| scholarly article | Q13442814 |
| P356 | DOI | 10.1074/JBC.M004847200 |
| P698 | PubMed publication ID | 10921923 |
| P2093 | author name string | A Chen | |
| K Wu | |||
| Z Q Pan | |||
| P2860 | cites work | Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway | Q22009414 |
| ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity | Q22009487 | ||
| RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination | Q22010577 | ||
| APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein | Q24310276 | ||
| Characterization of NEDD8, a Developmentally Down-regulated Ubiquitin-like Protein | Q24322977 | ||
| Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha | Q24554289 | ||
| The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2 | Q24597101 | ||
| Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34 | Q24602536 | ||
| Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein | Q24657293 | ||
| Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes | Q27766356 | ||
| The ubiquitin system | Q27860803 | ||
| Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complex | Q27933259 | ||
| F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex | Q27934075 | ||
| The E2-E3 interaction in the N-end rule pathway: the RING-H2 finger of E3 is required for the synthesis of multiubiquitin chain | Q27937065 | ||
| A novel protein modification pathway related to the ubiquitin system | Q27938072 | ||
| A Complex of Cdc4p, Skp1p, and Cdc53p/Cullin Catalyzes Ubiquitination of the Phosphorylated CDK Inhibitor Sic1p | Q27939049 | ||
| Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1. | Q27940059 | ||
| Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box proteincomplexes that regulate cell division and methionine biosynthesis in yeast | Q27940196 | ||
| Identification of NEDD8-conjugation site in human cullin-2 | Q28139623 | ||
| Covalent modification of all members of human cullin family proteins by NEDD8 | Q28140243 | ||
| The conserved RING-H2 finger of ROC1 is required for ubiquitin ligation | Q28140666 | ||
| Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha | Q28143121 | ||
| The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase | Q28145635 | ||
| Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase | Q28506124 | ||
| Modification of cullin-1 by ubiquitin-like protein Nedd8 enhances the activity of SCF(skp2) toward p27(kip1). | Q33898769 | ||
| The SCF(HOS/beta-TRCP)-ROC1 E3 ubiquitin ligase utilizes two distinct domains within CUL1 for substrate targeting and ubiquitin ligation | Q33962019 | ||
| The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity | Q35201819 | ||
| A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination | Q35687263 | ||
| sud1 + targets cyclin-dependent kinase-phosphorylated Cdc18 and Rum1 proteins for degradation and stops unwanted diploidization in fission yeast | Q36169732 | ||
| In vitro replication of duplex circular DNA containing the simian virus 40 DNA origin site | Q37529881 | ||
| cdc18+ regulates initiation of DNA replication in Schizosaccharomyces pombe. | Q37720644 | ||
| Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast | Q40430046 | ||
| The ts41 mutation in Chinese hamster cells leads to successive S phases in the absence of intervening G2, M, and G1 | Q41594394 | ||
| The ubiquitin-related protein RUB1 and auxin response in Arabidopsis | Q47982590 | ||
| P433 | issue | 41 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 32317-32324 | |
| P577 | publication date | 2000-10-01 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerization | |
| P478 | volume | 275 |
| Q90470287 | A cullin-RING ubiquitin ligase promotes thermotolerance as part of the intracellular pathogen response in Caenorhabditis elegans |
| Q37178794 | A targeted proteomic analysis of the ubiquitin-like modifier nedd8 and associated proteins. |
| Q24303664 | A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8 |
| Q37003539 | ASB2 targets filamins A and B to proteasomal degradation |
| Q33336974 | AXR1-ECR1-dependent conjugation of RUB1 to the Arabidopsis Cullin AtCUL1 is required for auxin response |
| Q37459809 | Adenovirus E1A inhibits SCF(Fbw7) ubiquitin ligase |
| Q24522556 | An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells |
| Q24563582 | Arabidopsis CAND1, an unmodified CUL1-interacting protein, is involved in multiple developmental pathways controlled by ubiquitin/proteasome-mediated protein Degradation |
| Q30985007 | Arabidopsis has two redundant Cullin3 proteins that are essential for embryo development and that interact with RBX1 and BTB proteins to form multisubunit E3 ubiquitin ligase complexes in vivo |
| Q92503635 | Are Inositol Polyphosphates the Missing Link in Dynamic Cullin RING Ligase Regulation by the COP9 Signalosome? |
| Q36844169 | Autoinhibitory regulation of SCF-mediated ubiquitination by human cullin 1's C-terminal tail |
| Q34399342 | Auxin signalling: the beginning, the middle and the end. |
| Q34648551 | Brap2 regulates temporal control of NF-κB localization mediated by inflammatory response |
| Q34202918 | C. elegans CAND-1 regulates cullin neddylation, cell proliferation and morphogenesis in specific tissues |
| Q40322697 | CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1. |
