Correlation between the biochemical pathways altered by mutated Parkinson-related genes and chronic exposure to manganese

journal article published in 2014

Correlation between the biochemical pathways altered by mutated Parkinson-related genes and chronic exposure to manganese is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.NEURO.2014.08.006
P2880NIOSHTIC-2 ID20046256
P3181OpenCitations bibliographic resource ID1235564
P698PubMed publication ID25149416

P2093author name stringJerome A. Roth
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Drosophila pink1 is required for mitochondrial function and interacts genetically with parkinQ29547423
LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activityQ29615144
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkinQ29615684
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagyQ29616005
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PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activityQ29617292
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PINK1-dependent recruitment of Parkin to mitochondria in mitophagyQ29620567
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Parkin uses the UPS to ship off dysfunctional mitochondriaQ38596770
The Vps35 D620N mutation linked to Parkinson's disease disrupts the cargo sorting function of retromerQ39072935
Genetic risk for Parkinson's disease correlates with alterations in neuronal manganese sensitivity between two human subjectsQ39253264
ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons.Q39300846
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α-Synuclein overexpression enhances manganese-induced neurotoxicity through the NF-κB-mediated pathwayQ39574142
DJ-1 protects against dopamine toxicityQ39922909
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Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stressQ40262236
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Analysis of targeted mutation in DJ-1 on cellular function in primary astrocytesQ33390827
PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's diseaseQ33412371
Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.Q33594388
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Immunohistochemical and subcellular localization of Parkin protein: absence of protein in autosomal recessive juvenile parkinsonism patientsQ33861614
Homeostatic and toxic mechanisms regulating manganese uptake, retention, and eliminationQ33995229
Mutant LRRK2 enhances glutamatergic synapse activity and evokes excitotoxic dendrite degenerationQ34086842
Regulation of Intracellular Manganese Homeostasis by Kufor-Rakeb Syndrome-associated ATP13A2 ProteinQ34197130
In vivo manganese exposure modulates Erk, Akt and Darpp-32 in the striatum of developing rats, and impairs their motor functionQ34200391
The role of the Parkinson's disease gene PARK9 in essential cellular pathways and the manganese homeostasis network in yeastQ34212205
Impaired Inflammatory Responses in Murine Lrrk2-Knockdown Brain MicrogliaQ34230271
The G2019S pathogenic mutation disrupts sensitivity of leucine-rich repeat kinase 2 to manganese kinase inhibitionQ34236070
Common Pathogenic Effects of Missense Mutations in the P-Type ATPase ATP13A2 (PARK9) Associated with Early-Onset ParkinsonismQ34286404
1B/(-)IRE DMT1 expression during brain ischemia contributes to cell death mediated by NF-κB/RelA acetylation at Lys310Q34292783
PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial bindingQ34322599
Loss of DJ-1 Does Not Affect Mitochondrial Respiration but Increases ROS Production and Mitochondrial Permeability Transition Pore OpeningQ34336431
Characterization of the P5 subfamily of P-type transport ATPases in miceQ34350143
DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagyQ34399382
Snaring the function of alpha-synucleinQ34465204
The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localizationQ34836156
Human leukocyte antigen variation and Parkinson's diseaseQ35028251
Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-SynucleinQ35063363
LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegansQ35080550
α-Synuclein, leucine-rich repeat kinase-2, and manganese in the pathogenesis of parkinson diseaseQ35100189
Effect of overexpression of wild-type or mutant parkin on the cellular response induced by toxic insultsQ40380055
Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stressQ40496111
Parkin attenuates manganese-induced dopaminergic cell deathQ40547152
alpha-Synuclein selectively increases manganese-induced viability loss in SK-N-MC neuroblastoma cells expressing the human dopamine transporter.Q40603357
Expression of mutant alpha-synuclein causes increased susceptibility to dopamine toxicityQ40844291
The effect of manganese on dopamine toxicity and dopamine transporter (DAT) in control and DAT transfected HEK cells.Q41876732
Cd2+, Mn2+, Ni2+ and Se2+ toxicity to Saccharomyces cerevisiae lacking YPK9p the orthologue of human ATP13A2Q41899742
