Manganese Is Essential for Neuronal Health

scientific article published on 13 May 2015

Manganese Is Essential for Neuronal Health is …
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P356DOI10.1146/ANNUREV-NUTR-071714-034419
P932PMC publication ID6525788
P698PubMed publication ID25974698

P50authorKyle J HorningQ86586076
Aaron B. BowmanQ37830327
Michael AschnerQ64778814
P2093author name stringK Grace Tipps
Samuel W Caito
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ATP13A2 (PARK9) polymorphisms influence the neurotoxic effects of manganeseQ28118761
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The iron transporter ferroportin can also function as a manganese exporterQ28255643
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Manganese exposure inhibits the clearance of extracellular GABA and influences taurine homeostasis in the striatum of developing ratsQ28384350
Manganese in human parenteral nutrition: considerations for toxicity and biomonitoringQ28385116
In vivo measurement of brain GABA concentrations by magnetic resonance spectroscopy in smelters occupationally exposed to manganeseQ28386303
Intranasal exposure to manganese disrupts neurotransmitter release from glutamatergic synapses in the central nervous system in vivoQ28388204
Increased APLP1 expression and neurodegeneration in the frontal cortex of manganese-exposed non-human primatesQ28388232
A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's diseaseQ28389607
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X-ray fluorescence imaging of the hippocampal formation after manganese exposureQ28394338
Changes in dietary iron exacerbate regional brain manganese accumulation as determined by magnetic resonance imagingQ34601416
Altered Expression of ZnT10 in Alzheimer's Disease BrainQ34761375
Reduced uptake of [ 18 F]FDOPA PET in asymptomatic welders with occupational manganese exposureQ34953746
Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradoxQ34961072
BDNF and Huntingtin protein modifications by manganese: implications for striatal medium spiny neuron pathology in manganese neurotoxicity.Q34976214
Iron accumulates in Huntington's disease neurons: protection by deferoxamineQ35023030
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DMT1: a mammalian transporter for multiple metalsQ35061952
Expression profiles for macrophage alternative activation genes in AD and in mouse models of ADQ35090548
Identification of binding sites in Huntingtin for the Huntingtin Interacting Proteins HIP14 and HIP14LQ35126285
Mutant Atp13a2 proteins involved in parkinsonism are degraded by ER-associated degradation and sensitize cells to ER-stress induced cell deathQ35175069
Simultaneous monitoring of cerebral metal accumulation in an experimental model of Wilson's disease by laser ablation inductively coupled plasma mass spectrometryQ35228998
Manganese exposure alters extracellular GABA, GABA receptor and transporter protein and mRNA levels in the developing rat brainQ35551662
Vesicular distribution of Secretory Pathway Ca2+-ATPase isoform 1 and a role in manganese detoxification in liver-derived polarized cellsQ35613955
Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport.Q35796864
Mutations in SLC30A10 Cause Parkinsonism and Dystonia with Hypermanganesemia, Polycythemia, and Chronic Liver DiseaseQ35843237
Effect of mineral-enriched diet and medicinal herbs on Fe, Mn, Zn, and Cu uptake in chickenQ35914330
Manganese: recent advances in understanding its transport and neurotoxicityQ35946187
Impact of manganese on and transfer across blood-brain and blood-cerebrospinal fluid barrier in vitro.Q36006864
Mechanistic analysis of iron accumulation by endothelial cells of the BBBQ36062978
Manganese superoxide dismutase protects mouse cortical neurons from chronic intermittent hypoxia-mediated oxidative damageQ36178648
Manganese-induced toxicity in normal and human B lymphocyte cell lines containing a homozygous mutation in parkin.Q36223221
Nutritional aspects of manganese homeostasis.Q36228729
Glutamine synthetase protects against neuronal degeneration in injured retinal tissueQ36247136
ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loadingQ36298311
The Discrimination between Magnesium and Manganese by Serum ProteinsQ36427692
