Yeast as a tool to select inhibitors of the cullin deneddylating enzyme Csn5.

scientific article

Yeast as a tool to select inhibitors of the cullin deneddylating enzyme Csn5. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3109/14756366.2016.1160901
P698PubMed publication ID27028668

P50authorTeresa RinaldiQ42838147
Mattia MoriQ80809826
P2093author name stringBruno Botta
Alessandro Stirpe
Angela Cirigliano
Domenico Dell'Edera
Elah Pick
Rodolfo Negri
Sergio Menta
P2860cites workJAMM: a metalloprotease-like zinc site in the proteasome and signalosomeQ21092836
Conservation of the COP9/signalosome in budding yeastQ24802982
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
Regulation of cancer-related pathways by protein NEDDylation and strategies for the use of NEDD8 inhibitors in the clinicQ26827548
Structure of the Jab1/MPN Domain and Its Implications for Proteasome FunctionQ27642237
The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitorsQ27657147
Insights into the regulation of the human COP9 signalosome catalytic subunit, CSN5/Jab1Q27675751
Crystal structure of the human COP9 signalosomeQ27694578
COP9 signalosome components play a role in the mating pheromone response of S. cerevisiae.Q27931782
The COP9 signalosome is involved in the regulation of lipid metabolism and of transition metals uptake in Saccharomyces cerevisiae.Q27931851
Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1.Q27931858
Dual function of Rpn5 in two PCI complexes, the 26S proteasome and COP9 signalosome.Q27937368
Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1Q28139243
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Jab1 interacts directly with HIF-1alpha and regulates its stabilityQ28205085
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FRED pose prediction and virtual screening accuracyQ30399715
Conformer generation with OMEGA: algorithm and validation using high quality structures from the Protein Databank and Cambridge Structural DatabaseQ30494222
The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domainQ31089679
A ‘Rule of Three’ for fragment-based lead discovery?Q33973131
The emerging role of the COP9 signalosome in cancerQ34147948
JAB1/CSN5: a new player in cell cycle control and cancerQ34292695
Genetic regulators of large-scale transcriptional signatures in cancerQ34537800
Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors.Q34981146
The TFIIH subunit Tfb3 regulates cullin neddylationQ35266319
COP9 signalosome: a multifunctional regulator of SCF and other cullin-based ubiquitin ligasesQ35541468
Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycyclineQ36020841
Jab1/CSN5 negatively regulates p27 and plays a role in the pathogenesis of nasopharyngeal carcinoma.Q36286462
CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progressionQ37106255
Investigating the selectivity of metalloenzyme inhibitorsQ37432771
PCI complexes: Beyond the proteasome, CSN, and eIF3 Troika.Q37580456
Moonlighting and pleiotropy within two regulators of the degradation machinery: the proteasome lid and the CSN.Q38268491
Discovery of a New Class of Potent MMP Inhibitors by Structure-Based Optimization of the Arylsulfonamide ScaffoldQ39777971
Stable form of JAB1 enhances proliferation and maintenance of hematopoietic progenitorsQ42095359
Crystal structure of a bacterial class 2 histone deacetylase homologueQ46767900
CSN- and CAND1-dependent remodelling of the budding yeast SCF complex.Q50336194
FRED and HYBRID docking performance on standardized datasets.Q51358561
The Nedd8-activating enzyme inhibitor MLN4924 induces autophagy and apoptosis to suppress liver cancer cell growth.Q53170777
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)1632-1637
P577publication date2016-03-30
P1433published inJournal of Enzyme Inhibition and Medicinal ChemistryQ15708877
P1476titleYeast as a tool to select inhibitors of the cullin deneddylating enzyme Csn5.
P478volume31

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cites work (P2860)
Q36376809Identification of a novel chalcone derivative that inhibits Notch signaling in T-cell acute lymphoblastic leukemia
Q48356771Potent and Selective Carboxylic Acid Inhibitors of Tumor-Associated Carbonic Anhydrases IX and XII.
Q59797449Proteasome lid bridges mitochondrial stress with Cdc53/Cullin1 NEDDylation status
Q39015104Roles of Multifunctional COP9 Signalosome Complex in Cell Fate and Implications for Drug Discovery

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