scholarly article | Q13442814 |
review article | Q7318358 |
P6179 | Dimensions Publication ID | 1012054610 |
P356 | DOI | 10.1038/NATURE03097 |
P3181 | OpenCitations bibliographic resource ID | 569790 |
P698 | PubMed publication ID | 15549093 |
P5875 | ResearchGate publication ID | 8178332 |
P50 | author | Jiří Bártek | Q12025039 |
P2093 | author name string | Michael B Kastan | |
P2860 | cites work | Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome | Q22011001 |
SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint | Q24292395 | ||
MDC1 is a mediator of the mammalian DNA damage checkpoint | Q24296229 | ||
The BRCT Domain Is a Phospho-Protein Binding Domain | Q24298428 | ||
Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase | Q24301325 | ||
Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome | Q24316811 | ||
The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response | Q24316950 | ||
Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention | Q24563397 | ||
Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation | Q24564847 | ||
Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage | Q24672492 | ||
Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance | Q24672646 | ||
Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin | Q24672721 | ||
Megabase chromatin domains involved in DNA double-strand breaks in vivo | Q24680284 | ||
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes | Q27860662 | ||
The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder | Q28115238 | ||
Checkpoints: controls that ensure the order of cell cycle events | Q28131705 | ||
A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome | Q28183834 | ||
Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase | Q28186851 | ||
ATM: genome stability, neuronal development, and cancer cross paths | Q28201456 | ||
An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication | Q28204037 | ||
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation | Q28206029 | ||
ATR and ATRIP: partners in checkpoint signaling | Q28207471 | ||
Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways | Q28207549 | ||
BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting | Q28212263 | ||
Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2 | Q28212276 | ||
MDC1 is required for the intra-S-phase DNA damage checkpoint | Q28212500 | ||
MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways | Q28212514 | ||
Interaction of FANCD2 and NBS1 in the DNA damage response | Q28215923 | ||
NFBD1, a novel nuclear protein with signature motifs of FHA and BRCT, and an internal 41-amino acid repeat sequence, is an early participant in DNA damage response | Q28217141 | ||
Cancer susceptibility and the functions of BRCA1 and BRCA2 | Q28217784 | ||
NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways | Q28218966 | ||
ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage | Q28266407 | ||
MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes | Q28274268 | ||
Claspin, a regulator of Chk1 in DNA replication stress pathway | Q28274299 | ||
ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background | Q28274709 | ||
Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks | Q28291639 | ||
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage | Q28364113 | ||
Regulating mammalian checkpoints through Cdc25 inactivation | Q28387035 | ||
Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice | Q28509807 | ||
Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities | Q28610054 | ||
Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability | Q28612074 | ||
Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems | Q29026493 | ||
ATM and related protein kinases: safeguarding genome integrity | Q29547735 | ||
Biallelic inactivation of BRCA2 in Fanconi anemia | Q29616130 | ||
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks | Q29617463 | ||
Chk1 and Chk2 kinases in checkpoint control and cancer | Q29617706 | ||
Cell cycle checkpoint signaling through the ATM and ATR kinases | Q29617837 | ||
Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17. | Q31134206 | ||
ATR and ATM regulate the timing of DNA replication origin firing | Q33204272 | ||
Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation | Q33558779 | ||
Regulation of the G2/M transition by p53. | Q33943437 | ||
The Mre11 complex is required for ATM activation and the G2/M checkpoint | Q34052273 | ||
Collaboration of Brca1 and Chk2 in tumorigenesis | Q34142447 | ||
53BP1, a mediator of the DNA damage checkpoint | Q34153067 | ||
53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer | Q34160527 | ||
Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage | Q34179079 | ||
Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation | Q34300338 | ||
Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex | Q34311086 | ||
Hypoxia links ATR and p53 through replication arrest | Q34324309 | ||
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner | Q34324643 | ||
Chk1 is haploinsufficient for multiple functions critical to tumor suppression | Q34334239 | ||
Opening of the clamp: an intimate view of an ATP-driven biological machine. | Q34381828 | ||
Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions | Q34440261 | ||
The evolution of diverse biological responses to DNA damage: insights from yeast and p53. | Q34487385 | ||
Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation. | Q34503454 | ||
The Mre11 complex: at the crossroads of dna repair and checkpoint signalling | Q34623788 | ||
p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice | Q34784963 | ||
The RB and p53 pathways in cancer | Q34804764 | ||
Toward maintaining the genome: DNA damage and replication checkpoints | Q34995489 | ||
Checking on the fork: the DNA-replication stress-response pathway | Q35006441 | ||
Checkpoint mediators: relaying signals from DNA strand breaks | Q35157595 | ||
The Fanconi road to cancer | Q35189910 | ||
Targeting the checkpoint kinases: chemosensitization versus chemoprotection | Q35679781 | ||
Checking on DNA damage in S phase | Q35906070 | ||
Requirement of the MRN complex for ATM activation by DNA damage | Q36267304 | ||
H2AX haploinsufficiency modifies genomic stability and tumor susceptibility | Q36533572 | ||
Topoisomerase Poisons: Harnessing the Dark Side of Enzyme Mechanism | Q40476934 | ||
The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways | Q40584861 | ||
The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways | Q40750310 | ||
Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway | Q40916856 | ||
Allosteric effects mediate CHK2 phosphorylation of the p53 transactivation domain. | Q41008574 | ||
The retinoblastoma protein pathway in cell cycle control and cancer | Q41673697 | ||
Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation | Q44817175 | ||
Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint | Q46058691 | ||
Loss of Rad52 partially rescues tumorigenesis and T-cell maturation in Atm-deficient mice | Q47662027 | ||
Chromosome instability induced in vitro with mitomycin C in five Seckel syndrome patients. | Q51945941 | ||
Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2. | Q52536019 | ||
Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis. | Q53397555 | ||
The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today | Q55872103 | ||
The cellular response to DNA double-strand breaks: defining the sensors and mediators | Q63383934 | ||
Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors | Q64387467 | ||
53BP1, an activator of ATM in response to DNA damage | Q64388924 | ||
Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice | Q75217030 | ||
P433 | issue | 7015 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | cell cycle checkpoint signaling | Q1068809 |
P304 | page(s) | 316-23 | |
P577 | publication date | 2004-11-18 | |
P1433 | published in | Nature | Q180445 |
P1476 | title | Cell-cycle checkpoints and cancer | |
P478 | volume | 432 |