Manganese-induced potentiation of in vitro proinflammatory cytokine production by activated microglial cells is associated with persistent activation of p38 MAPK.Q36440409
Speciation of manganese in cells and mitochondria: a search for the proximal cause of manganese neurotoxicityQ36502181
Manganese transport via the transferrin mechanismQ36622998
Huntingtin-interacting protein 14, a palmitoyl transferase required for exocytosis and targeting of CSP to synaptic vesiclesQ36639079
Manganese intoxication in the rhesus monkey: a clinical, imaging, pathologic, and biochemical studyQ36797290
Manganese accumulates primarily in nuclei of cultured brain cellsQ36813482
Basal ganglia intensity indices and diffusion weighted imaging in manganese-exposed weldersQ36837635
Increased risk of parkinsonism associated with welding exposureQ36837642
Alterations in brain transition metals in Huntington disease: an evolving and intricate storyQ36838442
Iron depletion increases manganese uptake and potentiates apoptosis through ER stressQ37164919
Arginase regulates red blood cell nitric oxide synthase and export of cardioprotective nitric oxide bioactivityQ37173246
Ceruloplasmin alters the tissue disposition and neurotoxicity of manganese, but not its loading onto transferrinQ37327124
Manganese disrupts astrocyte glutamine transporter expression and functionQ37372959
Cirrhosis presenting as ParkinsonismQ37628466
Manganese flux across the blood-brain barrier.Q37630415
Molecular identification of ancient and modern mammalian magnesium transportersQ37638953
Golgi phosphoprotein 4 (GPP130) is a sensitive and selective cellular target of manganese exposureQ37704540
Dopamine D2 receptor relies upon PPM/PP2C protein phosphatases to dephosphorylate huntingtin proteinQ37727587
Considerations on manganese (Mn) treatments for in vitro studiesQ37732149
Prevention of parenteral nutrition-associated liver disease: role of omega-3 fish oil.Q37760905
A biokinetic model for manganeseQ37908559
Role of manganese in neurodegenerative diseasesQ37941268
Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: mechanism for deficient glutamatergic transmission?Q38801058
Cellular manganese content is developmentally regulated in human dopaminergic neuronsQ38944860
Interleukin-6 enhances manganese accumulation in SH-SY5Y cells: implications of the up-regulation of ZIP14 and the down-regulation of ZnT10.Q39020276
Environmental manganese compounds accumulate as Mn(II) within the Golgi apparatus of dopamine cells: relationship between speciation, subcellular distribution, and cytotoxicity.Q39022912
Environmental Contamination and Human Exposure to Airborne Total and Respirable Manganese in MontrealQ39115412
Suppression of ZIP8 expression is a common feature of cadmium-resistant and manganese-resistant RBL-2H3 cells.Q39163939
Distribution of glutamine synthetase in the rat central nervous systemQ39269864
Glutamine synthetase down-regulation reduces astrocyte protection against glutamate excitotoxicity to neuronsQ39367072
Particulate matter and manganese exposures in Indianapolis, IndianaQ39590532
A new paradigm: manganese superoxide dismutase influences the production of H2O2 in cells and thereby their biological state.Q39682054
The SPCA1 Ca2+ pump and intracellular membrane traffickingQ39683990
Transition metal abnormalities in progressive dementias.Q39687509
Disease-toxicant screen reveals a neuroprotective interaction between Huntington's disease and manganese exposureQ39785057
Silencing the SPCA1 (secretory pathway Ca2+-ATPase isoform 1) impairs Ca2+ homeostasis in the Golgi and disturbs neural polarity.Q39793151
Evidence that TRPM7 is required for breast cancer cell proliferation.Q39839646
The A2A adenosine receptor rescues the urea cycle deficiency of Huntington's disease by enhancing the activity of the ubiquitin-proteasome systemQ39851269
Essential trace metals in man: manganese. A study in homeostasisQ40048107
Intrinsic mitochondrial dysfunction in ATM-deficient lymphoblastoid cellsQ40112631
Sub-cellular localization of manganese in the basal ganglia of normal and manganese-treated rats An electron spectroscopy imaging and electron energy-loss spectroscopy studyQ40164018
ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter family: characterization of transporter propertiesQ40287593
