| scholarly article | Q13442814 |
| P50 | author | Pravir Kumar | Q38328033 |
| P2093 | author name string | Henry W Querfurth | |
| Rashmi K Ambasta | |||
| Kaveri Pradhan | |||
| R Karunya | |||
| P2860 | cites work | Muscle Atrophy and Motor Neuron Degeneration in Human NEDL1 Transgenic Mice | Q21296753 |
| Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions | Q22010047 | ||
| Lewy Body Pathology in Alzheimer's Disease | Q22241400 | ||
| Alzheimer's Disease | Q22248111 | ||
| Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase | Q22254584 | ||
| Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity | Q24290192 | ||
| Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1 | Q24290518 | ||
| The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins | Q24290709 | ||
| Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7 | Q24291032 | ||
| U box proteins as a new family of ubiquitin-protein ligases | Q24291397 | ||
| An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin | Q24291412 | ||
| Hsp90: a specialized but essential protein-folding tool | Q24291482 | ||
| Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease | Q24291767 | ||
| The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction | Q24292709 | ||
| Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex | Q24294734 | ||
| TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in the brain of Parkinson's disease and dementia with Lewy bodies | Q24296382 | ||
| CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation | Q24296740 | ||
| Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity | Q24297369 | ||
| Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1 | Q24297466 | ||
| Parkin ubiquitinates and promotes the degradation of RanBP2 | Q24298223 | ||
| Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function | Q24298958 | ||
| The novel cytosolic RING finger protein dactylidin is up-regulated in brains of patients with Alzheimer's disease | Q24299624 | ||
| CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity | Q24302505 | ||
| Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation | Q24305254 | ||
| SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production | Q24307854 | ||
| Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress | Q24309549 | ||
| Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism | Q24309753 | ||
| Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity | Q24317318 | ||
| A novel brain-enriched E3 ubiquitin ligase RNF182 is up regulated in the brains of Alzheimer's patients and targets ATP6V0C for degradation | Q24317350 | ||
| Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease | Q24317702 | ||
| Parkin is ubiquitinated by Nrdp1 and abrogates Nrdp1-induced oxidative stress | Q24320160 | ||
| Identification, expression, and chromosomal localization of ubiquitin conjugating enzyme 7 (UBE2G2), a human homologue of the Saccharomyces cerevisiae ubc7 gene | Q24321463 | ||
| cDNA cloning, characterization, and chromosome mapping of UBE2E2 encoding a human ubiquitin-conjugating E2 enzyme | Q24336811 | ||
| CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein | Q41776375 | ||
| E3 ligase STUB1/CHIP regulates NAD(P)H:quinone oxidoreductase 1 (NQO1) accumulation in aged brain, a process impaired in certain Alzheimer disease patients | Q41817177 | ||
| Amyloid beta-peptide effects on synaptosomes from apolipoprotein E-deficient mice. | Q42485691 | ||
| The familial Parkinson disease gene PARK2 is a multisite tumor suppressor on chromosome 6q25.2-27 that regulates cyclin E. | Q42534456 | ||
| Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated A in AD models | Q42729244 | ||
| Tumor necrosis factor receptor-associated factor 6 (TRAF6) associates with huntingtin protein and promotes its atypical ubiquitination to enhance aggregate formation. | Q42813788 | ||
| CHIP-ping away at tau. | Q42947003 | ||
| Alterations of Hrd1 expression in various encephalic regional neurons in 6-OHDA model of Parkinson's disease | Q43130651 | ||
| BAG1 modulates huntingtin toxicity, aggregation, degradation, and subcellular distribution | Q43284919 | ||
| Variation in RTN3 and PPIL2 genes does not influence platelet membrane beta-secretase activity or susceptibility to alzheimer's disease in the northern Irish population | Q43294486 | ||
| TDP-43: an emerging new player in neurodegenerative diseases | Q43658300 | ||
| Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils | Q43718666 | ||
