Regulating the stability and localization of CDK inhibitor p27(Kip1) via CSN6-COP1 axis

scientific article

Regulating the stability and localization of CDK inhibitor p27(Kip1) via CSN6-COP1 axis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1080/15384101.2015.1046655
P932PMC publication ID4613181
P698PubMed publication ID25945542
P5875ResearchGate publication ID276071601

P50authorCristina IvanQ56435654
Lekun FangQ56493785
Mong-Hong LeeQ57066188
P2093author name stringHyun Ho Choi
Anil Sood
Keith Baggerly
Liem Phan
Sergei Guma
P2860cites workAssociation of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progressionQ22253912
Nuclear export regulation of COP1 by 14-3-3σ in response to DNA damageQ24299752
COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3σQ24304964
Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signalsQ24314293
A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunitsQ24322085
Mislocalization of p27 to the cytoplasm of breast cancer cells confers resistance to anti-HER2 targeted therapyQ27853119
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27Q28137860
The ubiquitin ligase COP1 is a critical negative regulator of p53Q28258057
ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damageQ28260019
Tumor suppressor ARF inhibits HER-2/neu-mediated oncogenic growthQ28273757
Constitutively active FOXO4 inhibits Akt activity, regulates p27 Kip1 stability, and suppresses HER2-mediated tumorigenicityQ28305487
Contact inhibition and high cell density deactivate the mammalian target of rapamycin pathway, thus suppressing the senescence programQ28972583
Making sense of the COP9 signalosome. A regulatory protein complex conserved from Arabidopsis to humanQ33594290
Antineoplastic effects of an Aurora B kinase inhibitor in breast cancerQ33732173
Effects of obesity on transcriptomic changes and cancer hallmarks in estrogen receptor-positive breast cancerQ33947907
High p27 protein levels in chronic lymphocytic leukemia are associated to low Myc and Skp2 expression, confer resistance to apoptosis and antagonize Myc effects on cell cycleQ34103991
The emerging role of the COP9 signalosome in cancerQ34147948
Negative regulators of cyclin-dependent kinases and their roles in cancersQ34477825
Reduction of cytosolic p27(Kip1) inhibits cancer cell motility, survival, and tumorigenicityQ34495990
CSN6 drives carcinogenesis by positively regulating Myc stability.Q34523341
The molecular classification of multiple myelomaQ34530992
Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancersQ34627210
Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice.Q34761024
Circadian Clock Gene CRY2 Degradation Is Involved in Chemoresistance of Colorectal Cancer.Q35691235
CSN6 deregulation impairs genome integrity in a COP1-dependent pathwayQ35828435
The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogrammingQ35865881
14-3-3sigma exerts tumor-suppressor activity mediated by regulation of COP1 stability.Q35979769
Aurora B kinase phosphorylates and instigates degradation of p53Q36066322
COP1 enhances ubiquitin-mediated degradation of p27Kip1 to promote cancer cell growth.Q36260630
p53 negatively regulates Aurora A via both transcriptional and posttranslational regulationQ36304176
HER2-Akt signaling in regulating COP9 signalsome subunit 6 and p53Q36472246
CDK inhibitor p57 (Kip2) is negatively regulated by COP9 signalosome subunit 6Q36581691
Roles of COP9 signalosome in cancer.Q37923711
Spotlight on the role of COP1 in tumorigenesisQ38016673
From photomorphogenesis to cancer: a CSN journeyQ38566090
COP1 is a tumour suppressor that causes degradation of ETS transcription factorsQ39542337
Roles for CSN5 in control of p53/MDM2 activities.Q40078645
Negative cell cycle regulator 14-3-3sigma stabilizes p27 Kip1 by inhibiting the activity of PKB/Akt.Q40305915
PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrestQ40702262
Correlation of p27 protein expression with HER-2/neu expression in breast cancer.Q40713599
Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27.Q40872982
Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycinQ41412030
Good COP1 or bad COP1? In vivo veritasQ42133928
p27Kip1 represses transcription by direct interaction with p130/E2F4 at the promoters of target genesQ42801936
p27 Kip1 inhibits HER2/neu-mediated cell growth and tumorigenesisQ42827384
P433issue14
P407language of work or nameEnglishQ1860
P1104number of pages9
P304page(s)2265-2273
P577publication date2015-05-06
P1433published inCell CycleQ1254166
P1476titleRegulating the stability and localization of CDK inhibitor p27(Kip1) via CSN6-COP1 axis
P478volume14

Reverse relations

cites work (P2860)
Q36413974COP9 signalosome subunit 6 (CSN6) regulates E6AP/UBE3A in cervical cancer
Q57462865COP9 signalosome subunit 6 mediates PDGF -induced pulmonary arterial smooth muscle cells proliferation
Q52715760COP9 signalosome subunit CSN5, but not CSN6, is upregulated in lung adenocarcinoma and predicts poor prognosis.
Q64921825CSN6 Promotes the Migration and Invasion of Cervical Cancer Cells by Inhibiting Autophagic Degradation of Cathepsin L.
Q36780798CSN6 positively regulates c-Jun in a MEKK1-dependent manner
Q90357681CSN6 promotes tumorigenesis of gastric cancer by ubiquitin-independent proteasomal degradation of p16INK4a
Q89524000CSN6: a promising target for cancer prevention and therapy
Q99234068RFWD2 induces cellular proliferation and selective proteasome inhibitor resistance by mediating P27 ubiquitination in multiple myeloma
Q27309007The DenA/DEN1 Interacting Phosphatase DipA Controls Septa Positioning and Phosphorylation-Dependent Stability of Cytoplasmatic DenA/DEN1 during Fungal Development
Q26782011The Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and Repair

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