Characterization of the mammalian family of DCN-type NEDD8 E3 ligases

scientific article published on 18 February 2016

Characterization of the mammalian family of DCN-type NEDD8 E3 ligases is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1242/JCS.181784
P932PMC publication ID4886823
P698PubMed publication ID26906416
P5875ResearchGate publication ID295082926

P50authorNicola T WoodQ57422668
Thimo KurzQ38803395
P2093author name stringAxel Knebel
Yann Thomas
Matthew J Keuss
Robin Mcarthur
P2860cites workGenome engineering using the CRISPR-Cas9 systemQ22122027
UV-damaged DNA-binding proteins are targets of CUL-4A-mediated ubiquitination and degradationQ24291831
The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiaeQ24306410
Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complexQ24310859
Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligasesQ24313433
Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugationQ24314520
E2-RING expansion of the NEDD8 cascade confers specificity to cullin modificationQ24316067
DCUN1D3, a novel UVC-responsive gene that is involved in cell cycle progression and cell growthQ24317079
SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylationQ24317319
TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexesQ24337489
NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligasesQ24337709
CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complexQ24337718
RNA-guided human genome engineering via Cas9Q24598394
SCCRO promotes glioma formation and malignant progression in miceQ24633442
Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8Q27640736
Dcn1 functions as a scaffold-type E3 ligase for cullin neddylationQ27649565
A Dual E3 Mechanism for Rub1 Ligation to Cdc53Q27664416
Structural Conservation of Distinctive N-terminal Acetylation-Dependent Interactions across a Family of Mammalian NEDD8 Ligation EnzymesQ27675332
The ubiquitin systemQ27860803
Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1.Q27931858
Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complexQ27933259
A novel protein modification pathway related to the ubiquitin systemQ27938072
USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responsesQ28115910
NEDD8 Overexpression Results in Neddylation of Ubiquitin Substrates by the Ubiquitin PathwayQ63976960
Function and regulation of cullin-RING ubiquitin ligasesQ28131707
Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosomeQ28187304
Radiation-mediated proteolysis of CDT1 by CUL4–ROC1 and CSN complexes constitutes a new checkpointQ28212584
Xeroderma pigmentosum group E cells lack a nuclear factor that binds to damaged DNAQ28292106
Cullin 4A associates with the UV-damaged DNA-binding protein DDBQ28619483
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancerQ29616732
The xeroderma pigmentosum group E gene product DDB2 is a specific target of cullin 4A in mammalian cellsQ34012408
Protein neddylation: beyond cullin-RING ligasesQ34042816
Oncogenic function of SCCRO5/DCUN1D5 requires its Neddylation E3 activity and nuclear localizationQ34314163
Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damageQ34353149
Neddylation promotes ubiquitylation and release of Ku from DNA-damage sites.Q34474077
Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomasQ34571296
SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1)Q34683293
Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrateQ34984389
The TFIIH subunit Tfb3 regulates cullin neddylationQ35266319
Mono-ubiquitination drives nuclear export of the human DCN1-like protein hDCNL1Q35311062
Improved genome editing in human cell lines using the CRISPR methodQ35321474
The COP9 signalosome is vital for timely repair of DNA double-strand breaksQ35786094
Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemiaQ36159459
Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteinsQ36850952
Function and regulation of protein neddylation. 'Protein modifications: beyond the usual suspects' review seriesQ36946992
The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranesQ37282361
The cullin protein familyQ37873586
Emerging roles of E3 ubiquitin ligases in autophagyQ38122815
SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair.Q38855830
The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interactionQ39986392
CAND1 controls in vivo dynamics of the cullin 1-RING ubiquitin ligase repertoireQ40136931
Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymesQ41141041
Distinct functional roles for the two SLX4 ubiquitin-binding UBZ domains mutated in Fanconi anemia.Q41482346
SCCRO (DCUN1D1) promotes nuclear translocation and assembly of the neddylation E3 complexQ42700446
CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensingQ47069271
Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans.Q47069590
E-CRISP: fast CRISPR target site identificationQ48332892
CSN- and CAND1-dependent remodelling of the budding yeast SCF complex.Q50336194
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)1441-1454
P577publication date2016-02-18
P1433published inJournal of Cell ScienceQ1524177
P1476titleCharacterization of the mammalian family of DCN-type NEDD8 E3 ligases
P478volume129

Reverse relations

cites work (P2860)
Q42621169A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation
Q38701253Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.
Q52729296Cand1-Mediated Adaptive Exchange Mechanism Enables Variation in F-Box Protein Expression.
Q50296656NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex
Q50296650NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex
Q112993662NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex
Q112993708NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex
Q50296654NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex
Q45317714Neddylation
Q88080896Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation
Q41543057SOCS2 Binds to and Regulates EphA2 through Multiple Mechanisms.
Q48594712Squamous cell carcinoma-related oncogene (SCCRO) neddylates Cul3 protein to selectively promote midbody localization and activity of Cul3KLHL21 protein complex during abscission.
Q55488054The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation.
Q63976958Unanchored tri-NEDD8 inhibits PARP-1 to protect from oxidative stress-induced cell death

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