Impairment of nigrostriatal dopamine neurotransmission by manganese is mediated by pre-synaptic mechanism(s): implications to manganese-induced parkinsonismQ41951153
Changes in GABA and glutamate concentrations during memory tasks in patients with Parkinson's disease undergoing DBS surgery.Q42007550
Lysosomal dysfunction in neurodegeneration: the role of ATP13A2/PARK9.Q42321201
The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathwayQ42509261
Oxidative stress involvement in manganese-induced alpha-synuclein oligomerization in organotypic brain slice culturesQ42519882
Activation of JNK Pathway and Induction of Apoptosis by Manganese in PC12 CellsQ42539432
Intrastriatal manganese chloride exposure causes acute locomotor impairment as well as partial activation of substantia nigra GABAergic neuronsQ42610629
Manganese accumulation in striatum of mice exposed to toxic doses is dependent upon a functional dopamine transporter.Q42729792
The case for manganese interaction with mitochondriaQ42779559
Differential effects of divalent manganese and magnesium on the kinase activity of leucine-rich repeat kinase 2 (LRRK2).Q43141823
Parkin regulates metal transport via proteasomal degradation of the 1B isoforms of divalent metal transporter 1.Q43188522
[18F]FDOPA PET and clinical features in parkinsonism due to manganismQ45222225
Human alpha-synuclein over-expression increases intracellular reactive oxygen species levels and susceptibility to dopamine.Q45711545
Manganese accumulation in membrane fractions of primary astrocytes is associated with decreased γ-aminobutyric acid (GABA) uptake, and is exacerbated by oleic acid and palmitateQ45722355
Dopamine and the dopamine oxidation product 5,6-dihydroxylindole promote distinct on-pathway and off-pathway aggregation of alpha-synuclein in a pH-dependent mannerQ46053822
Pathology of inherited manganese transporter deficiencyQ46134590
PET in LRRK2 mutations: comparison to sporadic Parkinson's disease and evidence for presymptomatic compensationQ46635617
Whole blood manganese correlates with high signal intensities on T1-weighted MRI in patients with liver cirrhosisQ48135465
Increased vulnerability of nigrostriatal terminals in DJ-1-deficient mice is mediated by the dopamine transporterQ48140823
Marked N-acetylaspartate and choline metabolite changes in Parkinson's disease patients with mild cognitive impairmentQ48254809
Alpha-synuclein induced membrane depolarization and loss of phosphorylation capacity of isolated rat brain mitochondria: implications in Parkinson's diseaseQ48274235
Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primatesQ48440122
Neurodegenerative disease: pink, parkin and the brainQ48482709
Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusionsQ48581414
Manganese and chronic liver diseaseQ48932332
Novel mutation in ATP13A2 widens the spectrum of Kufor-Rakeb syndrome (PARK9).Q49140091
Manganese induces oxidative impairment in cultured rat astrocytes.Q50469431
Intestinal DMT1 cotransporter is down-regulated by hepcidin via proteasome internalization and degradation.Q50529592
DJ-1 (PARK7) mutations are less frequent than Parkin (PARK2) mutations in early-onset Parkinson diseaseQ51051455
Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo.Q52678048
The role of LRRK2 in the regulation of monocyte adhesion to endothelial cellsQ54355801
ATP13A2‐related neurodegeneration (PARK9) without evidence of brain iron accumulationQ54598452
Manganese induces the overexpression of α-synuclein in PC12 cells via ERK activationQ54654107
The role of pathogenic DJ-1 mutations in Parkinson's disease.Q54757155
PARK9-LINKED PARKINSONISM IN EASTERN ASIA: MUTATION DETECTION IN ATP13A2 AND CLINICAL PHENOTYPEQ56772080
Degradation of alpha-synuclein by proteasomeQ73195792
Manganese-induced rat pheochromocytoma (PC12) cell death is independent of caspase activationQ73949371
DJ-1( PARK7), a novel gene for autosomal recessive, early onset parkinsonismQ79249169
DMT1: which metals does it transport?Q83183734
Chronic exposure to manganese decreases striatal dopamine turnover in human alpha-synuclein transgenic miceQ83443666
PINK1 points Parkin to mitochondriaQ84259115
ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagyQ84788113
Switching on ubiquitylation by phosphorylating a ubiquitous activatorQ87970816
P6195funding schemegrantQ230788
P407language of work or nameEnglishQ1860
P921main subjectgeneQ7187
metabolic pathwayQ68685
manufacturingQ187939
manganeseQ731
Parkinson's diseaseQ11085
toxicologyQ7218
proteinQ8054
P5008on focus list of Wikimedia projectWikimedia–NIOSH collaborationQ104416361
P304page(s)314-325
P12526performing organizationUniversity at BuffaloQ681025
P577publication date2014-09-01
P1433published inNeuroToxicologyQ15098069
P859sponsorNational Institute for Occupational Safety and HealthQ60346
P1476titleCorrelation between the biochemical pathways altered by mutated Parkinson-related genes and chronic exposure to manganese
P478volume44

Reverse relations

cites work (P2860)
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