| scholarly article | Q13442814 |
| P356 | DOI | 10.1093/HMG/DDX389 |
| P698 | PubMed publication ID | 29088368 |
| P50 | author | Darren J Moore | Q87693446 |
| P2093 | author name string | Bernard L Schneider | |
| Guillaume Daniel | |||
| Pamela Valdés | |||
| Md Shariful Islam | |||
| An Phu Tran Nguyen | |||
| P2860 | cites work | Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2. | Q21135493 |
| GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1 | Q21144926 | ||
| Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity | Q22254785 | ||
| Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice | Q24293070 | ||
| Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration | Q24298689 | ||
| LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth | Q24304347 | ||
| A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation | Q24310126 | ||
| Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily | Q24310218 | ||
| Localization of LRRK2 to membranous and vesicular structures in mammalian brain | Q24318643 | ||
| LRRK2 phosphorylates novel tau epitopes and promotes tauopathy | Q24338188 | ||
| Genome-wide association study reveals genetic risk underlying Parkinson's disease | Q24646654 | ||
| Transmission and spreading of tauopathy in transgenic mouse brain | Q24651334 | ||
| Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model | Q28115206 | ||
| Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology | Q28131833 | ||
| Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease | Q28244731 | ||
| CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation | Q28245143 | ||
| Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17 | Q28274687 | ||
| Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease | Q28292932 | ||
| Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S | Q28589899 | ||
| Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease | Q29614900 | ||
| Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study | Q29614953 | ||
| Tau-mediated neurodegeneration in Alzheimer's disease and related disorders | Q29618148 | ||
| Neurodegenerative tauopathies | Q29619895 | ||
| An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family. | Q30350674 | ||
| Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2. | Q30454029 | ||
| Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations | Q30596172 | ||
| Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse model | Q30667424 | ||
| Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data | Q33226682 | ||
| A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis | Q33720044 | ||
| Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease | Q33754793 | ||
| Leucine-rich repeat kinase 2 gene-associated disease: redefining genotype-phenotype correlation | Q33808789 | ||
| Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents | Q33825413 | ||
| LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice | Q35288337 | ||
| Zeroing in on LRRK2-linked pathogenic mechanisms in Parkinson's disease. | Q37313530 | ||
| Mechanisms of LRRK2-Mediated Neurodegeneration | Q37996364 | ||
| LRRK2 Facilitates tau Phosphorylation through Strong Interaction with tau and cdk5. | Q38844125 | ||
| Mechanisms of LRRK2-dependent neurodegeneration: role of enzymatic activity and protein aggregation. | Q39137358 | ||
| Propagation of Tau aggregates | Q39338832 | ||
| Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability--a point of convergence in parkinsonian neurodegeneration? | Q39834913 | ||
| Parkinsonism, Lrrk2 G2019S, and tau neuropathology | Q40216459 | ||
| Biochemical and pathological characterization of Lrrk2. | Q40324969 | ||
| Coordinate dual-gene transgenesis by lentiviral vectors carrying synthetic bidirectional promoters. | Q40477022 | ||
| LRRK2 Promotes Tau Accumulation, Aggregation and Release. | Q40899192 | ||
| Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies | Q41760966 | ||
| Distinct tau prion strains propagate in cells and mice and define different tauopathies | Q41904960 | ||
| Leucine-rich repeat kinase 2 functionally interacts with microtubules and kinase-dependently modulates cell migration | Q42826736 | ||
| LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3ß. | Q42873469 | ||
| A rat model of progressive nigral neurodegeneration induced by the Parkinson's disease-associated G2019S mutation in LRRK2. | Q43501182 | ||
| Targeted overexpression of the parkin substrate Pael-R in the nigrostriatal system of adult rats to model Parkinson's disease | Q43735682 | ||
| Lrrk2 and Lewy body disease | Q46912096 | ||
| Study of LRRK2 variation in tauopathy: Progressive supranuclear palsy and corticobasal degeneration | Q47161677 | ||
| Nigrostriatal overabundance of α-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity. | Q48006941 | ||
| Lack of exacerbation of neurodegeneration in a double transgenic mouse model of mutant LRRK2 and tau. | Q48264748 | ||
| Expression and localization of Parkinson's disease-associated leucine-rich repeat kinase 2 in the mouse brain | Q48372083 | ||
| P433 | issue | 1 | |
| P304 | page(s) | 120-134 | |
| P577 | publication date | 2018-01-01 | |
| P1433 | published in | Human Molecular Genetics | Q2720965 |
| P1476 | title | G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brain | |
| P478 | volume | 27 |
| Q55048859 | Cellular and Molecular Basis of Neurodegeneration in Parkinson Disease. |
| Q104504605 | Genetic determinants of survival in progressive supranuclear palsy: a genome-wide association study |
| Q98177378 | LRRK2 and Protein Aggregation in Parkinson's Disease: Insights From Animal Models |
| Q97066874 | LRRK2 and α-Synuclein: Distinct or Synergistic Players in Parkinson's Disease? |
| Q55122127 | Mutations in LRRK2 amplify cell-to-cell protein aggregate propagation: a hypothesis. |
| Q64059038 | Parkinson's disease-linked knockin mice manifest tau neuropathology and dopaminergic neurodegeneration |
| Q64265990 | Rab GTPases as Physiological Substrates of LRRK2 Kinase |
| Q92017939 | What Have We Learned from Cerebrospinal Fluid Studies about Biomarkers for Detecting LRRK2 Parkinson's Disease Patients and Healthy Subjects with Parkinson's-Associated LRRK2 Mutations? |
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