| scholarly article | Q13442814 |
| P50 | author | S. Lawrence Zipursky | Q21097906 |
| Eugene Koonin | Q3699974 | ||
| Aravind L Iyer | Q4784512 | ||
| P2093 | author name string | Greg S B Suh | |
| Gregory A Cope | |||
| Raymond J Deshaies | |||
| Sylvia E Schwarz | |||
| P433 | issue | 5593 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | COP9 signalosome catalytic subunit RRI1 YDL216C | Q27551476 |
| P304 | page(s) | 608-11 | |
| P577 | publication date | 2002-10-18 | |
| P1433 | published in | Science | Q192864 |
| P1476 | title | Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1. | |
| P478 | volume | 298 |
| Q92925263 | 14-3-3ζ targeting induced senescence in Hep-2 laryngeal cancer cell through deneddylation of Cullin1 in the Skp1-Cullin-F-box protein complex |
| Q39308261 | A gatekeeper residue for NEDD8-activating enzyme inhibition by MLN4924. |
| Q24597956 | A genomic analysis of rat proteases and protease inhibitors |
| Q33691600 | A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity |
| Q24337802 | A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation |
| Q27934969 | A longevity protein, Lag2, interacts with SCF complex and regulates SCF function |
| Q35973516 | A proteasome for all occasions |
| Q37622653 | A snapshot of ubiquitin chain elongation: lysine 48-tetra-ubiquitin slows down ubiquitination |
| Q35162583 | A superfamily of protein tags: ubiquitin, SUMO and related modifiers |
| Q34441358 | A systematic genetic screen identifies new factors influencing centromeric heterochromatin integrity in fission yeast |
| Q24676880 | AMSH is an endosome-associated ubiquitin isopeptidase |
| Q34575365 | Adapter protein NRBP associates with Jab1 and negatively regulates AP-1 activity |
| Q35808916 | An eight-subunit COP9 signalosome with an intact JAMM motif is required for fungal fruit body formation. |
| Q33436063 | Analysis of the role of COP9 Signalosome (CSN) subunits in K562; the first link between CSN and autophagy |
| Q24563582 | Arabidopsis CAND1, an unmodified CUL1-interacting protein, is involved in multiple developmental pathways controlled by ubiquitin/proteasome-mediated protein Degradation |
| Q47315840 | Arabidopsis ETA2, an apparent ortholog of the human cullin-interacting protein CAND1, is required for auxin responses mediated by the SCF(TIR1) ubiquitin ligase |
| Q41971949 | Archaeal JAB1/MPN/MOV34 metalloenzyme (HvJAMM1) cleaves ubiquitin-like small archaeal modifier proteins (SAMPs) from protein-conjugates |
| Q34170033 | Archaeal Ubiquitin-Like Proteins: Functional Versatility and Putative Ancestral Involvement in tRNA Modification Revealed by Comparative Genomic Analysis |
| Q92503635 | Are Inositol Polyphosphates the Missing Link in Dynamic Cullin RING Ligase Regulation by the COP9 Signalosome? |
| Q21284383 | Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome |
| Q51957599 | Auxin responses in mutants of the Arabidopsis CONSTITUTIVE PHOTOMORPHOGENIC9 signalosome. |
| Q89663750 | Basis for metabolite-dependent Cullin-RING ligase deneddylation by the COP9 signalosome |
| Q31152494 | Binding of JAB1/CSN5 to MIF is mediated by the MPN domain but is independent of the JAMM motif |
| Q28131738 | Breaking the chains: structure and function of the deubiquitinases |
| Q27027816 | Building and remodelling Cullin-RING E3 ubiquitin ligases |
| Q34202918 | C. elegans CAND-1 regulates cullin neddylation, cell proliferation and morphogenesis in specific tissues |
| Q40322697 | CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1. |
| Q35857063 | CIF-1, a shared subunit of the COP9/signalosome and eukaryotic initiation factor 3 complexes, regulates MEL-26 levels in the Caenorhabditis elegans embryo |
| Q33512913 | COP9 limits dendritic branching via Cullin3-dependent degradation of the actin-crosslinking BTB-domain protein Kelch |
| Q34388158 | COP9 signalosome component JAB1/CSN5 is necessary for T cell signaling through LFA-1 and HIV-1 replication |
| Q27931782 | COP9 signalosome components play a role in the mating pheromone response of S. cerevisiae. |
| Q37867729 | COP9 signalosome function in the DDR. |
| Q37454309 | COP9 signalosome interacts ATP-dependently with p97/valosin-containing protein (VCP) and controls the ubiquitination status of proteins bound to p97/VCP. |
| Q99603719 | COP9 signalosome is an essential and druggable parasite target that regulates protein degradation |
| Q28507707 | COP9 signalosome subunit 3 is essential for maintenance of cell proliferation in the mouse embryonic epiblast |
| Q55456531 | COP9 signalosome subunit 5A affects phenylpropanoid metabolism, trichome formation and transcription of key genes of a regulatory tri-protein complex in Arabidopsis. |
