| scholarly article | Q13442814 |
| P50 | author | Ted M. Dawson | Q56046960 |
| Darren J Moore | Q87693446 | ||
| P2093 | author name string | Valina L Dawson | |
| Andrew B West | |||
| Dustin A Dikeman | |||
| P2860 | cites work | Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase | Q22254584 |
| Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity | Q24290192 | ||
| Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1 | Q24290518 | ||
| An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin | Q24291412 | ||
| Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease | Q24291767 | ||
| The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction | Q24292709 | ||
| Parkin-mediated lysine 63-linked polyubiquitination: a link to protein inclusions formation in Parkinson's and other conformational diseases? | Q36280892 | ||
| Genetics of Parkinson's disease and parkinsonism | Q36636210 | ||
| In vivo evidence of CHIP up-regulation attenuating tau aggregation | Q39420644 | ||
| A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling | Q40252247 | ||
| Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species. | Q40261652 | ||
| Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death. | Q40379153 | ||
| Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress | Q40496111 | ||
| U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy | Q40511254 | ||
| The triage of damaged proteins: degradation by the ubiquitin-proteasome pathway or repair by molecular chaperones. | Q40839196 | ||
| Parkinson's disease. Second of two parts | Q40840040 | ||
| Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease | Q43874109 | ||
| Ubiquitylation of BAG-1 suggests a novel regulatory mechanism during the sorting of chaperone substrates to the proteasome | Q44151437 | ||
| Alpha-synuclein and parkin contribute to the assembly of ubiquitin lysine 63-linked multiubiquitin chains | Q45271574 | ||
| CHIP promotes proteasomal degradation of familial ALS-linked mutant SOD1 by ubiquitinating Hsp/Hsc70. | Q47339398 | ||
| Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age. | Q48199015 | ||
| Pathologic and biochemical studies of juvenile parkinsonism linked to chromosome 6q. | Q48390133 | ||
| Parkin: a multifaceted ubiquitin ligase | Q51116287 | ||
| Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin | Q51387140 | ||
| Complete genomic screen in Parkinson disease: evidence for multiple genes | Q53987803 | ||
| Diverse effects of pathogenic mutations of Parkin that catalyze multiple monoubiquitylation in vitro | Q81597727 | ||
| ??? | Q64867043 | ||
| Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation | Q24296620 | ||
| Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity | Q24297369 | ||
| Parkin ubiquitinates and promotes the degradation of RanBP2 | Q24298223 | ||
| CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity | Q24302505 | ||
| Recognition of the polyubiquitin proteolytic signal | Q24530006 | ||
| Parkin-mediated monoubiquitination of the PDZ protein PICK1 regulates the activity of acid-sensing ion channels | Q24679424 | ||
| Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain | Q27640694 | ||
| Mechanisms underlying ubiquitination | Q27860656 | ||
| The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI | Q28114820 | ||
| Staging of brain pathology related to sporadic Parkinson's disease | Q28131702 | ||
| The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome | Q28144546 | ||
| CHIP-Hsc70 Complex Ubiquitinates Phosphorylated Tau and Enhances Cell Survival | Q28183470 | ||
| SEPT5_v2 is a parkin-binding protein | Q28209755 | ||
| CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation | Q28216253 | ||
| Identification of far upstream element-binding protein-1 as an authentic Parkin substrate | Q28238133 | ||
| CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation | Q28245143 | ||
| S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function | Q28258212 | ||
| Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17 | Q28274687 | ||
| Polyubiquitin chains: polymeric protein signals | Q28294396 | ||
| CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70 | Q28303344 | ||
| Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation | Q28572388 | ||
| Association between early-onset Parkinson's disease and mutations in the parkin gene | Q29615733 | ||
| Neurodegenerative tauopathies | Q29619895 | ||
| Molecular Pathways of Neurodegeneration in Parkinson's Disease | Q29619903 | ||
| Parkinson's disease. First of two parts | Q29620416 | ||
| Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation | Q29622825 | ||
| Immunohistochemical and subcellular localization of Parkin protein: absence of protein in autosomal recessive juvenile parkinsonism patients | Q33861614 | ||
| The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration. | Q34202584 | ||
| Genetics of parkin-linked disease. | Q34290333 | ||
| Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity | Q34528753 | ||
| Complex relationship between Parkin mutations and Parkinson disease | Q34737305 | ||
| Genes and parkinsonism | Q35172294 | ||
| Role for the ubiquitin-proteasome system in Parkinson's disease and other neurodegenerative brain amyloidoses | Q35550995 | ||
| Molecular pathophysiology of Parkinson's disease | Q36196507 | ||
| P433 | issue | 5 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | protein ubiquitination | Q3547638 |
| P304 | page(s) | 1806-1819 | |
| P577 | publication date | 2008-02-01 | |
| P1433 | published in | Journal of Neurochemistry | Q6295643 |
