The COP9 signalosome: more than a protease

scientific article

The COP9 signalosome: more than a protease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.TIBS.2008.09.004
P698PubMed publication ID18926707
P5875ResearchGate publication ID23390959

P2093author name stringGiovanna Serino
Ning Wei
Xing-Wang Deng
P433issue12
P407language of work or nameEnglishQ1860
P1104number of pages9
P304page(s)592-600
P577publication date2008-10-14
P13046publication type of scholarly workreview articleQ7318358
P1433published inTrends in Biochemical SciencesQ1565711
P1476titleThe COP9 signalosome: more than a protease
P478volume33

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cites work (P2860)
Q9292526314-3-3ζ targeting induced senescence in Hep-2 laryngeal cancer cell through deneddylation of Cullin1 in the Skp1-Cullin-F-box protein complex
Q64063066A Convergent Study of Genetic Variants Associated With Crohn's Disease: Evidence From GWAS, Gene Expression, Methylation, eQTL and TWAS
Q34980308A cDNA microarray, UniShrimpChip, for identification of genes relevant to testicular development in the black tiger shrimp (Penaeus monodon)
Q36506583A complex containing the CPSF73 endonuclease and other polyadenylation factors associates with U7 snRNP and is recruited to histone pre-mRNA for 3'-end processing
Q39532510A cost-benefit analysis of multidimensional fractionation of affinity purification-mass spectrometry samples
Q34170651A novel framework for the comparative analysis of biological networks
Q34441358A systematic genetic screen identifies new factors influencing centromeric heterochromatin integrity in fission yeast
Q34699553A versatile platform for creating a comprehensive UAS-ORFeome library in Drosophila
Q39435071A wheat COP9 subunit 5-like gene is negatively involved in host response to leaf rust.
Q38134781Allosteric conformational barcodes direct signaling in the cell
Q34496715An Arrayed Genome-Scale Lentiviral-Enabled Short Hairpin RNA Screen Identifies Lethal and Rescuer Gene Candidates
Q29147481An organelle-specific protein landscape identifies novel diseases and molecular mechanisms
Q33436063Analysis of the role of COP9 Signalosome (CSN) subunits in K562; the first link between CSN and autophagy
Q34592459Arabidopsis CSN5B interacts with VTC1 and modulates ascorbic acid synthesis
Q21245512Atypical IκB proteins - nuclear modulators of NF-κB signaling
Q36597873Automated gas-phase purification for accurate, multiplexed quantification on a stand-alone ion-trap mass spectrometer
Q36646072Bench-to-bedside review: Immunoglobulin therapy for sepsis - biological plausibility from a critical care perspective
Q38019703Beyond ‘furballs’ and ‘dumpling soups’ – towards a molecular architecture of signaling complexes and networks
Q28384122Bioanalysis of Eukaryotic Organelles
Q36651360Breaking It Down: The Ubiquitin Proteasome System in Neuronal Morphogenesis
Q36756282Breaking down protein degradation mechanisms in cardiac muscle
Q36390433Breaking down the COP9 Signalsome in the heart: how inactivating a protein ubiquitin ligase increases protein ubiquitylation and protects the heart
Q41177523Breaking the silence: protein stabilization uncovers silenced biosynthetic gene clusters in the fungus Aspergillus nidulans.
Q41282832CLIC, a tool for expanding biological pathways based on co-expression across thousands of datasets
Q47676644COP1 regulates plant growth and development in response to light at the post-translational level
Q34388158COP9 signalosome component JAB1/CSN5 is necessary for T cell signaling through LFA-1 and HIV-1 replication
Q36259493COP9 signalosome controls the degradation of cytosolic misfolded proteins and protects against cardiac proteotoxicity
Q50296662COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes
Q50296663COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex
Q37867729COP9 signalosome function in the DDR
Q37454309COP9 signalosome interacts ATP-dependently with p97/valosin-containing protein (VCP) and controls the ubiquitination status of proteins bound to p97/VCP.
