| review article | Q7318358 |
| scholarly article | Q13442814 |
| P50 | author | Graham Dellaire | Q42775155 |
| P2093 | author name string | Dudley Chung | |
| P2860 | cites work | Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway | Q22009414 |
| The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway | Q22065419 | ||
| COP9 signalosome subunit Csn8 is involved in maintaining proper duration of the G1 phase | Q24293399 | ||
| Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis | Q24294864 | ||
| Rad23 ubiquitin-associated domains (UBA) inhibit 26 S proteasome-catalyzed proteolysis by sequestering lysine 48-linked polyubiquitin chains | Q24298011 | ||
| ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex | Q24298863 | ||
| TRIM40 promotes neddylation of IKKγ and is downregulated in gastrointestinal cancers | Q24299200 | ||
| The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage | Q24301297 | ||
| Conservation in the Mechanism of Nedd8 Activation by the Human AppBp1-Uba3 Heterodimer | Q24301571 | ||
| COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3σ | Q24304964 | ||
| The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae | Q24306410 | ||
| ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage | Q24306743 | ||
| The zinc finger of the CSN-associated deubiquitinating enzyme USP15 is essential to rescue the E3 ligase Rbx1 | Q24307443 | ||
| The COP9 complex, a novel multisubunit nuclear regulator involved in light control of a plant developmental switch | Q24309020 | ||
| A new group of conserved coactivators that increase the specificity of AP-1 transcription factors | Q24310680 | ||
| UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair | Q24310704 | ||
| Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair | Q24310767 | ||
| Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex | Q24310859 | ||
| The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks | Q24311761 | ||
| FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity | Q24314409 | ||
| Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation | Q24314520 | ||
| E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification | Q24316067 | ||
| Symmetrical modularity of the COP9 signalosome complex suggests its multifunctionality | Q24316309 | ||
| SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation | Q24317319 | ||
| Dynamic regulation of the COP9 signalosome in response to DNA damage | Q24319983 | ||
| A new NEDD8-ligating system for cullin-4A | Q24321773 | ||
| A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits | Q24322085 | ||
| Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein | Q24322977 | ||
| NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases | Q24337709 | ||
| CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne syndrome | Q24338620 | ||
| COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system | Q24545648 | ||
| Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome | Q24553124 | ||
| The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2 | Q24597101 | ||
| Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex | Q24604459 | ||
| Nedd8 on cullin: building an expressway to protein destruction. | Q33976667 | ||
| The COP9 signalosome: more than a protease | Q34014197 | ||
| Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses | Q34275810 | ||
| Cloning of a cDNA which encodes a novel ubiquitin-like protein. | Q34356906 | ||
| DDB2, the xeroderma pigmentosum group E gene product, is directly ubiquitylated by Cullin 4A-based ubiquitin ligase complex | Q34409053 | ||
| UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex. | Q34417183 | ||
| Understanding nucleotide excision repair and its roles in cancer and ageing. | Q34426055 | ||
| Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics | Q34433677 | ||
| Neddylation promotes ubiquitylation and release of Ku from DNA-damage sites. | Q34474077 | ||
| Nuclear position dictates DNA repair pathway choice | Q34518930 | ||
| Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4-signalosome complex to regulate DNA repair and cell death | Q34526364 | ||
| Control of multicellular development by the physically interacting deneddylases DEN1/DenA and COP9 signalosome | Q34585770 | ||
| Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers | Q34627210 | ||
| SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1) | Q34683293 | ||
| Forty years of research on xeroderma pigmentosum at the US National Institutes of Health. | Q35164298 | ||
| The TFIIH subunit Tfb3 regulates cullin neddylation | Q35266319 | ||
| Potential role of Jun activation domain-binding protein 1 as a negative regulator of p27kip1 in pancreatic adenocarcinoma | Q35607235 | ||
| Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor | Q35653286 | ||
| The COP9 signalosome is vital for timely repair of DNA double-strand breaks | Q35786094 | ||