| P1476 | title | Parkin mediates the degradation-independent ubiquitination of Hsp70 | |
| P478 | volume | 105 |
| Q33991036 | A caspase cleaved form of tau is preferentially degraded through the autophagy pathway |
| Q34994314 | A novel strategy to isolate ubiquitin conjugates reveals wide role for ubiquitination during neural development |
| Q38603276 | Alterations in the E3 ligases Parkin and CHIP result in unique metabolic signaling defects and mitochondrial quality control issues |
| Q24307382 | Autoregulation of Parkin activity through its ubiquitin-like domain |
| Q38973305 | BAG3 induces the sequestration of proteasomal clients into cytoplasmic puncta: implications for a proteasome-to-autophagy switch. |
| Q40987726 | Choice of biological source material supersedes oxidative stress in its influence on DJ-1 in vivo interactions with Hsp90. |
| Q34286404 | Common Pathogenic Effects of Missense Mutations in the P-Type ATPase ATP13A2 (PARK9) Associated with Early-Onset Parkinsonism |
| Q37958101 | Cross-functional E3 ligases Parkin and C-terminus Hsp70-interacting protein in neurodegenerative disorders. |
| Q90410907 | Disease-associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria |
| Q21135493 | Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2. |
| Q29615625 | Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin |
| Q37330543 | Emerging pathways in genetic Parkinson's disease: autosomal-recessive genes in Parkinson's disease--a common pathway? |
| Q39275975 | Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B. |
| Q21144926 | GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1 |
| Q34422582 | Genetic determinants at the interface of cancer and neurodegenerative disease |
| Q44644345 | Genome wide DNA-profiling of HIV-related B-cell lymphomas |
| Q24309613 | High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy |
| Q34012526 | Identification and characterization of a novel endogenous murine parkin mutation |
| Q92188518 | Loss of parkin reduces lung tumor development by blocking p21 degradation |
| Q90471304 | Mdm2 enhances ligase activity of parkin and facilitates mitophagy |
| Q38478383 | Mitochondrial proteomics investigation of a cellular model of impaired dopamine homeostasis, an early step in Parkinson's disease pathogenesis |
| Q37799850 | Molecular Chaperones as Rational Drug Targets for Parkinsons Disease Therapeutics |
| Q26747508 | Neuroprotective and Therapeutic Strategies against Parkinson's Disease: Recent Perspectives |
| Q85356388 | PARK2 and PACRG are commonly downregulated in clear-cell renal cell carcinoma and are associated with aggressive disease and poor clinical outcome |
| Q24301563 | Parkin Mono-ubiquitinates Bcl-2 and Regulates Autophagy |
| Q27308731 | Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1. |
| Q26770443 | Parkin Regulation and Neurodegenerative Disorders |
| Q39054548 | Parkin and PINK1 functions in oxidative stress and neurodegeneration |
| Q36823704 | Parkin deficiency contributes to pancreatic tumorigenesis by inducing spindle multipolarity and misorientation. |
| Q33750236 | Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling. |
| Q34119144 | Parkin in the regulation of fat uptake and mitochondrial biology: emerging links in the pathophysiology of Parkinson's disease |
| Q35208410 | Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells |
| Q28474988 | Parkin is protective against proteotoxic stress in a transgenic zebrafish model |
| Q64867155 | Parkin mediates the ubiquitination of VPS35 and modulates retromer-dependent endosomal sorting |
| Q39536018 | Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1 |
| Q39823278 | Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repair |
| Q28296466 | Parkin regulates Eg5 expression by Hsp70 ubiquitination-dependent inactivation of c-Jun NH2-terminal kinase |
| Q38271872 | Parkin reinvents itself to regulate fatty acid metabolism by tagging CD36 |
| Q47132104 | Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression. |
| Q33703497 | Parkin-mediated ubiquitination regulates phospholipase C-gamma1. |
| Q33799876 | Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1. |
| Q39145536 | Post translational modification of Parkin |
| Q37826616 | Protective role of heat shock proteins in Parkinson's disease |
| Q36554464 | Protein monoubiquitylation: targets and diverse functions |
| Q24648196 | Proteomic analysis reveals Hrs ubiquitin-interacting motif-mediated ubiquitin signaling in multiple cellular processes |
| Q38182404 | RBR E3-ligases at work |
| Q37718085 | Redox reactions induced by nitrosative stress mediate protein misfolding and mitochondrial dysfunction in neurodegenerative diseases |
| Q38086397 | Regulation of molecular chaperones through post-translational modifications: Decrypting the chaperone code |
| Q39009613 | Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies |
| Q37302453 | Targets for neuroprotection in Parkinson's disease |
| Q92267190 | The AMPK-Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome |
| Q49981917 | The M458L missense mutation disrupts the catalytic properties of Parkin. |
| Q37320375 | The role of PTEN-induced kinase 1 in mitochondrial dysfunction and dynamics |
| Q37699215 | The role of parkin in familial and sporadic Parkinson's disease |
| Q42173591 | Ubiquitin Ligase Parkin Promotes Mdm2–Arrestin Interaction but Inhibits Arrestin Ubiquitination |
| Q34372429 | Ubiquitin-Associated (UBA) Domain in Human Fas Associated Factor 1 Inhibits Tumor Formation by Promoting Hsp70 Degradation |
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