Activation of NF-kappaB by the latent vFLIP gene of Kaposi's sarcoma-associated herpesvirus is required for the spindle shape of virus-infected endothelial cells and contributes to their proinflammatory phenotype

scientific article published on July 2006

Activation of NF-kappaB by the latent vFLIP gene of Kaposi's sarcoma-associated herpesvirus is required for the spindle shape of virus-infected endothelial cells and contributes to their proinflammatory phenotype is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.01603-05
P932PMC publication ID1489050
P698PubMed publication ID16809323

P2093author name stringDon Ganem
Mihaela Skobe
Simona Podgrabinska
Claudia Grossmann
P2860cites workDirect expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytesQ24339405
Kaposi's sarcoma associated herpes virus-encoded viral FLICE inhibitory protein activates transcription from HIV-1 Long Terminal Repeat via the classical NF-kappaB pathway and functionally cooperates with TatQ24800209
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Deregulation of NF-kappaB and its upstream kinases in cancerQ28190190
Activation of interleukin-6 gene expression through the NF-kappa B transcription factorQ28646310
NF-kappaB at the crossroads of life and deathQ29619302
Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression.Q30453215
Expression of vascular endothelial growth factor receptor-3 and podoplanin suggests a lymphatic endothelial cell origin of Kaposi's sarcoma tumor cells.Q30653484
Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1)Q30990350
Spindle cell conversion by Kaposi's sarcoma-associated herpesvirus: formation of colonies and plaques with mixed lytic and latent gene expression in infected primary dermal microvascular endothelial cell culturesQ33841987
Molecular characterization of lymphatic endothelial cells.Q34415420
The Human Herpes Virus 8-Encoded Viral FLICE-inhibitory Protein Induces Cellular Transformation via NF-κB ActivationQ34542601
Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma.Q34548882
Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Induces Expression of the Helix-Loop-Helix Protein Id-1 in Human Endothelial CellsQ34976840
Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphomaQ35131811
NF-kappaB inhibits gammaherpesvirus lytic replicationQ35155154
Activation of alternative NF-kappa B pathway by human herpes virus 8-encoded Fas-associated death domain-like IL-1 beta-converting enzyme inhibitory protein (vFLIP).Q35319917
The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factorsQ36375370
KSHV vFLIP is essential for the survival of infected lymphoma cellsQ36399405
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptorsQ36852093
AIDS, Kaposi sarcoma, and the lymphatic system: update and reflections.Q37965529
NF-kappa B as inducible transcriptional activator of the granulocyte-macrophage colony-stimulating factor geneQ38341645
Nuclear factor-kappa B potently up-regulates the promoter activity of RANTES, a chemokine that blocks HIV infection.Q39269743
Limited transmission of Kaposi's sarcoma-associated herpesvirus in cultured cellsQ39580911
De novo infection and serial transmission of Kaposi's sarcoma-associated herpesvirus in cultured endothelial cellsQ39748116
Host Range of Kaposi's Sarcoma-Associated Herpesvirus in Cultured CellsQ39752549
Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cellsQ39877852
Inefficient establishment of KSHV latency suggests an additional role for continued lytic replication in Kaposi sarcoma pathogenesis.Q40364647
The human herpes virus 8-encoded viral FLICE inhibitory protein protects against growth factor withdrawal-induced apoptosis via NF-kappa B activationQ40693631
The human herpes virus 8-encoded viral FLICE inhibitory protein physically associates with and persistently activates the Ikappa B kinase complexQ40752466
Human herpesvirus 8 viral FLICE-inhibitory protein inhibits Fas-mediated apoptosis through binding and prevention of procaspase-8 maturation.Q40794971
Kaposi's sarcoma-associated herpesvirus induction of chromosome instability in primary human endothelial cellsQ42328529
Microtubule disruption utilizes an NFkappa B-dependent pathway to stabilize HIF-1alpha proteinQ44253539
KSHV vFLIP binds to IKK-gamma to activate IKK.Q44532483
Identification and culture of Kaposi's sarcoma-like spindle cells from the peripheral blood of human immunodeficiency virus-1-infected individuals and normal controlsQ45789684
Fluid shear stress activation of IkappaB kinase is integrin-dependentQ46721477
Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirusQ47675996
Kaposi's sarcoma cells: long-term culture with growth factor from retrovirus-infected CD4+ T cells.Q52833089
Angiogenic properties of Kaposi's sarcoma-derived cells after long-term culture in vitro.Q55242415
Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma–associated herpesvirusQ56794246
Vascular Endothelial Growth Factor-C (VEGF-C) and its Receptors KDR and flt-4 are Expressed in AIDS-Associated Kaposi’s SarcomaQ57382283
Shear Stress-Induced Cytoskeleton Rearrangement Mediates NF-κB-Dependent Endothelial Expression of ICAM-1Q57703713
Kaposi's sarcoma: a result of the interplay among inflammatory cytokines, angiogenic factors and viral agentsQ61641140
Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cellsQ71563744
Kaposi's sarcoma-associated herpesvirus encoded vFLIP induces cellular IL-6 expression: the role of the NF-kappaB and JNK/AP1 pathwaysQ73456324
Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivoQ73596145
Lymphatic endothelium and Kaposi's sarcoma spindle cells detected by antibodies against the vascular endothelial growth factor receptor-3Q74489252
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
NF-κBQ411114
P304page(s)7179-7185
P577publication date2006-07-01
P1433published inJournal of VirologyQ1251128
P1476titleActivation of NF-kappaB by the latent vFLIP gene of Kaposi's sarcoma-associated herpesvirus is required for the spindle shape of virus-infected endothelial cells and contributes to their proinflammatory phenotype
P478volume80

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