| scholarly article | Q13442814 |
| P50 | author | Titia Sixma | Q21402771 |
| P2093 | author name string | Judith J Smit | |
| P2860 | cites work | Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction | Q22001513 |
| Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor | Q22009068 | ||
| TRIADs: a new class of proteins with a novel cysteine-rich signature | Q22010435 | ||
| The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1 | Q22010656 | ||
| Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase | Q22254584 | ||
| Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1 | Q24290518 | ||
| A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity | Q24290890 | ||
| Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7 | Q24291032 | ||
| N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8 | Q24291166 | ||
| An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin | Q24291412 | ||
| LUBAC synthesizes linear ubiquitin chains via a thioester intermediate | Q24293061 | ||
| The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis | Q24293633 | ||
| TRIAD1 inhibits MDM2‐mediated p53 ubiquitination and degradation | Q24293959 | ||
| OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin | Q24294696 | ||
| Mutations in the intellectual disability gene Ube2a cause neuronal dysfunction and impair parkin-dependent mitophagy | Q39150269 | ||
| Linear ubiquitination of NEMO negatively regulates the interferon antiviral response through disruption of the MAVS-TRAF3 complex | Q39295722 | ||
| E3 ubiquitin ligase RNF31 cooperates with DAX-1 in transcriptional repression of steroidogenesis | Q39880486 | ||
| Identification of ubiquitin ligase activity of RBCK1 and its inhibition by splice variant RBCK2 and protein kinase Cbeta. | Q40008621 | ||
| Functional modulation of parkin through physical interaction with SUMO-1. | Q40235074 | ||
| A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling | Q40252247 | ||
| Transcription factor single-minded 2 (SIM2) is ubiquitinated by the RING-IBR-RING-type E3 ubiquitin ligases | Q40408101 | ||
| Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function. | Q40658225 | ||
| Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death. | Q40670474 | ||
| Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease | Q40795664 | ||
| The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension. | Q41774507 | ||
| Identification of the ubiquitin ligase Triad1 as a regulator of endosomal transport | Q42013252 | ||
| Analysis of nuclear factor-κB (NF-κB) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB. | Q42043277 | ||
| Comparative genomics of the RBR family, including the Parkinson's disease-related gene parkin and the genes of the ariadne subfamily | Q42049727 | ||
| The familial Parkinson disease gene PARK2 is a multisite tumor suppressor on chromosome 6q25.2-27 that regulates cyclin E. | Q42534456 | ||
| Target specificity of the E3 ligase LUBAC for ubiquitin and NEMO relies on different minimal requirements. | Q42925205 | ||
| S-nitrosylation regulates mitochondrial quality control via activation of parkin | Q43090462 | ||
| Downregulation of uridine-cytidine kinase like-1 decreases proliferation and enhances tumor susceptibility to lysis by apoptotic agents and natural killer cells | Q43298963 | ||
| Hox‐mediated regulation of doublesex sculpts sex‐specific abdomen morphology in Drosophila | Q43867627 | ||
| Alpha-synuclein and parkin contribute to the assembly of ubiquitin lysine 63-linked multiubiquitin chains | Q45271574 | ||
| Ubiquitin in the immune system | Q46551356 | ||
| Mechanism of lysine 48-linked ubiquitin-chain synthesis by the cullin-RING ubiquitin-ligase complex SCF-Cdc34. | Q46711534 | ||
| Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis. | Q48151205 | ||
| Understanding cell death in parkinson's disease | Q48389460 | ||
| Neddylation positively regulates the ubiquitin E3 ligase activity of parkin | Q48695224 | ||
| Identification of molecular determinants required for interaction of ubiquitin‐conjugating enzymes and RING finger proteins | Q77231665 | ||
| Diverse effects of pathogenic mutations of Parkin that catalyze multiple monoubiquitylation in vitro | Q81597727 | ||
| Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation | Q24296620 | ||
| OTULIN restricts Met1-linked ubiquitination to control innate immune signaling | Q24296844 | ||
| Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity | Q24297369 | ||
| Linear ubiquitination prevents inflammation and regulates immune signalling | Q24298581 | ||
| SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex | Q24298605 | ||
| SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis | Q24298626 | ||
| Structure of the C-terminal RING finger from a RING-IBR-RING/TRIAD motif reveals a novel zinc-binding domain distinct from a RING | Q24298636 | ||
| Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP | Q24299901 | ||
| A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7 | Q24300148 | ||
| UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids | Q24300880 | ||
| Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy | Q24300975 | ||
| Parkin Mono-ubiquitinates Bcl-2 and Regulates Autophagy | Q24301563 | ||
| The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis | Q24301611 | ||
| Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency | Q24301912 | ||
| A ubiquitin ligase complex assembles linear polyubiquitin chains | Q24305030 | ||
| Autoregulation of Parkin activity through its ubiquitin-like domain | Q24307382 | ||
| Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins | Q24307510 | ||
| p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1 | Q24307639 | ||
| Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism | Q24309753 | ||
| The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domains | Q24311700 | ||
| Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling | Q24313304 | ||
| Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation | Q24315943 | ||
| The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy | Q24316726 | ||
| Parkin is recruited selectively to impaired mitochondria and promotes their autophagy | Q24317471 | ||
| The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells | Q24317495 | ||
| The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO | Q24321825 | ||
| A human protein-protein interaction network: a resource for annotating the proteome | Q24324450 | ||
| A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system | Q24336529 | ||
| NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase | Q24337285 | ||
| TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes | Q24337489 | ||
| HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex | Q24338233 | ||
| Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network | Q24338947 | ||
| Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins | Q24548126 | ||
| Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells | Q24564511 | ||
| Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34 | Q24602536 | ||
| Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl | Q24621898 | ||
| Localization of a gene for an autosomal recessive form of juvenile Parkinsonism to chromosome 6q25.2-27 | Q24680250 | ||
| Ubiquitin in the immune system | Q26998711 | ||
| Mechanistic insights into active site-associated polyubiquitination by the ubiquitin-conjugating enzyme Ube2g2 | Q27653834 | ||
| Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation | Q27654230 | ||
| Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis | Q27670947 | ||
| Specific recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complex | Q27675967 | ||
| Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism | Q27678298 | ||
| Electron microscopy structure of human APC/CCDH1–EMI1 reveals multimodal mechanism of E3 ligase shutdown | Q27678304 | ||
| Structure of the human Parkin ligase domain in an autoinhibited state | Q27678455 | ||
| Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases | Q27678625 | ||
| A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease | Q27678628 | ||
| Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP | Q27680404 | ||
| Structure of parkin reveals mechanisms for ubiquitin ligase activation | Q27684576 | ||
| The Parkin-Like Human Homolog of Drosophila Ariadne-1 (HHARI) Can Induce Aggresome Formation in Mammalian Cells and Is Immunologically Detectable in Lewy Bodies | Q28117293 | ||
| Human Homolog of Drosophila Ariadne (HHARI) is a marker of cellular proliferation associated with nuclear bodies | Q28119176 | ||
| Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells | Q28137796 | ||
| Dorfin Localizes to Lewy Bodies and Ubiquitylates Synphilin-1 | Q28204442 | ||
| Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1 | Q28237491 | ||
| S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function | Q28258212 | ||
| ??? | Q64860635 | ||
| Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors | Q28258400 | ||
| Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6 | Q28397050 | ||
| ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system | Q28593507 | ||
| Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization | Q29615622 | ||
| Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin | Q29615625 | ||
| PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65 | Q29622844 | ||
| E3 ubiquitin-protein ligase activity of Parkin is dependent on cooperative interaction of RING finger (TRIAD) elements | Q30713868 | ||
| Parkin mediates apparent E2-independent monoubiquitination in vitro and contains an intrinsic activity that catalyzes polyubiquitination. | Q33916165 | ||
| PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice. | Q34093865 | ||
| Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity | Q34141572 | ||
| Parc: a cytoplasmic anchor for p53. | Q34170344 | ||
| The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration. | Q34202584 | ||