| Q57462865 | COP9 signalosome subunit 6 mediates PDGF -induced pulmonary arterial smooth muscle cells proliferation |
| Q24304964 | COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3σ |
| Q53524553 | COP9 signalosome subunit 8 is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence. |
| Q48026943 | COP9 signalosome subunit PfCsnE regulates secondary metabolism and conidial formation in Pestalotiopsis fici |
| Q42511084 | COP9 signalosome subunits protect Capicua from MAPK-dependent and -independent mechanisms of degradation |
| Q41790530 | COP9 signalosome- and 26S proteasome-dependent regulation of SCFTIR1 accumulation in Arabidopsis. |
| Q35541468 | COP9 signalosome: a multifunctional regulator of SCF and other cullin-based ubiquitin ligases |
| Q24315611 | COP9-associated CSN5 regulates exosomal protein deubiquitination and sorting |
| Q37063329 | COPS5 amplification and overexpression confers tamoxifen-resistance in ERα-positive breast cancer by degradation of NCoR. |
| Q47309504 | COPS5 and LASP1 synergistically interact to downregulate 14-3-3σ expression and promote colorectal cancer progression via activating PI3K/AKT pathway. |
| Q34147934 | COPing with hypoxia |
| Q38015388 | CRL Ubiquitin Ligases and DNA Damage Response |
| Q24307876 | CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process |
| Q24298155 | CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha |
| Q47845473 | CSN facilitates Cullin-RING ubiquitin ligase function by counteracting autocatalytic adapter instability |
| Q47072666 | CSN maintains the germline cellular microenvironment and controls the level of stem cell genes via distinct CRLs in testes of Drosophila melanogaster |
| Q50336194 | CSN- and CAND1-dependent remodelling of the budding yeast SCF complex. |
| Q37106255 | CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression |
| Q82045647 | CSN5/Jab1 controls multiple events in the mammalian cell cycle |
| Q91645998 | CSN5A Subunit of COP9 Signalosome Temporally Buffers Response to Heat in Arabidopsis |
| Q34523341 | CSN6 drives carcinogenesis by positively regulating Myc stability. |
| Q36860475 | CSN6, a subunit of the COP9 signalosome, is involved in early response to iron deficiency in Oryza sativa |
| Q28115049 | CSNAP Is a Stoichiometric Subunit of the COP9 Signalosome |
| Q92322597 | CSNAP, the smallest CSN subunit, modulates proteostasis through cullin-RING ubiquitin ligases |
| Q37609233 | CUL4A ubiquitin ligase: a promising drug target for cancer and other human diseases |
| Q52877633 | Can hyperthermic intraperitoneal chemotherapy efficiency be improved by blocking the DNA repair factor COP9 signalosome? |
| Q42791381 | Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. |
| Q79108304 | Cdc34: cycling on and off the SCF |
| Q44187495 | Characterisation of the COP9 signalosome in Schistosoma mansoni parasites |
| Q36159459 | Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia |
| Q38302730 | Characterization of the VIER F-BOX PROTEINE genes from Arabidopsis reveals their importance for plant growth and development. |
| Q24550811 | Characterization of the last subunit of the Arabidopsis COP9 signalosome: implications for the overall structure and origin of the complex |
| Q38791699 | Characterization of the mammalian family of DCN-type NEDD8 E3 ligases |
| Q35612223 | Characterization of the role of COP9 signalosome in regulating cullin E3 ubiquitin ligase activity |
| Q24796655 | Comparative genomics of Archaea: how much have we learned in six years, and what's next? |
| Q27939996 | Complementary roles for Rpn11 and Ubp6 in deubiquitination and proteolysis by the proteasome |
| Q34671745 | Composition, roles, and regulation of cullin-based ubiquitin e3 ligases. |
| Q24802982 | Conservation of the COP9/signalosome in budding yeast |
| Q38819169 | Constitutive photomorphogenesis protein 1 (COP1) and COP9 signalosome, evolutionarily conserved photomorphogenic proteins as possible targets of melatonin |
| Q44109926 | Constitutively active Cullin-RING-Ligases fail to rescue loss of NEDD8 conjugation in Schizosaccharomyces pombe |
| Q34585770 | Control of multicellular development by the physically interacting deneddylases DEN1/DenA and COP9 signalosome |
| Q35172996 | Control of protein degradation by E3 ubiquitin ligases in Drosophila eye development. |
| Q39895340 | Cop9/signalosome subunits and Pcu4 regulate ribonucleotide reductase by both checkpoint-dependent and -independent mechanisms |
| Q39816600 | Crosstalk between the NF-kappaB activating IKK-complex and the CSN signalosome |