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Q24648650 | 3' end mRNA processing: molecular mechanisms and implications for health and disease |
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Q34619746 | A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites. |
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Q35672227 | A dual role of BRCA1 in two distinct homologous recombination mediated repair in response to replication arrest |
Q34728646 | A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex |
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Q49787504 | A lethal synergy induced by phellinus linteus and camptothecin11 in colon cancer cells |
Q28472643 | A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint |
Q42659082 | A new in vitro system for activating the cell cycle checkpoint |
Q38256644 | A new pathway that regulates 53BP1 stability implicates cathepsin L and vitamin D in DNA repair |
Q34005051 | A novel ATM/TP53/p21-mediated checkpoint only activated by chronic γ-irradiation. |
Q44814438 | A novel DNA damage-induced alternative splicing pathway that regulates p53 and cellular senescence markers |
Q38756309 | A novel colchicine-based microtubule inhibitor exhibits potent antitumor activity by inducing mitochondrial mediated apoptosis in MIA PaCa-2 pancreatic cancer cells |
Q38987147 | A novel function of HER2/Neu in the activation of G2/M checkpoint in response to γ-irradiation |
Q37548532 | A phosphorylation-deubiquitination cascade regulates the BRCA2-RAD51 axis in homologous recombination |
Q36823687 | A prognostic signature of G(2) checkpoint function in melanoma cell lines |
Q34618971 | A rapid and optimization-free procedure allows the in vivo detection of subtle cell cycle and ploidy alterations in tissues by flow cytometry |
Q37339272 | A regulatory loop composed of RAP80-HDM2-p53 provides RAP80-enhanced p53 degradation by HDM2 in response to DNA damage. |
Q34308785 | A role for p21-activated kinase 7 in the development of gastric cancer |
Q41918028 | A role of the mitotic spindle checkpoint in the cellular response to DNA replication stress |
Q37595154 | A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity |
Q27683756 | A structure-specific nucleic acid-binding domain conserved among DNA repair proteins |
Q40629103 | A systematic approach to cancer: evolution beyond selection |
Q28482357 | A systems biology approach to characterize the regulatory networks leading to trabectedin resistance in an in vitro model of myxoid liposarcoma |
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Q37419375 | ADA3 regulates normal and tumor mammary epithelial cell proliferation through c-MYC. |
Q39652265 | AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling |
Q36956935 | APOBEC3A damages the cellular genome during DNA replication |
Q41552553 | APOBEC3G acts as a therapeutic target in mesenchymal gliomas by sensitizing cells to radiation-induced cell death |
Q33893554 | ASCIZ regulates lesion-specific Rad51 focus formation and apoptosis after methylating DNA damage |
Q28476006 | ATM Limits Incorrect End Utilization during Non-Homologous End Joining of Multiple Chromosome Breaks |
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Q33863002 | ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. |
Q27312743 | ATM functions at the peroxisome to induce pexophagy in response to ROS. |
Q38717766 | ATM in prevention of genomic instability |
Q33667539 | ATM is down-regulated by N-Myc-regulated microRNA-421. |
Q36228274 | ATM regulates ATR chromatin loading in response to DNA double-strand breaks |
Q37641542 | ATM regulates Cdt1 stability during the unperturbed S phase to prevent re-replication. |
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Q28387570 | ATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeres |
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Q26749612 | Cell Cycle Regulatory Functions of the KSHV Oncoprotein LANA |
Q53652625 | Cell biology: A BID for the pathway. |
Q35207826 | Cell cycle arrest and the evolution of chronic kidney disease from acute kidney injury |
Q28078268 | Cell cycle checkpoint in cancer: a therapeutically targetable double-edged sword |
Q36663023 | Cell cycle control as a basis for cancer chemoprevention through dietary agents |
Q38214442 | Cell cycle progression in response to oxygen levels. |
Q53477098 | Cell cycle regulation by FasL and Apo2L/TRAIL in human T-cell blasts. Implications for autoimmune lymphoproliferative syndromes. |
Q37962262 | Cell cycle regulation in hematopoietic stem cells |
Q36881426 | Cell cycle regulation of DNA replication. |
Q24314465 | Cell cycle, CDKs and cancer: a changing paradigm |
Q42828383 | Cell cycle-dependent expression of p42.3 promotes mitotic progression in malignant transformed cells |
Q64102496 | Cell division cycle associated 5 promotes colorectal cancer progression by activating the ERK signaling pathway |
Q47257517 | Cell-cycle Checkpoints and Aneuploidy on the Path to Cancer |
Q47172006 | Cell-cycle-specific Cellular Responses to Sonoporation |
Q37351727 | Cell-free Xenopus egg extracts for studying DNA damage response pathways. |
Q39627623 | Cellular and biomolecular responses of human ovarian cancer cells to cytostatic dinuclear platinum(II) complexes |
Q28297754 | Cellular checkpoint mechanisms monitoring proper initiation of DNA replication |
Q38313182 | Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery |
Q34569745 | Cellular senescence and DNA repair |
Q38075860 | Cellular-signaling pathways unveil the carcinogenic potential of chemicals |
Q38891869 | Central Role of Ubiquitination in Genome Maintenance: DNA Replication and Damage Repair |
Q64926047 | Chaetominine induces cell cycle arrest in human leukemia K562 and colon cancer SW1116 cells. |
Q92136735 | Challenges and Perspectives in Homology-Directed Gene Targeting in Monocot Plants |
Q33642043 | Characterization and optimization of a novel protein-protein interaction biosensor high-content screening assay to identify disruptors of the interactions between p53 and hDM2. |
Q30475089 | Characterization of 9-nitrocamptothecin liposomes: anticancer properties and mechanisms on hepatocellular carcinoma in vitro and in vivo |
Q36769867 | Checkpoint adaptation in human cells |
Q34411080 | Checkpoint genes and Exo1 regulate nearby inverted repeat fusions that form dicentric chromosomes in Saccharomyces cerevisiae |
Q35657580 | Checkpoint kinase 1 (Chk1)-short is a splice variant and endogenous inhibitor of Chk1 that regulates cell cycle and DNA damage checkpoints |
Q39012997 | Checkpoint kinase 2 (Chk2) supports sensitivity to platinum-based treatment in high grade serous ovarian cancer |
Q50522868 | Checkpoint kinase 2 is dispensable for regulation of the p53 response but is required for G2/M arrest and cell survival in cells with p53 defects under heat stress. |
Q37276862 | Checkpoint kinase phosphorylation in response to endogenous oxidative DNA damage in repair-deficient stationary-phase Saccharomyces cerevisiae |
Q35678658 | Checkpoint kinase1 (CHK1) is an important biomarker in breast cancer having a role in chemotherapy response |
Q37420602 | Checkpoint responses to unusual structures formed by DNA repeats. |
Q41832240 | Chemo-sensitisation of HeLa cells to etoposide by a benzoxazine in the absence of DNA-PK inhibition |
Q26773449 | Chemoprevention of Breast Cancer by Dietary Polyphenols |
Q39354541 | Chemotherapeutic Drugs: DNA Damage and Repair in Glioblastoma |
Q64226701 | Chk1 Inhibition Restores Inotuzumab Ozogamicin Citotoxicity in CD22-Positive Cells Expressing Mutant p53 |
Q24537422 | Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress |
Q41847676 | Chk1 regulates the density of active replication origins during the vertebrate S phase. |
Q34563205 | Chk1 requirement for high global rates of replication fork progression during normal vertebrate S phase |
Q40291415 | Chk1-dependent slowing of S-phase progression protects DT40 B-lymphoma cells against killing by the nucleoside analogue 5-fluorouracil. |
Q24310231 | Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair |
Q36558897 | Chromatin modulation and the DNA damage response |
Q34674660 | Chromatin relaxation-mediated induction of p19INK4d increases the ability of cells to repair damaged DNA. |
Q36740595 | Chromoanagenesis and cancer: mechanisms and consequences of localized, complex chromosomal rearrangements |
Q39255073 | Chromosomal Instability in Gastric Cancer Biology. |
Q35774465 | Chromosomes with delayed replication timing lead to checkpoint activation, delayed recruitment of Aurora B and chromosome instability. |
Q37388875 | Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements |
Q36058572 | Chronic myelogenous leukemia stem and progenitor cells demonstrate chromosomal instability related to repeated breakage-fusion-bridge cycles mediated by increased nonhomologous end joining |
Q90781394 | Chronic stress promotes gastric cancer progression and metastasis: an essential role for ADRB2 |
Q26747601 | Ciliogenesis and the DNA damage response: a stressful relationship |
Q34127839 | Circadian gene variants in cancer. |
Q36836276 | Classic "broken cell" techniques and newer live cell methods for cell cycle assessment |
Q28269044 | Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway |
Q37042308 | Clinicopathological correlates and prognostic significance of KRAS mutation status in a pooled prospective cohort of epithelial ovarian cancer |
Q50209900 | Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies |
Q92289996 | Co-Inhibition of the DNA Damage Response and CHK1 Enhances Apoptosis of Neuroblastoma Cells |
Q38834899 | Codelivery of dual drugs from polymeric micelles for simultaneous targeting of both cancer cells and cancer stem cells |
Q38018938 | Colorectal cancer chemoprevention by mesalazine and its derivatives. |
Q42277641 | Colorectal cancer is a paracrine deficiency syndrome amenable to oral hormone replacement therapy |
Q60950807 | Combination of Proteasome and Histone Deacetylase Inhibitors Overcomes the Impact of Gain-of-Function p53 Mutations |
Q34978486 | Combined CDKN1A/TP53 mutation in bladder cancer is a therapeutic target |
Q42204382 | Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress |
Q55369745 | Combining Pathway Identification and Breast Cancer Survival Prediction via Screening-Network Methods. |
Q53341657 | Comet sensitivity in assessing DNA damage and repair in different cell cycle stages. |
Q35562928 | Common genetic variants in cell cycle pathway are associated with survival in stage III-IV non-small-cell lung cancer |
Q33785780 | Comparative analyses of SUV420H1 isoforms and SUV420H2 reveal differences in their cellular localization and effects on myogenic differentiation |
Q38746087 | Comparison of human lung cancer cell radiosensitivity after irradiations with therapeutic protons and carbon ions |
Q47258706 | Computational analysis of mammalian cell division gated by a circadian clock: quantized cell cycles and cell size control |
Q30978560 | Computational assignment of cell-cycle stage from single-cell transcriptome data |
Q36682691 | Computational prediction of cancer-gene function |
Q37408969 | Computational systems biology of the cell cycle. |
Q85665197 | Concurrent DNA Copy-Number Alterations and Mutations in Genes Related to Maintenance of Genome Stability in Uninvolved Mammary Glandular Tissue from Breast Cancer Patients |
Q30300041 | Connecting the microtubule attachment status of each kinetochore to cell cycle arrest through the spindle assembly checkpoint |
Q27348581 | Contribution of caspase(s) to the cell cycle regulation at mitotic phase |
Q34011009 | Controlling the Mdm2-Mdmx-p53 Circuit |
Q35096543 | Cooperative role of the RNA-binding proteins Hzf and HuR in p53 activation |
Q90410952 | Coordinately Targeting Cell-Cycle Checkpoint Functions in Integrated Models of Pancreatic Cancer |
Q39521893 | Coordination of cell cycle, DNA repair and muscle gene expression in myoblasts exposed to genotoxic stress. |
Q34469073 | Copper chelation selectively kills colon cancer cells through redox cycling and generation of reactive oxygen species |
Q37267450 | Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress |
Q38503825 | Cross-species Functionome analysis identifies proteins associated with DNA repair, translation and aerobic respiration as conserved modulators of UV-toxicity. |
Q33639330 | Crosstalk between the DNA damage response, histone modifications and neovascularisation |
Q42757411 | CtIP interacts with TopBP1 and Nbs1 in the response to double-stranded DNA breaks (DSBs) in Xenopus egg extracts |
Q39753671 | CtIP links DNA double-strand break sensing to resection |
Q39666610 | Cutting edge: Chk1 directs senescence and mitotic catastrophe in recovery from G₂ checkpoint arrest |
Q34324101 | Cycles of chromosome instability are associated with a fragile site and are increased by defects in DNA replication and checkpoint controls in yeast |
Q28749707 | Cyclin D1 induction by benzo[a]pyrene-7,8-diol-9,10-epoxide via the phosphatidylinositol 3-kinase/Akt/MAPK- and p70s6k-dependent pathway promotes cell transformation and tumorigenesis |
Q34654891 | Cyclin I is involved in the regulation of cell cycle progression |
Q24317740 | Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis |
Q41357986 | Cytokinesis failure and attenuation: new findings in Fanconi anemia |
Q34017354 | Cytokinetically quiescent (G0/G1) human multiple myeloma cells are susceptible to simultaneous inhibition of Chk1 and MEK1/2. |
Q64943714 | Cytostatic and Cytotoxic Natural Products against Cancer Cell Models. |
Q38736960 | Cytotoxicity of withasteroids: withametelin induces cell cycle arrest at G2/M phase and mitochondria-mediated apoptosis in non-small cell lung cancer A549 cells |
Q35635574 | DDB1 is essential for genomic stability in developing epidermis |
Q55386114 | DN2 Thymocytes Activate a Specific Robust DNA Damage Response to Ionizing Radiation-Induced DNA Double-Strand Breaks. |
Q24302100 | DNA Damage Activates a Spatially Distinct Late Cytoplasmic Cell-Cycle Checkpoint Network Controlled by MK2-Mediated RNA Stabilization |
Q47398640 | DNA Damage Repair System in Plants: A Worldwide Research Update |
Q52640463 | DNA Damage, Mutagenesis and Cancer. |
Q30443388 | DNA damage activates the SAC in an ATM/ATR-dependent manner, independently of the kinetochore |
Q39942882 | DNA damage and homologous recombination signaling induced by thymidylate deprivation |
Q36488090 | DNA damage checkpoint, damage repair, and genome stability |
Q33908422 | DNA damage during G2 phase does not affect cell cycle progression of the green alga Scenedesmus quadricauda |
Q36939423 | DNA damage response and development of targeted cancer treatments |
Q29614217 | DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis |
Q35665297 | DNA damage response in neonatal and adult stromal cells compared with induced pluripotent stem cells |
Q28304920 | DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours |
Q37990061 | DNA damage response pathways and cell cycle checkpoints in colorectal cancer: current concepts and future perspectives for targeted treatment. |
Q42337472 | DNA damage response, genetic instability and cancer: from mechanistic insights to personalized treatment |
Q37803476 | DNA damage response. |
Q36402069 | DNA damage responses and their many interactions with the replication fork |
Q34296170 | DNA damage signaling is activated during cancer progression in human colorectal carcinoma |
Q33910490 | DNA damage signaling regulates age-dependent proliferative capacity of quiescent inner ear supporting cells |
Q38893748 | DNA damage signalling barrier, oxidative stress and treatment-relevant DNA repair factor alterations during progression of human prostate cancer |
Q37027188 | DNA damage signalling guards against activated oncogenes and tumour progression |
Q37785492 | DNA damage stress response in germ cells: role of c-Abl and clinical implications |
Q37187991 | DNA damage tolerance: a double-edged sword guarding the genome |
Q41989448 | DNA damage-dependent cyclin D1 proteolysis: GSK3beta holds the smoking gun |
