Defining the role for XAP2 in stabilization of the dioxin receptor

scientific article (publication date: 19 September 2003)

Defining the role for XAP2 in stabilization of the dioxin receptor is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M302430200
P698PubMed publication ID12837759

P50authorDaniel J. PeetQ37382862
P2093author name stringMurray L Whitelaw
Michael J Lees
P2860cites workIdentification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functionsQ22010047
Binding of aryl hydrocarbon receptor (AhR) to AhR-interacting protein - The role of hsp90Q23911835
2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced degradation of aryl hydrocarbon receptor (AhR) by the ubiquitin-proteasome pathway: role of the transcription activaton and DNA binding of AhRQ23919662
The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteinsQ24290709
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensingQ24291102
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylationQ24291783
pEF-BOS, a powerful mammalian expression vectorQ29547606
The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradationQ29616141
The PAS superfamily: sensors of environmental and developmental signalsQ29622907
Ligand discrimination by TPR domains. Relevance and selectivity of EEVD-recognition in Hsp70 x Hop x Hsp90 complexesQ30823415
Epstein-Barr virus encoded nuclear protein EBNA-3 binds XAP-2, a protein associated with Hepatitis B virus X antigenQ30860599
Induction of cytochrome P4501A1.Q33636653
Heat shock protein hsp90 regulates dioxin receptor function in vivoQ34333109
From the cradle to the grave: molecular chaperones that may choose between folding and degradationQ34400939
Cross-coupling of signal transduction pathways: the dioxin receptor mediates induction of cytochrome P-450IA1 expression via a protein kinase C-dependent mechanismQ36659973
A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) 1alpha and the HIF-like factor.Q38315547
Multiple roles of ligand in transforming the dioxin receptor to an active basic helix-loop-helix/PAS transcription factor complex with the nuclear protein ArntQ39446848
Regulation of subcellular localization of the aryl hydrocarbon receptor (AhR).Q40807907
Nucleocytoplasmic shuttling of the aryl hydrocarbon receptorQ40891643
ARA9 modifies agonist signaling through an increase in cytosolic aryl hydrocarbon receptorQ40897851
Degradation of the basic helix-loop-helix/Per-ARNT-Sim homology domain dioxin receptor via the ubiquitin/proteasome pathwayQ40912866
Comparison of the nuclear and cytosolic forms of the Ah receptor from Hepa 1c1c7 cells: charge heterogeneity and ATP binding propertiesQ41656014
Binding of hsp90-associated immunophilins to cytoplasmic dynein: direct binding and in vivo evidence that the peptidylprolyl isomerase domain is a dynein interaction domainQ42808452
Protein quality control: U-box-containing E3 ubiquitin ligases join the foldQ44061660
Ligand-dependent and independent modulation of aryl hydrocarbon receptor localization, degradation, and gene regulationQ44141135
PAS is a dimerization domain common to Drosophila period and several transcription factors.Q52545395
A conserved family of prolyl-4-hydroxylases that modify HIFQ24291794
FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activityQ24291819
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factorQ24300161
CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activityQ24302505
Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90Q24313523
Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivoQ24314469
Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activityQ24324699
The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactionsQ24533152
The hsp90 chaperone complex regulates intracellular localization of the dioxin receptorQ24550978
Analysis of the complex relationship between nuclear export and aryl hydrocarbon receptor-mediated gene regulationQ24552430
Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machineQ27622332
Coordination of circadian timing in mammalsQ27860673
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylationQ27860876
Subcellular localization of the aryl hydrocarbon receptor is modulated by the immunophilin homolog hepatitis B virus X-associated protein 2Q28138669
The immunophilin-like protein XAP2 regulates ubiquitination and subcellular localization of the dioxin receptorQ28140027
Evidence that the co-chaperone p23 regulates ligand responsiveness of the dioxin (Aryl hydrocarbon) receptorQ28142884
Molecular chaperones in the cytosol: from nascent chain to folded proteinQ28205903
ErbB2 degradation mediated by the co-chaperone protein CHIPQ28208008
Evidence that the peptidylprolyl isomerase domain of the hsp90-binding immunophilin FKBP52 is involved in both dynein interaction and glucocorticoid receptor movement to the nucleusQ28208238
A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilinsQ28212761
The hsp90 Co-chaperone XAP2 alters importin beta recognition of the bipartite nuclear localization signal of the Ah receptor and represses transcriptional activityQ28214778
CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylationQ28216253
Two distinct regions of the immunophilin-like protein XAP2 regulate dioxin receptor function and interaction with hsp90Q28216266
Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factorsQ28216930
Asparagine hydroxylation of the HIF transactivation domain a hypoxic switchQ28217194
Nuclear localization and export signals of the human aryl hydrocarbon receptorQ28260234
Definition of a minimal domain of the dioxin receptor that is associated with Hsp90 and maintains wild type ligand binding affinity and specificityQ28289572
Characterization of the Ah receptor-associated protein, ARA9Q28290424
A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxinQ28306680
Aryl hydrocarbon receptor imported into the nucleus following ligand binding is rapidly degraded via the cytosplasmic proteasome following nuclear exportQ28373219
P433issue38
P407language of work or nameEnglishQ1860
P304page(s)35878-35888
P577publication date2003-07-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleDefining the role for XAP2 in stabilization of the dioxin receptor
P478volume278