Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration

scientific article published on 14 March 2019

Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1112764909
P356DOI10.1186/S40478-019-0696-4
P932PMC publication ID6419482
P698PubMed publication ID30871620

P50authorDarren J MooreQ87693446
Jiyan MaQ88486038
P2093author name stringAndrew P Lieberman
Xinhe Wang
Katelyn Becker
Michelle Zhang
Nathan Levine
P2860cites workAlpha-synuclein promotes SNARE-complex assembly in vivo and in vitroQ24629968
α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodiesQ24653247
α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formationQ26269838
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Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivoQ42391404
Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cellsQ43718632
Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body diseaseQ46593989
Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.Q46884563
Localization of alpha-synuclein to mitochondria within midbrain of miceQ46988909
Distinct α-Synuclein strains and implications for heterogeneity among α-SynucleinopathiesQ48019506
Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson diseaseQ48353748
Lewy Bodies and the Mechanisms of Neuronal Cell Death in Parkinson's Disease and Dementia with Lewy BodiesQ49150099
Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein.Q50338475
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α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease.Q55221371
The Close Encounter Between Alpha-Synuclein and Mitochondria.Q55261587
Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathiesQ59066979
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Detecting Alpha Synuclein Seeding Activity in Formaldehyde-Fixed MSA Patient Tissue by PMCA.Q64912411
Mutation in the alpha-synuclein gene identified in families with Parkinson's diseaseQ27860459
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Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic MiceQ29620597
Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic miceQ30476254
Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice.Q30585365
alpha-Synuclein is phosphorylated in synucleinopathy lesionsQ34111460
The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous systemQ34318718
Identification of two distinct synucleins from human brainQ34341909
Region specific mitochondrial impairment in mice with widespread overexpression of alpha-synucleinQ34380871
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alpha-Synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently down-regulates complex I activityQ34980191
Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite-like aggregates.Q35215169
Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron deathQ35484581
Lewy-body formation is an aggresome-related process: a hypothesisQ35840040
Parkinson diseaseQ36319286
Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brainQ36727241
Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cellsQ36820108
The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's diseaseQ37054679
Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson modelQ37240678
α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's diseaseQ37242415
Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase.Q37329723
α-Synuclein is localized to mitochondria-associated ER membranesQ37399930
The Synucleinopathies: Twenty Years On.Q37693375
Neuropathology underlying clinical variability in patients with synucleinopathiesQ37896515
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The interaction between cytoplasmic prion protein and the hydrophobic lipid core of membrane correlates with neurotoxicityQ40305093
Early-onset parkinsonism caused by alpha-synuclein gene triplication: Clinical and genetic findings in a novel family.Q40833150
The energy cost of action potential propagation in dopamine neurons: clues to susceptibility in Parkinson's diseaseQ42197212
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectLewy bodyQ1822234
SynucleinQ24767155
Parkinson’s DiseaseQ39074077
P304page(s)41
P577publication date2019-03-14
P1433published inActa Neuropathologica CommunicationsQ27724912
P1476titlePathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration
P478volume7

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cites work (P2860)
Q89619563Alpha-Synuclein Physiology and Pathology: A Perspective on Cellular Structures and Organelles
Q92220037Alpha-Synuclein Preserves Mitochondrial Fusion and Function in Neuronal Cells
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Q90481704CNTNAP4 deficiency in dopaminergic neurons initiates parkinsonian phenotypes
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Q92856571Injection of α-syn-98 Aggregates Into the Brain Triggers α-Synuclein Pathology and an Inflammatory Response
Q90462428Insulin Resistance Promotes Parkinson's Disease through Aberrant Expression of α-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling
Q97066874LRRK2 and α-Synuclein: Distinct or Synergistic Players in Parkinson's Disease?
Q91637510Modeling Parkinson's Disease Using Induced Pluripotent Stem Cells
Q64759312Neuropathology and pathogenesis of extrapyramidal movement disorders: a critical update-I. Hypokinetic-rigid movement disorders
Q91710283Nuclear Factor-κB Dysregulation and α-Synuclein Pathology: Critical Interplay in the Pathogenesis of Parkinson's Disease
Q92187419Selective Neuronal Death in Neurodegenerative Diseases: The Ongoing Mystery
Q89790112The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration
Q90230159splitGFP Technology Reveals Dose-Dependent ER-Mitochondria Interface Modulation by α-Synuclein A53T and A30P Mutants

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