A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases

scientific article published on 28 February 2010

A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1021527198
P356DOI10.1038/NCB2035
P698PubMed publication ID20190741

P50authorMaria MasucciQ39683404
Stefano GastaldelloQ43078084
Omid R FaridaniQ55299926
P2093author name stringMia Palmkvist
Simone Callegari
Claudia Di Guglielmo
Sebastian Hildebrand
P2860cites workThe ubiquitin-proteasome proteolytic pathway: destruction for the sake of constructionQ24292709
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.Q24304921
Structural basis and specificity of human otubain 1-mediated deubiquitinationQ24309375
The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substratesQ24313484
Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugationQ24314520
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53Q24317677
RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradationQ24320385
Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1.Q24529121
Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymesQ24645701
Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymesQ27644017
Structure of a SUMO-binding-motif Mimic Bound to Smt3p–Ubc9p: Conservation of a Non-covalent Ubiquitin-like Protein–E2 Complex as a Platform for Selective Interactions within a SUMO PathwayQ27644674
Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damageQ28182301
NEDP1, a highly conserved cysteine protease that deNEDDylates CullinsQ28202321
Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalizationQ28243346
Modification of proteins by ubiquitin and ubiquitin-like proteinsQ28244250
Foscarnet. A review of its antiviral activity, pharmacokinetic properties and therapeutic use in immunocompromised patients with cytomegalovirus retinitisQ28270729
A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14Q28359750
The multiple checkpoint functions of CHK1 and CHK2 in maintenance of genome stabilityQ28611401
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screenQ29615061
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancerQ29616732
Epstein-Barr virus: 40 years onQ29617969
A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family HerpesviridaeQ31000683
The ubiquitin specific protease 4 (USP4) is a new player in the Wnt signalling pathwayQ33530227
The ubiquitin-mediated proteolytic pathway: mode of action and clinical implicationsQ33890102
Nedd8 on cullin: building an expressway to protein destruction.Q33976667
Histone H3 phosphorylation and cell divisionQ34290245
Virus and cell RNAs expressed during Epstein-Barr virus replicationQ34434702
Replication licensing and the DNA damage checkpoint.Q34547673
Molecular mechanisms of B-lymphocyte transformation by Epstein-Barr virusQ34881954
Inhibition of heavy chain and beta2-microglobulin synthesis as a mechanism of major histocompatibility complex class I downregulation during Epstein-Barr virus replicationQ35635291
Cullin-based ubiquitin ligase and its control by NEDD8-conjugating systemQ35794041
Potent inhibition of Epstein-Barr virus by phosphorothioate oligodeoxynucleotides without sequence specificationQ35816739
Cdt1 degradation to prevent DNA re-replication: conserved and non-conserved pathwaysQ35878420
Latent and lytic Epstein-Barr virus replication strategiesQ35896249
A herpesvirus ubiquitin-specific protease is critical for efficient T cell lymphoma formation.Q36289021
Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactionsQ36673300
G2/M cell cycle arrest in the life cycle of virusesQ36901310
Viral avoidance and exploitation of the ubiquitin system.Q37464765
Ubiquitination, ubiquitin-like modifiers, and deubiquitination in viral infectionQ37520106
Mutagenesis of the active-site cysteine in the ubiquitin-specific protease contained in large tegument protein pUL36 of pseudorabies virus impairs viral replication in vitro and neuroinvasion in vivoQ38609891
A gammaherpesvirus ubiquitin-specific protease is involved in the establishment of murine gammaherpesvirus 68 infectionQ39808338
Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathwayQ39992451
Reciprocal activities between herpes simplex virus type 1 regulatory protein ICP0, a ubiquitin E3 ligase, and ubiquitin-specific protease USP7.Q40373883
Epstein-Barr virus lytic replication elicits ATM checkpoint signal transduction while providing an S-phase-like cellular environment.Q40478598
Phosphorylation- and Skp1-independent in vitro ubiquitination of E2F1 by multiple ROC-cullin ligases.Q40821409
Herpes simplex virus DNA replicationQ40912250
Activation of latent EBV via anti-IgG-triggered, second messenger pathways in the Burkitt's lymphoma cell line Akata.Q41730838
Chk1 phosphorylation during mitosis: a new role for a master regulatorQ41963721
Epstein-barr virus encodes three bona fide ubiquitin-specific proteasesQ42157816
Skp2-mediated p27(Kip1) degradation during S/G2 phase progression of adipocyte hyperplasiaQ42833777
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectEpstein–Barr virusQ6900
P304page(s)351-361
P577publication date2010-02-28
P1433published inNature Cell BiologyQ1574111
P1476titleA deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases
P478volume12