| Effect of wild-type or mutant Parkin on oxidative damage, nitric oxide, antioxidant defenses, and the proteasome | Q44009269 | ||
| Brain proteasomal function in sporadic Parkinson's disease and related disorders | Q44060094 | ||
| Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons | Q44258606 | ||
| Relationship between beta-amyloid degradation and the 26S proteasome in neural cells | Q44395842 | ||
| Proteasomal inhibition causes the formation of protein aggregates containing a wide range of proteins, including nitrated proteins | Q44518991 | ||
| Endoplasmic reticulum-localized amyloid beta-peptide is degraded in the cytosol by two distinct degradation pathways | Q44702888 | ||
| CHIP suppresses polyglutamine aggregation and toxicity in vitro and in vivo. | Q45298680 | ||
| Modifications of p53 and the DNA Damage Response in Cells Expressing Mutant Form of the Protein Huntingtin | Q45302322 | ||
| Global changes to the ubiquitin system in Huntington's disease. | Q45305824 | ||
| Comparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases | Q45306884 | ||
| Age-related expression of STUB1 in senescence-accelerated mice and its response to anti-Alzheimer's disease traditional Chinese medicine. | Q45741127 | ||
| rAAV-mediated nigral human parkin over-expression partially ameliorates motor deficits via enhanced dopamine neurotransmission in a rat model of Parkinson's disease | Q45870012 | ||
| Parkin gene therapy could treat Parkinson's disease. | Q45881248 | ||
| Parkin gene therapy for alpha-synucleinopathy: a rat model of Parkinson's disease | Q45881923 | ||
| Parkinson's disease: viral vector delivery of parkin generates model results in rats | Q45883069 | ||
| Blocking Abeta42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: a mechanistic link between Abeta and tau pathology. | Q46081295 | ||
| Parkin deletion causes cerebral and systemic amyloidosis in human mutated tau over-expressing mice | Q46473399 | ||
| Proteasomal degradation of mutant superoxide dismutases linked to amyotrophic lateral sclerosis | Q46728737 | ||
| Differential regulation of proteasome activity in the nucleus and the synaptic terminals | Q46849589 | ||
| Parkin protects against mitochondrial toxins and beta-amyloid accumulation in skeletal muscle cells | Q46975934 | ||
| CHIP promotes proteasomal degradation of familial ALS-linked mutant SOD1 by ubiquitinating Hsp/Hsc70. | Q47339398 | ||
| Suppression of Parkin enhances nigrostriatal and motor neuron lesion in mice over-expressing human-mutated tau protein | Q47596565 | ||
| Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death | Q48110123 | ||
| Correlation between decrease in protein levels of ubiquitin ligase HRD1 and amyloid-beta production | Q48138326 | ||
| Multiple ubiquitin conjugates are present in rat brain synaptic membranes and postsynaptic densities | Q48171820 | ||
| The effects of parkin suppression on the behaviour, amyloid processing, and cell survival in APP mutant transgenic mice | Q48253251 | ||
| Basic Medical Research Award. The ubiquitin system | Q48372080 | ||
| Ubiquitin immunoreactivity of multiple polypeptides in rat brain synaptic membranes | Q48490108 | ||
| Ubiquitination of alpha-synuclein by Siah-1 promotes alpha-synuclein aggregation and apoptotic cell death | Q50336439 | ||
| Parkin: a multifaceted ubiquitin ligase | Q51116287 | ||
| Carboxyl terminus of heat-shock cognate 70-interacting protein degrades tau regardless its phosphorylation status without affecting the spatial memory of the rats | Q51575069 | ||
| AtCHIP, a U-box-containing E3 ubiquitin ligase, plays a critical role in temperature stress tolerance in Arabidopsis | Q51599660 | ||
| gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment | Q51776761 | ||
| Huntington's disease | Q51848755 | ||
| Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis | Q52655035 | ||
| Parkin directly modulates 26S proteasome activity. | Q52708971 | ||
| Targeting amyloid precursor protein | Q53421264 | ||
| Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo | Q53423798 | ||
| Amyotrophic lateral sclerosis | Q55877676 | ||
| A novel transactivation domain in parkin | Q56918492 | ||
| Recognition of p63 by the E3 ligase ITCH: Effect of an ectodermal dysplasia mutant | Q57081167 | ||
| The U box is a modified RING finger — a common domain in ubiquitination | Q57263070 | ||
| Dangerous liaisons: polyglutamine meets HMGB | Q57587742 | ||
