| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2010PNAS..10715145P |
| P356 | DOI | 10.1073/PNAS.1009941107 |
| P932 | PMC publication ID | 2930574 |
| P698 | PubMed publication ID | 20696900 |
| P5875 | ResearchGate publication ID | 45583345 |
| P50 | author | Feijun Luo | Q56798427 |
| George Poulogiannis | Q61826339 | ||
| P2093 | author name string | Mark J Arends | |
| David J Adams | |||
| John R Apps | |||
| Lewis C Cantley | |||
| Rebecca E McIntyre | |||
| Koichi Ichimura | |||
| Maria Dimitriadi | |||
| Andrew H Wyllie | |||
| Catherine H Wilson | |||
| P2860 | cites work | Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase | Q22254584 |
| Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity | Q24290192 | ||
| Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1 | Q24290518 | ||
| Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation | Q24296620 | ||
| Characterization of FRA6E and its potential role in autosomal recessive juvenile parkinsonism and ovarian cancer. | Q54763867 | ||
| A Prospective Cohort Study of Cancer Incidence Following the Diagnosis of Parkinson's Disease | Q56977229 | ||
| Loss of HLA class-I alleles, heavy chains and β2-microglobulin in colorectal cancer | Q57337239 | ||
| The order of genetic events associated with colorectal cancer progression inferred from meta-analysis of copy number changes | Q62583448 | ||
| The "Swiss roll": a simple technique for histological studies of the rodent intestine | Q70169765 | ||
| Fractional genomic alteration detected by array-based comparative genomic hybridization independently predicts survival after hepatic resection for metastatic colorectal cancer | Q81498333 | ||
| PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1 | Q24297155 | ||
| Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity | Q24297369 | ||
| Parkin ubiquitinates and promotes the degradation of RanBP2 | Q24298223 | ||
| Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism | Q24309753 | ||
| Small regions of overlapping deletions on 6q26 in human astrocytic tumours identified using chromosome 6 tile path array-CGH | Q24654938 | ||
| Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain | Q27640694 | ||
| A phosphatase associated with metastasis of colorectal cancer | Q28198115 | ||
| Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse | Q28585819 | ||
| Mitochondrial dysfunction and oxidative damage in parkin-deficient mice | Q28593859 | ||
| Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions | Q29614216 | ||
| Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene | Q29616490 | ||
| PINK1-dependent recruitment of Parkin to mitochondria in mitophagy | Q29620567 | ||
| A lentiviral cDNA library employing lambda recombination used to clone an inhibitor of human immunodeficiency virus type 1-induced cell death | Q31116850 | ||
| Genetics of parkin-linked disease. | Q34290333 | ||
| Parkin genetics: one model for Parkinson's disease | Q34300017 | ||
| Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemia | Q34467458 | ||
| Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement. | Q34472607 | ||
| Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity | Q34528753 | ||
| Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27 | Q35022507 | ||
| Large common fragile site genes and cancer | Q36671122 | ||
| Tumor immunoediting and immunosculpting pathways to cancer progression. | Q36896195 | ||
| An expression module of WIPF1-coexpressed genes identifies patients with favorable prognosis in three tumor types. | Q37206514 | ||
| Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies | Q39009613 | ||
| Signatures of mutation and selection in the cancer genome | Q39737975 | ||
| Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repair | Q39823278 | ||
| A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling | Q40252247 | ||
| Parkin enhances mitochondrial biogenesis in proliferating cells | Q40322753 | ||
| The molecular basis of fragile sites in human chromosomes | Q40406704 | ||
| Parkin stabilizes microtubules through strong binding mediated by three independent domains. | Q40452676 | ||
| Array comparative genomic hybridization analysis of colorectal cancer cell lines and primary carcinomas | Q40534910 | ||
| Alterations of the tumor suppressor gene Parkin in non-small cell lung cancer | Q40564111 | ||
| Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease | Q40795664 | ||
| Parkin as a tumor suppressor gene for hepatocellular carcinoma | Q42811415 | ||
| 1p36 is a preferential target of chromosome 1 deletions in astrocytic tumours and homozygously deleted in a subset of glioblastomas | Q43170049 | ||
| Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways. | Q43274553 | ||
| Prognostic relevance of DNA copy number changes in colorectal cancer. | Q44451476 | ||
| Alpha-synuclein and parkin contribute to the assembly of ubiquitin lysine 63-linked multiubiquitin chains | Q45271574 | ||
| Regulation of Wnt signaling by the nuclear pore complex | Q46624298 | ||
| Integrative approach for prioritizing cancer genes in sporadic colon cancer. | Q51802432 | ||
| P433 | issue | 34 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | colorectal cancer | Q188874 |
