| scholarly article | Q13442814 |
| P2093 | author name string | D R Alessi | |
| R A Currie | |||
| R M Biondi | |||
| M Deak | |||
| A Kieloch | |||
| P2860 | cites work | Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase | Q22010747 |
| Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation | Q24312168 | ||
| Phosphorylation and activation of p70s6k by PDK1 | Q24323433 | ||
| 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase | Q24336639 | ||
| Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2 | Q24531452 | ||
| The PI3K-PDK1 connection: more than just a road to PKB | Q24531972 | ||
| Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway | Q24534149 | ||
| Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions | Q24536356 | ||
| Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA | Q24600810 | ||
| A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans | Q24603590 | ||
| 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1. | Q27863657 | ||
| Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase | Q28141177 | ||
| A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1 | Q28141738 | ||
| Role of translocation in the activation and function of protein kinase B | Q28609902 | ||
| Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha | Q28616168 | ||
| Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B | Q28646376 | ||
| A conserved docking motif in MAP kinases common to substrates, activators and regulators | Q29619999 | ||
| Intracellular signalling: PDK1--a kinase at the hub of things | Q33533793 | ||
| Protein modification: docking sites for kinases | Q33632317 | ||
| Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction. | Q33690319 | ||
| Ribosomal S6 kinase signaling and the control of translation | Q33783527 | ||
| PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2. | Q33860504 | ||
| Cellular signaling: pivoting around PDK-1. | Q34073383 | ||
| 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro | Q34452063 | ||
| Multiple independent inputs are required for activation of the p70 S6 kinase | Q38295925 | ||
| A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1. | Q39922852 | ||
| A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation | Q40795858 | ||
| Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK. | Q40931970 | ||
| Phosphorylation sites in the autoinhibitory domain participate in p70(s6k) activation loop phosphorylation | Q41034632 | ||
| Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies | Q47954202 | ||
| Evidence That 3-Phosphoinositide-dependent Protein Kinase-1 Mediates Phosphorylation of p70 S6 Kinasein Vivoat Thr-412 as well as Thr-252 | Q58438131 | ||
| [29] Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf | Q58438199 | ||
| Mechanism of phosphorylation of protein kinase B/Akt by a constitutively active 3-phosphoinositide-dependent protein kinase-1 | Q73006592 | ||
| P433 | issue | 16 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | binding pocket | Q61659196 |
| P304 | page(s) | 4380-4390 | |
| P577 | publication date | 2001-08-01 | |
| P1433 | published in | The EMBO Journal | Q1278554 |
| P1476 | title | The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB. | |
| P478 | volume | 20 |
| Q37307044 | 3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma |
| Q36200417 | 3-phosphoinositide-dependent kinase 1 controls breast tumor growth in a kinase-dependent but Akt-independent manner |
| Q30986539 | A Coiled-Coil Enabled Split-Luciferase Three-Hybrid System: Applied Toward Profiling Inhibitors of Protein Kinases |
| Q36615429 | A liaison between mTOR signaling, ribosome biogenesis and cancer |
| Q34107179 | A novel pleckstrin homology domain-containing protein enhances insulin-stimulated Akt phosphorylation and GLUT4 translocation in adipocytes |
| Q24534951 | A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation |
| Q33558816 | A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1. |
| Q34830638 | A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1. |
| Q38134714 | AKT-independent PI3-K signaling in cancer - emerging role for SGK3. |
| Q34774491 | Activation of 3-phosphoinositide-dependent kinase 1 (PDK1) and serum- and glucocorticoid-induced protein kinase 1 (SGK1) by short-chain sphingolipid C4-ceramide rescues the trafficking defect of ΔF508-cystic fibrosis transmembrane conductance regula |
| Q92989379 | Activation of Insulin Signaling in Adipocytes and Myotubes by Sarcopoterium Spinosum Extract |
| Q92740085 | Activation of RSK by phosphomimetic substitution in the activation loop is prevented by structural constraints |