| Prevention of β-Amyloid Neurotoxicity by Blockade of the Ubiquitin-Proteasome Proteolytic Pathway | Q58331705 | ||
| Erratum: Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis | Q59048476 | ||
| Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy | Q24339224 | ||
| Akt and CHIP coregulate tau degradation through coordinated interactions | Q24656202 | ||
| Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain | Q27640694 | ||
| Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes | Q27650632 | ||
| S-nitrosylation of Drp1 links excessive mitochondrial fission to neuronal injury in neurodegeneration | Q27694603 | ||
| The ubiquitin system | Q27860803 | ||
| A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly. | Q27935265 | ||
| Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide | Q28131750 | ||
| The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases | Q28139237 | ||
| RING finger proteins: mediators of ubiquitin ligase activity | Q28139717 | ||
| CHIP-Hsc70 Complex Ubiquitinates Phosphorylated Tau and Enhances Cell Survival | Q28183470 | ||
| Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila | Q28187962 | ||
| Alpha-synuclein and neurodegenerative diseases | Q28204386 | ||
| From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS | Q28206361 | ||
| CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation | Q28216253 | ||
| Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment | Q28243433 | ||
| CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation | Q28245143 | ||
| S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function | Q28258212 | ||
| Regulation of the cytoplasmic quality control protein degradation pathway by BAG2 | Q28272894 | ||
| Ubiquitin ligase Hrd1 enhances the degradation and suppresses the toxicity of polyglutamine-expanded huntingtin | Q28276832 | ||
| RNA toxicity is a component of ataxin-3 degeneration in Drosophila | Q28278448 | ||
| CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70 | Q28303344 | ||
| HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS | Q28306195 | ||
| Progressive Purkinje cell degeneration in tambaleante mutant mice is a consequence of a missense mutation in HERC1 E3 ubiquitin ligase | Q28472238 | ||
| Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression | Q28566984 | ||
| The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4 | Q28573670 | ||
| Astrocytic but not neuronal increased expression and redistribution of parkin during unfolded protein stress | Q28579526 | ||
| p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition | Q28579903 | ||
| Cdk5 phosphorylates Cdh1 and modulates cyclin B1 stability in excitotoxicity | Q28580995 | ||
| Tau reduction prevents Abeta-induced defects in axonal transport. | Q28585545 | ||
| Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons | Q28590748 | ||
| Mitochondrial dysfunction and oxidative damage in parkin-deficient mice | Q28593859 | ||
| SCF and Cullin/Ring H2-based ubiquitin ligases | Q29547637 | ||
| Proteasomes and their kin: proteases in the machine age | Q29614359 | ||
| A synergistic dysfunction of mitochondrial fission/fusion dynamics and mitophagy in Alzheimer's disease | Q34073879 | ||
| Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity | Q34141572 | ||
| Regulation of PINK1-Parkin-mediated mitophagy. | Q34156755 | ||
| Amyotrophic lateral sclerosis. unfolding the toxicity of the misfolded | Q34175381 | ||
| Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease. | Q34189618 | ||
| Dorfin prevents cell death by reducing mitochondrial localizing mutant superoxide dismutase 1 in a neuronal cell model of familial amyotrophic lateral sclerosis | Q34306903 | ||
| Failure of the ubiquitin-proteasome system in Parkinson's disease | Q34325371 | ||
| Physical and functional interaction between Dorfin and Valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders | Q34354314 | ||
| Role of ubiquitin-proteasome-mediated proteolysis in nervous system disease | Q34372681 | ||
| Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation | Q34375535 | ||
| Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity | Q34443867 | ||
| Chaperones increase association of tau protein with microtubules | Q34470626 | ||
| Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains | Q34620363 | ||
| Activity-Dependent Ubiquitination of GluA1 Mediates a Distinct AMPA Receptor Endocytosis and Sorting Pathway | Q34814366 | ||
| Molecular mechanisms of proteasome assembly | Q34928594 | ||
