| scholarly article | Q13442814 |
| P2093 | author name string | Taiji Tsunemi | |
| Dimitri Krainc | |||
| P2860 | cites work | Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes | Q24299648 |
| Pathogenic effects of novel mutations in the P-type ATPase ATP13A2 (PARK9) causing Kufor-Rakeb syndrome, a form of early-onset parkinsonism | Q24301367 | ||
| Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies | Q24307627 | ||
| MT-III, a brain-specific member of the metallothionein gene family | Q24564603 | ||
| Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc | Q24568358 | ||
| The Cellular Trafficking and Zinc Dependence of Secretory and Lysosomal Sphingomyelinase, Two Products of the Acid Sphingomyelinase Gene | Q38335637 | ||
| Oxidative stress partially contributes to iron-induced α-synuclein aggregation in SK-N-SH cells | Q39716036 | ||
| Acetylation targets mutant huntingtin to autophagosomes for degradation | Q41773329 | ||
| Lysosomal dysfunction in neurodegeneration: the role of ATP13A2/PARK9. | Q42321201 | ||
| Effects of zinc exposure on zinc transporter expression in human intestinal cells of varying maturity | Q43060958 | ||
| Exchangeable zinc ions transiently accumulate in a vesicular compartment in the yeast Saccharomyces cerevisiae | Q45047306 | ||
| Oxidative stress involvement in alpha-synuclein oligomerization in Parkinson's disease cybrids | Q46418746 | ||
| Zinc causes loss of membrane potential and elevates reactive oxygen species in rat brain mitochondria | Q46629014 | ||
| Zinc and 4-hydroxy-2-nonenal mediate lysosomal membrane permeabilization induced by H2O2 in cultured hippocampal neurons. | Q46691835 | ||
| Elevated cortical zinc in Alzheimer disease | Q48475072 | ||
| Neuropathology of the acid sphingomyelinase knockout mouse model of Niemann-Pick A disease including structure-function studies associated with cerebellar Purkinje cell degeneration. | Q48933711 | ||
| Rapid induction of Alzheimer A beta amyloid formation by zinc | Q53316140 | ||
| Patterns of levels of biological metals in CSF differ among neurodegenerative diseases. | Q53316529 | ||
| ATP13A2 mutations impair mitochondrial function in fibroblasts from patients with Kufor-Rakeb syndrome. | Q54532651 | ||
| Zinc ions inhibit the QP center of bovine heart mitochondrial bc1 complex by blocking a protonatable group | Q71743413 | ||
| Zn2+ inhibits alpha-ketoglutarate-stimulated mitochondrial respiration and the isolated alpha-ketoglutarate dehydrogenase complex | Q73731266 | ||
| Zinc as an inducer of the membrane permeability transition in rat liver mitochondria | Q74525023 | ||
| Capture of extracellular zinc ions by astrocytes | Q79951219 | ||
| Alpha-Synuclein Induces Lysosomal Rupture and Cathepsin Dependent Reactive Oxygen Species Following Endocytosis | Q27323098 | ||
| Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity | Q27934988 | ||
| ATP13A2 regulates mitochondrial bioenergetics through macroautophagy | Q28116275 | ||
| Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase | Q28116395 | ||
| PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity | Q28117134 | ||
| Regulation of the zinc transporter ZnT-1 by dietary zinc | Q28379478 | ||
| ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration | Q28578855 | ||
| Femtomolar sensitivity of metalloregulatory proteins controlling zinc homeostasis | Q29615199 | ||
| PGC-1α rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function. | Q30583566 | ||
| Counting the zinc-proteins encoded in the human genome | Q33231024 | ||
| Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia | Q33322579 | ||
| Lysosome-related organelles in intestinal cells are a zinc storage site in C. elegans | Q33631965 | ||
| Regulation of Intracellular Manganese Homeostasis by Kufor-Rakeb Syndrome-associated ATP13A2 Protein | Q34197130 | ||
| Lysosomal acidification mechanisms | Q34254475 | ||
| Common Pathogenic Effects of Missense Mutations in the P-Type ATPase ATP13A2 (PARK9) Associated with Early-Onset Parkinsonism | Q34286404 | ||
| Evolution of substrate specificities in the P-type ATPase superfamily. | Q34451276 | ||
| A novel mechanism of lysosomal acid sphingomyelinase maturation: requirement for carboxyl-terminal proteolytic processing. | Q34536996 | ||