| Q28188498 | COP9 signalosome revisited: a novel mediator of protein degradation |
| Q35541468 | COP9 signalosome: a multifunctional regulator of SCF and other cullin-based ubiquitin ligases |
| Q24336508 | CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex |
| Q24301571 | Conservation in the Mechanism of Nedd8 Activation by the Human AppBp1-Uba3 Heterodimer |
| Q24802982 | Conservation of the COP9/signalosome in budding yeast |
| Q37827465 | Control of Cullin-Ring Ubiquitin Ligase Activity by Nedd8 |
| Q24647543 | Control of cell growth by the SCF and APC/C ubiquitin ligases |
| Q27694578 | Crystal structure of the human COP9 signalosome |
| Q26746956 | Cullin-RING ligases in regulation of autophagy |
| Q21203558 | Cullin-RING ubiquitin ligases: global regulation and activation cycles |
| Q28205415 | DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1 |
| Q34299011 | De Novo DNA Methyltransferase DNMT3b Interacts with NEDD8-modified Proteins |
| Q52150059 | Deneddylase 1 regulates deneddylase activity of the Cop9 signalosome in Drosophila melanogaster |
| Q28588169 | Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death |
| Q47070340 | Drosophila Cand1 regulates Cullin3-dependent E3 ligases by affecting the neddylation of Cullin3 and by controlling the stability of Cullin3 and adaptor protein |
| Q24675369 | Dysfunction of amyloid precursor protein signaling in neurons leads to DNA synthesis and apoptosis |
| Q24316067 | E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification |
| Q38933296 | Expression of neddylation-related proteins in melanoma cell lines and the effect of neddylation on melanoma proliferation |
| Q81453915 | Expression, purification, and characterization of the E1 for human NEDD8, the heterodimeric APPBP1-UBA3 complex |
| Q24314409 | FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity |
| Q47847570 | Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12p |
| Q28131707 | Function and regulation of cullin-RING ubiquitin ligases |
| Q27027897 | Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases |
| Q36392344 | Gln40 deamidation blocks structural reconfiguration and activation of SCF ubiquitin ligase complex by Nedd8. |
| Q34540701 | Glutamine Deamidation and Dysfunction of Ubiquitin/NEDD8 Induced by a Bacterial Effector Family |
| Q21091189 | Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease |
| Q36940407 | Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation |
| Q36098917 | Human papillomavirus type 16 E7 oncoprotein associates with the cullin 2 ubiquitin ligase complex, which contributes to degradation of the retinoblastoma tumor suppressor |
| Q35905381 | Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors. |
| Q40353544 | In vitro cleavage of Nedd8 from cullin 1 by COP9 signalosome and deneddylase 1. |
| Q34286428 | In vivo interference with Skp1 function leads to genetic instability and neoplastic transformation |
| Q30569769 | Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis |
| Q28473456 | Inference of protein complex activities from chemical-genetic profile and its applications: predicting drug-target pathways |
| Q37737112 | Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo. |
| Q54314728 | Inhibition of the NEDD8 Conjugation Pathway by shRNA to UBA3, the Subunit of the NEDD8-Activating Enzyme, Suppresses the Growth of Melanoma Cells |
| Q56978823 | Interactions between auxin and strigolactone in shoot branching control |
| Q41817100 | Jun activation domain-binding protein 1 (JAB1) is required for the optimal response to interferons. |
| Q35311062 | Mono-ubiquitination Drives Nuclear Export of the Human DCN1-like Protein hDCNL1 |
| Q37101488 | Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation |
| Q28541763 | Mutations in UBA3 confer resistance to the NEDD8-activating enzyme inhibitor MLN4924 in human leukemic cells |
| Q24311311 | Myxoma virus M-T5 protects infected cells from the stress of cell cycle arrest through its interaction with host cell cullin-1 |
| Q24337709 | NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases |
| Q39731260 | NEDD8 recruits E2-ubiquitin to SCF E3 ligase. |
| Q33976667 | Nedd8 on cullin: building an expressway to protein destruction. |
| Q40673171 | Nedd8-modification of Cul1 is promoted by Roc1 as a Nedd8-E3 ligase and regulates its stability |
| Q45317714 | Neddylation |
| Q47070899 | Neddylation and deneddylation regulate Cul1 and Cul3 protein accumulation. |
| Q48695224 | Neddylation positively regulates the ubiquitin E3 ligase activity of parkin |
| Q28215703 | Phosphorylation of the human ubiquitin-conjugating enzyme, CDC34, by casein kinase 2 |
| Q34467706 | Positive and negative regulation of APP amyloidogenesis by sumoylation. |
| Q40657672 | Preferential interaction of TIP120A with Cul1 that is not modified by NEDD8 and not associated with Skp1. |
| Q34925373 | Profiling the cross reactivity of ubiquitin with the Nedd8 activating enzyme by phage display |
| Q35040479 | Protein complexes mediate signalling in plant responses to hormones, light, sucrose and pathogens |
| Q24530602 | Proximity-induced activation of human Cdc34 through heterologous dimerization |
| Q36779662 | Rac GTPase instructs nuclear factor-kappaB activation by conveying the SCF complex and IkBalpha to the ruffling membranes |