Q99603719COP9 signalosome is an essential and druggable parasite target that regulates protein degradation
Q38988785COP9 signalosome regulates autophagosome maturation
Q55456531COP9 signalosome subunit 5A affects phenylpropanoid metabolism, trichome formation and transcription of key genes of a regulatory tri-protein complex in Arabidopsis.
Q39670608COP9 signalosome subunit 8 is required for postnatal hepatocyte survival and effective proliferation.
Q24293399COP9 signalosome subunit Csn8 is involved in maintaining proper duration of the G1 phase
Q48026943COP9 signalosome subunit PfCsnE regulates secondary metabolism and conidial formation in Pestalotiopsis fici
Q42430485COP9-Signalosome deneddylase activity is enhanced by simultaneous neddylation: insights into the regulation of an enzymatic protein complex
Q90392229COPS2 Antagonizes OCT4 to Accelerate the G2/M Transition of Mouse Embryonic Stem Cells
Q38015388CRL Ubiquitin Ligases and DNA Damage Response
Q39538233CSN1 inhibits c-Jun phosphorylation and down-regulates ectopic expression of JNK1
Q37189468CSN5/JAB1 Interacts with the Centromeric Components CENP-T and CENP-W and Regulates Their Proteasome-mediated Degradation
Q28115049CSNAP Is a Stoichiometric Subunit of the COP9 Signalosome
Q92322597CSNAP, the smallest CSN subunit, modulates proteostasis through cullin-RING ubiquitin ligases
Q33428448Changes in the spinal cord proteome of an amyotrophic lateral sclerosis murine model determined by differential in-gel electrophoresis
Q44187495Characterisation of the COP9 signalosome in Schistosoma mansoni parasites
Q35612223Characterization of the role of COP9 signalosome in regulating cullin E3 ubiquitin ligase activity
Q34460462Circadian rhythms. Decoupling circadian clock protein turnover from circadian period determination
Q41612554Connexin40 controls endothelial activation by dampening NFκB activation
Q38819169Constitutive photomorphogenesis protein 1 (COP1) and COP9 signalosome, evolutionarily conserved photomorphogenic proteins as possible targets of melatonin
Q37827465Control of Cullin-Ring Ubiquitin Ligase Activity by Nedd8
Q24647543Control of cell growth by the SCF and APC/C ubiquitin ligases
Q36937710Cops2 promotes pluripotency maintenance by Stabilizing Nanog Protein and Repressing Transcription
Q27694578Crystal structure of the human COP9 signalosome
Q52332768Csn5 Is Required for the Conidiogenesis and Pathogenesis of the Alternaria alternata Tangerine Pathotype
Q31095156Cul4B regulates neural progenitor cell growth
Q34785767Cullin E3 ligases and their rewiring by viral factors
Q47566862Cullin neddylation may allosterically tune polyubiquitin chain length and topology
Q38059746Cullin-RING Ligases as Attractive Anti-cancer Targets
Q26746956Cullin-RING ligases in regulation of autophagy
Q38064532Cullin‐RING Ubiquitin Ligase Family in Plant Abiotic Stress PathwaysF
Q39453442D27E mutation of VTC1 impairs the interaction with CSN5B and enhances ascorbic acid biosynthesis and seedling growth in Arabidopsis
Q58001200DENEDDYLASE1 deconjugates NEDD8 from non-cullin protein substrates in Arabidopsis thaliana
Q36216079Deconjugation of Nedd8 from Cul1 Is Directly Regulated by Skp1-F-box and Substrate, and the COP9 Signalosome Inhibits Deneddylated SCF by a Noncatalytic Mechanism
Q37873069Detecting UV-lesions in the genome: The modular CRL4 ubiquitin ligase does it best!
Q38533869Diversity of COP9 signalosome structures and functional consequences
Q38816822Down-regulation of the cyclin-dependent kinase inhibitor p57 is mediated by Jab1/Csn5 in hepatocarcinogenesis
Q27937368Dual function of Rpn5 in two PCI complexes, the 26S proteasome and COP9 signalosome.
Q51805240Dynamic analysis of epidermal cell divisions identifies specific roles for COP10 in Arabidopsis stomatal lineage development.