| Q27678871 | Crystal structure and versatile functional roles of the COP9 signalosome subunit 1 |
| Q24299598 | Crystal structure of human otubain 2. |
| Q27694578 | Crystal structure of the human COP9 signalosome |
| Q52332768 | Csn5 Is Required for the Conidiogenesis and Pathogenesis of the Alternaria alternata Tangerine Pathotype. |
| Q34520002 | Cul4A and DDB1 associate with Skp2 to target p27Kip1 for proteolysis involving the COP9 signalosome |
| Q31095156 | Cul4B regulates neural progenitor cell growth |
| Q47284253 | Cullin 3-Based Ubiquitin Ligases as Master Regulators of Mammalian Cell Differentiation. |
| Q34785767 | Cullin E3 ligases and their rewiring by viral factors |
| Q21203558 | Cullin-RING ubiquitin ligases: global regulation and activation cycles |
| Q39453442 | D27E mutation of VTC1 impairs the interaction with CSN5B and enhances ascorbic acid biosynthesis and seedling growth in Arabidopsis |
| Q33549610 | DDB2 complex-mediated ubiquitylation around DNA damage is oppositely regulated by XPC and Ku and contributes to the recruitment of XPA. |
| Q28205415 | DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1 |
| Q38336126 | DUBs, the regulation of cell identity and disease |
| Q36216079 | Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism |
| Q52150059 | Deneddylase 1 regulates deneddylase activity of the Cop9 signalosome in Drosophila melanogaster. |
| Q40222608 | Depletion of Jab1 inhibits proliferation of pancreatic cancer cell lines |
| Q36536393 | Design principles of a universal protein degradation machine |
| Q37873069 | Detecting UV-lesions in the genome: The modular CRL4 ubiquitin ligase does it best! |
| Q46847586 | Detection of modification by ubiquitin-like proteins |
| Q98771233 | Deubiquitinating Enzyme: A Potential Secondary Checkpoint of Cancer Immunity |
| Q28188326 | Deubiquitinating enzymes--the importance of driving in reverse along the ubiquitin-proteasome pathway |
| Q38730016 | Deubiquitination and Stabilization of PD-L1 by CSN5. |
| Q38125278 | Deubiquitylases from genes to organism |
| Q38193809 | Deubiquitylating enzymes and their emerging role in plant biology |
| Q35206250 | Developmental expression of p97/VCP (Valosin-containing protein) and Jab1/CSN5 in the rat testis and epididymis. |
| Q36278259 | Discovery of an Inhibitor of the Proteasome Subunit Rpn11. |
| Q28588169 | Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death |
| Q28086765 | Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B |
| Q89770809 | Diverse and dynamic roles of F-box proteins in plant biology |
| Q38533869 | Diversity of COP9 signalosome structures and functional consequences |
| Q34115607 | Drosophila COP9 signalosome subunit 7 interacts with multiple genomic loci to regulate development |
| Q47070340 | Drosophila Cand1 regulates Cullin3-dependent E3 ligases by affecting the neddylation of Cullin3 and by controlling the stability of Cullin3 and adaptor protein |
| Q35207883 | Drug discovery in the ubiquitin regulatory pathway |
| Q36525810 | Drug discovery in the ubiquitin-proteasome system. |
| Q27937368 | Dual function of Rpn5 in two PCI complexes, the 26S proteasome and COP9 signalosome. |
| Q33512518 | Dual regulation of dendritic morphogenesis in Drosophila by the COP9 signalosome |
| Q24319983 | Dynamic regulation of the COP9 signalosome in response to DNA damage |
| Q34433677 | Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics |
| Q38237803 | Emerging mechanistic insights into AAA complexes regulating proteasomal degradation |
| Q42928058 | Epidermal Growth Factor Receptor neddylation is regulated by a desmosomal-COP9 (Constitutive Photomorphogenesis 9) signalosome complex. |
| Q35691576 | Epstein-Barr virus oncogenesis and the ubiquitin-proteasome system. |
| Q52602278 | Ethylene-induced stabilization of ETHYLENE INSENSITIVE3 and EIN3-LIKE1 is mediated by proteasomal degradation of EIN3 binding F-box 1 and 2 that requires EIN2 in Arabidopsis. |
| Q44501209 | Evidence for a physical association of the COP9 signalosome, the proteasome, and specific SCF E3 ligases in vivo |
| Q24804620 | Evolutionary history, structural features and biochemical diversity of the NlpC/P60 superfamily of enzymes |
| Q21261220 | Expression analysis of the mouse S100A7/psoriasin gene in skin inflammation and mammary tumorigenesis |
| Q42150408 | F-box-directed CRL complex assembly and regulation by the CSN and CAND1 |
| Q47847570 | Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12p |
| Q27022509 | For security and stability: SGT1 in plant defense and development |
| Q28131707 | Function and regulation of cullin-RING ubiquitin ligases |