| Sensory-motor deficits and neurofilament disorganization in gigaxonin-null mice | Q34980848 | ||
| Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage | Q35030813 | ||
| CHIP: a quality-control E3 ligase collaborating with molecular chaperones | Q35097617 | ||
| The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg. | Q35558459 | ||
| Pael receptor, endoplasmic reticulum stress, and Parkinson’s disease | Q35568086 | ||
| Parkin mediates the degradation-independent ubiquitination of Hsp70 | Q35609973 | ||
| The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins | Q35629026 | ||
| Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies | Q35748069 | ||
| CHIP: a link between the chaperone and proteasome systems | Q35759085 | ||
| Functional alterations of the ubiquitin-proteasome system in motor neurons of a mouse model of familial amyotrophic lateral sclerosis | Q35819865 | ||
| SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer's disease amyloidosis and improves synaptic function | Q35838771 | ||
| Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies | Q35839667 | ||
| Ubiquitin-proteasome-mediated local protein degradation and synaptic plasticity | Q35863560 | ||
| Parkin and Hsp70 sacked by BAG5. | Q35986577 | ||
| Modulation of neurodegeneration by molecular chaperones | Q35990274 | ||
| Phosphorylated tau and the neurodegenerative foldopathies | Q35992172 | ||
| Molecular pathophysiology of Parkinson's disease | Q36196507 | ||
| Modulating apoptosis as a target for effective therapy | Q36229030 | ||
| CHIP activates HSF1 and confers protection against apoptosis and cellular stress | Q36266926 | ||
| AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss | Q29614850 | ||
| Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants | Q29615627 | ||
| Association between early-onset Parkinson's disease and mutations in the parkin gene | Q29615733 | ||
| The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation | Q29616141 | ||
| Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model | Q29617937 | ||
| Tau-mediated neurodegeneration in Alzheimer's disease and related disorders | Q29618148 | ||
| The ubiquitin-proteasome pathway: on protein death and cell life | Q29619270 | ||
| Molecular Pathways of Neurodegeneration in Parkinson's Disease | Q29619903 | ||
| PINK1-dependent recruitment of Parkin to mitochondria in mitophagy | Q29620567 | ||
| Lithium inhibits Abeta-induced stress in endoplasmic reticulum of rabbit hippocampus but does not prevent oxidative damage and tau phosphorylation | Q30310554 | ||
| Posttranslational quality control: folding, refolding, and degrading proteins. | Q30323825 | ||
| Chaperone functions of the E3 ubiquitin ligase CHIP. | Q30362083 | ||
| Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity | Q30448692 | ||
| Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred | Q31080866 | ||
| A genome wide analysis of ubiquitin ligases in APP processing identifies a novel regulator of BACE1 mRNA levels | Q33257770 | ||
| The interplay between PolyQ and protein context delays aggregation by forming a reservoir of protofibrils | Q33268282 | ||
| Can overexpression of parkin provide a novel strategy for neuroprotection in Parkinson's disease? | Q33341237 | ||
| Parkinson disease, 10 years after its genetic revolution: multiple clues to a complex disorder | Q33344464 | ||
| Huntingtin interacts with the cue domain of gp78 and inhibits gp78 binding to ubiquitin and p97/VCP. | Q33529116 | ||
| In vivo amyloid imaging in autopsy-confirmed Parkinson disease with dementia | Q33601277 | ||
| Parkin reverses intracellular beta-amyloid accumulation and its negative effects on proteasome function. | Q33749114 | ||
| Parkin-mediated ubiquitin signalling in aggresome formation and autophagy | Q33757729 | ||
| Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease | Q33841155 | ||
| Parkinson's disease: insights from pathways | Q33871291 | ||
| Expression of human amyloid precursor protein in the skeletal muscles of Drosophila results in age- and activity-dependent muscle weakness | Q33881587 | ||
| Reversing neurodegeneration: a promise unfolds | Q33897927 | ||
| C-terminus of heat shock protein 70-interacting protein facilitates degradation of apoptosis signal-regulating kinase 1 and inhibits apoptosis signal-regulating kinase 1-dependent apoptosis | Q33899695 | ||
| Rhes, a physiologic regulator of sumoylation, enhances cross-sumoylation between the basic sumoylation enzymes E1 and Ubc9. | Q33966800 | ||