High levels of Mn²⁺ inhibit secretory pathway Ca²⁺/Mn²⁺-ATPase (SPCA) activity and cause Golgi fragmentation in neurons and gliaQ47325714
Plasma manganese levels in the very low birth weight infant are high in early lifeQ47419011
Manganese distribution across the blood-brain barrier III. The divalent metal transporter-1 is not the major mechanism mediating brain manganese uptake.Q47956131
L-arginine uptake, the citrulline-NO cycle and arginase II in the rat brain: an in situ hybridization studyQ48162061
Manganese (Mn) transport across the rat blood-brain barrier: saturable and transferrin-dependent transport mechanismsQ48195948
Rapid Brain Uptake of Manganese(II) Across the Blood‐Brain BarrierQ48246042
Whole-blood manganese levels and brain manganese accumulation in children receiving long-term home parenteral nutritionQ48328035
Chronic parkinsonism associated with cirrhosis: a distinct subset of acquired hepatocerebral degenerationQ48329148
Reversible Parkinsonism and T1W pallidal hyperintensities in acute liver failureQ48415642
Mn2+ exerts stronger structural effects than the Mn-citrate complex on the human erythrocyte membrane and molecular modelsQ48419645
Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primatesQ48440122
Purification of a Multipotent Antideath Activity from Bovine Liver and Its Identification as Arginase: Nitric Oxide-Independent Inhibition of Neuronal ApoptosisQ48455614
Relationship between blood manganese levels and children's attention, cognition, behavior, and academic performance--a nationwide cross-sectional studyQ48459248
Manganese concentration in rat brain: manganese transport from the peripheral tissuesQ48506966
Distribution of secretory pathway Ca2+ ATPase (SPCA1) in neuronal and glial cell culturesQ48507674
Trafficking of Amino Acids between Neurons and Glia In Vivo. Effects of Inhibition of Glial Metabolism by FluoroacetateQ48589672
Anatomical region differences and age-related changes in copper, zinc, and manganese levels in the human brainQ48606536
A light and electron microscopic study of the iron transporter protein DMT-1 in the monkey cerebral neocortex and hippocampusQ48671196
Neurologic disorders due to brain manganese deposition in a jaundiced patient receiving long-term parenteral nutritionQ48821128
Acid Fibroblast Growth Factor and Peripheral Nerve Grafts Regulate Th2 Cytokine Expression, Macrophage Activation, Polyamine Synthesis, and Neurotrophin Expression in Transected Rat Spinal CordsQ48891043
Regional distribution of dopamine beta-hydroxylase and monoamine oxidase in the brains of rats exposed to manganeseQ48923458
Distribution of injected iron 59 and manganese 54 in hypotransferrinemic miceQ48937155
Influence of dietary manganese on the pharmacokinetics of inhaled manganese sulfate in male CD ratsQ48952979
Manganese transport across the blood-brain barrier: relationship to iron homeostasisQ48955117
Calcium sequestering ability of mitochondria modulates influx of calcium through glutamate receptor channelQ49093603
Activity and localization of the secretory pathway Ca2+-ATPase isoform 1 (SPCA1) in different areas of the mouse brain during postnatal development.Q49124159
Manganese induces oxidative impairment in cultured rat astrocytes.Q50469431
An inadequate intake of manganese may favour insulin resistance in girlsQ51365516
Iron, manganese, and cobalt transport by Nramp1 (Slc11a1) and Nramp2 (Slc11a2) expressed at the plasma membraneQ51837219
Epidemiological survey among workers exposed to manganese: effects on lung, central nervous system, and some biological indicesQ52134343
Superoxide dismutase activity and lipid peroxidation in the rat: developmental correlations affected by manganese deficiencyQ52278646
Electron paramagnetic resonance and difference ultraviolet studies of Mn2+ binding to serum transferrinQ52379021
Manganese metabolism in rats: an improved methodology for assessing gut endogenous lossesQ52404750
Patterns of levels of biological metals in CSF differ among neurodegenerative diseases.Q53316529
Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade ratQ54975411
Blood manganese levels in patients with hepatic encephalopathyQ56775939
