scholarly article | Q13442814 |
P6179 | Dimensions Publication ID | 1112764909 |
P356 | DOI | 10.1186/S40478-019-0696-4 |
P932 | PMC publication ID | 6419482 |
P698 | PubMed publication ID | 30871620 |
P50 | author | Darren J Moore | Q87693446 |
Jiyan Ma | Q88486038 | ||
P2093 | author name string | Andrew P Lieberman | |
Xinhe Wang | |||
Katelyn Becker | |||
Michelle Zhang | |||
Nathan Levine | |||
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α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation | Q26269838 | ||
Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities | Q26269871 | ||
Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo | Q42391404 | ||
Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells | Q43718632 | ||
Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease | Q46593989 | ||
Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. | Q46884563 | ||
Localization of alpha-synuclein to mitochondria within midbrain of mice | Q46988909 | ||
Distinct α-Synuclein strains and implications for heterogeneity among α-Synucleinopathies | Q48019506 | ||
Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease | Q48353748 | ||
Lewy Bodies and the Mechanisms of Neuronal Cell Death in Parkinson's Disease and Dementia with Lewy Bodies | Q49150099 | ||
Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein. | Q50338475 | ||
Genetic risk factors in Parkinson's disease | Q51763324 | ||
α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease. | Q55221371 | ||
The Close Encounter Between Alpha-Synuclein and Mitochondria. | Q55261587 | ||
Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies | Q59066979 | ||
Determinants of dopaminergic neuron loss in Parkinson's disease | Q64864824 | ||
Detecting Alpha Synuclein Seeding Activity in Formaldehyde-Fixed MSA Patient Tissue by PMCA. | Q64912411 | ||
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease | Q27860459 | ||
alpha-Synuclein locus triplication causes Parkinson's disease | Q27860533 | ||
Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain | Q28509158 | ||
Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein | Q28587358 | ||
Parkinson's disease: mechanisms and models | Q29547424 | ||
Alpha-synuclein locus duplication as a cause of familial Parkinson's disease | Q29614762 | ||
Aggresomes, inclusion bodies and protein aggregation | Q29615253 | ||
Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice | Q29620597 | ||
Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice | Q30476254 | ||
Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice. | Q30585365 | ||
alpha-Synuclein is phosphorylated in synucleinopathy lesions | Q34111460 | ||
The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system | Q34318718 | ||
Identification of two distinct synucleins from human brain | Q34341909 | ||
Region specific mitochondrial impairment in mice with widespread overexpression of alpha-synuclein | Q34380871 | ||
The many faces of α-synuclein: from structure and toxicity to therapeutic target | Q34972009 | ||
alpha-Synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently down-regulates complex I activity | Q34980191 | ||
Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite-like aggregates. | Q35215169 | ||
Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death | Q35484581 | ||
Lewy-body formation is an aggresome-related process: a hypothesis | Q35840040 | ||
Parkinson disease | Q36319286 | ||
Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain | Q36727241 | ||
Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells | Q36820108 | ||
The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease | Q37054679 | ||
Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model | Q37240678 | ||
α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease | Q37242415 | ||
Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase. | Q37329723 | ||
α-Synuclein is localized to mitochondria-associated ER membranes | Q37399930 | ||
The Synucleinopathies: Twenty Years On. | Q37693375 | ||
Neuropathology underlying clinical variability in patients with synucleinopathies | Q37896515 | ||
Post-translational modification of α-synuclein in Parkinson's disease | Q38529282 | ||
Selective neuronal vulnerability in Parkinson disease | Q39095738 | ||
The interaction between cytoplasmic prion protein and the hydrophobic lipid core of membrane correlates with neurotoxicity | Q40305093 | ||
Early-onset parkinsonism caused by alpha-synuclein gene triplication: Clinical and genetic findings in a novel family. | Q40833150 | ||
The energy cost of action potential propagation in dopamine neurons: clues to susceptibility in Parkinson's disease | Q42197212 | ||
P433 | issue | 1 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | Lewy body | Q1822234 |
Synuclein | Q24767155 | ||
Parkinson’s Disease | Q39074077 | ||
P304 | page(s) | 41 | |
P577 | publication date | 2019-03-14 | |
P1433 | published in | Acta Neuropathologica Communications | Q27724912 |
P1476 | title | Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration | |
P478 | volume | 7 |
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