Reverse relations

cites work (P2860)
Q54362634A bacterial attack on the ubiquitin-proteolytic system
Q57793019A microRNA derived from adenovirus virus-associated RNAII promotes virus infection post-transcriptional gene silencing
Q40884952A viral deubiquitylating enzyme targets viral RNA-dependent RNA polymerase and affects viral infectivity
Q33982295Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation
Q39320358Assembly and Egress of an Alphaherpesvirus Clockwork.
Q38388893At a Crossroads: Human DNA Tumor Viruses and the Host DNA Damage Response
Q52716630BGLF2 Increases Infectivity of Epstein-Barr Virus by Activating AP-1 upon De Novo Infection.
Q37609233CUL4A ubiquitin ligase: a promising drug target for cancer and other human diseases
Q35018053Caspase-1 promotes Epstein-Barr virus replication by targeting the large tegument protein deneddylase to the nucleus of productively infected cells
Q38596337Chromatin Structure of Epstein-Barr Virus Latent Episomes
Q41928398Complete genomic characterisation of two novel poxviruses (WKPV and EKPV) from western and eastern grey kangaroos.
Q34671745Composition, roles, and regulation of cullin-based ubiquitin e3 ligases.
Q30355292Conserved Tryptophan Motifs in the Large Tegument Protein pUL36 Are Required for Efficient Secondary Envelopment of Herpes Simplex Virus Capsids.
Q34785767Cullin E3 ligases and their rewiring by viral factors
Q38336126DUBs, the regulation of cell identity and disease
Q33836097Deubiquitinating enzymes as promising drug targets for infectious diseases
Q27320095Dynamic ubiquitination drives herpesvirus neuroinvasion
Q59356545Emerging Proviral Roles of Caspases during Lytic Replication of Gammaherpesviruses
Q33863563Enzymatic blockade of the ubiquitin-proteasome pathway
Q41775152Epstein-Barr virus BPLF1 deubiquitinates PCNA and attenuates polymerase η recruitment to DNA damage sites
Q39789708Epstein-Barr virus deubiquitinase downregulates TRAF6-mediated NF-κB signaling during productive replication.
Q35620244Epstein-Barr virus genetic variation in lymphoblastoid cell lines derived from Kenyan pediatric population
Q35105647Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling
Q47152702Gammaherpesviral Tegument Proteins, PML-Nuclear Bodies and the Ubiquitin-Proteasome System
Q33842180Genetic factors affecting EBV copy number in lymphoblastoid cell lines derived from the 1000 Genome Project samples.
Q34580906Hepatitis B virus HBx protein interactions with the ubiquitin proteasome system
Q28069273Hepatitis B: progress in understanding chronicity, the innate immune response, and cccDNA protection
Q47550353Herpesvirus deconjugases inhibit the IFN response by promoting TRIM25 autoubiquitination and functional inactivation of the RIG-I signalosome.
Q43819037In the family with ubiquitin.
Q90745741Interaction With 14-3-3 Correlates With Inactivation of the RIG-I Signalosome by Herpesvirus Ubiquitin Deconjugases
Q38107828Interplay between DNA tumor viruses and the host DNA damage response.
Q36205880Knockout of Epstein-Barr virus BPLF1 retards B-cell transformation and lymphoma formation in humanized mice
Q39196663Marek’s disease virus (MDV) ubiquitin-specific protease (USP) performs critical functions beyond its enzymatic activity during virus replication
Q28544735NEDDylation is essential for Kaposi's sarcoma-associated herpesvirus latency and lytic reactivation and represents a novel anti-KSHV target
Q34621887Nedd8 processing enzymes in Schizosaccharomyces pombe
Q33780955Noise cancellation: viral fine tuning of the cellular environment for its own genome replication.
Q39375624Nuclear Egress of Pseudorabies Virus Capsids Is Enhanced by a Subspecies of the Large Tegument Protein That Is Lost upon Cytoplasmic Maturation
Q37812728Pathogen-mediated posttranslational modifications: A re-emerging field
Q33716987Pathogenic bacteria target NEDD8-conjugated cullins to hijack host-cell signaling pathways
Q55380956Prion-like Domains in Eukaryotic Viruses.
Q40120026Small molecule perturbation of the CAND1-Cullin1-ubiquitin cycle stabilizes p53 and triggers Epstein-Barr virus reactivation.
Q39381317Structure and Function of Viral Deubiquitinating Enzymes.
Q101237287Structure of Epstein-Barr virus tegument protein complex BBRF2-BSRF1 reveals its potential role in viral envelopment
Q30424771The C terminus of the large tegument protein pUL36 contains multiple capsid binding sites that function differently during assembly and cell entry of herpes simplex virus
Q36195236The Epstein-Barr Virus Immunoevasins BCRF1 and BPLF1 Are Expressed by a Mechanism Independent of the Canonical Late Pre-initiation Complex
Q54245037The Immunomodulatory Capacity of an Epstein-Barr Virus Abortive Lytic Cycle: Potential Contribution to Viral Tumorigenesis
Q42222047The Rad6/18 ubiquitin complex interacts with the Epstein-Barr virus deubiquitinating enzyme, BPLF1, and contributes to virus infectivity
Q40116028The Translesion Polymerase Pol η Is Required for Efficient Epstein-Barr Virus Infectivity and Is Regulated by the Viral Deubiquitinating Enzyme BPLF1.
Q40271389The herpes simplex virus 1 UL36USP deubiquitinase suppresses DNA repair in host cells via deubiquitination of proliferating cell nuclear antigen
Q24310748The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation
Q36966125Trojan Horse Strategies Used by Pathogens to Influence the Small Ubiquitin-Like Modifier (SUMO) System of Host Eukaryotic Cells
Q90162112UL36 Encoded by Marek's Disease Virus Exhibits Linkage-Specific Deubiquitinase Activity
Q37992156Ubiquitin-Like Proteins
Q59351757Ubiquitination at the interface of tumor viruses and DNA damage responses
Q38921560Understanding Epstein-Barr Virus Life Cycle with Proteomics: A Temporal Analysis of Ubiquitination During Virus Reactivation.
Q37918803Viral Takeover of the Host Ubiquitin System
Q35014917microRNAs in circulation are altered in response to influenza A virus infection in humans

Search more.