An estimate of the calcium content of the sarcoplasmic reticulum in rat ventricular myocytesQ60182097
Microglial reaction in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induced Parkinson's disease mice modelQ67243728
Longitudinal changes of manganese-dependent superoxide dismutase and other indexes of manganese and iron status in womenQ68076886
Identification of transferrin as the major plasma carrier protein for manganese introduced orally or intravenously or after in vitro addition in the ratQ69386660
Manganese balance and clinical observations in young men fed a manganese-deficient dietQ69756105
Role of dopamine in manganese neurotoxicityQ69850146
The effect of age on manganese uptake and retention from milk and infant formulas in ratsQ70019339
Binding of manganese in human and rat plasmaQ70105307
Absence of preferential glutamine uptake into neurons--an indication of a net transfer of TCA constituents from nerve endings to astrocytes?Q70261436
Hepatic steatosis in total parenteral nutrition: failure of fatty infiltration to correlate with abnormal serum hepatic enzyme levelsQ70307276
Inhibition of bile flow in the isolated perfused rat liver by a synthetic parenteral amino acid mixture: associated net amino acid fluxesQ70462902
Speciation analysis of selected metals and determination of their total contents in paired serum and cerebrospinal fluid samples: An approach to investigate the permeability of the human blood-cerebrospinal fluid-barrierQ43507231
Theoretical models of catalytic domains of protein phosphatases 1 and 2A with Zn2+ and Mn2+ metal dications and putative bioligands in their catalytic centersQ43663957
Inhibition of the rat blood–brain barrier choline transporter by manganese chlorideQ43794678
Expression of arginase isozymes in mouse brainQ43825253
Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat.Q43825415
Increased whole blood manganese concentrations observed in children with iron deficiency anaemiaQ43884875
The effect of individual dietary components on manganese absorption in humansQ43908686
Impaired glutamate transport and glutamate-glutamine cycling: downstream effects of the Huntington mutationQ44075664
Mechanisms underlying the frequency dependence of contraction and [Ca(2+)](i) transients in mouse ventricular myocytesQ44136820
Glutamate/aspartate transporter (GLAST), taurine transporter and metallothionein mRNA levels are differentially altered in astrocytes exposed to manganese chloride, manganese phosphate or manganese sulfateQ44184685
Glutamine synthetase enhances the clearance of extracellular glutamate by the neural retinaQ44187190
Manganese causes differential regulation of glutamate transporter (GLAST) taurine transporter and metallothionein in cultured rat astrocytesQ44214172
Subtoxic concentration of manganese synergistically potentiates 1-methyl-4-phenylpyridinium-induced neurotoxicity in PC12 cellsQ44283395
Manganese distribution across the blood-brain barrier. I. Evidence for carrier-mediated influx of managanese citrate as well as manganese and manganese transferrinQ44300759
Manganese distribution across the blood-brain barrier. II. Manganese efflux from the brain does not appear to be carrier mediatedQ44300763
Phenotypic variability in a dystonia family with mutations in the manganese transporter gene.Q44434413
Arginase Reciprocally Regulates Nitric Oxide Synthase Activity and Contributes to Endothelial Dysfunction in Aging Blood VesselsQ44601105
Mutations of the Huntington's disease protein impact on the ATM-dependent signaling and repair pathways of the radiation-induced DNA double-strand breaks: corrective effect of statins and bisphosphonates.Q44666439
Inhibition of mitochondrial complex II alters striatal expression of genes involved in glutamatergic and dopaminergic signaling: possible implications for Huntington's diseaseQ44790407
Fe-saturation and proteolysis of human lactoferrin: effect on brush-border receptor-mediated uptake of Fe and Mn.Q44817659
Iron transporters are differentially regulated by dietary iron, and modifications are associated with changes in manganese metabolism in young pigs.Q44877561
Anti-apoptotic and pro-apoptotic effect of NEPP11 on manganese-induced apoptosis and JNK pathway activation in PC12 cells.Q45040732