| Chemistry and biology of mammalian metallothioneins. | Q34629949 | ||
| Deficiency of ATP13A2 leads to lysosomal dysfunction, α-synuclein accumulation, and neurotoxicity | Q34636872 | ||
| Pallido-pyramidal degeneration, supranuclear upgaze paresis and dementia: Kufor-Rakeb syndrome | Q34726815 | ||
| Trace elements in human physiology and pathology: zinc and metallothioneins | Q35598948 | ||
| Overview of mammalian zinc transporters | Q35620120 | ||
| Alterations in levels of iron, ferritin, and other trace metals in neurodegenerative diseases affecting the basal ganglia. The Royal Kings and Queens Parkinson's Disease Research Group | Q35753957 | ||
| Mammalian zinc transporters | Q35799862 | ||
| Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration. | Q36066469 | ||
| The neurobiology of zinc in health and disease | Q36126098 | ||
| Parkinson's disease and α-synuclein expression | Q36346542 | ||
| Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits | Q36787223 | ||
| Mechanisms of mammalian zinc-regulated gene expression | Q37330399 | ||
| Mammalian zinc transporters: nutritional and physiologic regulation | Q37463198 | ||
| Zinc in the physiology and pathology of the CNS. | Q37614216 | ||
| Lysosomal Lipid Storage Diseases | Q37866549 | ||
| Zinc homeostasis and signaling in health and diseases: Zinc signaling | Q37887564 | ||
| Zinc coordination, function, and structure of zinc enzymes and other proteins | Q37946601 | ||
| P433 | issue | 11 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | ATPase cation transporting 13A2 | Q21115193 |
| ATPase type 13A2 | Q21499116 | ||
| lysosomal protein catabolic process | Q24464894 | ||
| regulation of lysosomal protein catabolic process | Q24494365 | ||
| regulation of glucosylceramidase activity | Q24498220 | ||
| negative regulation of glucosylceramidase activity | Q24498221 | ||
| positive regulation of glucosylceramidase activity | Q24498287 | ||
| Synuclein | Q24767155 | ||
| P304 | page(s) | 2791–2801 | |
| P577 | publication date | 2014-06-01 | |
| P1433 | published in | Human Molecular Genetics | Q2720965 |
| P1476 | title | Zn²⁺ dyshomeostasis caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation | |
| P478 | volume | 23 |
| Q38765455 | A familial ATP13A2 mutation enhances alpha-synuclein aggregation and promotes cell death |
| Q28115404 | A lipid switch unlocks Parkinson's disease-associated ATP13A2 |
| Q28116203 | ATP13A2 and Alpha-synuclein: a Metal Taste in Autophagy |
| Q90411150 | ATP13A2 facilitates HDAC6 recruitment to lysosome to promote autophagosome-lysosome fusion |
| Q34774337 | ATP13A2/PARK9 Deficiency Neither Cause Lysosomal Impairment Nor Alter α-Synuclein Metabolism in SH-SY5Y Cells |
| Q45865997 | ATP13A2/PARK9 regulates endo-/lysosomal cargo sorting and proteostasis through a novel PI(3, 5)P2-mediated scaffolding function. |
| Q28118666 | ATP13A2/PARK9 regulates secretion of exosomes and α-synuclein |
| Q37110592 | Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons. |
| Q64782437 | Are we listening to everything the PARK genes are telling us? |
| Q38237519 | Biological metals and metal-targeting compounds in major neurodegenerative diseases |
| Q27003886 | Cellular function and pathological role of ATP13A2 and related P-type transport ATPases in Parkinson's disease and other neurological disorders |
| Q47408660 | Copper and Zinc Homeostasis: Lessons from Drosophila melanogaster |
| Q23914777 | Correlation between the biochemical pathways altered by mutated Parkinson-related genes and chronic exposure to manganese |
| Q33819153 | Decreased circulating Zinc levels in Parkinson's disease: a meta-analysis study |
| Q33642938 | Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder |
| Q38768341 | Direct Comparison of Manganese Detoxification/Efflux Proteins and Molecular Characterization of ZnT10 Protein as a Manganese Transporter. |
| Q98386568 | Downregulation of ATP13A2 in midbrain dopaminergic neurons is related to defective autophagy in a mouse model of Parkinson's disease |
| Q92811394 | Dysregulated Interorganellar Crosstalk of Mitochondria in the Pathogenesis of Parkinson's Disease |
| Q64780601 | Emerging links between pediatric lysosomal storage diseases and adult parkinsonism |