| Alzheimer disease with amygdala Lewy bodies: a distinct form of alpha-synucleinopathy | Q33997481 | ||
| Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions | Q39610788 | ||
| Loss of HRD1-mediated protein degradation causes amyloid precursor protein accumulation and amyloid-beta generation | Q39726471 | ||
| Overexpression of the cochaperone CHIP enhances Hsp70-dependent folding activity in mammalian cells. | Q39777855 | ||
| Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation. | Q39815864 | ||
| Parkin promotes intracellular Abeta1-42 clearance | Q39844881 | ||
| Increased Abeta1-42 production sensitizes neuroblastoma cells for ER stress toxicity | Q39929283 | ||
| Parkin attenuates wild-type tau modification in the presence of beta-amyloid and alpha-synuclein | Q39971393 | ||
| CHIP targets toxic alpha-Synuclein oligomers for degradation | Q39988391 | ||
| Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease | Q40043261 | ||
| Cellular turnover of the polyglutamine disease protein ataxin-3 is regulated by its catalytic activity | Q40095134 | ||
| CHIP and HSPs interact with beta-APP in a proteasome-dependent manner and influence Abeta metabolism. | Q40167651 | ||
| Inhibition of proteasomal activity causes inclusion formation in neuronal and non-neuronal cells overexpressing Parkin | Q40195899 | ||
| Endoplasmic reticulum chaperones inhibit the production of amyloid-beta peptides. | Q40203503 | ||
| Co-chaperone CHIP promotes aggregation of ataxin-1. | Q40204311 | ||
| Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species. | Q40261652 | ||
| Parkin is protective for substantia nigra dopamine neurons in a tau gene transfer neurodegeneration model | Q40301036 | ||
| Parkin enhances mitochondrial biogenesis in proliferating cells | Q40322753 | ||
| Cdh1/Hct1-APC is essential for the survival of postmitotic neurons. | Q40376240 | ||
| The chaperone-associated ubiquitin ligase CHIP is able to target p53 for proteasomal degradation | Q40418287 | ||
| The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways | Q40432113 | ||
| Parkin stabilizes microtubules through strong binding mediated by three independent domains. | Q40452676 | ||
| Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes. | Q40467483 | ||
| Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells | Q40483602 | ||
| U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy | Q40511254 | ||
| Co-chaperone CHIP associates with mutant Cu/Zn-superoxide dismutase proteins linked to familial amyotrophic lateral sclerosis and promotes their degradation by proteasomes | Q40517277 | ||
| Parkin is not regulated by the unfolded protein response in human neuroblastoma cells | Q40657291 | ||
| Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function. | Q40658225 | ||
| Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death. | Q40670474 | ||
| Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease | Q40795664 | ||
| Proteasome inhibition in oxidative stress neurotoxicity: implications for heat shock proteins. | Q40804834 | ||
| Antisense targeting of E6AP elevates p53 in HPV-infected cells but not in normal cells | Q41128329 | ||
| The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability | Q41301586 | ||
| Hydrogen peroxide mediates amyloid beta protein toxicity | Q41460857 | ||
| ??? | Q22251293 | ||
| Diseases of unstable repeat expansion: mechanisms and common principles | Q36277192 | ||
| A foldable CFTR{Delta}F508 biogenic intermediate accumulates upon inhibition of the Hsc70-CHIP E3 ubiquitin ligase | Q36322876 | ||
| Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice | Q36534628 | ||
| Brain CHIP: removing the culprits in neurodegenerative disease | Q36663834 | ||
| Multiple pathways contribute to the pathogenesis of Huntington disease | Q36686156 | ||
| Mitochondrial dysfunction in aging and Alzheimer's disease: strategies to protect neurons | Q36909218 | ||
| The parkin protein as a therapeutic target in Parkinson's disease | Q37004729 | ||
| CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins | Q37021183 | ||
| Ubiquitin-proteasome system dysfunction in Parkinson's disease: current evidence and controversies | Q37027500 | ||
| Imaging amyloid deposition in Lewy body diseases | Q37087766 | ||
| S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease | Q37140171 | ||
| In vivo suppression of polyglutamine neurotoxicity by C-terminus of Hsp70-interacting protein (CHIP) supports an aggregation model of pathogenesis. | Q37142961 | ||