| Q31032769 | Function of COP9 signalosome in regulation of mouse oocytes meiosis by regulating MPF activity and securing degradation |
| Q90426519 | Functional characterization of BRCC3 mutations in acute myeloid leukemia with t(8;21)(q22;q22.1) |
| Q35583065 | Genetic Interaction Landscape Reveals Critical Requirements for Schizosaccharomyces pombe Brc1 in DNA Damage Response Mutants |
| Q36751582 | Genetic analysis of CAND1-CUL1 interactions in Arabidopsis supports a role for CAND1-mediated cycling of the SCFTIR1 complex |
| Q37170500 | Genomic analysis of COP9 signalosome function in Drosophila melanogaster reveals a role in temporal regulation of gene expression |
| Q89519289 | Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics |
| Q47070864 | Growth suppression induced by the TRC8 hereditary kidney cancer gene is dependent upon JAB1/CSN5. |
| Q38700926 | HDM2 Promotes NEDDylation of Hepatitis B Virus HBx To Enhance Its Stability and Function |
| Q28184208 | Human and mouse proteases: a comparative genomic approach |
| Q30668623 | Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability |
| Q28205400 | Identification and characterization of DEN1, a deneddylase of the ULP family |
| Q30164676 | Identification of AMSH-LP containing a Jab1/MPN domain metalloenzyme motif |
| Q64100818 | Identification of COP9 Signalosome Subunit Genes in s and Functional Analysis of in Female Fecundity |
| Q50488789 | Immunodepletion and Immunopurification as Approaches for CSN Research. |
| Q36020841 | Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline |
| Q27003218 | Inhibition of NEDD8-conjugation pathway by novel molecules: potential approaches to anticancer therapy |
| Q37737112 | Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo. |
| Q36770693 | Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function |
| Q33775208 | Insights into the evolution of Archaea and eukaryotic protein modifier systems revealed by the genome of a novel archaeal group. |
| Q27675751 | Insights into the regulation of the human COP9 signalosome catalytic subunit, CSN5/Jab1 |
| Q41110823 | Integration of the catalytic subunit activates deneddylase activity in vivo as final step in fungal COP9 signalosome assembly |
| Q38341652 | Interaction between glucose-regulated destruction domain of DNA topoisomerase IIalpha and MPN domain of Jab1/CSN5. |
| Q55690843 | Interaction between parasite-encoded JAB1/CSN5 and macrophage migration inhibitory factor proteins attenuates its proinflammatory function. |
| Q38316360 | JAB1/CSN5 inhibits the activity of Luman/CREB3 by promoting its degradation |
| Q34292695 | JAB1/CSN5: a new player in cell cycle control and cancer |
| Q21092836 | JAMM: a metalloprotease-like zinc site in the proteasome and signalosome |
| Q40290179 | Jab1 induces the cytoplasmic localization and degradation of p53 in coordination with Hdm2. |
| Q40249081 | Jab1 mediates cytoplasmic localization and degradation of West Nile virus capsid protein. |
| Q52657204 | Jab1/COPS5 as a Novel Biomarker for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Human Cancer. |
| Q41817100 | Jun activation domain-binding protein 1 (JAB1) is required for the optimal response to interferons. |
| Q46723101 | Jun activation domain-binding protein 1 is required for mitotic checkpoint activation via its involvement in hyperphosphorylation of 53BP1. |
| Q24310641 | K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1 |
| Q36407994 | Knockdown of subunit 3 of the COP9 signalosome inhibits C2C12 myoblast differentiation via NF-KappaB signaling pathway |
| Q33878746 | Lack of SMALL ACIDIC PROTEIN 1 (SMAP1) causes increased sensitivity to an inhibitor of RUB/NEDD8-activating enzyme in Arabidopsis seedlings |
| Q37415096 | Lessons from fungal F-box proteins |
| Q53673743 | Loss of the CONSTITUTIVE PHOTOMORPHOGENIC9 signalosome subunit 5 is sufficient to cause the cop/det/fus mutant phenotype in Arabidopsis. |
| Q42425195 | MIF coordinates the cell cycle with DNA damage checkpoints. Lessons from knockout mouse models |
| Q58021549 | MLN4924 is an efficient inhibitor of NEDD8 conjugation in plants |
| Q26823231 | Manipulation of fungal development as source of novel secondary metabolites for biotechnology |
| Q36163496 | Mapping the protein interaction network of the human COP9 signalosome complex using a label-free QTAX strategy |
| Q89576595 | Meloidogyne incognita PASSE-MURAILLE (MiPM) Gene Encodes a Cell-Penetrating Protein That Interacts With the CSN5 Subunit of the COP9 Signalosome |
| Q34928594 | Molecular mechanisms of proteasome assembly |
| Q38298148 | Molecular regulation of UV-induced DNA repair |
