Hsp90 regulates the phosphorylation and activity of serum- and glucocorticoid-regulated kinase-1.

scientific article published on 2 May 2008

Hsp90 regulates the phosphorylation and activity of serum- and glucocorticoid-regulated kinase-1. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M803289200
P932PMC publication ID2441554
P698PubMed publication ID18456663

P50authorSanjeev Kumar SharmaQ38327480
P2093author name stringDeanna R Brickley
Suzanne D Conzen
Larissa Belova
Betty Ky
P2860cites workIdentification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functionsQ22010047
The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteinsQ24290709
Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitinationQ24297821
Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 functionQ24304442
Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alphaQ24320638
C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life spanQ24324828
Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2Q24531452
Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasomeQ24533430
Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathwayQ24534149
Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stabilityQ24535623
Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformationQ24564127
Modulation of Akt kinase activity by binding to Hsp90Q24648565
An amphipathic helix targets serum and glucocorticoid-induced kinase 1 to the endoplasmic reticulum-associated ubiquitin-conjugation machineryQ24676953
Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agentQ27736012
C-terminal Hsp-interacting protein slows androgen receptor synthesis and reduces its rate of degradationQ28206370
ErbB2 degradation mediated by the co-chaperone protein CHIPQ28208008
Phosphorylation and hsp90 binding mediate heat shock stabilization of p53Q28214608
Ubiquitin modification of serum and glucocorticoid-induced protein kinase-1 (SGK-1)Q28221408
Association of the 90-kDa heat shock protein does not affect the ligand-binding ability of androgen receptorQ28271808
The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.Q28345841
Heat shock protein 90 and the nuclear transport of progesterone receptorQ28361515
Interaction of the chicken progesterone receptor with heat shock protein (HSP) 90Q69449162
Dynamics of heat shock protein 90-progesterone receptor binding and the disactivation loop model for steroid receptor complexesQ72669705
Control of estrogen receptor ligand binding by Hsp90Q73815845
Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G(1) phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complexQ74296246
A novel N-terminal hydrophobic motif mediates constitutive degradation of serum- and glucocorticoid-induced kinase-1 by the ubiquitin-proteasome pathwayQ79832374
Coordinate expression of the PI3-kinase downstream effectors serum and glucocorticoid-induced kinase (SGK-1) and Akt-1 in human breast cancerQ81397130
Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO releaseQ28609861
The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradationQ29616141
Hsp90 inhibition transiently activates Src kinase and promotes Src-dependent Akt and Erk activationQ30477813
BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinaseQ30659210
Drug-induced ubiquitylation and degradation of ErbB receptor tyrosine kinases: implications for cancer therapyQ34088024
Expression of the serum- and glucocorticoid-inducible protein kinase, Sgk, is a cell survival response to multiple types of environmental stress stimuli in mammary epithelial cellsQ34165571
Serum and glucocorticoid inducible kinases in the regulation of the cardiac sodium channel SCN5A.Q34185321
Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/NeuQ34190181
Maturation of the tyrosine kinase c-src as a kinase and as a substrate depends on the molecular chaperone Hsp90.Q34792400
ATPases as drug targets: learning from their structureQ34810356
Multiple translational isoforms give functional specificity to serum- and glucocorticoid-induced kinase 1.Q35810566
New insights into the role of serum- and glucocorticoid-inducible kinase SGK1 in the regulation of renal function and blood pressure.Q35977199
A foldable CFTR{Delta}F508 biogenic intermediate accumulates upon inhibition of the Hsc70-CHIP E3 ubiquitin ligaseQ36322876
Nuclear progesterone receptor is mainly heat shock protein 90-free in vivoQ36379145
Heat-shock protein hsp90 governs the activity of pp60v-src kinaseQ36449591
Mutational analysis of hsp90 binding to the progesterone receptor.Q38315811
Ubiquitin-proteasome degradation of serum- and glucocorticoid-regulated kinase-1 (SGK-1) is mediated by the chaperone-dependent E3 ligase CHIPQ39660079
