| scholarly article | Q13442814 |
| P2093 | author name string | Jerome A Roth | |
| Michelle Eichhorn | |||
| P2860 | cites work | Manganese-induced cytotoxicity in dopamine-producing cells | Q23912025 |
| Dopaminergic neurotoxicity following pulmonary exposure to manganese-containing welding fumes | Q23916359 | ||
| The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites | Q24313336 | ||
| The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro | Q24322792 | ||
| Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity | Q27934988 | ||
| Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology | Q28131833 | ||
| Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice | Q28507051 | ||
| LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity | Q29615144 | ||
| R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice. | Q30483115 | ||
| Manganese neurotoxicity: a review of clinical features, imaging and pathology. | Q30578662 | ||
| Expression, purification and preliminary biochemical and structural characterization of the leucine rich repeat namesake domain of leucine rich repeat kinase 2. | Q54344107 | ||
| Occupational exposure to manganese, copper, lead, iron, mercury and zinc and the risk of Parkinson's disease. | Q64860249 | ||
| Manganese injection into the rat striatum produces excitotoxic lesions by impairing energy metabolism | Q70669958 | ||
| Chronic manganese poisoning. Individual susceptibility and absorption of iron | Q71339163 | ||
| Increased manganese concentrations in pallidum of cirrhotic patients | Q72618489 | ||
| Role of oxidative stress in the manganese and 1-methyl-4-(2'-ethylphenyl)-1,2,3,6-tetrahydropyridine-induced apoptosis in PC12 cells | Q73504495 | ||
| Manganese-induced rat pheochromocytoma (PC12) cell death is independent of caspase activation | Q73949371 | ||
| Manganese and Parkinson's disease: a critical review and new findings | Q82717987 | ||
| Genetics of Parkinson's disease | Q83299983 | ||
| Chronic exposure to manganese decreases striatal dopamine turnover in human alpha-synuclein transgenic mice | Q83443666 | ||
| Welding-related parkinsonism: clinical features, treatment, and pathophysiology | Q31810965 | ||
| Progression of dopaminergic dysfunction in a LRRK2 kindred: a multitracer PET study | Q33668068 | ||
| Manganese and calcium transport in mitochondria: implications for manganese toxicity | Q33673100 | ||
| LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding | Q33999270 | ||
| Preferential transformation of human neuronal cells by human adenoviruses and the origin of HEK 293 cells | Q34124828 | ||
| Impaired Inflammatory Responses in Murine Lrrk2-Knockdown Brain Microglia | Q34230271 | ||
| The G2019S pathogenic mutation disrupts sensitivity of leucine-rich repeat kinase 2 to manganese kinase inhibition | Q34236070 | ||
| Progression after chronic manganese exposure | Q34352765 | ||
| LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans | Q35080550 | ||
| Iron interactions and other biological reactions mediating the physiological and toxic actions of manganese | Q35159007 | ||
| Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study | Q35525896 | ||
| Manganese-induced toxicity in normal and human B lymphocyte cell lines containing a homozygous mutation in parkin. | Q36223221 | ||
| Cellular effects of LRRK2 mutations | Q36325683 | ||
| Manganese intoxication in the rhesus monkey: a clinical, imaging, pathologic, and biochemical study | Q36797290 | ||
| Reduced uptake of FDOPA PET in end-stage liver disease with elevated manganese levels | Q36817049 | ||
| LRRK2 and neurodegeneration | Q37368006 | ||
| Are there common biochemical and molecular mechanisms controlling manganism and parkisonism | Q37598121 | ||
| Genetic characteristics of leucine-rich repeat kinase 2 (LRRK2) associated Parkinson's disease | Q37884907 | ||
| Quantitative assessment of the effect of LRRK2 exonic variants on the risk of Parkinson's disease: a meta-analysis | Q38009093 | ||
