Strategies for mining fungal natural products

scientific article published on 22 October 2013

Strategies for mining fungal natural products is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S10295-013-1366-3
P698PubMed publication ID24146366
P5875ResearchGate publication ID258065578

P50authorPhilipp WiemannQ40370771
P2093author name stringNancy P Keller
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The Aspergillus nidulans npeA locus consists of three contiguous genes required for penicillin biosynthesisQ41201189
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A fungal ketoreductase domain that displays substrate-dependent stereospecificityQ41765701
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Distinct amino acids of histone H3 control secondary metabolism in Aspergillus nidulansQ42106844
Sumoylation of the yeast Gcn5 protein.Q42164197
Biosynthesis of fusarubins accounts for pigmentation of Fusarium fujikuroi peritheciaQ42188930
Overexpression of the Aspergillus nidulans histone 4 acetyltransferase EsaA increases activation of secondary metabolite productionQ42389163
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HdaA, a class 2 histone deacetylase of Aspergillus fumigatus, affects germination and secondary metabolite production.Q42574442
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The cluster of penicillin biosynthetic genes. Identification and characterization of the pcbAB gene encoding the alpha-aminoadipyl-cysteinyl-valine synthetase and linkage to the pcbC and penDE genesQ42630634
Discovery of cryptic polyketide metabolites from dermatophytes using heterologous expression in Aspergillus nidulansQ42670448
Increased penicillin production in Penicillium chrysogenum production strains via balanced overexpression of isopenicillin N acyltransferaseQ42688830
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Aspernidine A and B, prenylated isoindolinone alkaloids from the model fungus Aspergillus nidulansQ42957172
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First heterologous reconstruction of a complete functional fungal biosynthetic multigene cluster.Q43006806
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A gene cluster containing two fungal polyketide synthases encodes the biosynthetic pathway for a polyketide, asperfuranone, in Aspergillus nidulansQ37395784
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Discovery and characterization of a group of fungal polycyclic polyketide prenyltransferases.Q37522818
Diversity, regulation, and evolution of the gibberellin biosynthetic pathway in fungi compared to plants and bacteriaQ37533370
Aspects on evolution of fungal beta-lactam biosynthesis gene clusters and recruitment of trans-acting factors.Q37623163
Epigenome manipulation as a pathway to new natural product scaffolds and their congenersQ37660083
Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulansQ37716071
FtmOx1, a non-heme Fe(II) and alpha-ketoglutarate-dependent dioxygenase, catalyses the endoperoxide formation of verruculogen in Aspergillus fumigatusQ43274945
Sphingoid base levels in humans consuming fumonisin-contaminated maize in rural areas of the former Transkei, South Africa: a cross-sectional study.Q43292126
Continuous cultivations of a Penicillium chrysogenum strain expressing the expandase gene from Streptomyces clavuligerus: Kinetics of adipoyl-7-aminodeacetoxycephalosporanic acid and byproduct formationsQ43941532
A dedicated glutathione S-transferase mediates carbon-sulfur bond formation in gliotoxin biosynthesisQ44053648
Differential expression of silent polyketide biosynthesis gene clusters in chemostat cultures of Aspergillus nidulansQ44143600
Multifactorial induction of an orphan PKS-NRPS gene cluster in Aspergillus terreusQ44392953
Lae1 regulates expression of multiple secondary metabolite gene clusters in Fusarium verticillioidesQ44456472
Fragmentation of an aflatoxin-like gene cluster in a forest pathogenQ44480385
Strain improvement by overexpression of the laeA gene in Monascus pilosus for the production of monascus-fermented riceQ45094661
Improved tryprostatin B production by heterologous gene expression in Aspergillus nidulansQ46047362
Evidence for two catalytically independent clusters of active sites in a functional modular polyketide synthaseQ46114155
A chemical epigenetics approach for engineering the in situ biosynthesis of a cryptic natural product from Aspergillus niger.Q46155513
Discovery of a novel superfamily of type III polyketide synthases in Aspergillus oryzaeQ46449797
The CTB1 gene encoding a fungal polyketide synthase is required for cercosporin biosynthesis and fungal virulence of Cercospora nicotianaeQ46509263
VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolismQ46537897
Overproduction, purification and characterization of FtmPT1, a brevianamide F prenyltransferase from Aspergillus fumigatusQ46586773
Sequence-specific binding by Aspergillus nidulans AflR, a C6 zinc cluster protein regulating mycotoxin biosynthesisQ47782454
Identification and characterization of Penicillium citrinum VeA and LaeA as global regulators for ML-236B productionQ48053462
Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.Q48080782
Discovery of aspoquinolones A-D, prenylated quinoline-2-one alkaloids from Aspergillus nidulans, motivated by genome miningQ48428193
Production of novel fusarielins by ectopic activation of the polyketide synthase 9 cluster in Fusarium graminearum.Q50518783
The biosynthetic pathway for aurofusarin in Fusarium graminearum reveals a close link between the naphthoquinones and naphthopyrones.Q51723456
Two Polyketide Synthase-Encoding Genes Are Required for Biosynthesis of the Polyketide Virulence Factor, T-toxin, byCochliobolus heterostrophusQ57992861
Modulation of Polyketide Synthase Activity by Accessory Proteins During Lovastatin BiosynthesisQ60480995
Bacterium induces cryptic meroterpenoid pathway in the pathogenic fungus Aspergillus fumigatusQ61582713
Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungiQ61582718
FtmPT2, an N-prenyltransferase from Aspergillus fumigatus, catalyses the last step in the biosynthesis of fumitremorgin BQ61588333
Identification of a hybrid PKS/NRPS required for pseurotin A biosynthesis in the human pathogen Aspergillus fumigatusQ61589462
Bacterium Induces Cryptic Meroterpenoid Pathway in the Pathogenic FungusAspergillus fumigatusQ61774164
Fusion PCR and gene targeting in Aspergillus nidulansQ62658531
Genomic mining for Aspergillus natural productsQ62658783
Accurate prediction of the Aspergillus nidulans terrequinone gene cluster boundaries using the transcriptional regulator LaeAQ62668613
Penicillin biosynthesis in Aspergillus oryzae and its overproduction by genetic engineeringQ62765879
Epigenetic remodeling of the fungal secondary metabolomeQ63350474
Cloning and heterologous expression of the penicillin biosynthetic gene cluster from penicillum chrysogenumQ67529095
Azaspirene: a novel angiogenesis inhibitor containing a 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione skeleton produced by the fungus Neosartorya spQ74618878
Unprecedented mechanism of chain length determination in fungal aromatic polyketide synthasesQ80482860
Rapid cloning and expression of a fungal polyketide synthase gene involved in squalestatin biosynthesisQ80873937
Cytotoxicity, metabolism and cellular uptake of the mycotoxin deoxynivalenol in human proximal tubule cells and lung fibroblasts in primary cultureQ81159645
Neurosporaxanthin production by Neurospora and FusariumQ84404357
Regulatory cross talk and microbial induction of fungal secondary metabolite gene clustersQ85239104
Tools for manipulation of secondary metabolism pathways: rapid promoter replacements and gene deletions in Aspergillus nidulansQ87443316
Reconstitution of a secondary metabolite biosynthetic pathway in a heterologous fungal hostQ87443319
FfVel1 and FfLae1, components of a velvet-like complex in Fusarium fujikuroi, affect differentiation, secondary metabolism and virulenceQ34341591
Comparative amino acid sequence analysis of the C6 zinc cluster family of transcriptional regulators.Q34411110
GIP2, a putative transcription factor that regulates the aurofusarin biosynthetic gene cluster in Gibberella zeaeQ34431368
Cyclosporin A, a Peptide Metabolite from Trichoderma polysporum (Link ex Pers.) Rifai, with a remarkable immunosuppressive activityQ34460513
The fumitremorgin gene cluster of Aspergillus fumigatus: identification of a gene encoding brevianamide F synthetaseQ34535018
Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogensQ34565854
Recombination-mediated PCR-directed plasmid construction in vivo in yeastQ34624355
Accurate prediction of secondary metabolite gene clusters in filamentous fungiQ34646585
Genomic basis for natural product biosynthetic diversity in the actinomycetesQ34711979
Phylogenomic analysis of type I polyketide synthase genes in pathogenic and saprobic ascomycetes.Q34790450
Synthesis and assembly of fungal melaninQ35054788
Genome-based deletion analysis reveals the prenyl xanthone biosynthesis pathway in Aspergillus nidulansQ35057853
DNA assembler: a synthetic biology tool for characterizing and engineering natural product gene clustersQ35064599
Identification of cryptic products of the gliotoxin gene cluster using NMR-based comparative metabolomics and a model for gliotoxin biosynthesisQ35150476
Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylationQ35180919
Linkage among genes responsible for fumonisin biosynthesis in Gibberella fujikuroi mating population A.Q35192164
The genome portal of the Department of Energy Joint Genome InstituteQ35630989
The Fusarium verticillioides FUM gene cluster encodes a Zn(II)2Cys6 protein that affects FUM gene expression and fumonisin productionQ35947094
Engineering of an "unnatural" natural product by swapping polyketide synthase domains in Aspergillus nidulansQ35954467
Two separate gene clusters encode the biosynthetic pathway for the meroterpenoids austinol and dehydroaustinol in Aspergillus nidulans.Q35954478
Illuminating the diversity of aromatic polyketide synthases in Aspergillus nidulansQ35977059
Genome-based cluster deletion reveals an endocrocin biosynthetic pathway in Aspergillus fumigatusQ36018002
Molecular characterization of aflR, a regulatory locus for aflatoxin biosynthesisQ36056775
Characterization of a silent azaphilone gene cluster from Aspergillus niger ATCC 1015 reveals a hydroxylation-mediated pyran-ring formationQ36192706
Advances in cloning, functional analysis and heterologous expression of fungal polyketide synthase genesQ36485111
Functional analyses of Trichoderma reesei LAE1 reveal conserved and contrasting roles of this regulatorQ36589008
A Zn(II)2Cys6 DNA binding protein regulates the sirodesmin PL biosynthetic gene cluster in Leptosphaeria maculansQ36683779
A genetic and molecular toolbox for analyzing histone ubiquitylation and sumoylation in yeast.Q36723292
Evidence for a gene cluster involving trichothecene-pathway biosynthetic genes in Fusarium sporotrichioidesQ36757116
Gene cluster involved in melanin biosynthesis of the filamentous fungus Alternaria alternataQ36771790
Natural products of filamentous fungi: enzymes, genes, and their regulationQ36772397
Partial reconstruction of the ergot alkaloid pathway by heterologous gene expression in Aspergillus nidulansQ36807205
Molecular genetic mining of the Aspergillus secondary metabolome: discovery of the emericellamide biosynthetic pathwayQ36807325
The fumagillin biosynthetic gene cluster in Aspergillus fumigatus encodes a cryptic terpene cyclase involved in the formation of β-trans-bergamoteneQ36840486
P433issue2
P921main subjectnatural productQ901227
P304page(s)301-313
P577publication date2013-10-22
P1433published inJournal of Industrial Microbiology & BiotechnologyQ1709847
P1476titleStrategies for mining fungal natural products
P478volume41

Reverse relations

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