PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity

scientific journal article

PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/HMG/DDR606
P3181OpenCitations bibliographic resource ID1574846
P932PMC publication ID3465694
P698PubMed publication ID22186024
P5875ResearchGate publication ID51903811

P50authorElpida TsikaQ56670281
David RamonetQ56827676
Alzbeta TrancikovaQ57027886
Darren J MooreQ87693446
Liliane GlauserQ115628702
Klodjan StafaQ115628703
P2093author name stringJuan C. Troncoso
Olga Pletnikova
Sarah Sonnay
Agata Podhajska
P2860cites workDopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.Q21135493
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activityQ22254785
Pathogenic effects of novel mutations in the P-type ATPase ATP13A2 (PARK9) causing Kufor-Rakeb syndrome, a form of early-onset parkinsonismQ24301367
Localization of LRRK2 to membranous and vesicular structures in mammalian brainQ24318643
Subversion of cellular autophagosomal machinery by RNA virusesQ24522711
Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagyQ24683089
Rab7 associates with early endosomes to mediate sorting and transport of Semliki forest virus to late endosomesQ24810483
A noncytotoxic DsRed variant for whole-cell labelingQ27652674
Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicityQ27934988
Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPaseQ28116395
The E646D-ATP13A4 mutation associated with autism reveals a defect in calcium regulationQ28506199
How to interpret LC3 immunoblottingQ29614175
Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagyQ29614178
Autophagy gone awry in neurodegenerative diseasesQ29614849
The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapsesQ29615239
Regulation of Intracellular Manganese Homeostasis by Kufor-Rakeb Syndrome-associated ATP13A2 ProteinQ34197130
Characterization of the P5 subfamily of P-type transport ATPases in miceQ34350143
Kufor Rakeb disease: autosomal recessive, levodopa-responsive parkinsonism with pyramidal degeneration, supranuclear gaze palsy, and dementiaQ34429799
Novel ATP13A2 (PARK9) homozygous mutation in a family with marked phenotype variabilityQ34534474
Pallido-pyramidal degeneration, supranuclear upgaze paresis and dementia: Kufor-Rakeb syndromeQ34726815
α-Synuclein impairs macroautophagy: implications for Parkinson's disease.Q35005567
Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-SynucleinQ35063363
Mutant Atp13a2 proteins involved in parkinsonism are degraded by ER-associated degradation and sensitize cells to ER-stress induced cell deathQ35175069
Molecular pathophysiology of Parkinson's diseaseQ36196507
Genetics of Parkinson's disease and parkinsonismQ36636210
Functions and dysfunctions of mitochondrial dynamicsQ36967747
Mendelian forms of Parkinson's diseaseQ37376999
Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body diseaseQ37402225
Regulation of mammalian autophagy in physiology and pathophysiology.Q37801517
Rab proteins mediate Golgi transport of caveola-internalized glycosphingolipids and correct lipid trafficking in Niemann-Pick C cellsQ39738033
A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization.Q40601003
Visualization of retroviral replication in living cells reveals budding into multivesicular bodies.Q40616484
Cd2+, Mn2+, Ni2+ and Se2+ toxicity to Saccharomyces cerevisiae lacking YPK9p the orthologue of human ATP13A2Q41899742
Clinical spectrum of Kufor-Rakeb syndrome in the Chilean kindred with ATP13A2 mutationsQ42947297
ATP13A2 mutations (PARK9) cause neurodegeneration with brain iron accumulationQ43121326
ATP13A2 variants in early-onset Parkinson's disease patients and controlsQ44289614
Localization of MAP1-LC3 in vulnerable neurons and Lewy bodies in brains of patients with dementia with Lewy bodiesQ46184361
Novel ATP13A2 variant associated with Parkinson disease in Taiwan and SingaporeQ46241226
PARK9-LINKED PARKINSONISM IN EASTERN ASIA: MUTATION DETECTION IN ATP13A2 AND CLINICAL PHENOTYPEQ56772080
Juvenile dystonia-parkinsonism and dementia caused by a novel ATP13A2 frameshift mutationQ61782148
Biochemical Fractionation of Brain Tissue for Studies of Receptor Distribution and TraffickingQ62607676
P4510describes a project that usesImageJQ1659584
P433issue8
P921main subjectATPase cation transporting 13A2Q21115193
ATPase type 13A2Q21499116
autophagosome organizationQ24458610
P304page(s)1725–1743
P577publication date2012-04-15
P1433published inHuman Molecular GeneticsQ2720965
P1476titlePARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity
P478volume21

