The subunit CSN6 of the COP9 signalosome is cleaved during apoptosis

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The subunit CSN6 of the COP9 signalosome is cleaved during apoptosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M609587200
P698PubMed publication ID17337451

P2093author name stringJean da Silva Correia
Nikki Leonard
Yvonne Miranda
Richard J Ulevitch
P2860cites workOrdering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent mannerQ22008727
Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaBQ22010046
Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosisQ22010649
CATERPILLER: a novel gene family important in immunity, cell death, and diseasesQ24298131
The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damageQ24301297
The COP9 complex, a novel multisubunit nuclear regulator involved in light control of a plant developmental switchQ24309020
Role of SCF ubiquitin-ligase and the COP9 signalosome in the N gene-mediated resistance response to Tobacco mosaic virusQ45731733
The COP9 Signalosome Promotes Degradation of Cyclin E during Early Drosophila OogenesisQ46973380
Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12pQ47847570
Nod1 Participates in the Innate Immune Response toPseudomonas aeruginosaQ57245053
Light inactivation of Arabidopsis photomorphogenic repressor COP1 involves a cell-specific regulation of its nucleocytoplasmic partitioningQ71988136
Activation of a pro-apoptotic amplification loop through inhibition of NF-kappaB-dependent survival signals by caspase-mediated inactivation of RIPQ73487705
p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytesQ73505007
Proteolytic activation of protein kinase C-epsilon by caspase-mediated processing and transduction of antiapoptotic signalsQ74666995
The RAR1 interactor SGT1, an essential component of R gene-triggered disease resistanceQ77643553
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosisQ24310597
A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunitsQ24322085
Nod1-mediated endothelial cell activation by Chlamydophila pneumoniaeQ24338210
COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin systemQ24545648
Protein kinase CK2 and protein kinase D are associated with the COP9 signalosomeQ24553124
Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1.Q27931858
Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1Q28139243
Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosomeQ28187304
Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1Q28203933
Functional consequences of caspase activation in cardiac myocytesQ28215640
Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosisQ28250587
The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complexQ28279874
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymeraseQ28302692
CARD4/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri.Q28344579
COP9 signalosome subunit 3 is essential for maintenance of cell proliferation in the mouse embryonic epiblastQ28507707
Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic deathQ28588169
The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin AQ28610837
Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycanQ29618544
p53 ubiquitination: Mdm2 and beyondQ29619502
An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acidQ29620015
Binding of JAB1/CSN5 to MIF is mediated by the MPN domain but is independent of the JAMM motifQ31152494
Caspase-dependent inactivation of proteasome function during programmed cell death in Drosophila and man.Q33204112
Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosisQ33716955
MEK kinase 1, a substrate for DEVD-directed caspases, is involved in genotoxin-induced apoptosisQ33996873
Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity islandQ34359740
NOD-LRR proteins: role in host-microbial interactions and inflammatory diseaseQ34426050
Unique and overlapping substrate specificities of caspase-8 and caspase-10.Q34454210
Nod1-dependent control of tumor growthQ34478644
Many cuts to ruin: a comprehensive update of caspase substratesQ35091412
Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis.Q35917233
IAPs, RINGs and ubiquitylationQ36085601
Stimulation of the cytosolic receptor for peptidoglycan, Nod1, by infection with Chlamydia trachomatis or Chlamydia muridarum.Q37862344
Regulation of Nod1-mediated signaling pathwaysQ40191060
Caspase activation inhibits proteasome function during apoptosisQ40569376
Caspase 8 mediated apoptotic cell death induced by beta-sheet forming polyalanine peptidesQ40611899
Dephosphorylation targets Bcl-2 for ubiquitin-dependent degradation: a link between the apoptosome and the proteasome pathway.Q42110512
Multiple ubiquitin ligase-mediated processes require COP9 signalosome and AXR1 functionQ44170752
P433issue17
P407language of work or nameEnglishQ1860
P921main subjectNucleotide binding oligomerization domain containing 2Q416481
apoptotic processQ14599311
Nucleotide binding oligomerization domain containing 1Q21124880
protein-containing complex bindingQ22312857
P304page(s)12557-65
P577publication date2007-04-27
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe subunit CSN6 of the COP9 signalosome is cleaved during apoptosis
P478volume282

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cites work (P2860)
Q34980308A cDNA microarray, UniShrimpChip, for identification of genes relevant to testicular development in the black tiger shrimp (Penaeus monodon).
Q24311222COP9 signalosome controls the Carma1-Bcl10-Malt1 complex upon T-cell stimulation
Q89524000CSN6: a promising target for cancer prevention and therapy
Q49907436Corrected and Republished from: The COP9 Signalosome Interacts with and Regulates Interferon Regulatory Factor 5 Protein Stability
Q24649031Global mapping of the topography and magnitude of proteolytic events in apoptosis
Q36407994Knockdown of subunit 3 of the COP9 signalosome inhibits C2C12 myoblast differentiation via NF-KappaB signaling pathway
Q36902817Mammalian NLR proteins; discriminating foe from friend
Q99634865Proteomics Reveals the Potential Protective Mechanism of Hydrogen Sulfide on Retinal Ganglion Cells in an Ischemia/Reperfusion Injury Animal Model
Q36667465RETRACTED: The COP9 signalosome interacts with and regulates interferon regulatory factor 5 protein stability
Q92724115Role of the COP9 Signalosome (CSN) in Cardiovascular Diseases
Q39015104Roles of Multifunctional COP9 Signalosome Complex in Cell Fate and Implications for Drug Discovery
Q24683802SGT1 is essential for Nod1 activation
Q34245895The COP9 signalosome subunit 6 (CSN6): a potential oncogene
Q24337194The Nodosome: Nod1 and Nod2 control bacterial infections and inflammation
Q31089679The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain

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