| Q38268491 | Moonlighting and pleiotropy within two regulators of the degradation machinery: the proteasome lid and the CSN. |
| Q91802178 | Mouse spermatogenesis-associated protein 1 (SPATA1), an IFT20 binding partner, is an acrosomal protein |
| Q28504831 | Multiple functions of Jab1 are required for early embryonic development and growth potential in mice |
| Q38598847 | Murine Myocardial Transcriptome Analysis Reveals a Critical Role of COPS8 in the Gene Expression of Cullin-RING Ligase Substrate Receptors and Redox and Vesicle Trafficking Pathways |
| Q24301019 | Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3 |
| Q28116360 | Myeloma overexpressed 2 (Myeov2) regulates L11 subnuclear localization through Nedd8 modification |
| Q37312247 | NEDD8 ultimate buster-1 long (NUB1L) protein promotes transfer of NEDD8 to proteasome for degradation through the P97UFD1/NPL4 complex |
| Q28202321 | NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins |
| Q73781347 | Nedd8 hydrolysis by UCH proteases in Plasmodium parasites. |
| Q33976667 | Nedd8 on cullin: building an expressway to protein destruction. |
| Q34621887 | Nedd8 processing enzymes in Schizosaccharomyces pombe |
| Q45317714 | Neddylation |
| Q40322425 | Neddylation and CAND1 independently stimulate SCF ubiquitin ligase activity in Candida albicans |
| Q47069590 | Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans. |
| Q47070899 | Neddylation and deneddylation regulate Cul1 and Cul3 protein accumulation. |
| Q34288710 | Neddylation dysfunction in Alzheimer's disease |
| Q34474077 | Neddylation promotes ubiquitylation and release of Ku from DNA-damage sites. |
| Q41947999 | Nep1, a Schizosaccharomyces pombe deneddylating enzyme |
| Q28483644 | Neurospora COP9 signalosome integrity plays major roles for hyphal growth, conidial development, and circadian function |
| Q44258787 | New tricks for ubiquitin and friends |
| Q36953350 | Ni(II), Cu(II), and Zn(II) diethyldithiocarbamate complexes show various activities against the proteasome in breast cancer cells. |
| Q42094573 | Novel aspects of COP9 signalosome functions revealed through analysis of hypomorphic csn mutants |
| Q35581416 | On again – off again: COP9 signalosome turns the key on protein degradation |
| Q41668145 | Overexpression of COP9 signalosome subunits, CSN7A and CSN7B, exerts different effects on adipogenic differentiation |
| Q83835605 | Overexpression of Jun activation domain-binding protein 1 in nonsmall cell lung cancer and its significance in p27 expression and clinical features |
| Q37630908 | Oxidized LDL-induced JAB1 influences NF-κB independent inflammatory signaling in human macrophages during foam cell formation |
| Q24815484 | PCI proteins eIF3e and eIF3m define distinct translation initiation factor 3 complexes |
| Q42806283 | Participation of the proteasomal lid subunit Rpn11 in mitochondrial morphology and function is mapped to a distinct C-terminal domain |
| Q41894165 | Pathogen and circadian controlled 1 (PCC1) protein is anchored to the plasma membrane and interacts with subunit 5 of COP9 signalosome in Arabidopsis. |
| Q49539596 | Plant Deubiquitinases and Their Role in the Control of Gene Expression Through Modification of Histones |
| Q35348599 | Plant ubiquitin-proteasome pathway and its role in gibberellin signaling |
| Q37401250 | Polyubiquitin binding and disassembly by deubiquitinating enzymes |
| Q37299632 | Porcine JAB1 significantly enhances apoptosis induced by staurosporine |
| Q38061206 | Post-translation modification in Archaea: lessons from Haloferax volcanii and other haloarchaea |
| Q26824233 | Posttranslational modifications of proteins in the pathobiology of medically relevant fungi |
| Q24811581 | Prediction of a common structural scaffold for proteasome lid, COP9-signalosome and eIF3 complexes |
| Q40657672 | Preferential interaction of TIP120A with Cul1 that is not modified by NEDD8 and not associated with Skp1. |
| Q59797449 | Proteasome lid bridges mitochondrial stress with Cdc53/Cullin1 NEDDylation status |
| Q36597934 | Proteasomes from structure to function: perspectives from Archaea |
| Q24553124 | Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome |
| Q48538797 | Protein neddylation and its alterations in human cancers for targeted therapy |
| Q34042816 | Protein neddylation: beyond cullin-RING ligases |
| Q38326912 | Purification of the COP9 signalosome complex and binding partners from human T cells |
| Q40353550 | Purification of the COP9 signalosome from porcine spleen, human cell lines, and Arabidopsis thaliana plants. |