Reverse relations

cites work (P2860)
Q38211382A mitocentric view of Parkinson's disease.
Q67230494A pH-correctable, DNA-based fluorescent reporter for organellar calcium
Q33715666ATP13A2 (PARK9) protein levels are reduced in brain tissue of cases with Lewy bodies
Q28116203ATP13A2 and Alpha-synuclein: a Metal Taste in Autophagy
Q28119120ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons
Q50299651ATP13A2 transports cations from cytosol to lysosomal lumen
Q34774337ATP13A2/PARK9 Deficiency Neither Cause Lysosomal Impairment Nor Alter α-Synuclein Metabolism in SH-SY5Y Cells
Q28118666ATP13A2/PARK9 regulates secretion of exosomes and α-synuclein
Q51732455Alpha-synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation.
Q98224600Biofluid Markers for Prodromal Parkinson's Disease: Evidence From a Catecholaminergic Perspective
Q35018773CATP-6, a C. elegans ortholog of ATP13A2 PARK9, positively regulates GEM-1, an SLC16A transporter
Q38080980Cell biology and function of neuronal ceroid lipofuscinosis-related proteins
Q27003886Cellular function and pathological role of ATP13A2 and related P-type transport ATPases in Parkinson's disease and other neurological disorders
Q35795120Characterization of cellular protective effects of ATP13A2/PARK9 expression and alterations resulting from pathogenic mutants
Q92686541Clinical and genetic analysis of ATP13A2 in hereditary spastic paraplegia expands the phenotype
Q34286404Common Pathogenic Effects of Missense Mutations in the P-Type ATPase ATP13A2 (PARK9) Associated with Early-Onset Parkinsonism
Q30653185Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration
Q23914777Correlation between the biochemical pathways altered by mutated Parkinson-related genes and chronic exposure to manganese
Q47169769Crosstalk between Lysosomes and Mitochondria in Parkinson's Disease
Q52095699Diagnosis of CoPAN by whole exome sequencing: Waking up a sleeping tiger's eye.
Q92875576Emerging Role of Genetic Alterations Affecting Exosome Biology in Neurodegenerative Diseases
Q26764724Emerging preclinical pharmacological targets for Parkinson's disease
Q38684233Endocytic membrane trafficking and neurodegenerative disease
Q50176511Exacerbation of sensorimotor dysfunction in mice deficient in Atp13a2 and overexpressing human wildtype alpha-synuclein
Q36210852Exercise-mimetic AICAR transiently benefits brain function
Q39057306Exosomes in Parkinson's Disease
Q38557027Genes associated with Parkinson's disease: regulation of autophagy and beyond
Q50248457Genetic analysis of the ATP1B4 gene in Chinese Han patients with Parkinson's disease
Q22242985Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease
Q94586186Genetic perspective on the synergistic connection between vesicular transport, lysosomal and mitochondrial pathways associated with Parkinson's disease pathogenesis
Q34550197Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways
Q64073224Glial phagocytic clearance in Parkinson's disease
Q24337043Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity
Q28510024Impaired Glucose Tolerance in a Mouse Model of Sidt2 Deficiency
Q39044609Impulse control disorder, lysosomal malfunction and ATP13A2 insufficiency in Parkinsonism
Q34629875Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis
Q39377457Influence of iron metabolism on manganese transport and toxicity
Q92213047Investigation of somatic CNVs in brains of synucleinopathy cases using targeted SNCA analysis and single cell sequencing
Q28588670LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance
Q47813940Loss-of-function mutations in the ATP13A2/PARK9 gene cause complicated hereditary spastic paraplegia (SPG78).
Q37461364Lysosomal impairment in Parkinson's disease
Q38479949Manganese Is Essential for Neuronal Health
Q36100354Mannose 6-Phosphate Receptor Is Reduced in -Synuclein Overexpressing Models of Parkinsons Disease
Q39247520Mechanisms of Gene-Environment Interactions in Parkinson's Disease
Q52332617Mitochondrial Dysfunction in Parkinson's Disease: New Mechanistic Insights and Therapeutic Perspectives.
Q92129107Mitophagy in Parkinson's Disease: From Pathogenesis to Treatment
Q38887346Molecular changes in the postmortem parkinsonian brain
Q64109210Mutations in ATP13A2 (PARK9) are associated with an amyotrophic lateral sclerosis-like phenotype, implicating this locus in further phenotypic expansion
Q34100399Mutations in the ATP13A2 gene and Parkinsonism: a preliminary review
Q92275527Neurodegeneration with Brain Iron Accumulation
Q64230486Neurodegeneration with Brain Iron Accumulation Disorders: Valuable Models Aimed at Understanding the Pathogenesis of Iron Deposition
Q21129274Neurodegeneration with brain iron accumulation: update on pathogenic mechanisms
Q59812935New Perspectives on Roles of Alpha-Synuclein in Parkinson's Disease
Q36381145On the complexity of clinical and molecular bases of neurodegeneration with brain iron accumulation
Q90310268PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson's disease
Q50418431Parkinson disease related ATP13A2 evolved early in animal evolution.
Q26746899Parkinson's Disease: The Mitochondria-Iron Link
Q33582743Parkinson's disease-associated human ATP13A2 (PARK9) deficiency causes zinc dyshomeostasis and mitochondrial dysfunction
Q33991769Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration
Q38727638Parkinson's disease: acid-glucocerebrosidase activity and alpha-synuclein clearance
Q94371699Parkinson’s Disease
Q53387936Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression
Q34481921Pathways to Parkinsonism Redux: convergent pathobiological mechanisms in genetics of Parkinson's disease
Q36800670Review: Insights into molecular mechanisms of disease in neurodegeneration with brain iron accumulation: unifying theories.
Q64915273Synergistic Effect of Mitochondrial and Lysosomal Dysfunction in Parkinson's Disease.
Q38434200The role of ATP13A2 in Parkinson's disease: Clinical phenotypes and molecular mechanisms
Q39281423The role of Ca2+ signaling in Parkinson's disease
Q38765856Therapeutic potential of autophagy-enhancing agents in Parkinson's disease.
Q28116171Zn²⁺ dyshomeostasis caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation

Search more.