| Q27686867 | Regulation of Abiotic Stress Signal Transduction by E3 Ubiquitin Ligases in Arabidopsis |
| Q34252986 | Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases |
| Q35249854 | Role of the NEDD8 modification of Cul2 in the sequential activation of ECV complex |
| Q24317319 | SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation |
| Q42700446 | SCCRO (DCUN1D1) promotes nuclear translocation and assembly of the neddylation E3 complex |
| Q24297139 | SCFHOS ubiquitin ligase mediates the ligand-induced down-regulation of the interferon- receptor |
| Q42609853 | Saccharomyces cerevisiae ubiquitin-like protein Rub1 conjugates to cullin proteins Rtt101 and Cul3 in vivo. |
| Q34551647 | Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins |
| Q48594712 | Squamous cell carcinoma-related oncogene (SCCRO) neddylates Cul3 protein to selectively promote midbody localization and activity of Cul3KLHL21 protein complex during abscission. |
| Q38346254 | Stability of homologue of Slimb F-box protein is regulated by availability of its substrate |
| Q24314520 | Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation |
| Q37289330 | Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex |
| Q40180176 | TBP-interacting protein 120B (TIP120B)/cullin-associated and neddylation-dissociated 2 (CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation |
| Q24299200 | TRIM40 promotes neddylation of IKKγ and is downregulated in gastrointestinal cancers |
| Q24313441 | TRIP12 functions as an E3 ubiquitin ligase of APP-BP1 |
| Q25256814 | Targeted silencing of Jab1/Csn5 in human cells downregulates SCF activity through reduction of F-box protein levels |
| Q38059505 | Targeting neddylation in cancer therapy |
| Q52086696 | The Arabidopsis CSN5A and CSN5B subunits are present in distinct COP9 signalosome complexes, and mutations in their JAMM domains exhibit differential dominant negative effects on development |
| Q48243627 | The Arabidopsis MALE MEIOCYTE DEATH1 gene encodes a PHD-finger protein that is required for male meiosis |
| Q51111655 | The COP9 Signalosome |
| Q38355120 | The COP9 Signalosome Interacts Physically with SCFCOI1 and Modulates Jasmonate Responses |
| Q28544912 | The COP9 signalosome converts temporal hormone signaling to spatial restriction on neural competence |
| Q51815311 | The COP9 signalosome counteracts the accumulation of cullin SCF ubiquitin E3 RING ligases during fungal development |
| Q40736705 | The COP9 signalosome inhibits p27(kip1) degradation and impedes G1-S phase progression via deneddylation of SCF Cul1. |
| Q58882257 | The COP9 signalosome is a repressor of replicative stress responses and polyploidization in the regenerating liver |
| Q24685712 | The Cullin3 ubiquitin ligase functions as a Nedd8-bound heterodimer |
| Q36873556 | The Cyclomodulin Cycle Inhibiting Factor (CIF) Alters Cullin Neddylation Dynamics |
| Q34647751 | The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor |
| Q34202686 | The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy |
| Q42520141 | The NEDD8 pathway is essential for SCF(beta -TrCP)-mediated ubiquitination and processing of the NF-kappa B precursor p105. |
| Q28592951 | The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice |
| Q28201996 | The Nedd8-conjugated ROC1-CUL1 Core Ubiquitin Ligase Utilizes Nedd8 Charged Surface Residues for Efficient Polyubiquitin Chain Assembly Catalyzed by Cdc34 |
| Q34985980 | The RUB/Nedd8 conjugation pathway is required for early development in Arabidopsis |
| Q44097478 | The SCF(COI1) ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis |
| Q28202908 | The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27 |
| Q34770671 | The eta7/csn3-3 auxin response mutant of Arabidopsis defines a novel function for the CSN3 subunit of the COP9 signalosome. |
| Q24802316 | The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned8p |
| Q42720645 | The loop-less tmCdc34 E2 mutant defective in polyubiquitination in vitro and in vivo supports yeast growth in a manner dependent on Ubp14 and Cka2. |
| Q34130702 | The role of regulated protein degradation in auxin response |
| Q38346195 | The ubiquitin C-terminal hydrolase UCH-L1 regulates B-cell proliferation and integrin activation |
| Q28203455 | The von Hippel-Lindau tumor suppressor gene |
| Q34132816 | The von Hippel-Lindau tumor suppressor protein |
| Q37591349 | The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor |
| Q28206411 | Themes and variations on ubiquitylation |
| Q46040247 | Triggering ubiquitination of a CDK inhibitor at origins of DNA replication. |
| Q34225698 | Twists and turns in ubiquitin‐like protein conjugation cascades |
| Q34248457 | UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation |
| Q28593538 | Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP |
| Q36946774 | Ubiquitin ligases in cancer: ushers for degradation |
| Q35082720 | Ubiquitin pathway in VHL cancer syndrome |
| Q33576532 | Ubiquitin, hormones and biotic stress in plants |
| Q34667508 | Ubiquitination and auxin signaling: a degrading story |
| Q28201553 | VACM-1, a cul-5 gene, inhibits cellular growth by a mechanism that involves MAPK and p53 signaling pathways |
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