| colorectal carcinoma | Q25493920 | ||
| P304 | page(s) | 15145-15150 | |
| P577 | publication date | 2010-08-09 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice | |
| P478 | volume | 107 |
| Q51770889 | A Futile Battle? Protein Quality Control and the Stress of Aging. |
| Q34996429 | A PARK2 polymorphism associated with delayed neuropsychological sequelae after carbon monoxide poisoning |
| Q54487776 | A high resolution genomic portrait of bladder cancer: correlation between genomic aberrations and the DNA damage response. |
| Q42239902 | A selected group of large common fragile site genes have decreased expression in oropharyngeal squamous cell carcinomas. |
| Q33784960 | A strategy to identify dominant point mutant modifiers of a quantitative trait |
| Q38168127 | An emerging role of PARK2 in cancer |
| Q57498219 | Autophagy and Hallmarks of Cancer |
| Q37876679 | Autophagy as a target for anticancer therapy |
| Q28086785 | Autophagy in thyroid cancer: present knowledge and future perspectives |
| Q27010076 | Autophagy modulation as a potential therapeutic target for diverse diseases |
| Q24307382 | Autoregulation of Parkin activity through its ubiquitin-like domain |
| Q47836565 | BRCA1 gene: function and deficiency |
| Q42812189 | Characterization of ATF2 in Rel/NFκB oncogenesis reveals its role in the regulation of Ras signaling |
| Q21184064 | Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer |
| Q54314557 | Clinically significant copy number alterations and complex rearrangements of MYB and NFIB in head and neck adenoid cystic carcinoma. |
| Q34557827 | Common fragile site tumor suppressor genes and corresponding mouse models of cancer |
| Q26825040 | Common fragile sites: genomic hotspots of DNA damage and carcinogenesis |
| Q34175304 | Construction and analysis of the protein-protein interaction networks for schizophrenia, bipolar disorder, and major depression |
| Q39402100 | Contribution of germline mutations to PARK2 gene inactivation in lung adenocarcinoma. |
| Q52726771 | DEAD-box helicase 27 promotes colorectal cancer growth and metastasis and predicts poor survival in CRC patients. |
| Q26862285 | DNA replication stress: causes, resolution and disease |
| Q30300009 | DNA secondary structure at chromosomal fragile sites in human disease |
| Q34359802 | Discovery of structural alterations in solid tumor oligodendroglioma by single molecule analysis |
| Q60456019 | Disease connections |
| Q28086796 | Dysregulation of ubiquitin ligases in cancer |
| Q47636038 | E3 ubiquitin ligases in cancer and implications for therapies |
| Q51051634 | Elevated TRAF2/6 expression in Parkinson's disease is caused by the loss of Parkin E3 ligase activity. |
| Q42332007 | Emerging role of mitophagy in human diseases and physiology. |
| Q54116465 | Evaluation of Prexasertib, a Checkpoint Kinase 1 Inhibitor, in a Phase Ib Study of Patients with Squamous Cell Carcinoma. |
| Q27020991 | Evolution of the cancer genome |
| Q38912486 | Expression pattern of parkin isoforms in lung adenocarcinomas. |
| Q40774089 | Fanconi Anemia Proteins Function in Mitophagy and Immunity |
| Q48593906 | Genetic and epigenetic alterations affecting PARK-2 expression in cervical neoplasm among North Indian patients |
| Q84396290 | Genome-wide copy number analyses identified novel cancer genes in hepatocellular carcinoma |
| Q35562809 | Genomic and Functional Analysis of the E3 Ligase PARK2 in Glioma |
| Q38315813 | Glioma tumor grade correlates with parkin depletion in mutant p53-linked tumors and results from loss of function of p53 transcriptional activity. |
| Q57810923 | HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons |
| Q36879136 | IRS2 is a candidate driver oncogene on 13q34 in colorectal cancer. |
| Q57094735 | Identification of a shared protective genetic susceptibility locus for colorectal cancer and gastric cancer |
| Q35075615 | Identification of candidate driver genes in common focal chromosomal aberrations of microsatellite stable colorectal cancer |
| Q93337407 | Implication of alterations in Parkin gene among North Indian patients with colorectal cancer |
| Q38709886 | Inactivation of parkin by promoter methylation correlated with lymph node metastasis and genomic instability in nasopharyngeal carcinoma |
| Q36301055 | Lack of association between cancer history and PARKIN genotype: a family based study in PARKIN/Parkinson's families |
| Q29617664 | Landscape of somatic retrotransposition in human cancers |
| Q27310261 | Mechanisms of mitophagy |
| Q41651606 | Melatonin-induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy |
| Q37029655 | Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration |
| Q26995343 | Mitochondria and the autophagy-inflammation-cell death axis in organismal aging |
| Q38811534 | Mitochondrial control of cell bioenergetics in Parkinson's disease. |
| Q38021865 | Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences |
| Q92839769 | Mitophagy and Oxidative Stress in Cancer and Aging: Focus on Sirtuins and Nanomaterials |
| Q64979433 | Mitophagy in Cancer: A Tale of Adaptation. |
| Q28390998 | Mitophagy mechanisms and role in human diseases |
| Q26776469 | Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy |
| Q47371897 | Modulators of Redox Metabolism in Head and Neck Cancer. |
| Q38250822 | Molecular characterization of common fragile sites as a strategy to discover cancer susceptibility genes |
| Q26744251 | Molecular pathological classification of colorectal cancer |
| Q37536837 | Multiple-level validation identifies PARK2 in the development of lung cancer and chronic obstructive pulmonary disease |
| Q46402658 | PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation |
| Q90053575 | PARK2 Suppresses Proliferation and Tumorigenicity in Non-small Cell Lung Cancer |
| Q85356388 | PARK2 and PACRG are commonly downregulated in clear-cell renal cell carcinoma and are associated with aggressive disease and poor clinical outcome |
| Q52728102 | PARK2 inhibits osteosarcoma cell growth through the JAK2/STAT3/VEGF signaling pathway. |
| Q47325325 | PARK2 loss promotes cancer progression via redox-mediated inactivation of PTEN. |
| Q41611419 | PARK2 negatively regulates the metastasis and epithelial-mesenchymal transition of glioblastoma cells via ZEB1. |
| Q38810658 | PARKIN Inactivation Links Parkinson's Disease to Melanoma |
| Q90438669 | PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis |
| Q37542446 | Pan-Cancer Analysis Links PARK2 to BCL-XL-Dependent Control of Apoptosis |
| Q34610662 | Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins |
| Q89008606 | Parkin New Cargos: a New ROS Independent Role for Parkin in Regulating Cell Division |
| Q38946190 | Parkin and mitophagy in cancer. |
| Q36823704 | Parkin deficiency contributes to pancreatic tumorigenesis by inducing spindle multipolarity and misorientation. |
| Q92723071 | Parkin gene mutations are not common, but its epigenetic inactivation is a frequent event and predicts poor survival in advanced breast cancer patients |
| Q49936958 | Parkin in Parkinson's Disease and Cancer: a Double-Edged Sword |
| Q42273308 | Parkin induces upregulation of 40S ribosomal protein SA and posttranslational modification of cytokeratins 8 and 18 in human cervical cancer cells |
| Q63359720 | Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy |
| Q92267182 | Parkin inhibits necroptosis to prevent cancer |
| Q55226339 | Parkin protein expression and its impact on survival of patients with advanced colorectal cancer. |
| Q47132104 | Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression. |
| Q35239585 | Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect |
| Q34448273 | Parkin-mediated K63-polyubiquitination targets ubiquitin C-terminal hydrolase L1 for degradation by the autophagy-lysosome system |
| Q64866434 | Parkinson's disease-associated protein Parkin: an unusual player in cancer |
| Q27853146 | Personalized treatment of Sézary syndrome by targeting a novel CTLA4:CD28 fusion. |
| Q38182404 | RBR E3-ligases at work |
| Q42239663 | Redox regulation of cysteine-dependent enzymes in neurodegeneration |
| Q38148991 | Regulation and function of mitophagy in development and cancer. |
| Q99630261 | Regulation of Hippo/YAP signaling and Esophageal Squamous Carcinoma progression by an E3 ubiquitin ligase PARK2 |
| Q92500806 | Role of tumor and host autophagy in cancer metabolism |
| Q34396844 | Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation. |
| Q85639976 | Somatic mutation of PARK2 tumor suppressor gene is not common in common solid cancers |
| Q42426458 | Sorafenib targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1-Parkin pathway and modulate cellular drug response. |
| Q27678455 | Structure of the human Parkin ligase domain in an autoinhibited state |
| Q92267190 | The AMPK-Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome |
| Q57064754 | The Interplay among PINK1/PARKIN/Dj-1 Network during Mitochondrial Quality Control in Cancer Biology: Protein Interaction Analysis |
| Q29619914 | The clonal and mutational evolution spectrum of primary triple-negative breast cancers |
| Q38992751 | The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy |
| Q36614219 | The regulation of cellular metabolism by tumor suppressor p53. |
| Q38178169 | The role and therapeutic implications of RING-finger E3 ubiquitin ligases in hepatocellular carcinoma |
| Q28385846 | To be or not to be? How selective autophagy and cell death govern cell fate |
| Q28070247 | Tumor Suppressor Genes within Common Fragile Sites Are Active Players in the DNA Damage Response |
| Q34785286 | Two Distinct Categories of Focal Deletions in Cancer Genomes |
| Q89187341 | UBE2M Is a Stress-Inducible Dual E2 for Neddylation and Ubiquitylation that Promotes Targeted Degradation of UBE2F |
| Q46609299 | Ubiquitin ligases in oncogenic transformation and cancer therapy |
| Q38258543 | Very large common fragile site genes and their potential role in cancer development |
| Q38321093 | WWOX, large common fragile site genes, and cancer |
| Q52720818 | Zinc finger protein 746 promotes colorectal cancer progression via c-Myc stability mediated by glycogen synthase kinase 3β and F-box and WD repeat domain-containing 7. |
| Q33911222 | α-Synuclein expression selectively affects tumorigenesis in mice modeling Parkinson's disease |
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