HDM2 Promotes NEDDylation of Hepatitis B Virus HBx To Enhance Its Stability and Function

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HDM2 Promotes NEDDylation of Hepatitis B Virus HBx To Enhance Its Stability and Function is …
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scholarly articleQ13442814

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P356DOI10.1128/JVI.00340-17
P8608Fatcat IDrelease_bjifwsynxjgbbmakevehuyuvva
P932PMC publication ID5533936
P698PubMed publication ID28592528

P2093author name stringXin Zhao
Zhiwei Li
Xin Ye
Jianhua Zhu
Pu Yang
Jinfang Zhang
Jianping Jin
Wenxia Li
Xiaohai Yang
Ningning Liu
Jirun Peng
Tong Jiao
P2860cites workIdentification of the activating and conjugating enzymes of the NEDD8 conjugation pathwayQ22009414
TRIM40 promotes neddylation of IKKγ and is downregulated in gastrointestinal cancersQ24299200
Regulation of nucleolar signalling to p53 through NEDDylation of L11Q24310534
Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugationQ24314520
Hepatitis B and C virus infection and hepatocellular carcinoma in China: a review of epidemiology and control measuresQ26829313
Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1.Q27931858
NEDP1, a highly conserved cysteine protease that deNEDDylates CullinsQ28202321
Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activityQ28270986
NEDDylation is essential for Kaposi's sarcoma-associated herpesvirus latency and lytic reactivation and represents a novel anti-KSHV targetQ28544735
Hepatocarcinogenesis in viral Hepatitis B infection: the role of HBx and p53.Q33256371
Hepatitis B virus biologyQ33855246
Recombinant covalently closed circular hepatitis B virus DNA induces prolonged viral persistence in immunocompetent mice.Q33900276
Nedd8 on cullin: building an expressway to protein destruction.Q33976667
Protein neddylation: beyond cullin-RING ligasesQ34042816
SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1)Q34683293
Neddylation and deneddylation in cardiac biologyQ34987403
MLN4924 Synergistically Enhances Cisplatin-induced Cytotoxicity via JNK and Bcl-xL Pathways in Human Urothelial CarcinomaQ36305476
RNF111-dependent neddylation activates DNA damage-induced ubiquitinationQ36677932
Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells.Q36785312
The global burden of liver disease: the major impact of ChinaQ36901892
Function and regulation of protein neddylation. 'Protein modifications: beyond the usual suspects' review seriesQ36946992
HIV relies on neddylation for ubiquitin ligase-mediated functionsQ37348072
NEDDylation of PB2 Reduces Its Stability and Blocks the Replication of Influenza A VirusQ37676272
E3 Ubiquitin Ligase Siah-1 is Down-regulated and Fails to Target Natural HBx Truncates for Degradation in Hepatocellular CarcinomaQ38355232
Hepatitis B Virus X and Regulation of Viral Gene ExpressionQ38690987
New therapeutic agents for chronic hepatitis B.Q38706158
Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA.Q39021951
Hepatitis B virus (HBV) induces the expression of interleukin-8 that in turn reduces HBV sensitivity to interferon-alpha.Q39119845
NEDDylation regulates E2F-1-dependent transcriptionQ39307613
Hepatitis B virus X protein modulates oncogene Yes-associated protein by CREB to promote growth of hepatoma cells.Q39329758
Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer.Q39542346
Chemotherapy induces NEDP1-mediated destabilization of MDM2.Q39794548
Negative cross-talk between Nur77 and small heterodimer partner and its role in apoptotic cell death of hepatoma cells.Q40476155
MLN4924 suppresses neddylation and induces cell cycle arrest, senescence, and apoptosis in human osteosarcomaQ40851893
Phosphorylation and rapid turnover of hepatitis B virus X-protein expressed in HepG2 cells from a recombinant vaccinia virusQ42624587
c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type II receptorQ42827155
Chemotherapy-induced apoptosis in hepatocellular carcinoma involves the p53 family and is mediated via the extrinsic and the intrinsic pathwayQ45188173
Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinasesQ45345757
Hepatitis B virus X protein stabilizes amplified in breast cancer 1 protein and cooperates with it to promote human hepatocellular carcinoma cell invasivenessQ45358578
MDM2 and p53 polymorphisms are associated with the development of hepatocellular carcinoma in patients with chronic hepatitis B virus infectionQ45396018
The hepatitis B virus X protein functionally interacts with CREB-binding protein/p300 in the regulation of CREB-mediated transcription.Q45409349
Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligasesQ47071554
The Nedd8-activating enzyme inhibitor MLN4924 induces autophagy and apoptosis to suppress liver cancer cell growth.Q53170777
MDM2 promoter SNP309 is associated with the risk of hepatocellular carcinoma in patients with chronic hepatitis CQ80129017
Cancer: Mdm2-regulated stabilization of HuR by neddylation in HCC and colon cancer--a possible target for therapyQ82895187
P4510describes a project that usesImageJQ1659584
P433issue16
P407language of work or nameEnglishQ1860
P921main subjectHepatitis B virusQ6844
protein neddylationQ21115705
P577publication date2017-06-07
P1433published inJournal of VirologyQ1251128
P1476titleHDM2 Promotes NEDDylation of Hepatitis B Virus HBx To Enhance Its Stability and Function
P478volume91

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cites work (P2860)
Q59360684Hepatitis B Virus-Upregulated LNC-HUR1 Promotes Cell Proliferation and Tumorigenesis by Blocking p53 Activity
Q92577509LncRNA SAMD12-AS1 promotes cell proliferation and inhibits apoptosis by interacting with NPM1
Q91173730PITPNA-AS1 abrogates the inhibition of miR-876-5p on WNT5A to facilitate hepatocellular carcinoma progression
Q90755927Pevonedistat, a Neuronal Precursor Cell-Expressed Developmentally Down-Regulated Protein 8-Activating Enzyme Inhibitor, Is a Potent Inhibitor of Hepatitis B Virus
Q59137720Post-translational Modification Control of HBV Biological Processes
Q47572699Roles of neddylation against viral infections
Q90126839Targeting Hepatitis B Virus Covalently Closed Circular DNA and Hepatitis B Virus X Protein: Recent Advances and New Approaches
Q92413946The interaction of hepatitis B virus with the ubiquitin proteasome system in viral replication and associated pathogenesis