Neddylation positively regulates the ubiquitin E3 ligase activity of parkin

scientific article published on 24 January 2012

Neddylation positively regulates the ubiquitin E3 ligase activity of parkin is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/JNR.22828
P8608Fatcat IDrelease_zogcb2yu2rafdhqqyr73t6qxhm
P698PubMed publication ID22271254
P5875ResearchGate publication ID221771766

P50authorYohan OhQ47697053
P2093author name stringJi Won Um
Kwang Chul Chung
Kyung Ah Han
Eunju Im
Kyule Lee
P2860cites workIdentification of the activating and conjugating enzymes of the NEDD8 conjugation pathwayQ22009414
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligaseQ22254584
Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activityQ24290192
Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1Q24290518
An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of ParkinQ24291412
Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson diseaseQ24291767
Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicityQ24297369
Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signalingQ24297849
Parkin ubiquitinates and promotes the degradation of RanBP2Q24298223
Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitinationQ24306353
Ribosomal proteins are targets for the NEDD8 pathwayQ24313502
BAG5 inhibits parkin and enhances dopaminergic neuron degenerationQ24322908
Characterization of NEDD8, a developmentally down-regulated ubiquitin-like proteinQ24322977
NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligasesQ24337709
Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalphaQ24554289
14-3-3eta is a novel regulator of parkin ubiquitin ligaseQ28115387
S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective functionQ28258212
Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activityQ28270986
Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activityQ30448692
Nedd8 on cullin: building an expressway to protein destruction.Q33976667
The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration.Q34202584
Novel substrates and functions for the ubiquitin-like molecule NEDD8.Q34827554
Ubiquitin and ubiquitin-like modifications of the p53 familyQ35082705
Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodiesQ35748069
Lewy-body formation is an aggresome-related process: a hypothesisQ35840040
Protection of cullin-RING E3 ligases by CSN-UBP12.Q36500718
Role of ubiquitin- and Ubl-binding proteins in cell signalingQ36736630
Function and regulation of protein neddylation. 'Protein modifications: beyond the usual suspects' review seriesQ36946992
pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor developmentQ37275211
NEDD8 recruits E2-ubiquitin to SCF E3 ligase.Q39731260
Molecular interaction between parkin and PINK1 in mammalian neuronal cellsQ39891186
Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation.Q40165778
Functional modulation of parkin through physical interaction with SUMO-1.Q40235074
Parkin protects against neurotoxicity in the 6-hydroxydopamine rat model for Parkinson's diseaseQ40242764
Effect of overexpression of wild-type or mutant parkin on the cellular response induced by toxic insultsQ40380055
Parkin phosphorylation and modulation of its E3 ubiquitin ligase activityQ40489168
Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function.Q40658225
NEDD8 protein is involved in ubiquitinated inclusion bodiesQ40676519
Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's diseaseQ40795664
Parkinson's disease. Second of two partsQ40840040
Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerizationQ45345753
Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinasesQ45345757
Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation functionQ45345758
Susceptibility to rotenone is increased in neurons from parkin null mice and is reduced by minocyclineQ48599725
Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity.Q51088435
Parkin: a multifaceted ubiquitin ligase.Q51116287
P433issue5
P921main subjectprotein neddylationQ21115705
P304page(s)1030-1042
P577publication date2012-01-24
P1433published inJournal of Neuroscience ResearchQ6295654
P1476titleNeddylation positively regulates the ubiquitin E3 ligase activity of parkin
P478volume90