| Recognition of DNA damage by XPC coincides with disruption of the XPC-RAD23 complex | Q35841757 | ||
| Role of DNA-PK in the cellular response to DNA double-strand breaks | Q35848450 | ||
| p53: traffic cop at the crossroads of DNA repair and recombination | Q36028209 | ||
| A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage | Q36119231 | ||
| CUL4B ubiquitin ligase in mouse development: a model for human X-linked mental retardation syndrome? | Q36137839 | ||
| Regulating the stability and localization of CDK inhibitor p27(Kip1) via CSN6-COP1 axis | Q36183877 | ||
| Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism | Q36216079 | ||
| Nucleotide excision repair | Q36226849 | ||
| Requirement of the MRN complex for ATM activation by DNA damage | Q36267304 | ||
| Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase. | Q36387773 | ||
| Essential roles of Jab1 in cell survival, spontaneous DNA damage and DNA repair | Q36391333 | ||
| gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes | Q36418967 | ||
| The organization of a CSN5-containing subcomplex of the COP9 signalosome | Q36451967 | ||
| HER2-Akt signaling in regulating COP9 signalsome subunit 6 and p53 | Q36472246 | ||
| UV-induced ubiquitination of RNA polymerase II: a novel modification deficient in Cockayne syndrome cells | Q24605185 | ||
| The DNA-damage response in human biology and disease | Q24606586 | ||
| Human CtIP promotes DNA end resection | Q24646062 | ||
| A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein | Q24672229 | ||
| Conservation of the COP9/signalosome in budding yeast | Q24802982 | ||
| DNA repair factor XPC is modified by SUMO-1 and ubiquitin following UV irradiation | Q24813820 | ||
| Nucleotide excision repair in eukaryotes | Q26850656 | ||
| Building and remodelling Cullin-RING E3 ubiquitin ligases | Q27027816 | ||
| The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1 | Q27642844 | ||
| Dcn1 functions as a scaffold-type E3 ligase for cullin neddylation | Q27649565 | ||
| Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ | Q27659474 | ||
| A Dual E3 Mechanism for Rub1 Ligation to Cdc53 | Q27664416 | ||
| Structural Conservation of Distinctive N-terminal Acetylation-Dependent Interactions across a Family of Mammalian NEDD8 Ligation Enzymes | Q27675332 | ||
| Insights into the regulation of the human COP9 signalosome catalytic subunit, CSN5/Jab1 | Q27675751 | ||
| The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation | Q27675805 | ||
| Crystal structure and versatile functional roles of the COP9 signalosome subunit 1 | Q27678871 | ||
| Crystal structure of the human COP9 signalosome | Q27694578 | ||
| The DNA Damage Response: Making It Safe to Play with Knives | Q27861055 | ||
| Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1. | Q27931858 | ||
| Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein | Q27933995 | ||
| A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3. | Q27936509 | ||
| The COP9 signalosome-like complex in S. cerevisiae and links to other PCI complexes | Q27939717 | ||
| A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice | Q28000121 | ||
| Myeloma overexpressed 2 (Myeov2) regulates L11 subnuclear localization through Nedd8 modification | Q28116360 | ||
| Factors determining DNA double-strand break repair pathway choice in G2 phase | Q28118755 | ||
| Function and regulation of cullin-RING ubiquitin ligases | Q28131707 | ||
| Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1 | Q28139243 | ||
| Covalent modification of all members of human cullin family proteins by NEDD8 | Q28140243 | ||
| Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome | Q28187304 | ||
| Identification of a set of genes with developmentally down-regulated expression in the mouse brain | Q28187594 | ||
| ATM phosphorylates histone H2AX in response to DNA double-strand breaks | Q28188651 | ||
| NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins | Q28202321 | ||
| Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1 | Q28203933 | ||
| The UBA2 domain functions as an intrinsic stabilization signal that protects Rad23 from proteasomal degradation. | Q52563832 | ||
| Can hyperthermic intraperitoneal chemotherapy efficiency be improved by blocking the DNA repair factor COP9 signalosome? | Q52877633 | ||
| The ATM-mediated DNA-damage response: taking shape. | Q53618038 | ||
| DENEDDYLASE1 deconjugates NEDD8 from non-cullin protein substrates in Arabidopsis thaliana | Q58001200 | ||
| The COP9 signalosome is a repressor of replicative stress responses and polyploidization in the regenerating liver | Q58882257 | ||
| The COP9/signalosome complex is conserved in fission yeast and has a role in S phase | Q63383722 | ||
| Jun activation domain-binding protein 1 expression in breast cancer inversely correlates with the cell cycle inhibitor p27(Kip1) | Q64377657 | ||