Kinetics of manganese transport and gene expressions of manganese transport carriers in Caco-2 cell monolayersQ45129400
Manganese potentiates in vitro production of proinflammatory cytokines and nitric oxide by microglia through a nuclear factor kappa B-dependent mechanismQ45188778
[18F]FDOPA PET and clinical features in parkinsonism due to manganismQ45222225
A novel isoform of the secretory pathway Ca2+,Mn(2+)-ATPase, hSPCA2, has unusual properties and is expressed in the brainQ45242024
Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease.Q45290323
Changes in nine enzyme markers for neurons, glia, and endothelial cells in agonal state and Huntington's disease caudate nucleusQ45296650
Dietary arginine alters time of symptom onset in Huntington's disease transgenic miceQ45301108
Glutamine synthetase activity in Huntington's disease.Q45303751
Altered neuronal nitric oxide synthase expression contributes to disease progression in Huntington's disease transgenic miceQ45306085
Increased synthesis of spermidine as a result of upregulation of arginase I promotes axonal regeneration in culture and in vivo.Q45916523
Assessing manganese efflux using SEA0400 and cardiac T1-mapping manganese-enhanced MRI in a murine model.Q45931776
Effect of microglia activation on dopaminergic neuronal injury induced by manganese, and its possible mechanism.Q45969405
Brain accumulation and toxicity of Mn(II) and Mn(III) exposures.Q45974456
Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease.Q46009075
Pathology of inherited manganese transporter deficiencyQ46134590
The secretory pathway Ca2+/Mn2+-ATPase 2 is a Golgi-localized pump with high affinity for Ca2+ ionsQ46438644
Manganese oxidation state and its implications for toxicityQ46521122
Manganese distribution across the blood-brain barrier. IV. Evidence for brain influx through store-operated calcium channels.Q46526917
Manganese transport by rat brain endothelial (RBE4) cell-based transwell model in the presence of astrocyte conditioned mediaQ46538546
Molecular mechanism of manganese exposure-induced dopaminergic toxicityQ46576361
Asymptomatic hypermanganesemia in long-term home parenteral nutrition patientsQ46599688
Manganese absorption from human milk, cow's milk, and infant formulas in humansQ46683636
Characteristics of manganese (Mn) transport in rat brain endothelial (RBE4) cells, an in vitro model of the blood-brain barrierQ46708505
Measuring brain manganese and iron accumulation in rats following 14 weeks of low-dose manganese treatment using atomic absorption spectroscopy and magnetic resonance imagingQ46782343
Follow-up of patients affected by manganese-induced Parkinsonism after treatment with CaNa2EDTA.Q46791984
Manganese species from human serum, cerebrospinal fluid analyzed by size exclusion chromatography-, capillary electrophoresis coupled to inductively coupled plasma mass spectrometry.Q46881571
Manganese concentrations in maternal-infant blood and birth weightQ47186119
Dietary calcium and manganese effects on menstrual cycle symptomsQ70728788
In vivo intestinal absorption of manganese in the ratQ71147454
Binding of manganese and transferrin in rat serumQ71617945
Manganese-induced oxidative DNA damage in neuronal SH-SY5Y cells: Attenuation of thymine base lesions by glutathione and N-acetylcysteineQ28396499
APLP1, Alzheimer's-like pathology and neurodegeneration in the frontal cortex of manganese-exposed non-human primatesQ28396938
Metallomic profiling and linkage map analysis of early Parkinson's disease: a new insight to aluminum marker for the possible diagnosisQ28474584
Dysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's diseaseQ28505492
Manganese intoxication decreases the expression of manganoproteins in the rat basal ganglia: an immunohistochemical studyQ28564327
Reducing arginase activity via dietary manganese deficiency enhances endothelium-dependent vasorelaxation of rat aortaQ28579218
Intracellular localization and subsequent redistribution of metal transporters in a rat choroid plexus model following exposure to manganese or ironQ28579788
Iron deficient and manganese supplemented diets alter metals and transporters in the developing rat brainQ28581267
The expression, activity and localisation of the secretory pathway Ca2+ -ATPase (SPCA1) in different mammalian tissuesQ28582924