| Q39266844 | Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P3-dependent mechanisms leading to resistance to PDK1 inhibitors |
| Q37951353 | Aldosterone stimulates nuclear factor-kappa B activity and transcription of intercellular adhesion molecule-1 and connective tissue growth factor in rat mesangial cells via serum- and glucocorticoid-inducible protein kinase-1. |
| Q38624678 | Aldosterone-stimulated SGK1 activity mediates profibrotic signaling in the mesangium |
| Q24317058 | Allosteric activation of the protein kinase PDK1 with low molecular weight compounds |
| Q36139887 | Alternative Activation Mechanisms of Protein Kinase B Trigger Distinct Downstream Signaling Responses |
| Q29614563 | An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1 |
| Q46868178 | Arabidopsis TARGET OF RAPAMYCIN interacts with RAPTOR, which regulates the activity of S6 kinase in response to osmotic stress signals |
| Q46240581 | Association of SGK 1 Gene polymorphisms with type 2 diabetes |
| Q36510739 | Baculovirus-mediated expression, purification, and characterization of a fully activated catalytic kinase domain construct of the 70 kDa 40S ribosomal protein S6 kinase-1 alphaII isoform (S6K1alphaII). |
| Q27642001 | Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change |
| Q37175584 | Blunted IgE-mediated activation of mast cells in mice lacking the serum- and glucocorticoid-inducible kinase SGK3 |
| Q34466975 | Blunted hypertensive effect of combined fructose and high-salt diet in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase SGK1. |
| Q24324828 | C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span |
| Q24321723 | Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial protein that sensitizes cells to apoptosis |
| Q47172594 | Cell Size and Growth Rate Are Modulated by TORC2-Dependent Signals |
| Q39668305 | Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). |
| Q24645183 | Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1 |
| Q30427499 | Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase |
| Q40710176 | Characterization of phosphatidylinositol 3-kinase-dependent phosphorylation of the hydrophobic motif site Thr(389) in p70 S6 kinase 1. |
| Q42043253 | Characterization of the mechanisms controlling Greatwall activity |
| Q28508972 | Characterization of the p90 ribosomal S6 kinase 2 carboxyl-terminal domain as a protein kinase |
| Q34777003 | Concerted action of ENaC, Nedd4-2, and Sgk1 in transepithelial Na(+) transport |
| Q35089685 | Concerted roles of SGK1 and the Na+/H+ exchanger regulatory factor 2 (NHERF2) in regulation of NHE3. |
| Q89995766 | Control of Akt activity and substrate phosphorylation in cells |
| Q40583829 | Critical role of T-loop and H-motif phosphorylation in the regulation of S6 kinase 1 by the tuberous sclerosis complex |
| Q33676590 | Cross-talk between sirtuin and mammalian target of rapamycin complex 1 (mTORC1) signaling in the regulation of S6 kinase 1 (S6K1) phosphorylation |
| Q27648914 | Crystal structure of the kinase domain of serum and glucocorticoid-regulated kinase 1 in complex with AMP-PNP |
| Q27684745 | Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif |
| Q36246003 | Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia |
| Q30529898 | Deletion of Rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complex |
| Q92955269 | Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader |
| Q39939547 | Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic. |
| Q40056726 | Differential regulation of serum- and glucocorticoid-inducible kinase 1 (SGK1) splice variants based on alternative initiation of transcription |
| Q42524332 | Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase |
| Q33552984 | Discovery of PDK1 kinase inhibitors with a novel mechanism of action by ultrahigh throughput screening |
| Q40523781 | Discovery of a Potent Allosteric Kinase Modulator by Combining Computational and Synthetic Methods |
| Q28679130 | Docking interactions in the mitogen-activated protein kinase cascades |
| Q41485386 | Dysregulation of epithelial Na+ absorption induced by inhibition of the kinases TORC1 and TORC2. |
| Q38272783 | ERAP1 in the pathogenesis of ankylosing spondylitis. |
| Q36900522 | Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors |
| Q36213543 | Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors |
| Q43283870 | Epinephrine-induced hyperpolarization of pancreatic islet cells is sensitive to PI3K-PDK1 signaling |
| Q36159027 | Epithelial Na⁺ channel activity in human airway epithelial cells: the role of serum and glucocorticoid-inducible kinase 1. |
| Q24534217 | Essential role of PDK1 in regulating cell size and development in mice |
| Q28509286 | Essential role of PDK1 in regulating endothelial cell migration |
