFTR processing and function when co-expressed in human airway epithelia and in mouse nasal mucosa |
| Q36501370 | Therapy through chaperones: sense or antisense? Cystic fibrosis as a model disease |
| Q34609152 | Towards the pharmacogenomics of cystic fibrosis. |
| Q38913048 | Trafficking and function of the cystic fibrosis transmembrane conductance regulator: a complex network of posttranslational modifications |
| Q39125264 | Turning off estrogen receptor beta-mediated transcription requires estrogen-dependent receptor proteolysis. |
| Q58378466 | Two Hrd1p homologues in the yeast Yarrowia lipolytica which act in different pathways |
| Q24597133 | Two Hsp70 family members expressed in atherosclerotic lesions |
| Q24291397 | U box proteins as a new family of ubiquitin-protein ligases |
| Q28609695 | U-box proteins as a new family of ubiquitin ligases |
| Q35566815 | UBR1 promotes protein kinase quality control and sensitizes cells to Hsp90 inhibition. |
| Q51485232 | UBXN2A regulates nicotinic receptor degradation by modulating the E3 ligase activity of CHIP. |
| Q35122358 | UPR, autophagy, and mitochondria crosstalk underlies the ER stress response |
| Q39376341 | Ubc13 and COOH terminus of Hsp70-interacting protein (CHIP) are required for growth hormone receptor endocytosis |
| Q28593538 | Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP |
| Q33799710 | Ubiquitin C-terminal hydrolase-L1 protects cystic fibrosis transmembrane conductance regulator from early stages of proteasomal degradation |
| Q35691524 | Ubiquitin-like protein activation. |
| Q39660079 | Ubiquitin-proteasome degradation of serum- and glucocorticoid-regulated kinase-1 (SGK-1) is mediated by the chaperone-dependent E3 ligase CHIP |
| Q35027877 | Ubiquitin-proteasome pathway and cellular responses to oxidative stress |
| Q34789796 | Ubiquitination and degradation of CFTR by the E3 ubiquitin ligase MARCH2 through its association with adaptor proteins CAL and STX6 |
| Q40062013 | Ubiquitination and degradation of Tal1/SCL are induced by notch signaling and depend on Skp2 and CHIP. |
| Q55371625 | Ubiquitination and deubiquitination emerge as players in idiopathic pulmonary fibrosis pathogenesis and treatment. |
| Q39033646 | Ubiquitination and the Regulation of Membrane Proteins |
| Q37387802 | Ubiquitination-dependent quality control of hERG K+ channel with acquired and inherited conformational defect at the plasma membrane |
| Q36478232 | Ubiquitination-mediated protein degradation and modification: an emerging theme in plant-microbe interactions. |
| Q44151437 | Ubiquitylation of BAG-1 suggests a novel regulatory mechanism during the sorting of chaperone substrates to the proteasome |
| Q24306256 | Ubiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligase |
| Q27930363 | Ubr1 and Ubr2 function in a quality control pathway for degradation of unfolded cytosolic proteins |
| Q50073383 | Unfolded Protein Response of the Endoplasmic Reticulum in Tumor Progression and Immunogenicity. |
| Q35911798 | Unfolded protein stress in the endoplasmic reticulum and mitochondria: a role in neurodegeneration |
| Q44504087 | Use of modular substrates demonstrates mechanistic diversity and reveals differences in chaperone requirement of ERAD. |
| Q36141393 | Use of yeast as a model system to investigate protein conformational diseases |
| Q34362524 | VX-809 corrects folding defects in cystic fibrosis transmembrane conductance regulator protein through action on membrane-spanning domain 1. |
| Q50587818 | WPP-domain proteins mimic the activity of the HSC70-1 chaperone in preventing mistargeting of RanGAP1-anchoring protein WIT1. |
| Q39768529 | Ydj1 protects nascent protein kinases from degradation and controls the rate of their maturation. |
| Q38683556 | hERG quality control and the long QT syndrome |
| Q38364252 | p97 functions as an auxiliary factor to facilitate TM domain extraction during CFTR ER-associated degradation |
| Q39703906 | ΔF508 CFTR surface stability is regulated by DAB2 and CHIP-mediated ubiquitination in post-endocytic compartments |
| Q40006173 | ∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis |
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