Arginase 1 regulation of nitric oxide production is key to survival of trophic factor-deprived motor neuronsQ28584077
Null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2 impairs calcium transport into milkQ28589621
Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient miceQ28592978
Enhanced Phosphorylation of p53 by ATM in Response to DNA DamageQ28609838
SLC30A10 is a cell surface-localized manganese efflux transporter, and parkinsonism-causing mutations block its intracellular trafficking and efflux activityQ28910400
Translocation of inhaled ultrafine manganese oxide particles to the central nervous systemQ29615577
Altered palmitoylation and neuropathological deficits in mice lacking HIP14.Q30462477
Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer's diseaseQ30489145
Pharmacokinetic data needs to support risk assessments for inhaled and ingested manganese.Q30578660
Purification and characterization of ATM from human placenta. A manganese-dependent, wortmannin-sensitive serine/threonine protein kinaseQ30845708
SMF-1, SMF-2 and SMF-3 DMT1 orthologues regulate and are regulated differentially by manganese levels in C. elegansQ30895194
Manganese toxicity upon overexposureQ30979177
Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx.Q31035888
Application of pharmacokinetic data to the risk assessment of inhaled manganeseQ31038385
Molecular cloning and tissue distribution of alternatively spliced mRNAs encoding possible mammalian homologues of the yeast secretory pathway calcium pumpQ31171355
Welding-related parkinsonism: clinical features, treatment, and pathophysiologyQ31810965
Mice with a partial deficiency of manganese superoxide dismutase show increased vulnerability to the mitochondrial toxins malonate, 3-nitropropionic acid, and MPTP.Q31848128
Dietary Standards for Manganese: Overlap between Nutritional and Toxicological Studies ,Q32111253
Maternal blood manganese level and birth weight: a MOCEH birth cohort studyQ33576767
Synergistic dopaminergic neurotoxicity of manganese and lipopolysaccharide: differential involvement of microglia and astrogliaQ33601778
Nutritional aspects of manganese from experimental studies.Q33673068
Functional properties of human ferroportin, a cellular iron exporter reactive also with cobalt and zincQ33702877
Probing the metal-homeostatis effects of the administration of chromium(vi) to mice by ICP MS and size-exclusion chromatography-ICP MS.Q33745287
Three-dimensional elemental bio-imaging of Fe, Zn, Cu, Mn and P in a 6-hydroxydopamine lesioned mouse brainQ33745298
Manganese-induced trafficking and turnover of the cis-Golgi glycoprotein GPP130.Q33761520
Rat brain endothelial cells are a target of manganese toxicityQ33770822
Pyruvate carboxylase deficiency: clinical and biochemical response to anaplerotic diet therapyQ33985896
Homeostatic and toxic mechanisms regulating manganese uptake, retention, and eliminationQ33995229
Altered manganese homeostasis and manganese toxicity in a Huntington's disease striatal cell model are not explained by defects in the iron transport system.Q34071987
ATM Activation by Oxidative StressQ34145092
Cycling of early Golgi proteins via the cell surface and endosomes upon lumenal pH disruptionQ34145523
Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14.Q34189409
Regulation of Intracellular Manganese Homeostasis by Kufor-Rakeb Syndrome-associated ATP13A2 ProteinQ34197130
In vivo manganese exposure modulates Erk, Akt and Darpp-32 in the striatum of developing rats, and impairs their motor functionQ34200391
Essential Nutrients for Bone Health and a Review of their Availability in the Average North American DietQ34270082
The excretion of trace metals in human sweatQ34272188
Manganese modulation of MAPK pathways: effects on upstream mitogen activated protein kinase kinases and mitogen activated kinase phosphatase-1 in microglial cellsQ34367745
Intrinsic mitochondrial DNA repair defects in Ataxia Telangiectasia.Q34392155
Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effectQ34408366
The role of mitochondrial dysfunction and neuronal nitric oxide in animal models of neurodegenerative diseasesQ34440280
Identification of a gain-of-function mutation in a Golgi P-type ATPase that enhances Mn2+ efflux and protects against toxicity.Q34490557