Q24319983Dynamic regulation of the COP9 signalosome in response to DNA damage
Q37636445Effect of Aluminum Treatment on Proteomes of Radicles of Seeds Derived from Al-Treated Tomato Plants
Q43239980Effect of overexpression of Arabidopsis damaged DNA-binding protein 1A on de-etiolated 1.
Q41844955Effector candidates in the secretome of Piriformospora indica, a ubiquitous plant-associated fungus.
Q37683027Emerging roles of Jab1/CSN5 in DNA damage response, DNA repair, and cancer.
Q41627370Emerging roles of the single EF-hand Ca2+ sensor tescalcin in the regulation of gene expression, cell growth and differentiation.
Q40525719Epigenetic regulation of WNT signaling in chronic lymphocytic leukemia.
Q85848761Exposing the subunit diversity within protein complexes: a mass spectrometry approach
Q34281731Expression profile of the Schistosoma japonicum degradome reveals differential protease expression patterns and potential anti-schistosomal intervention targets
Q44015001Formation of alternative proteasomes: same lady, different cap?
Q38566090From photomorphogenesis to cancer: a CSN journey
Q31032769Function of COP9 Signalosome in Regulation of Mouse Oocytes Meiosis by Regulating MPF Activity and Securing Degradation
Q53313579Functional characterization of the tomato cyclin-dependent kinase inhibitor SlKRP1 domains involved in protein-protein interactions
Q44004792Geminiviruses subvert ubiquitination by altering CSN-mediated derubylation of SCF E3 ligase complexes and inhibit jasmonate signaling in Arabidopsis thaliana.
Q36176252Gene Expression Dynamics Accompanying the Sponge Thermal Stress Response.
Q42122571Genetic Interactions of Arabidopsis thaliana Damaged DNA Binding Protein 1B (DDB1B) With DDB1A, DET1, and COP1
Q37844343Genetic dissection of chloroplast biogenesis and development: an overview
Q34975601Genetically Encodable Fluorescent Biosensors for Tracking Signaling Dynamics in Living Cells
Q34803110Gfer inhibits Jab1-mediated degradation of p27kip1to restrict proliferation of hematopoietic stem cells
Q91650778Global gene expression analysis in etiolated and de-etiolated seedlings in conifers
Q34809043Hepatic deficiency of COP9 signalosome subunit 8 induces ubiquitin-proteasome system impairment and Bim-mediated apoptosis in murine livers.
Q46340985Herbaspirillum rubrisubalbicans, a mild pathogen impairs growth of rice by augmenting ethylene levels.
Q34350965Histone H2B monoubiquitination facilitates the rapid modulation of gene expression during Arabidopsis photomorphogenesis
Q35902773Histone H4 acetylation required for chromatin decompaction during DNA replication
Q39905088How far can we go with structural mass spectrometry of protein complexes?
Q45306753Huntingtin with an expanded polyglutamine repeat affects the Jab1-p27(Kip1) pathway
Q64100818Identification of COP9 Signalosome Subunit Genes in s and Functional Analysis of in Female Fecundity
Q34485267Identification of Genes Required for Alternative Oxidase Production in the Neurospora crassa Gene Knockout Library
Q36560473Identification of factors that function in Drosophila salivary gland cell death during development using proteomics.
Q50488789Immunodepletion and Immunopurification as Approaches for CSN Research
Q37168605In the land of the rising sun with the COP9 signalosome and related Zomes. Symposium on the COP9 signalosome, Proteasome and eIF3
Q36020841Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline
Q37252729Inhibition of CUL4A Neddylation causes a reversible block to SAMHD1-mediated restriction of HIV-1
Q37737112Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo.
Q91774381Inhibition of neddylation induces mitotic defects and alters MKLP1 accumulation at the midbody during cytokinesis
Q34526364Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4-signalosome complex to regulate DNA repair and cell death
Q27675751Insights into the regulation of the human COP9 signalosome catalytic subunit, CSN5/Jab1
Q41110823Integration of the catalytic subunit activates deneddylase activity in vivo as final step in fungal COP9 signalosome assembly
Q28115758Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy
Q55690843Interaction between parasite-encoded JAB1/CSN5 and macrophage migration inhibitory factor proteins attenuates its proinflammatory function.