| Q58437933 | Evaluation of Approaches to Generation of Tissue-specific Knock-in Mice |
| Q38060722 | Evolutionary Adaptations of Plant AGC Kinases: From Light Signaling to Cell Polarity Regulation |
| Q36902840 | Expanding mTOR signaling |
| Q36517733 | Fluorescence resonance energy transfer in quantum dot-protein kinase assemblies |
| Q36898940 | Freud-1/Aki1, a novel PDK1-interacting protein, functions as a scaffold to activate the PDK1/Akt pathway in epidermal growth factor signaling |
| Q35014198 | Frontier of epilepsy research - mTOR signaling pathway |
| Q27728461 | Germinal-center kinase-like kinase co-crystal structure reveals a swapped activation loop and C-terminal extension |
| Q64245765 | Getting the Akt Together: Guiding Intracellular Akt Activity by PI3K |
| Q33528957 | Grb7 upregulation is a molecular adaptation to HER2 signaling inhibition due to removal of Akt-mediated gene repression |
| Q27639475 | High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site |
| Q38638905 | How can the structure of germinal-center kinase-like kinase help us in drug discovery? |
| Q36739599 | Hsp90 regulates the phosphorylation and activity of serum- and glucocorticoid-regulated kinase-1. |
| Q35067891 | Hydrophobic motif phosphorylation is not required for activation loop phosphorylation of p70 ribosomal protein S6 kinase 1 (S6K1). |
| Q40119436 | IL-2 signals through Sgk1 and inhibits proliferation and apoptosis in kidney cancer cells |
| Q34804514 | IL-6 activates serum and glucocorticoid kinase via p38alpha mitogen-activated protein kinase pathway |
| Q24303936 | Identification of Protor as a novel Rictor-binding component of mTOR complex-2 |
| Q38838098 | Identification of an oncogenic RAB protein |
| Q39831998 | In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation |
| Q34145575 | Inhibition of protein kinase B/Akt. implications for cancer therapy |
| Q36623662 | Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase |
| Q44170442 | Insulin upregulates the expression of epithelial sodium channel in vitro and in a mouse model of acute lung injury: role of mTORC2/SGK1 pathway |
| Q41819887 | Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B. |
| Q34612149 | InterAKTions with FKBPs--mutational and pharmacological exploration |
| Q36757048 | Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation but dispensable for neuronal survival |
| Q92417835 | Lipid-dependent Akt-ivity: where, when, and how |
| Q50033963 | Listeriolysin O Causes ENaC Dysfunction in Human Airway Epithelial Cells |
| Q37943416 | Mammalian TOR signaling to the AGC kinases |
| Q28568275 | Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation |
| Q37371620 | Mechanism of PDK1-catalyzed Thr-229 phosphorylation of the S6K1 protein kinase |
| Q47390421 | Mechanism of activation of SGK3 by growth factors via the Class 1 and Class 3 PI3Ks |
| Q44315431 | Mitotic regulation of ribosomal S6 kinase 1 involves Ser/Thr, Pro phosphorylation of consensus and non-consensus sites by Cdc2. |
| Q89479913 | Modulation of TORC2 Signaling by a Conserved Lkb1 Signaling Axis in Budding Yeast |
| Q28218728 | Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo |
| Q33722849 | Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor |
| Q28646131 | Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B |
| Q35810566 | Multiple translational isoforms give functional specificity to serum- and glucocorticoid-induced kinase 1. |
| Q42101485 | Muscarinic receptor-mediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: permissive role of phosphoinositide 3-kinase |
| Q37416272 | New insights into the regulation and function of serine/threonine kinases in T lymphocytes |
| Q41953543 | Notch-induced T cell development requires phosphoinositide-dependent kinase 1. |
| Q38187867 | Overview of Recent Progress in Protein-Expression Technologies for Small-Molecule Screening |
| Q35952627 | PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation |
| Q39119229 | PDK1 controls upstream PI3K expression and PIP3 generation. |
| Q38356458 | PDK1 disruptors and modulators: a patent review |
| Q38162915 | PDK1 inhibitors |
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| Q30585894 | PDK1-mediated activation of MRCKα regulates directional cell migration and lamellipodia retraction. |
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| Q34389540 | PKB/AKT: functional insights from genetic models |
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| Q47275222 | Pharmacological inhibition of S6K1 facilitates platelet activation by enhancing Akt phosphorylation |
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