| Mitochondrial hexokinase HKI is a novel substrate of the Parkin ubiquitin ligase | Q34306228 | ||
| PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding | Q34322599 | ||
| Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity | Q34528753 | ||
| Gene expression profiling of acute myeloid leukemia with translocation t(8;16)(p11;p13) and MYST3-CREBBP rearrangement reveals a distinctive signature with a specific pattern of HOX gene expression. | Q34569216 | ||
| Novel Regulation of Parkin Function through c-Abl-Mediated Tyrosine Phosphorylation: Implications for Parkinson's Disease | Q34577087 | ||
| Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon Induction | Q34760296 | ||
| HoxA10 Influences Protein Ubiquitination by Activating Transcription of ARIH2, the Gene Encoding Triad1 | Q34947670 | ||
| Oxidative modifications of alpha-synuclein. | Q35170996 | ||
| Parkin mediates the degradation-independent ubiquitination of Hsp70 | Q35609973 | ||
| Parkin and relatives: the RBR family of ubiquitin ligases | Q35777606 | ||
| Structure of an E3:E2~Ub complex reveals an allosteric mechanism shared among RING/U-box ligases. | Q36291328 | ||
| PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy | Q36476931 | ||
| The ring between ring fingers (RBR) protein family | Q36762636 | ||
| Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains | Q37191956 | ||
| The ubiquitin ligase parkin mediates resistance to intracellular pathogens | Q37458253 | ||
| MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia | Q38294261 | ||
| P433 | issue | 2 | |
| P304 | page(s) | 142-154 | |
| P577 | publication date | 2014-01-27 | |
| P1433 | published in | EMBO Reports | Q5323356 |
| P1476 | title | RBR E3-ligases at work | |
| P478 | volume | 15 |
| Q47578909 | ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages. |
| Q92671206 | Auxiliary-assisted chemical ubiquitylation of NEMO and linear extension by HOIP |
| Q39031354 | Conventional and unconventional ubiquitination in plant immunity. |
| Q41864550 | Determination of the pKa of the N-terminal amino group of ubiquitin by NMR. |
| Q38326071 | Deubiquitinases and the new therapeutic opportunities offered to cancer |
| Q37707531 | Dynamic survey of mitochondria by ubiquitin. |
| Q47636038 | E3 ubiquitin ligases in cancer and implications for therapies |
| Q92105561 | Enzymatic Logic of Ubiquitin Chain Assembly |
| Q30387805 | Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity |
| Q39265294 | Linear ubiquitin chains: enzymes, mechanisms and biology |
| Q38201971 | Lysine-targeting specificity in ubiquitin and ubiquitin-like modification pathways. |
| Q45974291 | Mechanism of ubiquitin chain synthesis employed by a HECT domain ubiquitin ligase. |
| Q64915831 | Mitofusins: Disease Gatekeepers and Hubs in Mitochondrial Quality Control by E3 Ligases. |
| Q38822748 | Monitoring Target Engagement of Deubiquitylating Enzymes Using Activity Probes: Past, Present, and Future |
| Q36318995 | Posttranslational Modification of HOIP Blocks Toll-Like Receptor 4-Mediated Linear-Ubiquitin-Chain Formation |
| Q28830194 | Probes of ubiquitin E3 ligases enable systematic dissection of parkin activation |
| Q36554464 | Protein monoubiquitylation: targets and diverse functions |
| Q47925372 | RING-Between-RING E3 Ligases: Emerging Themes amid the Variations. |
| Q55234320 | RING-Domain E3 Ligase-Mediated Host-Virus Interactions: Orchestrating Immune Responses by the Host and Antagonizing Immune Defense by Viruses. |
| Q26799441 | Regulating the Regulators: Recent Revelations in the Control of E3 Ubiquitin Ligases |
| Q111285544 | Regulation of Cancer Metabolism by Deubiquitinating Enzymes: The Warburg Effect |
| Q36281694 | Regulation of RNF144A E3 Ubiquitin Ligase Activity by Self-association through Its Transmembrane Domain |
| Q60045805 | Regulation of germ cell development by ARI1 family ubiquitin ligases in C. elegans |
| Q37707515 | Regulation of stem cell function by protein ubiquitylation |
| Q28831032 | Structural insights into Parkin substrate lysine targeting from minimal Miro substrates |
| Q38916854 | Structural insights into the catalysis and regulation of E3 ubiquitin ligases |
| Q38530646 | The multifaceted role of the E3 ubiquitin ligase HOIL-1: beyond linear ubiquitination |
| Q28067104 | The ubiquitin system: a critical regulator of innate immunity and pathogen-host interactions |
| Q34336982 | The ubiquitination machinery of the ubiquitin system |
| Q39317949 | Ubiquitin enzymes in the regulation of immune responses |
| Q26751380 | Ubiquitin modifications |
| Q36410188 | Ubiquitin-Activated Interaction Traps (UBAITs) identify E3 ligase binding partners |
| Q39033646 | Ubiquitination and the Regulation of Membrane Proteins |
| Q42113382 | Ubiquitination of ERMES components by the E3 ligase Rsp5 is involved in mitophagy |
| Q55328184 | Ubiquitination regulation of inflammatory responses through NF-κB pathway. |
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