Overexpression of the cochaperone CHIP enhances Hsp70-dependent folding activity in mammalian cells.Q39777855
Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cellsQ40128062
Antiapoptotic effect of serum and glucocorticoid-inducible protein kinase is mediated by novel mechanism activating I{kappa}B kinase.Q40461361
Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex.Q40473008
The heat shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of AKT in ErbB2 overexpressing breast cancer cells.Q40614350
Glucocorticoid-stimulated lung epithelial Na(+) transport is associated with regulated ENaC and sgk1 expressionQ40746673
Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1.Q40758558
Effects of the serine/threonine kinase SGK1 on the epithelial Na(+) channel (ENaC) and CFTR: implications for cystic fibrosisQ40785423
Glucocorticoid receptor-mediated protection from apoptosis is associated with induction of the serine/threonine survival kinase gene, sgk-1.Q40816743
The heat shock protein 90 antagonist geldanamycin alters chaperone association with p210bcr-abl and v-src proteins before their degradation by the proteasomeQ40862241
The protein-protein complex between pp60v-src and hsp90 is stabilized by molybdate, vanadate, tungstate, and an endogenous cytosolic metalQ41613530
Characterization of progesterone receptor binding to the 90- and 70-kDa heat shock proteins.Q41657175
Evidence that the 90-kDa heat shock protein (HSP90) exists in cytosol in heteromeric complexes containing HSP70 and three other proteins with Mr of 63,000, 56,000, and 50,000.Q41687428
Mapping the HSP90 binding region of the glucocorticoid receptor.Q41727927
The steroid-binding properties of recombinant glucocorticoid receptor: a putative role for heat shock protein hsp90.Q42635423
Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathwayQ44019897
17AAG: low target binding affinity and potent cell activity--finding an explanationQ44317123
Microarray analysis reveals glucocorticoid-regulated survival genes that are associated with inhibition of apoptosis in breast epithelial cellsQ44783902
Immunoanalysis of calf uterine progesterone receptor: modulation of receptor-associated 90 kDa heat-shock protein. f.Q44868981
Transcriptional targets of DAF-16 insulin signaling pathway protect C. elegans from extreme hypertonic stressQ45116957
CFTR: new members join the fold.Q51802162
Interaction of the 90-kDa heat shock protein with native and in vitro translated androgen receptor and receptor fragmentsQ52229737
Mutational analysis of Hsp90 alpha dimerization and subcellular localization: dimer disruption does not impede "in vivo' interaction with estrogen receptor.Q52521481
Selective Interaction of hsp90 with an Estrogen Receptor Ligand-binding Domain Containing a Point MutationQ57089555
Hsp90 Recognizes a Common Surface on Client KinasesQ58008219
Hsp90 Regulates Androgen Receptor Hormone Binding Affinityin VivoQ62059794
Direct evidence that the glucocorticoid receptor binds to hsp90 at or near the termination of receptor translation in vitroQ69385768
P433issue27
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)18821-18831
P577publication date2008-05-02
P1433published inJournal of Biological ChemistryQ867727
P1476titleHsp90 regulates the phosphorylation and activity of serum- and glucocorticoid-regulated kinase-1
P478volume283

Reverse relations

cites work (P2860)
Q37387798Activation of serum/glucocorticoid-induced kinase 1 (SGK1) underlies increased glycogen levels, mTOR activation, and autophagy defects in Lafora disease
Q28854310Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex
Q51696607External induction of heat shock stimulates the immune response and longevity of Caenorhabditis elegans towards pathogen exposure.
Q36679783Hsp90 Inhibition Results in Glucocorticoid Receptor Degradation in Association with Increased Sensitivity to Paclitaxel in Triple-Negative Breast Cancer
Q35161906Hsp90 is an essential regulator of EphA2 receptor stability and signaling: implications for cancer cell migration and metastasis
Q34612149InterAKTions with FKBPs--mutational and pharmacological exploration
Q37943416Mammalian TOR signaling to the AGC kinases
Q37477760Serum and glucocorticoid-regulated kinase 1 (SGK1) activation in breast cancer: requirement for mTORC1 activity associates with ER-alpha expression
Q37289311Serum- and glucocorticoid-induced protein kinase 1 (SGK1) is regulated by store-operated Ca2+ entry and mediates cytoprotection against necrotic cell death

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