| Q24307586 | RIG-G as a key mediator of the antiproliferative activity of interferon-related pathways through enhancing p21 and p27 proteins |
| Q41226375 | Rbf1 degron dysfunction enhances cellular DNA replication |
| Q34032707 | Rbx1 flexible linker facilitates cullin-RING ligase function before neddylation and after deneddylation |
| Q29547616 | Recognition and processing of ubiquitin-protein conjugates by the proteasome |
| Q28486840 | Reconstitution of a new cysteine biosynthetic pathway in Mycobacterium tuberculosis |
| Q34470982 | Recruitment of the inhibitor Cand1 to the cullin substrate adaptor site mediates interaction to the neddylation site |
| Q35886677 | Regulated proteolysis and plant development |
| Q24645701 | Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes |
| Q24300495 | Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair |
| Q33687600 | Regulation of Cop9 signalosome activity by the EF-hand Ca2+-binding protein tescalcin |
| Q34949214 | Regulation of DNA damage response pathways by the cullin-RING ubiquitin ligases |
| Q36457732 | Regulation of DNA repair by ubiquitylation |
| Q37995682 | Regulation of NF-κB by deubiquitinases |
| Q24337729 | Regulation of cullin RING E3 ubiquitin ligases by CAND1 in vivo |
| Q38120938 | Regulation of proteolysis by human deubiquitinating enzymes |
| Q34252986 | Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases |
| Q34967074 | Revisiting the COP9 signalosome as a transcriptional regulator |
| Q91986481 | Rice black-streaked dwarf virus-encoded P5-1 regulates the ubiquitination activity of SCF E3 ligases and inhibits jasmonate signaling to benefit its infection in rice |
| Q33769567 | Role of individual subunits of the Neurospora crassa CSN complex in regulation of deneddylation and stability of cullin proteins |
| Q92724115 | Role of the COP9 Signalosome (CSN) in Cardiovascular Diseases |
| Q79793647 | Role of the MPN subunits in COP9 signalosome assembly and activity, and their regulatory interaction with Arabidopsis Cullin3-based E3 ligases |
| Q35182131 | Role of ubiquitination in the regulation of plant defence against pathogens. |
| Q37923711 | Roles of COP9 signalosome in cancer. |
| Q39015104 | Roles of Multifunctional COP9 Signalosome Complex in Cell Fate and Implications for Drug Discovery |
| Q37765014 | SAMPyling proteins in archaea |
| Q38102567 | SCFs in the new millennium |
| Q42009353 | SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function |
| Q48085230 | SUMO-conjugating and SUMO-deconjugating enzymes from Arabidopsis |
| Q43095196 | Similar active sites in lysostaphins and D-Ala-D-Ala metallopeptidases |
| Q40458488 | Small Jab1-containing subcomplex is regulated in an anchorage- and cell cycle-dependent manner, which is abrogated by ras transformation. |
| Q34551647 | Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins |
| Q35558119 | Stat3 and CCAAT/enhancer binding protein beta (C/EBP-beta) regulate Jab1/CSN5 expression in mammary carcinoma cells |
| Q51016592 | Structural Insight into Ubiquitin-Like Protein Recognition and Oligomeric States of JAMM/MPN+ Proteases. |
| Q28542494 | Structural and biochemical characterization of the Cop9 signalosome CSN5/CSN6 heterodimer |
| Q36932100 | Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle |
| Q36988986 | Structural basis for a reciprocal regulation between SCF and CSN. |
| Q92832463 | Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome |
| Q24529121 | Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1. |
| Q46613519 | Structural biology: Corralling a protein-degradation regulator |
| Q89601765 | Structural dynamics of the human COP9 signalosome revealed by cross-linking mass spectrometry and integrative modeling |
| Q35151712 | Structural regulation of cullin-RING ubiquitin ligase complexes |
| Q52322457 | Structure and Function of the 26S Proteasome. |
| Q24313433 | Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases |
| Q57262729 | Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1-Npl4 |
| Q26751372 | Substrate specificity of the ubiquitin and Ubl proteases |
| Q34627210 | Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers |
| Q52649730 | Suppression of Jab1 expression inhibits proliferation and promotes apoptosis of AMC-HN-8 cells. |
| Q24316309 | Symmetrical modularity of the COP9 signalosome complex suggests its multifunctionality |
| Q47960868 | TIP120A associates with unneddylated cullin 1 and regulates its neddylation |
| Q36502887 | Targeted inactivation of the COP9 signalosome impairs multiple stages of T cell development |
| Q37364323 | Targeted inhibition of the COP9 signalosome for treatment of cancer |