Q35479405Interaction of Arabidopsis DET1 with CCA1 and LHY in mediating transcriptional repression in the plant circadian clock.
Q54324604JAB1 Is Essential for B Cell Development and Germinal Center Formation and Inversely Regulates Fas Ligand and Bcl6 Expression
Q34292695JAB1/CSN5: a new player in cell cycle control and cancer
Q52657204Jab1/COPS5 as a Novel Biomarker for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Human Cancer
Q39470047Jab1/CSN5 mediates E2F dependent expression of mitotic and apoptotic but not DNA replication targets
Q41817100Jun activation domain-binding protein 1 (JAB1) is required for the optimal response to interferons.
Q34147546Loss of jab1 in osteochondral progenitor cells severely impairs embryonic limb development in mice
Q38201971Lysine-targeting specificity in ubiquitin and ubiquitin-like modification pathways.
Q44490549MIDGET connects COP1-dependent development with endoreduplication in Arabidopsis thaliana
Q26823231Manipulation of fungal development as source of novel secondary metabolites for biotechnology
Q37983242Many jobs for one good cop – The COP9 signalosome guards development and defense
Q36163496Mapping the protein interaction network of the human COP9 signalosome complex using a label-free QTAX strategy
Q35177578Meiotic nuclear movements in fission yeast are regulated by the transcription factor Mei4 downstream of a Cds1-dependent replication checkpoint pathway
Q89576595Meloidogyne incognita PASSE-MURAILLE (MiPM) Gene Encodes a Cell-Penetrating Protein That Interacts With the CSN5 Subunit of the COP9 Signalosome
Q30502702Molecular targeting of CSN5 in human hepatocellular carcinoma: a mechanism of therapeutic response
Q37680800Molecules that modulate Apaf-1 activity
Q38268491Moonlighting and pleiotropy within two regulators of the degradation machinery: the proteasome lid and the CSN.
Q26739932Multiple Roles of the Small GTPase Rab7
Q38598847Murine Myocardial Transcriptome Analysis Reveals a Critical Role of COPS8 in the Gene Expression of Cullin-RING Ligase Substrate Receptors and Redox and Vesicle Trafficking Pathways
Q34102961Mycobacterium tuberculosis alters the metalloprotease activity of the COP9 signalosome
Q28116360Myeloma Overexpressed 2 (Myeov2) Regulates L11 Subnuclear Localization through Nedd8 Modification
Q45317714Neddylation
Q34987403Neddylation and deneddylation in cardiac biology
Q34288710Neddylation dysfunction in Alzheimer's disease
Q34656362New components of Drosophila leg development identified through genome wide association studies
Q40037571Nitric Oxide, Ethylene, and Auxin Cross Talk Mediates Greening and Plastid Development in Deetiolating Tomato Seedlings
Q34681633Novel mechanism by which histone deacetylase inhibitors facilitate topoisomerase IIα degradation in hepatocellular carcinoma cells
Q41668145Overexpression of COP9 signalosome subunits, CSN7A and CSN7B, exerts different effects on adipogenic differentiation
Q37630908Oxidized LDL-induced JAB1 influences NF-κB independent inflammatory signaling in human macrophages during foam cell formation
Q33743600PEA15 regulates the DNA damage-induced cell cycle checkpoint and oncogene-directed transformation
Q30846922PSEA-Quant: a protein set enrichment analysis on label-free and label-based protein quantification data
Q34313430Paradoxical Instability–Activity Relationship Defines a Novel Regulatory Pathway for Retinoblastoma Proteins
Q34474447Perturbation of cullin deneddylation via conditional Csn8 ablation impairs the ubiquitin-proteasome system and causes cardiomyocyte necrosis and dilated cardiomyopathy in mice.