| Huntington's disease: from pathology and genetics to potential therapies | Q37157909 | ||
| FTD and ALS: A Tale of Two Diseases | Q37241079 | ||
| A sporadic Parkinson disease model via silencing of the ubiquitin-proteasome/E3 ligase component SKP1A | Q37432159 | ||
| The molecular links between TDP-43 dysfunction and neurodegeneration | Q37593727 | ||
| Does impairment of the ubiquitin-proteasome system or the autophagy-lysosome pathway predispose individuals to neurodegenerative disorders such as Parkinson's disease? | Q37671438 | ||
| Paired helical filaments from Alzheimer disease patients contain cytoskeletal components | Q37690892 | ||
| Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease | Q37713838 | ||
| TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration | Q37733168 | ||
| Unraveling the complexity of amyotrophic lateral sclerosis: recent advances from the transgenic mutant SOD1 mice. | Q37762566 | ||
| Towards the treatment of polyglutamine diseases: the modulatory role of protein context | Q37772530 | ||
| Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease | Q37776087 | ||
| Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease | Q37807753 | ||
| Proteasomal dysfunction in aging and Huntington disease | Q37818887 | ||
| Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease | Q37824813 | ||
| The role of the ubiquitin proteasome system in Alzheimer's disease | Q37850624 | ||
| The relationship between parkin and protein aggregation in neurodegenerative diseases | Q37855544 | ||
| The role of mutant TAR DNA-binding protein 43 in amyotrophic lateral sclerosis and frontotemporal lobar degeneration | Q37905135 | ||
| GSK3 and p53 - is there a link in Alzheimer's disease? | Q39394658 | ||
| Molecular chaperone-mediated tau protein metabolism counteracts the formation of granular tau oligomers in human brain | Q39420620 | ||
| In vivo evidence of CHIP up-regulation attenuating tau aggregation | Q39420644 | ||
| P433 | issue | 3 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | neurodegeneration | Q1755122 |
| P304 | page(s) | 350-370 | |
| P577 | publication date | 2011-12-21 | |
| P1433 | published in | Journal of Neurochemistry | Q6295643 |
| P1476 | title | Cross-functional E3 ligases Parkin and C-terminus Hsp70-interacting protein in neurodegenerative disorders | |
| P478 | volume | 120 |
| Q28078724 | A Decade of Boon or Burden: What Has the CHIP Ever Done for Cellular Protein Quality Control Mechanism Implicated in Neurodegeneration and Aging? |
| Q38603276 | Alterations in the E3 ligases Parkin and CHIP result in unique metabolic signaling defects and mitochondrial quality control issues |
| Q30418755 | Ataxia and hypogonadism caused by the loss of ubiquitin ligase activity of the U box protein CHIP |
| Q28685920 | Ataxia, dementia, and hypogonadotropism caused by disordered ubiquitination |
| Q37738855 | Cancer stem-like cell related protein CD166 degrades through E3 ubiquitin ligase CHIP in head and neck cancer |
| Q47222331 | Chaperone-Mediated Regulation of Choline Acetyltransferase Protein Stability and Activity by HSC/HSP70, HSP90, and p97/VCP. |
| Q26822726 | Dysregulation of Glutathione Homeostasis in Neurodegenerative Diseases |
| Q36286010 | Enhancement of ubiquitin conjugation activity reduces intracellular aggregation of V76D mutant γD-crystallin |
| Q50989461 | Genetic Screening for Mutations in the Chip Gene in Intracranial Aneurysm Patients of Chinese Han Nationality |
| Q44125640 | Increased vulnerability of parkin knock down PC12 cells to hydrogen peroxide toxicity: The role of salsolinol and NM-salsolinol |
| Q28084859 | Legal but lethal: functional protein aggregation at the verge of toxicity |
| Q35578036 | Linking aβ42-induced hyperexcitability to neurodegeneration, learning and motor deficits, and a shorter lifespan in an Alzheimer's model |
| Q38071648 | Mechanisms underlying synaptic vulnerability and degeneration in neurodegenerative disease |
| Q64779041 | Mitochondrial and calcium perturbations in rat CNS neurons induce calpain-cleavage of Parkin: Phosphatase inhibition stabilizes pSer65Parkin reducing its calpain-cleavage |
| Q41427586 | NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease |
| Q59393040 | Neuronal Preconditioning Requires the Mitophagic Activity of C-terminus of HSC70-Interacting Protein |
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