| Q25256814 | Targeted silencing of Jab1/Csn5 in human cells downregulates SCF activity through reduction of F-box protein levels |
| Q34043797 | Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation |
| Q59830619 | Targeting Metalloenzymes for Therapeutic Intervention |
| Q38059505 | Targeting neddylation in cancer therapy |
| Q37610623 | The 26 S proteasome: from basic mechanisms to drug targeting |
| Q27652505 | The Arabidopsis COP9 Signalosome Subunit 7 Is a Model PCI Domain Protein with Subdomains Involved in COP9 Signalosome Assembly |
| Q52086696 | The Arabidopsis CSN5A and CSN5B subunits are present in distinct COP9 signalosome complexes, and mutations in their JAMM domains exhibit differential dominant negative effects on development. |
| Q51111655 | The COP9 Signalosome |
| Q38355120 | The COP9 Signalosome Interacts Physically with SCFCOI1 and Modulates Jasmonate Responses |
| Q33338332 | The COP9 Signalosome Interacts with SCFUFO and Participates in Arabidopsis Flower Development |
| Q46973380 | The COP9 Signalosome Promotes Degradation of Cyclin E during Early Drosophila Oogenesis |
| Q50422504 | The COP9 Signalosome regulates seed germination by facilitating protein degradation of RGL2 and ABI5. |
| Q42018353 | The COP9 signalosome controls jasmonic acid synthesis and plant responses to herbivory and pathogens |
| Q51815311 | The COP9 signalosome counteracts the accumulation of cullin SCF ubiquitin E3 RING ligases during fungal development. |
| Q49887000 | The COP9 signalosome inhibits Cullin-RING E3 ubiquitin ligases independently of its deneddylase activity |
| Q27931851 | The COP9 signalosome is involved in the regulation of lipid metabolism and of transition metals uptake in Saccharomyces cerevisiae. |
| Q37111543 | The COP9 signalosome is required for light-dependent timeless degradation and Drosophila clock resetting |
| Q37066433 | The COP9 signalosome negatively regulates proteasome proteolytic function and is essential to transcription. |
| Q40237851 | The COP9 signalosome regulates Skp2 levels and proliferation of human cells. |
| Q33891920 | The COP9 signalosome regulates the Neurospora circadian clock by controlling the stability of the SCFFWD-1 complex |
| Q34245895 | The COP9 signalosome subunit 6 (CSN6): a potential oncogene |
| Q41877791 | The COP9 signalosome, cullin 3 and Keap1 supercomplex regulates CHOP stability and adipogenesis |
| Q27939717 | The COP9 signalosome-like complex in S. cerevisiae and links to other PCI complexes |
| Q28188435 | The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases? |
| Q50800615 | The COP9 signalosome: its regulation of cullin-based E3 ubiquitin ligases and role in photomorphogenesis. |
| Q39990453 | The COP9/signalosome increases the efficiency of von Hippel-Lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination |
| Q30368429 | The CSN/COP9 signalosome regulates synaptonemal complex assembly during meiotic prophase I of Caenorhabditis elegans. |
| Q60921003 | The CSN3 subunit of the COP9 signalosome interacts with the HD region of Sos1 regulating stability of this GEF protein |
| Q24685712 | The Cullin3 ubiquitin ligase functions as a Nedd8-bound heterodimer |
| Q27309007 | The DenA/DEN1 Interacting Phosphatase DipA Controls Septa Positioning and Phosphorylation-Dependent Stability of Cytoplasmatic DenA/DEN1 during Fungal Development |
| Q34155445 | The Lys63-specific deubiquitinating enzyme BRCC36 is regulated by two scaffold proteins localizing in different subcellular compartments |
| Q21129204 | The NEDD8 modification pathway in plants |
| Q93127517 | The Proteasome Lid Triggers COP9 Signalosome Activity during the Transition of Saccharomyces cerevisiae Cells into Quiescence |
| Q26782011 | The Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and Repair |
| Q92074840 | The Salix SmSPR1 Involved in Light-Regulated Cell Expansion by Modulating Microtubule Arrangement |
| Q35266319 | The TFIIH subunit Tfb3 regulates cullin neddylation |
| Q24294805 | The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways |
| Q28276361 | The assembly pathway of the 19S regulatory particle of the yeast 26S proteasome |
| Q24306410 | The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae |
| Q27679008 | The crystal structure of the MPN domain from the COP9 signalosome subunit CSN6 |
| Q24309182 | The crystal structure of the human Mov34 MPN domain reveals a metal-free dimer |
| Q41954250 | The csnD/csnE signalosome genes are involved in the Aspergillus nidulans DNA damage response. |
| Q37873586 | The cullin protein family |
| Q36873556 | The cyclomodulin cycle inhibiting factor (CIF) alters cullin neddylation dynamics |