| Leucine-rich repeat kinase 2 induces alpha-synuclein expression via the extracellular signal-regulated kinase pathway | Q38267597 | ||
| Genetic risk for Parkinson's disease correlates with alterations in neuronal manganese sensitivity between two human subjects | Q39253264 | ||
| Effect of glutamate and riluzole on manganese-induced apoptotic cell signaling in neuronally differentiated mouse P19 Cells | Q39356957 | ||
| Antioxidants prevent the cytotoxicity of manganese in RBE4 cells | Q39947503 | ||
| RNA interference of LRRK2-microarray expression analysis of a Parkinson's disease key player | Q40032027 | ||
| Protein kinase Cdelta is a key downstream mediator of manganese-induced apoptosis in dopaminergic neuronal cells. | Q40479277 | ||
| Activation of ERK1 and ERK2 is required for manganese-induced neurite outgrowth in rat pheochromocytoma (PC12) cells | Q40932380 | ||
| Manganese induces apoptosis of human B cells: caspase-dependent cell death blocked by bcl-2. | Q40946081 | ||
| Changes in the brain mitochondrial proteome of male Sprague-Dawley rats treated with manganese chloride | Q41166588 | ||
| Vulnerability of mitochondrial complex I in PC12 cells exposed to manganese | Q41260388 | ||
| Early Manifestations of Manganese Neurotoxicity in Humans: An Update | Q41602431 | ||
| Manganese and chronic hepatic encephalopathy | Q41678344 | ||
| Impairment of nigrostriatal dopamine neurotransmission by manganese is mediated by pre-synaptic mechanism(s): implications to manganese-induced parkinsonism | Q41951153 | ||
| Manganese exposure is cytotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia | Q42277260 | ||
| Activation of JNK Pathway and Induction of Apoptosis by Manganese in PC12 Cells | Q42539432 | ||
| The case for manganese interaction with mitochondria | Q42779559 | ||
| Manganese‐induced downregulation of astroglial glutamine transporter SNAT3 involves ubiquitin‐mediated proteolytic system | Q42926703 | ||
| Differential effects of divalent manganese and magnesium on the kinase activity of leucine-rich repeat kinase 2 (LRRK2). | Q43141823 | ||
| Parkin regulates metal transport via proteasomal degradation of the 1B isoforms of divalent metal transporter 1. | Q43188522 | ||
| Effect of manganese (II) bis(glycinate)dichloride on Ca2+ channel function in cultured chick atrial cells | Q43494952 | ||
| Manganese mimics the action of 1-methyl-4-phenylpyridinium ion, a dopaminergic neurotoxin, in rat striatal tissue slices | Q43755718 | ||
| Oxidative stress involves in astrocytic alterations induced by manganese | Q43992538 | ||
| Anti-apoptotic and pro-apoptotic effect of NEPP11 on manganese-induced apoptosis and JNK pathway activation in PC12 cells. | Q45040732 | ||
| PET in LRRK2 mutations: comparison to sporadic Parkinson's disease and evidence for presymptomatic compensation | Q46635617 | ||
| Manganese: A transition metal protects nigrostriatal neurons from oxidative stress in the iron-induced animal model of Parkinsonism | Q48422450 | ||
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | cellular response to manganese ion | Q14916304 |
| P304 | page(s) | 100-7 | |
| P577 | publication date | 2013-07-01 | |
| P1433 | published in | NeuroToxicology | Q15098069 |
| P1476 | title | Down-regulation of LRRK2 in control and DAT transfected HEK cells increases manganese-induced oxidative stress and cell toxicity | |
| P478 | volume | 37 |
| Q23914777 | Correlation between the biochemical pathways altered by mutated Parkinson-related genes and chronic exposure to manganese |
| Q46266048 | Luteolin inhibits multi-heavy metal mixture-induced HL7702 cell apoptosis through downregulation of ROS-activated mitochondrial pathway |
| Q64811522 | The role of posttranslational modifications of α-synuclein and LRRK2 in Parkinson's disease: Potential contributions of environmental factors |
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