Q39125363 | DNA damage-induced cell cycle regulation and function of novel Chk2 phosphoresidues. |
Q24652996 | DNA damage-induced ubiquitylation of RFC2 subunit of replication factor C complex |
Q42750184 | DNA helicases Sgs1 and BLM promote DNA double-strand break resection |
Q84632174 | DNA hypermethylation biomarkers to predict response to cisplatin treatment, radiotherapy or chemoradiation: the present state of art |
Q38893619 | DNA intercalative 4-butylaminopyrimido[4',5':4,5]thieno(2,3-b)quinoline induces cell cycle arrest and apoptosis in leukemia cells |
Q37962577 | DNA methylation of tumor suppressor miRNA genes: a lesson from the miR-34 family |
Q37146966 | DNA protein kinase-dependent G2 checkpoint revealed following knockdown of ataxia-telangiectasia mutated in human mammary epithelial cells |
Q36610563 | DNA repair capacity as a possible biomarker of breast cancer risk in female BRCA1 mutation carriers |
Q37368873 | DNA repair deficiency and neurological disease |
Q34183328 | DNA repair deficiency in neurodegeneration. |
Q38061847 | DNA repair dysregulation from cancer driver to therapeutic target |
Q29615572 | DNA repair pathways as targets for cancer therapy |
Q37154126 | DNA strand breaks, neurodegeneration and aging in the brain |
Q28116227 | DNA-PKcs-PIDDosome: a nuclear caspase-2-activating complex with role in G2/M checkpoint maintenance |
Q39881890 | DNA-damage response, survival and differentiation in vitro of a human neural stem cell line in relation to ATM expression. |
Q24312094 | DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint |
Q31055841 | Data on cell cycle in breast cancer cell line, MDA-MB-231 with ferulic acid treatment |
Q37135368 | Death through a tragedy: mitotic catastrophe |
Q38695071 | Decision for cell fate: deubiquitinating enzymes in cell cycle checkpoint |
Q37966330 | Deconstructing p53 transcriptional networks in tumor suppression |
Q33911206 | Decreased DNA repair activity in bone marrow due to low expression of DNA damage repair proteins |
Q41908765 | Decreased translation of p21waf1 mRNA causes attenuated p53 signaling in some p53 wild-type tumors |
Q60922825 | Deduction of Novel Genes Potentially Involved in Upper Tract Urothelial Carcinoma Using Next-Generation Sequencing and Bioinformatics Approaches |
Q40114129 | Defective cell cycle checkpoint functions in melanoma are associated with altered patterns of gene expression |
Q51057019 | Deficient innate immunity, thymopoiesis, and gene expression response to radiation in survivors of childhood acute lymphoblastic leukemia. |
Q33734684 | Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation |
Q33991135 | Deinococcus radiodurans - the consummate survivor |
Q36341493 | Deoxycytidine kinase regulates the G2/M checkpoint through interaction with cyclin-dependent kinase 1 in response to DNA damage |
Q48225463 | Deoxyschizandrin, Isolated from Schisandra Berries, Induces Cell Cycle Arrest in Ovarian Cancer Cells and Inhibits the Protumoural Activation of Tumour-Associated Macrophages |
Q40373985 | Depletion of Chk1 leads to premature activation of Cdc2-cyclin B and mitotic catastrophe |
Q38721629 | Depletion of NFBD1/MDC1 Induces Apoptosis in Nasopharyngeal Carcinoma Cells Through the p53-ROS-Mitochondrial Pathway |
Q38190332 | Deregulation of cell signaling in cancer |
Q33847620 | Derivation and experimental comparison of cell-division probability densities |
Q33951823 | Design, synthesis, mechanisms of action, and toxicity of novel 20(s)-sulfonylamidine derivatives of camptothecin as potent antitumor agents |
Q47310421 | Developing an Agent-Based Drug Model to Investigate the Synergistic Effects of Drug Combinations |
Q36039774 | Development and Characterization of a Novel in vitro Progression Model for UVB-Induced Skin Carcinogenesis |
Q34046125 | Development of a regulatable oncolytic herpes simplex virus type 1 recombinant virus for tumor therapy |
Q90380896 | Development of hydroxamate-based histone deacetylase inhibitors of bis-substituted aromatic amides with antitumor activities |
Q34253229 | Development of serous ovarian cancer is associated with the expression of homologous recombination pathway proteins |
Q49537557 | Differences in MWCNT- and SWCNT-induced DNA methylation alterations in association with the nuclear deposition |
Q37111110 | Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS |
Q38864150 | Differential PAX5 levels promote malignant B-cell infiltration, progression and drug resistance, and predict a poor prognosis in MCL patients independent of CCND1. |
Q38973197 | Differential effects of lipid fractions from silver carp brain on human cervical carcinoma cells in vitro |
Q42584836 | Differential localization of ATM is correlated with activation of distinct downstream signaling pathways |
Q36289902 | Differential regulation of p21 (waf1) protein half-life by DNA damage and Nutlin-3 in p53 wild-type tumors and its therapeutic implications |
Q39971219 | Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation |
Q39110541 | Digalloylresveratrol, a novel resveratrol analog inhibits the growth of human pancreatic cancer cells. |
Q99630195 | Digitoxin inhibits proliferation of multidrug-resistant HepG2 cells through G2/M cell cycle arrest and apoptosis |
Q90399896 | Diplatin, a Novel and Low-Toxicity Anti-Lung Cancer Platinum Complex, Activation of Cell Death in Tumors via a ROS/JNK/p53-Dependent Pathway, and a Low Rate of Acquired Treatment Resistance |
Q31054756 | Discovering Biology in Periodic Data through Phase Set Enrichment Analysis (PSEA). |
Q41761375 | Discovery of 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as selective, orally bioavailable CHK1 inhibitors. |
Q35808778 | Discovery of dachshund 2 protein as a novel biomarker of poor prognosis in epithelial ovarian cancer |
Q34049279 | Disruption of G1-phase phospholipid turnover by inhibition of Ca2+-independent phospholipase A2 induces a p53-dependent cell-cycle arrest in G1 phase |
Q33561346 | Dissect the Dynamic Molecular Circuits of Cell Cycle Control through Network Evolution Model. |
Q37579636 | Dissecting the role of ubiquitylation in the DNA damage response checkpoint in G2. |
Q30803682 | Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans |
Q59797742 | Distinct prognostic value of dynactin subunit 4 (DCTN4) and diagnostic value of DCTN1, DCTN2, and DCTN4 in colon adenocarcinoma |
Q37876491 | Do bacterial genotoxins contribute to chronic inflammation, genomic instability and tumor progression? |
Q54346146 | Docking-based 3D-QSAR study of pyridyl aminothiazole derivatives as checkpoint kinase 1 inhibitors. |
Q58572952 | Downregulation of 5-hydroxytryptamine receptor 3A expression exerts an anticancer activity against cell growth in colorectal carcinoma cells |
Q92015501 | Dracorhodin perchlorate induces apoptosis and G2/M cell cycle arrest in human esophageal squamous cell carcinoma through inhibition of the JAK2/STAT3 and AKT/FOXO3a pathways |
Q33800164 | Drf1-dependent kinase interacts with Claspin through a conserved protein motif |
Q33802649 | Dual expression of Epstein-Barr virus, latent membrane protein-1 and human papillomavirus-16 E6 transform primary mouse embryonic fibroblasts through NF-κB signaling |
Q33390327 | Dual regulation of Cdc25A by Chk1 and p53-ATF3 in DNA replication checkpoint control |
Q47154984 | Dynamic Reorganization of the Cytoskeleton during Apoptosis: The Two Coffins Hypothesis |
Q36320732 | Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1 |
Q36720112 | Dynamics of the DNA damage response: insights from live-cell imaging |
Q33879479 | E2F1 promotes the recruitment of DNA repair factors to sites of DNA double-strand breaks |
Q36824489 | E2F4 function in G2: maintaining G2-arrest to prevent mitotic entry with damaged DNA. |
Q36996106 | E2F4 regulates a stable G2 arrest response to genotoxic stress in prostate carcinoma |
Q40330305 | ECM overrides DNA damage-induced cell cycle arrest and apoptosis in small-cell lung cancer cells through beta1 integrin-dependent activation of PI3-kinase |
