The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain

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The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain is …
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scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...743980P
P356DOI10.1371/JOURNAL.PONE.0043980
P932PMC publication ID3431379
P698PubMed publication ID22956996
P5875ResearchGate publication ID230812175

P50authorTomohiko TsugeQ56679015
Yehonatan SharabyQ57029153
P2093author name stringKay Hofmann
Ning Wei
Elah Pick
Amnon Golan
Liquan Guo
Jacob Z Zimbler
P2860cites workJAMM: a metalloprotease-like zinc site in the proteasome and signalosomeQ21092836
Functional organization of the yeast proteome by systematic analysis of protein complexesQ24292209
The subunit CSN6 of the COP9 signalosome is cleaved during apoptosisQ24299081
The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damageQ24301297
COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3σQ24304964
The zinc finger of the CSN-associated deubiquitinating enzyme USP15 is essential to rescue the E3 ligase Rbx1Q24307443
The crystal structure of the human Mov34 MPN domain reveals a metal-free dimerQ24309182
K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1Q24310641
The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activationQ24310748
Symmetrical modularity of the COP9 signalosome complex suggests its multifunctionalityQ24316309
NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint controlQ24317325
CandidaDB: a multi-genome database for Candida species and related SaccharomycotinaQ24649825
Conservation of the COP9/signalosome in budding yeastQ24802982
Prediction of a common structural scaffold for proteasome lid, COP9-signalosome and eIF3 complexesQ24811581
The COP9 signalosome inhibits p27(kip1) degradation and impedes G1-S phase progression via deneddylation of SCF Cul1.Q40736705
Mammalian DET1 regulates Cul4A activity and forms stable complexes with E2 ubiquitin-conjugating enzymes.Q41990818
ZOMES III: the interface between signalling and proteolysis. Meeting on The COP9 Signalosome, Proteasome and eIF3.Q43119146
The COP9 SignalosomeQ51111655
COP9 signalosome subunit 8 is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence.Q53524553
Life Is Degrading—Thanks to Some ZomesQ58021666
Role of the MPN subunits in COP9 signalosome assembly and activity, and their regulatory interaction with Arabidopsis Cullin3-based E3 ligasesQ79793647
The Arabidopsis COP9 Signalosome Subunit 7 Is a Model PCI Domain Protein with Subdomains Involved in COP9 Signalosome AssemblyQ27652505
The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activationQ27675805
The crystal structure of the MPN domain from the COP9 signalosome subunit CSN6Q27679008
COP9 signalosome components play a role in the mating pheromone response of S. cerevisiae.Q27931782
Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1.Q27931858
Subunit interaction maps for the regulatory particle of the 26S proteasome and the COP9 signalosome.Q27931947
A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicingQ27932638
Dual function of Rpn5 in two PCI complexes, the 26S proteasome and COP9 signalosome.Q27937368
The COP9 signalosome-like complex in S. cerevisiae and links to other PCI complexesQ27939717
The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domainQ28140082
Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosomeQ28187304
Complete subunit architecture of the proteasome regulatory particleQ28257212
The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complexQ28279874
Downregulation of COP9 signalosome subunits differentially affects the CSN complex and target protein stabilityQ33311403
Role of individual subunits of the Neurospora crassa CSN complex in regulation of deneddylation and stability of cullin proteinsQ33769567
The minimal proteome in the reduced mitochondrion of the parasitic protist Giardia intestinalisQ33842273
The COP9 signalosome: more than a proteaseQ34014197
Transactivation of Schizosaccharomyces pombe cdt2+ stimulates a Pcu4-Ddb1-CSN ubiquitin ligaseQ34133608
Differential regulation of JAMM domain deubiquitinating enzyme activity within the RAP80 complexQ34155439
Identification of noncoding transcripts from within CENP-A chromatin at fission yeast centromeres.Q34181375
Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8pQ34486872
eIF3: a versatile scaffold for translation initiation complexesQ34558903
Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancersQ34627210
Identification and characterization of the mitochondrial RNA polymerase and transcription factor in the fission yeast Schizosaccharomyces pombeQ35088048
Stealing the spotlight: CUL4-DDB1 ubiquitin ligase docks WD40-repeat proteins to destroyQ35651812
The COP9 signalosome negatively regulates proteasome proteolytic function and is essential to transcription.Q37066433
Regulation of cullin RING ligasesQ37150345
In the land of the rising sun with the COP9 signalosome and related Zomes. Symposium on the COP9 signalosome, Proteasome and eIF3Q37168605
PCI complexes: Beyond the proteasome, CSN, and eIF3 Troika.Q37580456
The COP9 signalosome and its role in plant developmentQ37662889
Fungal development and the COP9 signalosome.Q37799161
Centrosomal Chk2 in DNA damage responses and cell cycle progressionQ39676551
Cop9/signalosome subunits and Pcu4 regulate ribonucleotide reductase by both checkpoint-dependent and -independent mechanismsQ39895340
The COP9 signalosome-mediated deneddylation is stimulated by caspases during apoptosisQ40039393
Purification of the COP9 signalosome from porcine spleen, human cell lines, and Arabidopsis thaliana plants.Q40353550
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)e43980
P577publication date2012-08-30
P1433published inPLOS OneQ564954
P1476titleThe minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain
P478volume7

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cites work (P2860)
Q52715760COP9 signalosome subunit CSN5, but not CSN6, is upregulated in lung adenocarcinoma and predicts poor prognosis.
Q24293399COP9 signalosome subunit Csn8 is involved in maintaining proper duration of the G1 phase
Q98939377CSN6 aggravates Ang II-induced cardiomyocyte hypertrophy via inhibiting SIRT2
Q27694578Crystal structure of the human COP9 signalosome
Q38533869Diversity of COP9 signalosome structures and functional consequences
Q24319983Dynamic regulation of the COP9 signalosome in response to DNA damage
Q50488789Immunodepletion and Immunopurification as Approaches for CSN Research.
Q41110823Integration of the catalytic subunit activates deneddylase activity in vivo as final step in fungal COP9 signalosome assembly
Q59797449Proteasome lid bridges mitochondrial stress with Cdc53/Cullin1 NEDDylation status
Q28542494Structural and biochemical characterization of the Cop9 signalosome CSN5/CSN6 heterodimer
Q27931851The COP9 signalosome is involved in the regulation of lipid metabolism and of transition metals uptake in Saccharomyces cerevisiae.
Q34245895The COP9 signalosome subunit 6 (CSN6): a potential oncogene
Q30368429The CSN/COP9 signalosome regulates synaptonemal complex assembly during meiotic prophase I of Caenorhabditis elegans.
Q27309007The DenA/DEN1 Interacting Phosphatase DipA Controls Septa Positioning and Phosphorylation-Dependent Stability of Cytoplasmatic DenA/DEN1 during Fungal Development
Q28603054The Evolution of COP9 Signalosome in Unicellular and Multicellular Organisms
Q93127517The Proteasome Lid Triggers COP9 Signalosome Activity during the Transition of Saccharomyces cerevisiae Cells into Quiescence
Q38615247The devil is in the details: comparison between COP9 signalosome (CSN) and the LID of the 26S proteasome
Q36451967The organization of a CSN5-containing subcomplex of the COP9 signalosome
Q35974190Yeast as a tool to select inhibitors of the cullin deneddylating enzyme Csn5.

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