| Expression of p27(Kip1) and c-Jun activation binding protein 1 are inversely correlated in systemic anaplastic large cell lymphoma | Q73112899 | ||
| Electron microscopy and subunit-subunit interaction studies reveal a first architecture of COP9 signalosome | Q74027608 | ||
| Clinical implications of CSN6 protein expression and correlation with mutant-type P53 protein in breast cancer | Q86494027 | ||
| c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type II receptor | Q42827155 | ||
| COP9 signalosome subunits 4 and 5 regulate multiple pleiotropic pathways in Drosophila melanogaster | Q44132450 | ||
| The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis | Q45345755 | ||
| Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinases | Q45345757 | ||
| DEN1 deneddylates non-cullin proteins in vivo. | Q45345762 | ||
| The COP9 signalosome is essential for development of Drosophila melanogaster | Q47070977 | ||
| The COP9 signalosome regulates cell proliferation of Dictyostelium discoideum | Q47200529 | ||
| Arabidopsis eIF3e (INT-6) associates with both eIF3c and the COP9 signalosome subunit CSN7. | Q47822595 | ||
| Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12p | Q47847570 | ||
| Arabidopsis COP9 is a component of a novel signaling complex mediating light control of development | Q48080929 | ||
| Light-induced COP9 signalosome expression in the Indian false vampire bat Megaderma lyra | Q48447524 | ||
| CSN- and CAND1-dependent remodelling of the budding yeast SCF complex. | Q50336194 | ||
| Characterization of two subunits of Arabidopsis 19S proteasome regulatory complex and its possible interaction with the COP9 complex. | Q52180842 | ||
| Characterization and purification of the mammalian COP9 complex, a conserved nuclear regulator initially identified as a repressor of photomorphogenesis in higher plants. | Q52184936 | ||
| Identification and characterization of DEN1, a deneddylase of the ULP family | Q28205400 | ||
| DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1 | Q28205415 | ||
| Radiation-mediated proteolysis of CDT1 by CUL4–ROC1 and CSN complexes constitutes a new checkpoint | Q28212584 | ||
| The DNA damage response: ten years after | Q28261230 | ||
| Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity | Q28270986 | ||
| Cell-cycle checkpoints and cancer | Q28293996 | ||
| CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis | Q28508809 | ||
| Structural and biochemical characterization of the Cop9 signalosome CSN5/CSN6 heterodimer | Q28542494 | ||
| Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death | Q28588169 | ||
| DNA-binding polarity of human replication protein A positions nucleases in nucleotide excision repair | Q28628567 | ||
| MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings | Q29614424 | ||
| Single-strand break repair and genetic disease | Q29615347 | ||
| Base-excision repair of oxidative DNA damage | Q29615373 | ||
| Cisplatin: mode of cytotoxic action and molecular basis of resistance | Q29615385 | ||
| PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways | Q29616041 | ||
| An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer | Q29616732 | ||
| NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cells | Q30429284 | ||
| Cleavage of the C-terminus of NEDD8 by UCH-L3. | Q31990233 | ||
| Differential recruitment of DNA Ligase I and III to DNA repair sites | Q33251083 | ||
| Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination | Q33302634 | ||
| Subunit 3 of the COP9 signalosome is poised to facilitate communication between the extracellular matrix and the nucleus through the muscle-specific beta1D integrin | Q33382154 | ||
| DDB2 complex-mediated ubiquitylation around DNA damage is oppositely regulated by XPC and Ku and contributes to the recruitment of XPA. | Q33549610 | ||
| Nonhomologous end joining: a good solution for bad ends | Q33625010 | ||
| Comparison of human COP9 signalsome and 26S proteasome lid'. | Q33654852 | ||
| Rad23 stabilizes Rad4 from degradation by the Ub/proteasome pathway | Q33754377 | ||
| Regulation of homologous recombination in eukaryotes | Q33966065 | ||
| CSN5 specifically interacts with CDK2 and controls senescence in a cytoplasmic cyclin E-mediated manner | Q36524979 | ||
| Suppression of Jab1/CSN5 induces radio- and chemo-sensitivity in nasopharyngeal carcinoma through changes to the DNA damage and repair pathways | Q36592296 | ||
| RNF111-dependent neddylation activates DNA damage-induced ubiquitination | Q36677932 | ||
| Depletion of ribosomal protein L37 occurs in response to DNA damage and activates p53 through the L11/MDM2 pathway. | Q36736875 | ||
| Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins | Q36850952 | ||
| Beyond repair foci: subnuclear domains and the cellular response to DNA damage | Q36895195 | ||
| RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response | Q36917589 | ||
| Structural basis for a reciprocal regulation between SCF and CSN. | Q36988986 | ||
| Transcription-coupled nucleotide excision repair in mammalian cells: molecular mechanisms and biological effects | Q37048164 | ||
| Jab1 mediates protein degradation of the Rad9-Rad1-Hus1 checkpoint complex | Q37267542 | ||
| The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes | Q37282361 | ||
| An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases | Q37289496 | ||
| Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response | Q37497709 | ||
| Collaboration and competition between DNA double‐strand break repair pathways | Q37638191 | ||
| COP9 signalosome function in the DDR. | Q37867729 | ||
| Reading, writing, and repair: the role of ubiquitin and the ubiquitin-like proteins in DNA damage signaling and repair | Q38095917 | ||
| DNA double-strand break repair in a cellular context | Q38196085 | ||
| The spatial organization of non-homologous end joining: from bridging to end joining | Q38196597 | ||
| DNA-binding and strand-annealing activities of human Mre11: implications for its roles in DNA double-strand break repair pathways | Q38303463 | ||
| SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair. | Q38855830 | ||
| Neddylation inhibits CtIP-mediated resection and regulates DNA double strand break repair pathway choice | Q38922310 | ||
| Arkadia, a novel SUMO-targeted ubiquitin ligase involved in PML degradation | Q39175550 | ||
| Recruitment of RPL11 at promoter sites of p53-regulated genes upon nucleolar stress through NEDD8 and in an Mdm2-dependent manner | Q39256295 | ||
| WEE1 accumulation and deregulation of S-phase proteins mediate MLN4924 potent inhibitory effect on Ewing sarcoma cells | Q39340936 | ||
| Deletion mutants in COP9/signalosome subunits in fission yeast Schizosaccharomyces pombe display distinct phenotypes | Q39357496 | ||
| The COP9 signalosome mediates beta-catenin degradation by deneddylation and blocks adenomatous polyposis coli destruction via USP15. | Q39829611 | ||
| Jab1 is a target of EGFR signaling in ERalpha-negative breast cancer | Q39974866 | ||
| CAND1 controls in vivo dynamics of the cullin 1-RING ubiquitin ligase repertoire | Q40136931 | ||
| Jab1 induces the cytoplasmic localization and degradation of p53 in coordination with Hdm2. | Q40290179 | ||
| ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation | Q40570996 | ||
| HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation | Q40767550 | ||
| Ultraviolet radiation-induced ubiquitination and proteasomal degradation of the large subunit of RNA polymerase II. Implications for transcription-coupled DNA repair | Q41056225 | ||
| Electron microscopy and in vitro deneddylation reveal similar architectures and biochemistry of isolated human and Flag-mouse COP9 signalosome complexes | Q41608034 | ||
| The mitomycin bioreductive antitumor agents: cross-linking and alkylation of DNA as the molecular basis of their activity | Q41735615 | ||
| The csnD/csnE signalosome genes are involved in the Aspergillus nidulans DNA damage response. | Q41954250 | ||
| F-box-directed CRL complex assembly and regulation by the CSN and CAND1 | Q42150408 | ||
| Structural insights into the COP9 signalosome and its common architecture with the 26S proteasome lid and eIF3. | Q42152342 | ||
| CtIP tetramer assembly is required for DNA-end resection and repair | Q42152346 | ||
| RNF168-mediated H2A neddylation antagonizes ubiquitylation of H2A and regulates DNA damage repair | Q42455830 | ||
| SCCRO (DCUN1D1) promotes nuclear translocation and assembly of the neddylation E3 complex | Q42700446 | ||
| P275 | copyright license | Creative Commons Attribution | Q6905323 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 4 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | DNA repair | Q210538 |
| DNA damage | Q5205747 | ||
| enzyme | Q8047 | ||
| protein neddylation | Q21115705 | ||
| macromolecular substance | Q75174158 | ||
| P304 | page(s) | 2388-416 | |
| P577 | publication date | 2015-01-01 | |
| 2015-09-30 | |||
| P1433 | published in | Biomolecules | Q23929963 |
| P1476 | title | The Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and Repair | |
| P478 | volume | 5 |
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| Q58623046 | Identification of highly penetrant Rb-related synthetic lethal interactions in triple negative breast cancer |
| Q91774381 | Inhibition of neddylation induces mitotic defects and alters MKLP1 accumulation at the midbody during cytokinesis |
| Q57289570 | Renal COP9 Signalosome Deficiency Alters CUL3-KLHL3-WNK Signaling Pathway |
| Q39700634 | The Fungus Candida albicans Tolerates Ambiguity at Multiple Codons. |
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