The cyclomodulin cycle inhibiting factor (CIF) alters cullin neddylation dynamics

scientific article published on 15 April 2013

The cyclomodulin cycle inhibiting factor (CIF) alters cullin neddylation dynamics is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M112.448258
P932PMC publication ID3663497
P698PubMed publication ID23589306

P2093author name stringTasha B Toro
Matthew D Petroski
Julia I Toth
P2860cites workCullin-RING ubiquitin ligases: global regulation and activation cyclesQ21203558
ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activityQ22009487
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complexQ24294734
The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiaeQ24306410
Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugationQ24314520
Systematic and quantitative assessment of the ubiquitin-modified proteomeQ24634631
Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanismQ36216079
Function and regulation of protein neddylation. 'Protein modifications: beyond the usual suspects' review seriesQ36946992
Structural basis for a reciprocal regulation between SCF and CSN.Q36988986
Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugationQ37101488
Cif type III effector protein: a smart hijacker of the host cell cycleQ37590318
Targeting protein neddylation: a novel therapeutic strategy for the treatment of cancerQ37827165
Control of cullin-ring ubiquitin ligase activity by nedd8.Q37827465
The cullin protein familyQ37873586
A gatekeeper residue for NEDD8-activating enzyme inhibition by MLN4924.Q39308261
Treatment-emergent mutations in NAEβ confer resistance to the NEDD8-activating enzyme inhibitor MLN4924.Q39375403
The bacterial effector Cif interferes with SCF ubiquitin ligase function by inhibiting deneddylation of Cullin1Q39654433
Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymesQ41141041
Saccharomyces cerevisiae ubiquitin-like protein Rub1 conjugates to cullin proteins Rtt101 and Cul3 in vivo.Q42609853
Evaluation of a diffusion-driven mechanism for substrate ubiquitination by the SCF-Cdc34 ubiquitin ligase complexQ44333860
Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerizationQ45345753
Targeting NEDD8-activated cullin-RING ligases for the treatment of cancer.Q45976197
Enteropathogenic and enterohaemorrhagic Escherichia coli deliver a novel effector called Cif, which blocks cell cycle G2/M transitionQ48217964
Inhibition of Cullin RING Ligases by Cycle Inhibiting Factor: Evidence for Interference with Nedd8-Induced Conformational ControlQ58096387
NEDD8 Overexpression Results in Neddylation of Ubiquitin Substrates by the Ubiquitin PathwayQ63976960
Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor functionQ24682460
Conservation of the COP9/signalosome in budding yeastQ24802982
Dcn1 functions as a scaffold-type E3 ligase for cullin neddylationQ27649565
Structure of the Cyclomodulin Cif from Pathogenic Escherichia coliQ27652466
A bacterial type III effector family uses the papain-like hydrolytic activity to arrest the host cell cycleQ27653841
Crystal Structures of Cif from Bacterial Pathogens Photorhabdus luminescens and Burkholderia pseudomalleiQ27655471
A Dual E3 Mechanism for Rub1 Ligation to Cdc53Q27664416
N-Terminal Acetylation Acts as an Avidity Enhancer Within an Interconnected Multiprotein ComplexQ27674398
Structural mechanism of ubiquitin and NEDD8 deamidation catalyzed by bacterial effectors that induce macrophage-specific apoptosisQ27675204
Cycle inhibiting factors (cifs): cyclomodulins that usurp the ubiquitin-dependent degradation pathway of host cells.Q27692621
RING domain E3 ubiquitin ligasesQ27860546
Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiaeQ27861085
Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1.Q27931858
Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complexQ27933259
Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteinsQ27933764
A novel protein modification pathway related to the ubiquitin systemQ27938072
Three new dominant drug resistance cassettes for gene disruption in Saccharomyces cerevisiaeQ28131610
Function and regulation of cullin-RING ubiquitin ligasesQ28131707
Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosomeQ28187304
The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?Q28188435
The ubiquitin E1 enzyme Ube1 mediates NEDD8 activation under diverse stress conditionsQ28260754
The SCF ubiquitin ligase: insights into a molecular machineQ28279993
Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiaeQ29546523
Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol methodQ29547550
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancerQ29616732
Type III secretion-dependent cell cycle block caused in HeLa cells by enteropathogenic Escherichia coli O103.Q33552605
Pathogenic bacteria target NEDD8-conjugated cullins to hijack host-cell signaling pathwaysQ33716987
Nedd8 on cullin: building an expressway to protein destruction.Q33976667
The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and TherapyQ34202686
Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomicsQ34433677
Glutamine Deamidation and Dysfunction of Ubiquitin/NEDD8 Induced by a Bacterial Effector FamilyQ34540701
The enteropathogenic Escherichia coli effector Cif induces delayed apoptosis in epithelial cellsQ35005496
Enteropathogenic Escherichia coli O103 from rabbit elicits actin stress fibers and focal adhesions in HeLa epithelial cells, cytopathic effects that are linked to an analog of the locus of enterocyte effacementQ35550312
The molecular basis of ubiquitin-like protein NEDD8 deamidation by the bacterial effector protein Cif.Q36079517
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectprotein neddylationQ21115705
P304page(s)14716-14726
P577publication date2013-04-15
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe cyclomodulin cycle inhibiting factor (CIF) alters cullin neddylation dynamics
P478volume288

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cites work (P2860)
Q36226432Enteric pathogens deploy cell cycle inhibiting factors to block the bactericidal activity of Perforin-2
Q38209804Exploitation of the host ubiquitin system by human bacterial pathogens
Q36392344Gln40 deamidation blocks structural reconfiguration and activation of SCF ubiquitin ligase complex by Nedd8.
Q55153771Phylogenetic relationships of fluorescent pseudomonads deduced from the sequence analysis of 16S rRNA, Pseudomonas-specific and rpoD genes.
Q91892092Structural insights into the mechanism and inhibition of transglutaminase-induced ubiquitination by the Legionella effector MavC
Q24299638Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8
Q93127517The Proteasome Lid Triggers COP9 Signalosome Activity during the Transition of Saccharomyces cerevisiae Cells into Quiescence
Q37264197What a difference a Dalton makes: bacterial virulence factors modulate eukaryotic host cell signaling systems via deamidation

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