Q28271191 | EDD mediates DNA damage-induced activation of CHK2 |
Q34050547 | EGFR-targeted plasmonic magnetic nanoparticles suppress lung tumor growth by abrogating G2/M cell-cycle arrest and inducing DNA damage |
Q48240259 | EMAP-II sensitize U87MG and glioma stem-like cells to temozolomide via induction of autophagy-mediated cell death and G2/M arrest. |
Q33848050 | EMSY overexpression disrupts the BRCA2/RAD51 pathway in the DNA-damage response: implications for chromosomal instability/recombination syndromes as checkpoint diseases |
Q34210998 | Early G2/M checkpoint failure as a molecular mechanism underlying etoposide-induced chromosomal aberrations. |
Q43076205 | Effect of Methanolic Leaf Extract of Ocimum basilicum L. on Benzene-Induced Hematotoxicity in Mice |
Q47605330 | Effect of cell cycle duration on somatic evolutionary dynamics |
Q54309472 | Effect of heparin-derived oligosaccharide on vascular smooth muscle cell proliferation. |
Q36556389 | Effective intra-S checkpoint responses to UVC in primary human melanocytes and melanoma cell lines |
Q36350849 | Effects of Low-Dose Bisphenol A on DNA Damage and Proliferation of Breast Cells: The Role of c-Myc |
Q28551456 | Efficient Activation of Apoptotic Signaling during Mitotic Arrest with AK301 |
Q92809614 | Eimeria tenella ROP kinase EtROP1 induces G0/G1 cell cycle arrest and inhibits host cell apoptosis |
Q34566631 | Elevated DNA damage response in pancreatic cancer |
Q33889555 | Emergence of rationally designed therapeutic strategies for breast cancer targeting DNA repair mechanisms |
Q36816885 | Emerging links between the biological clock and the DNA damage response |
Q35975127 | Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapy |
Q37359491 | Enhanced levels of double-strand DNA break repair proteins protect ovarian cancer cells against genotoxic stress-induced apoptosis |
Q35574213 | Enhancement of cytotoxicity of artemisinin toward cancer cells by transferrin-mediated carbon nanotubes nanoparticles |
Q36610767 | Enhancement of radiation response by inhibition of Aurora-A kinase using siRNA or a selective Aurora kinase inhibitor PHA680632 in p53-deficient cancer cells |
Q46847084 | Enhancement of radiation response in p53-deficient cancer cells by the Aurora-B kinase inhibitor AZD1152. |
Q40048494 | Enhancing proteotoxic stress as an anticancer strategy |
Q41617336 | Epidermal Growth Factor Receptor activation promotes ADA3 acetylation through the AKT-p300 pathway |
Q99711836 | Epigenetic based synthetic lethal strategies in human cancers |
Q38871275 | Epstein-Barr virus BZLF1 protein impairs accumulation of host DNA damage proteins at damage sites in response to DNA damage. |
Q42166975 | Eroded human telomeres are more prone to remain uncapped and to trigger a G2 checkpoint response. |
Q39691899 | Essential role of TRPC6 channels in G2/M phase transition and development of human glioma. |
Q46875154 | Essential roles of PI-3K/Akt/IKKbeta/NFkappaB pathway in cyclin D1 induction by arsenite in JB6 Cl41 cells |
Q37262148 | Estrogen inhibits ATR signaling to cell cycle checkpoints and DNA repair |
Q33772035 | Evaluating putative mechanisms of the mitotic spindle checkpoint |
Q33925006 | Evaluation of [18F]-ATRi as PET tracer for in vivo imaging of ATR in mouse models of brain cancer. |
Q36392155 | Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment |
Q33754132 | Evaluation of cytotoxic and chemotherapeutic properties of boldine in breast cancer using in vitro and in vivo models |
Q37145413 | Evidence for regulation of mitotic progression through temporal phosphorylation and dephosphorylation of CK2alpha |
Q34387784 | Evidence for the importance of personalized molecular profiling in pancreatic cancer |
Q42199612 | Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency |
Q33979535 | Expression of arf tumor suppressor in spermatogonia facilitates meiotic progression in male germ cells |
Q44484798 | Expression of cell cycle regulatory factors hus1, gadd45a, rb1, cdkn2a and mre11a correlates with expression of clock gene per2 in human colorectal carcinoma tissue |
Q64386984 | Expression of γ-H2AX in endometrial carcinomas: an immunohistochemical study with p53 |
Q41574502 | FANCD2 and DNA Damage. |
Q35828658 | FBXW7 and USP7 regulate CCDC6 turnover during the cell cycle and affect cancer drugs susceptibility in NSCLC. |
Q36659141 | FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage |
Q89156992 | Facile construction of fused benzimidazole-isoquinolinones that induce cell-cycle arrest and apoptosis in colorectal cancer cells |
Q37341109 | Family cancer syndromes: inherited deficiencies in systems for the maintenance of genomic integrity |
Q49340516 | Fanconi Anemia Signaling and Cancer |
Q39731350 | Fangchinoline induced G1/S arrest by modulating expression of p27, PCNA, and cyclin D in human prostate carcinoma cancer PC3 cells and tumor xenograft |
Q83796996 | Finding disease-specific coordinated functions by multi-function genes: insight into the coordination mechanisms in diseases |
Q36057574 | Folate levels modulate oncogene-induced replication stress and tumorigenicity |
Q45346807 | Forced activation of Cdk1 via wee1 inhibition impairs homologous recombination |
Q26822694 | From scourge to cure: tumour-selective viral pathogenesis as a new strategy against cancer |
Q89660218 | Fucoidan Inhibition of Osteosarcoma Cells Is Species and Molecular Weight Dependent |
Q33279576 | Function of the ATR N-terminal domain revealed by an ATM/ATR chimera |
Q38910507 | Functional Genetic Screen Identifies Increased Sensitivity to WEE1 Inhibition in Cells with Defects in Fanconi Anemia and HR Pathways. |
Q58195585 | Functional characterization of TIP60 sumoylation in UV-irradiated DNA damage response |
Q37171572 | Functional interaction between FOXO3a and ATM regulates DNA damage response |
Q38221703 | Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress. |
Q39126232 | Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer |
Q33235763 | Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses |
Q47133044 | G2/M-Phase Checkpoint Adaptation and Micronuclei Formation as Mechanisms That Contribute to Genomic Instability in Human Cells |
Q47949771 | GBM radiosensitizers: dead in the water…or just the beginning? |
Q35742357 | Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression |
Q37539997 | Gartanin induces cell cycle arrest and autophagy and suppresses migration involving PI3K/Akt/mTOR and MAPK signalling pathway in human glioma cells |
Q39115018 | Gefitinib enhances the effects of combined radiotherapy and 5-fluorouracil in a colorectal cancer cell line. |
Q40982895 | Gene expression profiling via bioinformatics analysis reveals biomarkers in laryngeal squamous cell carcinoma |
Q46344151 | Generation of an indestructible cyclin B1 by caspase-6-dependent cleavage during mitotic catastrophe. |
Q92563348 | Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency |
Q46605059 | Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53. |
Q36735336 | Genetic studies of bone diseases: evidence for involvement of DNA damage response proteins in bone remodeling |
Q37566958 | Genetic variants in the cell cycle control pathways contribute to early onset colorectal cancer in Lynch syndrome |
Q39012783 | Genetics of primary ovarian insufficiency. |
Q34564108 | Genistein abrogates G2 arrest induced by curcumin in p53 deficient T47D cells |
Q39038235 | Genistein exhibits anti-cancer effects via down-regulating FoxM1 in H446 small-cell lung cancer cells |
Q41831833 | Genistein-induced G2/M cell cycle arrest of human intestinal colon cancer Caco-2 cells is associated with Cyclin B1 and Chk2 down-regulation |
Q35676284 | Genome maintenance defects in cultured cells and mice following partial inactivation of the essential cell cycle checkpoint gene Hus1. |
Q34248736 | Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations |
Q30836392 | Genome-scale RNAi profiling of cell division in human tissue culture cells |
Q24815105 | Genome-wide requirements for resistance to functionally distinct DNA-damaging agents |
