| human | Q5 |
| P496 | ORCID iD | 0000-0003-2359-5679 |
| P1153 | Scopus author ID | 57198586316 |
| P69 | educated at | University of Cambridge | Q35794 |
| University of East Anglia | Q1045828 | ||
| Johns Hopkins Medicine | Q50363516 | ||
| P108 | employer | Michigan State University | Q270222 |
| ETH Zurich | Q11942 | ||
| Johns Hopkins Medicine | Q50363516 | ||
| Van Andel Institute | Q7913119 | ||
| P734 | family name | Moore | Q10588869 |
| P735 | given name | Darren | Q1166608 |
| Darren | Q1166608 | ||
| P106 | occupation | researcher | Q1650915 |
| Q24296968 | A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity |
| Q40601003 | A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization. |
| Q37402225 | Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease |
| Q42158210 | Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease. |
| Q40496111 | Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress |
| Q37115256 | CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity |
| Q34286404 | Common Pathogenic Effects of Missense Mutations in the P-Type ATPase ATP13A2 (PARK9) Associated with Early-Onset Parkinsonism |
| Q30653185 | Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration |
| Q37294051 | Conditional transgenic mice expressing C-terminally truncated human alpha-synuclein (alphaSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons |
| Q37686991 | Contribution of GTPase activity to LRRK2-associated Parkinson disease |
| Q64870017 | Deciphering the role of VPS35 in Parkinson's disease. |
| Q97422536 | Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity |
| Q21135493 | Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2. |
| Q33307626 | Dynamic and redundant regulation of LRRK2 and LRRK1 expression |
| Q48372083 | Expression and localization of Parkinson's disease-associated leucine-rich repeat kinase 2 in the mouse brain |
| Q24310218 | Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily |
| Q47582501 | G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brain. |
| Q33553458 | GTPase activity plays a key role in the pathobiology of LRRK2. |
| Q48450468 | Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson's disease |
| Q42149865 | LRRK2 secretion in exosomes is regulated by 14-3-3. |
| Q36366189 | Lessons from Drosophila models of DJ-1 deficiency |
| Q24298689 | Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration |
| Q24318643 | Localization of LRRK2 to membranous and vesicular structures in mammalian brain |
| Q48162781 | Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain |
| Q37996364 | Mechanisms of LRRK2-Mediated Neurodegeneration |
| Q39137358 | Mechanisms of LRRK2-dependent neurodegeneration: role of enzymatic activity and protein aggregation. |
| Q35799109 | Mitochondrial dysfunction in genetic animal models of Parkinson's disease |
| Q24304952 | Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis |
| Q35172264 | Modeling LRRK2 Pathobiology in Parkinson's Disease: From Yeast to Rodents |
| Q36196507 | Molecular pathophysiology of Parkinson's disease |
| Q30454029 | Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2. |
| Q28117134 | PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity |
| Q29620567 | PINK1-dependent recruitment of Parkin to mitochondria in mitophagy |
| Q48005750 | Parkin functionally interacts with PGC-1α to preserve mitochondria and protect dopaminergic neurons |
| Q35609973 | Parkin mediates the degradation-independent ubiquitination of Hsp70 |
| Q64867155 | Parkin mediates the ubiquitination of VPS35 and modulates retromer-dependent endosomal sorting |
| Q39536018 | Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1 |
| Q38271872 | Parkin reinvents itself to regulate fatty acid metabolism by tagging CD36 |
| Q24338647 | Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity |
| Q22254785 | Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity |
| Q64059038 | Parkinson's disease-linked knockin mice manifest tau neuropathology and dopaminergic neurodegeneration |
| Q33991769 | Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration |
| Q64091665 | Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration |
| Q34452296 | Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations |
| Q34121655 | Reevaluation of phosphorylation sites in the Parkinson disease-associated leucine-rich repeat kinase 2 |
| Q54737968 | Revelations and revolutions in the understanding of Parkinson's disease. |
| Q35550995 | Role for the ubiquitin-proteasome system in Parkinson's disease and other neurodegenerative brain amyloidoses |
| Q33292556 | The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2. |
| Q91652831 | Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils |
| Q36985668 | Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1. |
| Q39206431 | Understanding the GTPase Activity of LRRK2: Regulation, Function, and Neurotoxicity. |
| Q33708940 | VPS35, the Retromer Complex and Parkinson's Disease. |
| Q30412016 | Value of genetic models in understanding the cause and mechanisms of Parkinson's disease |
| Q34252869 | α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer |
| Q35475433 | α-Synuclein-induced dopaminergic neurodegeneration in a rat model of Parkinson's disease occurs independent of ATP13A2 (PARK9). |
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