| Q30009879 | The deubiquitinating enzyme AMSH1 and the ESCRT-III subunit VPS2.1 are required for autophagic degradation in Arabidopsis |
| Q43027496 | The deubiquitinating enzyme AMSH3 is required for intracellular trafficking and vacuole biogenesis in Arabidopsis thaliana |
| Q34480316 | The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability |
| Q38615247 | The devil is in the details: comparison between COP9 signalosome (CSN) and the LID of the 26S proteasome |
| Q35590355 | The diverse roles of ubiquitin and the 26S proteasome in the life of plants |
| Q38842175 | The emerging roles of Jab1/CSN5 in cancer |
| Q33927244 | The essential functions of NEDD8 are mediated via distinct surface regions, and not by polyneddylation in Schizosaccharomyces pombe |
| Q34770671 | The eta7/csn3-3 auxin response mutant of Arabidopsis defines a novel function for the CSN3 subunit of the COP9 signalosome. |
| Q90482001 | The functions and properties of cullin-5, a potential therapeutic target for cancers |
| Q41720395 | The genomic landscape of human cellular circadian variation points to a novel role for the signalosome. |
| Q24307181 | The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7 |
| Q33225887 | The hepatitis B virus X protein enhances AP-1 activation through interaction with Jab1. |
| Q39717057 | The human COP9 signalosome protects ubiquitin-conjugating enzyme 3 (UBC3/Cdc34) from beta-transducin repeat-containing protein (betaTrCP)-mediated degradation |
| Q31089679 | The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain |
| Q34081793 | The molecular determinants of NEDD8 specific recognition by human SENP8. |
| Q36451967 | The organization of a CSN5-containing subcomplex of the COP9 signalosome |
| Q30820062 | The prokaryotic antecedents of the ubiquitin-signaling system and the early evolution of ubiquitin-like beta-grasp domains |
| Q33336573 | The proto-oncogene Int6 is essential for neddylation of Cul1 and Cul3 in Drosophila. |
| Q26746044 | The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions |
| Q24299081 | The subunit CSN6 of the COP9 signalosome is cleaved during apoptosis |
| Q24310748 | The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation |
| Q24306674 | The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation |
| Q24301297 | The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage |
| Q40224086 | The ubiquitin- and proteasome-dependent degradation of COX-2 is regulated by the COP9 signalosome and differentially influenced by coxibs |
| Q35973064 | The ubiquitin-proteasome pathway and plant development |
| Q36268060 | The ubiquitin-proteasome system of Saccharomyces cerevisiae |
| Q37735375 | The ubiquitin-proteasome system regulates plant hormone signaling |
| Q24307443 | The zinc finger of the CSN-associated deubiquitinating enzyme USP15 is essential to rescue the E3 ligase Rbx1 |
| Q46325214 | Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases |
| Q34133608 | Transactivation of Schizosaccharomyces pombe cdt2+ stimulates a Pcu4-Ddb1-CSN ubiquitin ligase |
| Q42640783 | Translational regulation via 5' mRNA leader sequences revealed by mutational analysis of the Arabidopsis translation initiation factor subunit eIF3h |
| Q36491390 | UUCD: a family-based database of ubiquitin and ubiquitin-like conjugation |
| Q28253282 | UV-induced ubiquitylation of XPC complex, the UV-DDB-ubiquitin ligase complex, and DNA repair |
| Q34486872 | Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p |
| Q35023485 | Ubiquitin system: JAMMing in the name of the lid. |
| Q33576532 | Ubiquitin, hormones and biotic stress in plants |
| Q29616461 | Ubiquitin-binding domains |
| Q40620950 | Ubiquitin-like small archaeal modifier proteins (SAMPs) in Haloferax volcanii |
| Q36478232 | Ubiquitination-mediated protein degradation and modification: an emerging theme in plant-microbe interactions. |
| Q28087342 | Ubiquitylation, neddylation and the DNA damage response |
| Q24681220 | Use of RNA interference and complementation to study the function of the Drosophila and human 26S proteasome subunit S13 |
| Q35974190 | Yeast as a tool to select inhibitors of the cullin deneddylating enzyme Csn5. |
| Q37336467 | Zinc-dependent interaction between JAB1 and pre-S2 mutant large surface antigen of hepatitis B virus and its implications for viral hepatocarcinogenesis |
| Q43564565 | incurvata13, a novel allele of AUXIN RESISTANT6, reveals a specific role for auxin and the SCF complex in Arabidopsis embryogenesis, vascular specification, and leaf flatness |
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