Q38776454 | Genomic sequencing and precision medicine in head and neck cancers |
Q26851196 | Genotoxic anti-cancer agents and their relationship to DNA damage, mitosis, and checkpoint adaptation in proliferating cancer cells |
Q36994736 | Genotoxic stress-induced cyclin D1 phosphorylation and proteolysis are required for genomic stability |
Q39052116 | Geraniin induces apoptotic cell death in human lung adenocarcinoma A549 cells in vitro and in vivo |
Q27860541 | Glioma stem cells promote radioresistance by preferential activation of the DNA damage response |
Q54525472 | Glycogen synthase kinase (GSK)-3 and mammalian target of rapamycin complex 1 (mTORC1) cooperate to regulate protein S6 kinase 1 (S6K1). |
Q33510863 | HARPing on about the DNA damage response during replication |
Q47551132 | HBV infection potentiates resistance to S-phase arrest-inducing chemotherapeutics by inhibiting CHK2 pathway in diffuse large B-cell lymphoma |
Q39012457 | HBXIP, a binding protein of HBx, regulates maintenance of the G2/M phase checkpoint induced by DNA damage and enhances sensitivity to doxorubicin-induced cytotoxicity |
Q28294885 | HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability |
Q45214462 | HCLK2 is required for activity of the DNA damage response kinase ATR. |
Q34062580 | HDAC inhibitor, valproic acid, induces p53-dependent radiosensitization of colon cancer cells |
Q34579692 | HERC2-USP20 axis regulates DNA damage checkpoint through Claspin |
Q42952064 | HP1 proteins are essential for a dynamic nuclear response that rescues the function of perturbed heterochromatin in primary human cells. |
Q92129884 | Hair Growth Promoting Effect of 4HGF Encapsulated with PGA Nanoparticles (PGA-4HGF) by β-Catenin Activation and Its Related Cell Cycle Molecules |
Q35501750 | Haplotypes of DNA repair and cell cycle control genes, X-ray exposure, and risk of childhood acute lymphoblastic leukemia |
Q47883962 | Haspin has Multiple Functions in the Plant Cell Division Regulatory Network. |
Q35847836 | Heat shock protein 90 inhibition sensitizes acute myelogenous leukemia cells to cytarabine |
Q26764740 | Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment |
Q33711869 | Hemizygosity for Atm and Brca1 influence the balance between cell transformation and apoptosis |
Q46145732 | Hepatocyte nuclear factor 1β induced by chemical stress accelerates cell proliferation and increases genomic instability in mouse liver |
Q53319587 | Herbal isoprenols induce apoptosis in human colon cancer cells through transcriptional activation of PPARgamma. |
Q40056381 | High Spicy Food Intake and Risk of Cancer: A Meta-analysis of Case-control Studies |
Q33392443 | Highly variable response to cytotoxic chemotherapy in carcinoma-associated fibroblasts (CAFs) from lung and breast |
Q44307145 | Histone deacetylase induces accelerated maturation in Xenopus laevis oocytes |
Q33983255 | Histone deacetylase inhibitor (HDACI) mechanisms of action: emerging insights |
Q52674720 | Histone deacetylase inhibitor chidamide induces growth inhibition and apoptosis in NK/T lymphoma cells through ATM-Chk2-p53-p21 signalling pathway. |
Q36283075 | Histone deacetylase inhibitor-mediated cell death is distinct from its global effect on chromatin |
Q26991616 | Histone displacement during nucleotide excision repair |
Q41825478 | Histone dosage regulates DNA damage sensitivity in a checkpoint-independent manner by the homologous recombination pathway |
Q35227435 | Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics the radiosensitivity syndrome of ataxia-telangiectasia |
Q28478749 | Honokiol arrests cell cycle, induces apoptosis, and potentiates the cytotoxic effect of gemcitabine in human pancreatic cancer cells |
Q38296672 | Hsk1 kinase and Cdc45 regulate replication stress-induced checkpoint responses in fission yeast |
Q33995584 | Human LINE-1 retrotransposon induces DNA damage and apoptosis in cancer cells |
Q24529887 | Human MMS21/NSE2 is a SUMO ligase required for DNA repair |
Q36616893 | Human Tim-Tipin complex affects the biochemical properties of the replicative DNA helicase and DNA polymerases. |
Q33320538 | Human VRK1 is an early response gene and its loss causes a block in cell cycle progression |
Q40420099 | Human aldehyde dehydrogenase 3A1 inhibits proliferation and promotes survival of human corneal epithelial cells |
Q64388257 | Human cancer cells require ATR for cell cycle progression following exposure to ionizing radiation |
Q34479791 | Human cytomegalovirus inhibits a DNA damage response by mislocalizing checkpoint proteins |
Q37380692 | Human cytomegalovirus protein UL38 inhibits host cell stress responses by antagonizing the tuberous sclerosis protein complex |
Q42425307 | Human papilloma virus type16 E6 deregulates CHK1 and sensitizes human fibroblasts to environmental carcinogens independently of its effect on p53. |
Q35758483 | Human prostate epithelium lacks Wee1A-mediated DNA damage-induced checkpoint enforcement |
Q35665702 | Hypergrowth mTORC1 signals translationally activate the ARF tumor suppressor checkpoint |
Q27331358 | Hypersensitivity to DNA damage in antephase as a safeguard for genome stability. |
Q53064517 | Hypoxia enhances the radioresistance of mouse mesenchymal stromal cells. |
Q35048958 | Hypoxia-induced reactive oxygen species cause chromosomal abnormalities in endothelial cells in the tumor microenvironment |
Q40335511 | Hzf, a p53-responsive gene, regulates maintenance of the G2 phase checkpoint induced by DNA damage |
Q42376094 | ID3 regulates the MDC1-mediated DNA damage response in order to maintain genome stability |
Q52320159 | IDH2 deficiency accelerates skin pigmentation in mice via enhancing melanogenesis. |
Q40331218 | IKK alpha regulates estrogen-induced cell cycle progression by modulating E2F1 expression |
Q34148484 | IKK and NF-kappaB-mediated regulation of Claspin impacts on ATR checkpoint function |
Q47213314 | IMMUNEPOTENT CRP induces cell cycle arrest and caspase-independent regulated cell death in HeLa cells through reactive oxygen species production |
Q53132557 | ING3 promotes UV-induced apoptosis via Fas/caspase-8 pathway in melanoma cells. |
Q35212640 | Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines |
Q37065125 | Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks. |
Q51100217 | Identification of a DNA Damage-Induced Alternative Splicing Pathway That Regulates p53 and Cellular Senescence Markers. |
Q92640003 | Identification of a small mutation panel of coding sequences to predict the efficacy of immunotherapy for lung adenocarcinoma |
Q39276310 | Identification of insulin-like growth factor 2 mRNA-binding protein 3 as a radioresistance factor in squamous esophageal cancer cells |
Q92383038 | Identification of key candidate tumor biomarkers in non-small-cell lung cancer by in silico analysis |
Q52726915 | Identification of key differentially expressed genes associated with non‑small cell lung cancer by bioinformatics analyses. |
Q46146825 | Identification of novel aminothiazole and aminothiadiazole conjugated cyanopyridines as selective CHK1 inhibitors |
Q33234550 | Identification of pathways regulating cell size and cell-cycle progression by RNAi |
Q38633652 | Identification of potential key genes associated with glioblastoma based on the gene expression profile |
Q37619647 | Identification of the lncRNA, AK156230, as a novel regulator of cellular senescence in mouse embryonic fibroblasts |
Q89513477 | Identifying Cell Cycle Modulators That Selectively Target ARID1A Deficiency Using High-Throughput Image-Based Screening |
Q36179331 | Imaging of protein movement induced by chromosomal breakage: tiny 'local' lesions pose great 'global' challenges |
Q35770249 | Immunohistochemical markers of prognosis in non-small cell lung cancer: a review and proposal for a multiphase approach to marker evaluation |
Q40303796 | Impairment of double-strand breaks repair and aberrant splicing of ATM and MRE11 in leukemia-lymphoma cell lines with microsatellite instability |
