NEDDylation is essential for Kaposi's sarcoma-associated herpesvirus latency and lytic reactivation and represents a novel anti-KSHV target

scientific article (publication date: March 2015)

NEDDylation is essential for Kaposi's sarcoma-associated herpesvirus latency and lytic reactivation and represents a novel anti-KSHV target is …
instance of (P31):
scholarly articleQ13442814

External links are
P5530Altmetric DOI10.1371/JOURNAL.PPAT.1004771
P6409CORE ID150366511
P6179Dimensions Publication ID1019831223
P356DOI10.1371/JOURNAL.PPAT.1004771
P953full work available at URLhttp://eprints.whiterose.ac.uk/85927/
https://doi.org/10.1371/journal.ppat.1004771
P3181OpenCitations bibliographic resource ID4163705
P932PMC publication ID4368050
P698PubMed publication ID25794275
P5875ResearchGate publication ID273833792
P1154Scopus EID2-s2.0-84926429511

P50authorDavid J HughesQ55190003
Belinda Baquero-PerezQ84429529
Brian JacksonQ55163166
Adrian WhitehouseQ38319323
P2093author name stringJennifer J Wood
P2860cites workIdentification of the receptor component of the IkappaBalpha-ubiquitin ligaseQ22008569
Kaposi's sarcoma-associated herpesvirus ORF57 protein interacts with PYM to enhance translation of viral intronless mRNAsQ24309306
Phosphorylation meets ubiquitination: the control of NF-[kappa]B activityQ27860643
Induction of APOBEC3G Ubiquitination and Degradation by an HIV-1 Vif-Cul5-SCF ComplexQ28210666
Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3GQ28484619
X-linked mental retardation gene CUL4B targets ubiquitylation of H3K4 methyltransferase component WDR5 and regulates neuronal gene expressionQ28578733
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancerQ29616732
EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressorsQ33261811
Regulation of NF-kappaB inhibitor IkappaBalpha and viral replication by a KSHV microRNAQ33625562
Kinetics of Kaposi's sarcoma-associated herpesvirus gene expressionQ33653424
Pathogenic bacteria target NEDD8-conjugated cullins to hijack host-cell signaling pathwaysQ33716987
Caspase-7 cleavage of Kaposi sarcoma-associated herpesvirus ORF57 confers a cellular function against viral lytic gene expressionQ33799694
An interaction between KSHV ORF57 and UIF provides mRNA-adaptor redundancy in herpesvirus intronless mRNA export.Q33981279
Efficacy of bortezomib in a direct xenograft model of primary effusion lymphomaQ34059058
The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and TherapyQ34202686
Regulation of DNA damage responses by ubiquitin and SUMO.Q34328184
The Herpesvirus Saimiri open reading frame 73 gene product interacts with the cellular protein p32.Q34355898
Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomicsQ34433677
HCMV-infected cells maintain efficient nucleotide excision repair of the viral genome while abrogating repair of the host genomeQ34499369
MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-{kappa}B-dependent lymphomaQ43043795
A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligasesQ43146813
Clinical features and outcome of primary effusion lymphoma in HIV-infected patients: a single-institution study.Q44633978
The proteasome inhibitor bortezomib (PS-341) inhibits growth and induces apoptosis in primary effusion lymphoma cellsQ45232203
Bortezomib (PS-341) in patients with human herpesvirus 8-associated primary effusion lymphomaQ46701461
Kaposi' s sarcoma in HIV-positive patients: the state of art in the HAART-era.Q34656252
Global changes in Kaposi's sarcoma-associated virus gene expression patterns following expression of a tetracycline-inducible Rta transactivatorQ34782463
Regulation of DNA damage response pathways by the cullin-RING ubiquitin ligasesQ34949214
A novel mechanism inducing genome instability in Kaposi's sarcoma-associated herpesvirus infected cellsQ35161728
Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50/Rta lytic switch protein functions as a tetramerQ35857736
Kaposi's sarcoma-associated herpesvirus ori-Lyt-dependent DNA replication: involvement of host cellular factorsQ36484112
Kaposi's sarcoma and its associated herpesvirusQ36487309
RNF111-dependent neddylation activates DNA damage-induced ubiquitinationQ36677932
Kaposi's sarcoma-associated herpesvirus ori-Lyt-dependent DNA replication: cis-acting requirements for replication and ori-Lyt-associated RNA transcriptionQ36684599
H2AX phosphorylation is important for LANA-mediated Kaposi's sarcoma-associated herpesvirus episome persistenceQ36760020
Efficacious proteasome/HDAC inhibitor combination therapy for primary effusion lymphomaQ36890993
Function and regulation of protein neddylation. 'Protein modifications: beyond the usual suspects' review seriesQ36946992
NF-kappaB serves as a cellular sensor of Kaposi's sarcoma-associated herpesvirus latency and negatively regulates K-Rta by antagonizing the RBP-Jkappa coactivator.Q37157187
KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbetaQ37406535
Antiviral roles of APOBEC proteins against HIV-1 and suppression by Vif.Q37577736
NF-kappaB signaling modulation by EBV and KSHV.Q37745983
The cullin protein familyQ37873586
Human herpesvirus 8-associated neoplasms: the roles of viral replication and antiviral treatment.Q37888397
Human pathogens and the host cell SUMOylation systemQ37954599
Proteasome inhibitors: an expanding army attacking a unique targetQ37979388
DNA viruses and the cellular DNA-damage responseQ38031476
Interplay between viruses and host sumoylation pathwaysQ38102561
Kaposi sarcoma associated herpesvirus pathogenesis (KSHV)--an updateQ38114627
Deletion of Kaposi's sarcoma-associated herpesvirus FLICE inhibitory protein, vFLIP, from the viral genome compromises the activation of STAT1-responsive cellular genes and spindle cell formation in endothelial cellsQ38748567
Inhibition of NEDD8-activating enzyme induces rereplication and apoptosis in human tumor cells consistent with deregulating CDT1 turnoverQ39559719
Transcripts encoding K12, v-FLIP, v-cyclin, and the microRNA cluster of Kaposi's sarcoma-associated herpesvirus originate from a common promoter.Q39612221
Distinct p53, p53:LANA, and LANA complexes in Kaposi's Sarcoma--associated Herpesvirus LymphomasQ39744147
Kaposi's sarcoma-associated herpesvirus RTA promotes degradation of the Hey1 repressor protein through the ubiquitin proteasome pathwayQ39860632
Identification of substrates for F-box proteinsQ40341917
Prostratin and bortezomib are novel inducers of latent Kaposi's sarcoma-associated herpesvirus.Q40363267
Use of the red fluorescent protein as a marker of Kaposi's sarcoma-associated herpesvirus lytic gene expressionQ40537413
Activation of NF-kappaB by the latent vFLIP gene of Kaposi's sarcoma-associated herpesvirus is required for the spindle shape of virus-infected endothelial cells and contributes to their proinflammatory phenotypeQ41494543
Co-opting the Fanconi anemia genomic stability pathway enables herpesvirus DNA synthesis and productive growthQ42210707
The carboxy terminus of the herpesvirus saimiri ORF 57 gene contains domains that are required for transactivation and transrepressionQ42632122
Interaction of Kaposi's sarcoma-associated herpesvirus ORF59 with oriLyt is dependent on binding with K-RtaQ42779536
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectprotein neddylationQ21115705
P304page(s)e1004771
P577publication date2015-03-20
P1433published inPLOS PathogensQ283209
P859sponsorVirus-mediated nucleolar polyadenylation: a novel mechanism of RNA processing compartmentalisation to escape global mRNA degradationQ63368447
P1476titleNEDDylation is essential for Kaposi's sarcoma-associated herpesvirus latency and lytic reactivation and represents a novel anti-KSHV target
P478volume11