Q39737412Physical interaction of Jab1 with human serotonin 6 G-protein-coupled receptor and their possible roles in cell survival
Q35348599Plant ubiquitin-proteasome pathway and its role in gibberellin signaling
Q59797449Proteasome lid bridges mitochondrial stress with Cdc53/Cullin1 NEDDylation status
Q33570167Proteasome regulation, plant growth and stress tolerance
Q36431922Proteome-Wide Effect of 17-β-Estradiol and Lipoxin A4 in an Endometriotic Epithelial Cell Line
Q34049926Proteomic analysis of nuclei isolated from cancer cell lines treated with indenoisoquinoline NSC 724998, a novel topoisomerase I inhibitor
Q40173963RNAi Screen and Proteomics Reveal NXF1 as a Novel Regulator of IRF5 Signaling
Q33801141Rational association of genes with traits using a genome-scale gene network for Arabidopsis thaliana
Q41226375Rbf1 degron dysfunction enhances cellular DNA replication
Q34876039Recruitment of the Host Plant Heat Shock Protein 70 by Tomato Yellow Leaf Curl Virus Coat Protein Is Required for Virus Infection
Q37538298Regulation of ascorbic acid synthesis in plants
Q28119045Regulation of autophagy by the Rab GTPase network
Q38120938Regulation of proteolysis by human deubiquitinating enzymes
Q27026139Reproductive competence: a recurrent logic module in eukaryotic development
Q34967074Revisiting the COP9 signalosome as a transcriptional regulator
Q91986481Rice black-streaked dwarf virus-encoded P5-1 regulates the ubiquitination activity of SCF E3 ligases and inhibits jasmonate signaling to benefit its infection in rice
Q39193390Rig-G negatively regulates SCF-E3 ligase activities by disrupting the assembly of COP9 signalosome complex
Q43424639Role of CSN5/JAB1 in Wnt/β‐catenin activation in colorectal cancer cells
Q36998296Role of MIF/CD74 signaling pathway in the development of pleural mesothelioma
Q53213546Role of p97/Valosin-containing protein (VCP) and Jab1/CSN5 in testicular ischaemia-reperfusion injury.
Q92724115Role of the COP9 Signalosome (CSN) in Cardiovascular Diseases
Q38267996SCF ubiquitin ligase-targeted therapies.
Q35558119Stat3 and CCAAT/enhancer binding protein beta (C/EBP-beta) regulate Jab1/CSN5 expression in mammary carcinoma cells
Q36009215Steroid receptor coactivator 3 regulates autophagy in breast cancer cells through macrophage migration inhibitory factor
Q28727730Stomatal development: a plant's perspective on cell polarity, cell fate transitions and intercellular communication
Q38154539Strategies for mining fungal natural products
Q27671597Structural and functional characterization of Rpn12 identifies residues required for Rpn10 proteasome incorporation
Q89601765Structural dynamics of the human COP9 signalosome revealed by cross-linking mass spectrometry and integrative modeling
Q34575899Substrate Phosphorylation and Feedback Regulation in JFK-promoted p53 Destabilization
Q52649730Suppression of Jab1 expression inhibits proliferation and promotes apoptosis of AMC-HN-8 cells
Q64234612TCTP and CSN4 control cell cycle progression and development by regulating CULLIN1 neddylation in plants and animals
Q36489467THE COP9 SIGNALOSOME, A NOVEL, ESSENTIAL REGULATOR OF SKELETAL DEVELOPMENT AND TUMORIGENESIS.
Q34563129Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy
Q50422504The COP9 Signalosome regulates seed germination by facilitating protein degradation of RGL2 and ABI5.
Q35659448The COP9 signalosome and cullin-RING ligases in the heart
Q42018353The COP9 signalosome controls jasmonic acid synthesis and plant responses to herbivory and pathogens
Q28544912The COP9 signalosome converts temporal hormone signaling to spatial restriction on neural competence
Q27931851The COP9 signalosome is involved in the regulation of lipid metabolism and of transition metals uptake in Saccharomyces cerevisiae.
Q37329092The COP9 signalosome is required for autophagy, proteasome-mediated proteolysis, and cardiomyocyte survival in adult mice.