Q30985752 | Implementation of a 220,000-compound HCS campaign to identify disruptors of the interaction between p53 and hDM2 and characterization of the confirmed hits |
Q37776824 | Importance of DNA damage checkpoints in the pathogenesis of human cancers |
Q59813798 | In Vitro Evaluation of Sulforaphane and a Natural Analog as Potent Inducers of 5-Fluorouracil Anticancer Activity |
Q39917387 | In silico method for identification of promising anticancer drug targets. |
Q39896689 | Inappropriate activation of cyclin-dependent kinases by the phosphatase Cdc25b results in premature mitotic entry and triggers a p53-dependent checkpoint |
Q66476157 | Incineration of nanoclay composites leads to byproducts with reduced cellular reactivity |
Q38801460 | Increased activity of CHK enhances the radioresistance of MCF-7 breast cancer stem cells |
Q47812607 | Increased aldehyde reductase expression mediates acquired radioresistance of laryngeal cancer cells via modulating p53. |
Q35120757 | Increased expression of p21WAF1/CIP1 in kidney proximal tubules mediates fibrosis |
Q37021730 | Increased tumorigenicity and sensitivity to ionizing radiation upon loss of chromosomal protein HMGN1. |
Q38492674 | Induction of G1 arrest and apoptosis by schisandrin C isolated from Schizandra chinensis Baill in human leukemia U937 cells |
Q24313318 | Induction of SOX4 by DNA damage is critical for p53 stabilization and function |
Q37508259 | Induction of a Cellular DNA Damage Response by Porcine Circovirus Type 2 Facilitates Viral Replication and Mediates Apoptotic Responses |
Q37376949 | Induction of a reversible, non-cytotoxic S-phase delay by resveratrol: implications for a mechanism of lifespan prolongation and cancer protection |
Q40063881 | Induction of mitotic cell death in cancer cells by small interference RNA suppressing the expression of RecQL1 helicase |
Q37667275 | Inflammation, DNA Damage, Helicobacter pylori and Gastric Tumorigenesis |
Q28390752 | Influence of cell cycle on responses of MCF-7 cells to benzo[a]pyrene |
Q23919671 | Influence of light on aryl hydrocarbon receptor signaling and consequences in drug metabolism, physiology and disease |
Q34786416 | Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation |
Q34230848 | Inhibition of TFII-I-dependent cell cycle regulation by p53. |
Q46603127 | Inhibition of cell cycle progression by the hydroxytyrosol-cetuximab combination yields enhanced chemotherapeutic efficacy in colon cancer cells |
Q39443786 | Inhibition of checkpoint kinase 1 abrogates G2/M checkpoint activation and promotes apoptosis under heat stress |
Q39289009 | Inhibition of proliferation and induction of G1-phase cell-cycle arrest by dFMGEN, a novel genistein derivative, in lung carcinoma A549 cells |
Q47128274 | Inhibition of the IGF signaling pathway reverses cisplatin resistance in ovarian cancer cells |
Q43270533 | Inhibition of the c-Abl-TAp63 pathway protects mouse oocytes from chemotherapy-induced death |
Q33645805 | Inhibitory effect of PMC, a potent hydrophilic α-tocopherol derivative, on vascular smooth muscle cell proliferation: The pivotal role of PKC-α translocation |
Q37361994 | Inhibitory effect of quercetin on epithelial to mesenchymal transition in SK-MEL-28 human melanoma cells defined by in vitro analysis on 3D collagen gels |
Q46858853 | Inhibitory effects of 2,3,4',5-tetrahydroxystilbene-2-O-β-D-glucoside on angiotensin II-induced proliferation of vascular smooth muscle cells |
Q36613829 | Inhibitory effects of retinoic acid metabolism blocking agents (RAMBAs) on the growth of human prostate cancer cells and LNCaP prostate tumour xenografts in SCID mice. |
Q47786231 | Initial testing (stage 1) of M6620 (formerly VX-970), a novel ATR inhibitor, alone and combined with cisplatin and melphalan, by the Pediatric Preclinical Testing Program. |
Q36891684 | Integrating S-phase checkpoint signaling with trans-lesion synthesis of bulky DNA adducts |
Q35694419 | Integrating genetic and gene expression evidence into genome-wide association analysis of gene sets |
Q64883630 | Integrating the DNA damage and protein stress responses during cancer development and treatment. |
Q90380099 | Integrative Analysis of MicroRNA and Gene Interactions for Revealing Candidate Signatures in Prostate Cancer |
Q92542684 | Integrative Bioinformatics Approaches to Map Potential Novel Genes and Pathways Involved in Ovarian Cancer |
Q24302320 | Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cells |
Q33812133 | Interaction between human mismatch repair recognition proteins and checkpoint sensor Rad9-Rad1-Hus1 |
Q42953216 | Interactions Between Ataxia Telangiectasia Mutated Kinase Inhibition, Poly(ADP-ribose) Polymerase-1 Inhibition and BRCA1 Status in Breast Cancer Cells |
Q39574453 | Interactions between Swi1-Swi3, Mrc1 and S phase kinase, Hsk1 may regulate cellular responses to stalled replication forks in fission yeast |
Q28384376 | Interactions of nucleolin and ribosomal protein L26 (RPL26) in translational control of human p53 mRNA |
Q30850865 | International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways |
Q90117667 | Interplay between DNA damage repair and apoptosis shapes cancer evolution through aneuploidy and microsatellite instability |
Q36868759 | Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor-induced DNA damage in vitro and in vivo in human multiple myeloma cells |
Q96172104 | Intrinsic and acquired resistance to CDK4/6 inhibitors and potential overcoming strategies |
Q37856596 | Ion channels and transporters in cancer. 1. Ion channels and cell proliferation in cancer |
Q38895233 | Ionizing radiation increases primary cilia incidence and induces multiciliation in C2C12 myoblasts |
Q37530284 | Is activation of the intra-S checkpoint in human fibroblasts an important factor in protection against UV-induced mutagenesis? |
Q39120994 | Isoalantolactone, a sesquiterpene lactone, induces apoptosis in SGC-7901 cells via mitochondrial and phosphatidylinositol 3-kinase/Akt signaling pathways. |
Q35144843 | Isorhamnetin flavonoid synergistically enhances the anticancer activity and apoptosis induction by cis-platin and carboplatin in non-small cell lung carcinoma (NSCLC). |
Q37112305 | Jungermannenone A and B induce ROS- and cell cycle-dependent apoptosis in prostate cancer cells in vitro |
Q64098604 | K1 gene transformation activities in AIDS-related and classic type Kaposi's sarcoma: Correlation with clinical presentation |
Q36227159 | Killing of Kras-mutant colon cancer cells via Rac-independent actin remodeling by the βGBP cytokine, a physiological PI3K inhibitor therapeutically effective in vivo |
Q37235809 | Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. |
Q36516789 | Knock-down of hypoxia-induced carbonic anhydrases IX and XII radiosensitizes tumor cells by increasing intracellular acidosis |
Q38762742 | Knockdown of NFBD1/MDC1 enhances chemosensitivity to cisplatin or 5-fluorouracil in nasopharyngeal carcinoma CNE1 cells |
Q92517055 | Knockdown of SP1/Syncytin1 axis inhibits the proliferation and metastasis through the AKT and ERK1/2 signaling pathways in non-small cell lung cancer |
Q39414227 | Knockdown of eukaryotic translation initiation factors 3B (EIF3B) inhibits proliferation and promotes apoptosis in glioblastoma cells |
Q39632383 | Korean Scutellaria baicalensis water extract inhibits cell cycle G1/S transition by suppressing cyclin D1 expression and matrix-metalloproteinase-2 activity in human lung cancer cells |
Q21245753 | Krüppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts |
Q37139954 | L1 mobile element expression causes multiple types of toxicity. |
Q41962409 | L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1. |
Q46527246 | LDH, proliferation curves and cell cycle analysis are the most suitable assays to identify and characterize new phytotherapeutic compounds |
Q38878616 | LW-213 induces G2/M cell cycle arrest through AKT/GSK3β/β-catenin signaling pathway in human breast cancer cells |