| Q26764724 | Emerging preclinical pharmacological targets for Parkinson's disease |
| Q38822081 | Endolysosomal dysfunction in Parkinson's disease: Recent developments and future challenges. |
| Q50176511 | Exacerbation of sensorimotor dysfunction in mice deficient in Atp13a2 and overexpressing human wildtype alpha-synuclein |
| Q38557027 | Genes associated with Parkinson's disease: regulation of autophagy and beyond |
| Q94586186 | Genetic perspective on the synergistic connection between vesicular transport, lysosomal and mitochondrial pathways associated with Parkinson's disease pathogenesis |
| Q34550197 | Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways |
| Q64104278 | Lysosomal dysfunction in proteinopathic neurodegenerative disorders: possible therapeutic roles of cAMP and zinc |
| Q38479949 | Manganese Is Essential for Neuronal Health |
| Q28080482 | Manganese homeostasis in the nervous system |
| Q28391985 | Manganese-induced Neurotoxicity: From C. elegans to Humans |
| Q52332617 | Mitochondrial Dysfunction in Parkinson's Disease: New Mechanistic Insights and Therapeutic Perspectives. |
| Q47611385 | Molecular mechanisms of α-synuclein and GBA1 in Parkinson's disease |
| Q34100399 | Mutations in the ATP13A2 gene and Parkinsonism: a preliminary review |
| Q87030479 | Neurodegeneration with Brain Iron Accumulation |
| Q21129274 | Neurodegeneration with brain iron accumulation: update on pathogenic mechanisms |
| Q59812935 | New Perspectives on Roles of Alpha-Synuclein in Parkinson's Disease |
| Q92498342 | Overexpression of human Atp13a2Isoform-1 protein protects cells against manganese and starvation-induced toxicity |
| Q52430850 | Overlapping expression patterns and functions of three paralogous P5B ATPases in Caenorhabditis elegans |
| Q35374621 | PARK2 patient neuroprogenitors show increased mitochondrial sensitivity to copper |
| Q50418431 | Parkinson disease related ATP13A2 evolved early in animal evolution. |
| Q38727638 | Parkinson's disease: acid-glucocerebrosidase activity and alpha-synuclein clearance |
| Q59099056 | Physiological and pathological functions of LRRK2: implications from substrate proteins |
| Q57647180 | Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing |
| Q28118364 | Regulation of ATP13A2 via PHD2-HIF1α Signaling Is Critical for Cellular Iron Homeostasis: Implications for Parkinson's Disease |
| Q64864833 | Regulation of membrane dynamics by Parkinson's disease-associated genes |
| Q36800670 | Review: Insights into molecular mechanisms of disease in neurodegeneration with brain iron accumulation: unifying theories. |
| Q39043644 | Role of neurotoxicants and traumatic brain injury in α-synuclein protein misfolding and aggregation. |
| Q90073258 | Targeting α-synuclein for PD Therapeutics: A Pursuit on All Fronts |
| Q35833984 | The Interplay between Alpha-Synuclein Clearance and Spreading |
| Q42288817 | The Neuroprotective Role of Protein Quality Control in Halting the Development of Alpha-Synuclein Pathology |
| Q42576627 | The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway |
| Q38530500 | The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and Metabolism. |
| Q38434200 | The role of ATP13A2 in Parkinson's disease: Clinical phenotypes and molecular mechanisms |
| Q38511739 | The secret life of extracellular vesicles in metal homeostasis and neurodegeneration |
| Q35860759 | Unbiased Cell-based Screening in a Neuronal Cell Model of Batten Disease Highlights an Interaction between Ca2+ Homeostasis, Autophagy, and CLN3 Protein Function |
| Q47311644 | Zinc Detoxification: A Functional Genomics and Transcriptomics Analysis in Drosophila melanogaster Cultured Cells. |
| Q47371072 | Zinc Signal in Brain Diseases. |
| Q64101581 | Zinc Toxicity and Iron-Sulfur Cluster Biogenesis in |
| Q92181348 | Zn homeostasis in genetic models of Parkinson's disease in Caenorhabditis elegans |
| Q38912683 | α-Synuclein-carrying extracellular vesicles in Parkinson's disease: deadly transmitters |
| Q35307748 | α-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal Parkinsonism protein Atp13a2. |
| Q39124651 | α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies |
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