Q41877791The COP9 signalosome, cullin 3 and Keap1 supercomplex regulates CHOP stability and adipogenesis
Q50800615The COP9 signalosome: its regulation of cullin-based E3 ubiquitin ligases and role in photomorphogenesis
Q30368429The CSN/COP9 signalosome regulates synaptonemal complex assembly during meiotic prophase I of Caenorhabditis elegans.
Q60921003The CSN3 subunit of the COP9 signalosome interacts with the HD region of Sos1 regulating stability of this GEF protein
Q37849305The Cullin-RING Ubiquitin-Protein Ligases
Q27309007The DenA/DEN1 Interacting Phosphatase DipA Controls Septa Positioning and Phosphorylation-Dependent Stability of Cytoplasmatic DenA/DEN1 during Fungal Development
Q36798907The GAIT system: a gatekeeper of inflammatory gene expression.
Q34202686The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy
Q84872905The Photomorphogenic Protein, DE-ETIOLATED 1, Is a Critical Transcriptional Corepressor in the Central Loop of the Arabidopsis Circadian Clock
Q93127517The Proteasome Lid Triggers COP9 Signalosome Activity during the Transition of Saccharomyces cerevisiae Cells into Quiescence
Q37728992The Regulations of Deubiquitinase USP15 and Its Pathophysiological Mechanisms in Diseases
Q36656176The Role of F-Box Proteins during Viral Infection
Q26782011The Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and Repair
Q94538452The crucial p53-dependent oncogenic role of JAB1 in osteosarcoma in vivo
Q38615247The devil is in the details: comparison between COP9 signalosome (CSN) and the LID of the 26S proteasome
Q38842175The emerging roles of Jab1/CSN5 in cancer
Q39717057The human COP9 signalosome protects ubiquitin-conjugating enzyme 3 (UBC3/Cdc34) from beta-transducin repeat-containing protein (betaTrCP)-mediated degradation
Q91374425The involvement of post-translational modifications in cardiovascular pathologies: Focus on SUMOylation, neddylation, succinylation, and prenylation
Q28751580The making of a chloroplast
Q31089679The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain
Q36451967The organization of a CSN5-containing subcomplex of the COP9 signalosome
Q38019271The photomorphogenic repressors COP1 and DET1: 20 years later
Q37714303The regulatory crosstalk between kinases and proteases in cancer
Q36702566The transcriptional co-regulator Jab1 is crucial for chondrocyte differentiation in vivo
Q35533889The translation initiation complex eIF3 in trypanosomatids and other pathogenic excavates--identification of conserved and divergent features based on orthologue analysis
Q37188181The ubiquitin conjugating enzyme, UbcM2, engages in novel interactions with components of cullin-3 based E3 ligases
Q33554497The ubiquitin-proteasome system in cardiac proteinopathy: a quality control perspective
Q37735375The ubiquitin-proteasome system regulates plant hormone signaling
Q37818721The value of Arabidopsis research in understanding human disease states
Q52646095Tidal and diel orchestration of behaviour and gene expression in an intertidal mollusc.
Q39211167Transcriptional networks controlling the cell cycle.
Q37349886Transcriptome analysis of cortical tissue reveals shared sets of downregulated genes in autism and schizophrenia
Q53792877UV-dependent phosphorylation of COP9/signalosome in UV-induced apoptosis.
Q47104172Ubiquitin Specific Peptidase 15 (USP15) suppresses glioblastoma cell growth via stabilization of HECTD1 E3 ligase attenuating WNT pathway activity.
Q89768702Ubiquitin and ubiquitin-like molecules in DNA double strand break repair
Q41991165Ubiquitin ligase switch in plant photomorphogenesis: A hypothesis
Q37264197What a difference a Dalton makes: bacterial virulence factors modulate eukaryotic host cell signaling systems via deamidation
Q28578733X-Linked Mental Retardation Gene CUL4B Targets Ubiquitylation of H3K4 Methyltransferase Component WDR5 and Regulates Neuronal Gene Expression
Q34985454p53 mediates cigarette smoke-induced apoptosis of pulmonary endothelial cells: inhibitory effects of macrophage migration inhibitor factor

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