Glucosamine, chondroitin, and manganese ascorbate for degenerative joint disease of the knee or low back: a randomized, double-blind, placebo-controlled pilot study.Q34502483
Manganese induces oligomerization to promote down-regulation of the intracellular trafficking receptor used by Shiga toxinQ34504082
Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH122 low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritisQ34510491
Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities.Q40311425
Dissection of the functional differences between human secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and 2 isoenzymes by steady-state and transient kinetic analyses.Q40342843
Trace elements in nutrition for premature infants.Q40544811
Parkin attenuates manganese-induced dopaminergic cell deathQ40547152
Nutritional aspects of soy formulaQ40582679
Molecular and functional characterization of the melastatin-related cation channel TRPM3.Q40658876
ATP activates ataxia-telangiectasia mutated (ATM) in vitro. Importance of autophosphorylationQ40662922
Manganese induces endoplasmic reticulum (ER) stress and activates multiple caspases in nigral dopaminergic neuronal cells, SN4741Q40766780
Manganese transport by Caco-2 cellsQ40969298
Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction.Q41067625
Changes in the brain mitochondrial proteome of male Sprague-Dawley rats treated with manganese chlorideQ41166588
Higher retention of manganese in suckling than in adult rats is not due to maturational differences in manganese uptake by rat small intestineQ41306348
Selective vulnerability of glutathione metabolism and cellular defense mechanisms in rat striatum to manganese.Q41347591
Astrocytes and glutamate homoeostasis in Alzheimer's disease: a decrease in glutamine synthetase, but not in glutamate transporter-1, in the prefrontal cortexQ41861166
The effect of manganese on dopamine toxicity and dopamine transporter (DAT) in control and DAT transfected HEK cells.Q41876732
Cd2+, Mn2+, Ni2+ and Se2+ toxicity to Saccharomyces cerevisiae lacking YPK9p the orthologue of human ATP13A2Q41899742
Changes in the striatal proteome of YAC128Q mice exhibit gene-environment interactions between mutant huntingtin and manganeseQ42070989
Distribution of divalent metal transporter-1 in the monkey basal gangliaQ42467966
Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brainQ42477525
Regional cerebral metabolism in mouse under chronic manganese exposure: Implications for ManganismQ42497826
Manganese-exposed developing rats display motor deficits and striatal oxidative stress that are reversed by TroloxQ42520354
Loss of the Atp2c1 secretory pathway Ca(2+)-ATPase (SPCA1) in mice causes Golgi stress, apoptosis, and midgestational death in homozygous embryos and squamous cell tumors in adult heterozygotesQ42624776
KHSRP participates in manganese-induced neurotoxicity in rat striatum and PC12 cellsQ42704822
Postnatal manganese exposure alters the expression of D2L and D2S receptor isoforms: relationship to PKA activity and Akt levels.Q42743103
Acute effects of moderate and strenuous running on trace element distribution in the brain, liver, and spleen of trained ratsQ42757449
Manganese and calcium efflux kinetics in brain mitochondria. Relevance to manganese toxicityQ42793706
Manganese induces tau hyperphosphorylation through the activation of ERK MAPK pathway in PC12 cellsQ42862131
Calorimetric studies on the tight binding metal interactions of Escherichia coli manganese superoxide dismutase.Q43015446
Parkin regulates metal transport via proteasomal degradation of the 1B isoforms of divalent metal transporter 1.Q43188522
Potentiation of neurotoxicity of Lathyrus sativus by manganese: alterations in blood-brain barrier permeabilityQ43271991
High extracellular glutamate modulates expression of glutamate transporters and glutamine synthetase in cultured astrocytesQ43281304
P407language of work or nameEnglishQ1860
P304page(s)71-108
P577publication date2015-05-13
P13046publication type of scholarly workreview articleQ7318358
P1433published inAnnual Review of NutritionQ4769675
P1476titleManganese Is Essential for Neuronal Health
P478volume35

Reverse relations

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