Q35636826 | Label-Free Protein-RNA Interactome Analysis Identifies Khsrp Signaling Downstream of the p38/Mk2 Kinase Complex as a Critical Modulator of Cell Cycle Progression |
Q34609906 | Lack of Bcl11b tumor suppressor results in vulnerability to DNA replication stress and damages |
Q64947321 | Large-scale gene expression analysis reveals robust gene signatures for prognosis prediction in lung adenocarcinoma. |
Q64268094 | Leucine zipper and ICAT domain containing (LZIC) protein regulates cell cycle transitions in response to ionizing radiation |
Q59010467 | Ligand-Based Pharmacophore Modeling and Virtual Screening of RAD9 Inhibitors |
Q37198572 | Living on a break: cellular senescence as a DNA-damage response |
Q91936408 | LncRNA MAGI2-AS3 is involved in cervical squamous cell carcinoma development through CDK6 up-regulation |
Q90705873 | Long non-coding RNA small nucleolar RNA host gene 7 is upregulated and promotes cell proliferation in thyroid cancer |
Q34241484 | Long-distance inflammatory and genotoxic impact of cancer in vivo |
Q35245608 | Long-term prognostic value of the combination of EORTC risk group calculator and molecular markers in non-muscle-invasive bladder cancer patients treated with intravesical Bacille Calmette-Guérin |
Q34288868 | Loss of CCDC6, the first identified RET partner gene, affects pH2AX S139 levels and accelerates mitotic entry upon DNA damage. |
Q47615958 | Loss of DNA Damage Response in Neuroblastoma and Utility of a PARP Inhibitor. |
Q61800245 | Loss of NFBD1/MDC1 disrupts homologous recombination repair and sensitizes nasopharyngeal carcinoma cells to PARP inhibitors |
Q37190502 | MAPK15 upregulation promotes cell proliferation and prevents DNA damage in male germ cell tumors. |
Q27336474 | MASTL(Greatwall) regulates DNA damage responses by coordinating mitotic entry after checkpoint recovery and APC/C activation |
Q49434689 | MED28 increases the colony-forming ability of breast cancer cells by stabilizing the ZNF224 protein upon DNA damage |
Q34972637 | MET Inhibition Results in DNA Breaks and Synergistically Sensitizes Tumor Cells to DNA-Damaging Agents Potentially by Breaching a Damage-Induced Checkpoint Arrest |
Q43201212 | MG132 as a proteasome inhibitor induces cell growth inhibition and cell death in A549 lung cancer cells via influencing reactive oxygen species and GSH level |
Q54940409 | MIIP gene expression is associated with radiosensitivity in human nasopharyngeal carcinoma cells. |
Q42317541 | MK-8776, a novel chk1 kinase inhibitor, radiosensitizes p53-defective human tumor cells |
Q37086224 | MMP-13 is involved in oral cancer cell metastasis |
Q26738970 | Maintaining Genome Stability in Defiance of Mitotic DNA Damage |
Q38023979 | Maintenance of genomic integrity after DNA double strand breaks in the human prostate and seminal vesicle epithelium: the best and the worst |
Q34369429 | Maintenance of the DNA-damage checkpoint requires DNA-damage-induced mediator protein oligomerization |
Q35712405 | Massive interstitial copy-neutral loss-of-heterozygosity as evidence for cancer being a disease of the DNA-damage response |
Q92661447 | Maternal Obesity Alters Placental Cell Cycle Regulators in the First Trimester of Human Pregnancy: New Insights for BRCA1 |
Q36373215 | Mcm10 is required for oogenesis and early embryogenesis in Drosophila |
Q33788018 | Mdm2 links genotoxic stress and metabolism to p53. |
Q35652897 | Mechanism of T-oligo-induced cell cycle arrest in Mia-PaCa pancreatic cancer cells |
Q34181806 | Mechanism-based screen establishes signalling framework for DNA damage-associated G1 checkpoint response |
Q38134308 | Mechanisms of action of non-steroidal anti-inflammatory drugs (NSAIDs) and mesalazine in the chemoprevention of colorectal cancer. |
Q91814938 | Mechanistic Understanding of Curcumin's Therapeutic Effects in Lung Cancer |
Q38909263 | Mediator subunit 23 overexpression as a novel target for suppressing proliferation and tumorigenesis in hepatocellular carcinoma |
Q37581224 | Membrane oestrogen receptor alpha signalling to cell functions |
Q91297715 | Mesenchymal stem cells in suppression or progression of hematologic malignancy: current status and challenges |
Q38061051 | Mesenchymal stromal cells: radio-resistant members of the bone marrow |
Q36157320 | Methylferulate from Tamarix aucheriana inhibits growth and enhances chemosensitivity of human colorectal cancer cells: possible mechanism of action |
Q34079217 | MiR-34a expression has an effect for lower risk of metastasis and associates with expression patterns predicting clinical outcome in breast cancer |
Q53137197 | MicroRNA and cancer. |
Q41053612 | MicroRNA inhibition fine-tunes and provides robustness to the restriction point switch of the cell cycle |
Q37823782 | MicroRNAs: new players in the DNA damage response |
Q39005124 | Microbeads mediated oral plasmid DNA delivery using polymethacrylate vectors: an effectual groundwork for colorectal cancer. |
Q54445373 | Millepachine, a novel chalcone, induces G2/M arrest by inhibiting CDK1 activity and causing apoptosis via ROS-mitochondrial apoptotic pathway in human hepatocarcinoma cells in vitro and in vivo. |
Q37878159 | Mind the gap: keeping UV lesions in check. |
Q33292086 | Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection |
Q87035654 | Missense mutations (p.H371Y, p.D438Y) in gene CHEK2 are associated with breast cancer risk in women of Balochistan origin |
Q35549264 | Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions |
Q30581882 | Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress |
Q38053055 | Mitosis-targeted anti-cancer therapies: where they stand. |
Q37187176 | Mode of action of the chloroethylating and carbamoylating moieties of the prodrug cloretazine |
Q36286487 | Modeling of autosomal-dominant retinitis pigmentosa in Caenorhabditis elegans uncovers a nexus between global impaired functioning of certain splicing factors and cell type-specific apoptosis |
Q39355026 | Molecular Basis for K63-Linked Ubiquitination Processes in Double-Strand DNA Break Repair: A Focus on Kinetics and Dynamics. |
Q38999366 | Molecular Network Dynamics of Cell Cycle Control: Periodicity of Start and Finish |
Q38541699 | Molecular Pathways: Overcoming Radiation Resistance by Targeting DNA Damage Response Pathways |
Q33312958 | Molecular characterization of spontaneous mesenchymal stem cell transformation |
Q37826346 | Molecular mechanisms of ultraviolet radiation-induced DNA damage and repair |
Q37176648 | Molecular signature of pancreatic adenocarcinoma: an insight from genotype to phenotype and challenges for targeted therapy |
Q36792626 | Molecular targets and mechanisms of radiosensitization using DNA damage response pathways |
Q38204290 | Molecularly targeting the PI3K-Akt-mTOR pathway can sensitize cancer cells to radiotherapy and chemotherapy. |
Q50604424 | Monitoring oxidative stress and DNA damage induced by heavy metals in yeast expressing a redox-sensitive green fluorescent protein. |
Q36602578 | Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects |
Q37155146 | Mouse models of DNA double-strand break repair and neurological disease |
Q51409558 | Moving forward with actionable therapeutic targets and opportunities in endometrial cancer: A NCI clinical trials planning meeting report. |
Q39282629 | Multiple facets of the DNA damage response contribute to the radioresistance of mouse mesenchymal stromal cell lines |
Q36499765 | Multiple functions of rad9 for preserving genomic integrity |
Q36438934 | Multiple isoforms of CDC25 oppose ATM activity to maintain cell proliferation during vertebrate development |
Q24594847 | Multiple roles of ATM in monitoring and maintaining DNA integrity |
Q33248434 | Murine Wee1 plays a critical role in cell cycle regulation and pre-implantation stages of embryonic development |
Q37078650 | Mus81, Rhp51(Rad51), and Rqh1 form an epistatic pathway required for the S-phase DNA damage checkpoint |
Q35598807 | Mutant BRAF induces DNA strand breaks, activates DNA damage response pathway, and up-regulates glucose transporter-1 in nontransformed epithelial cells |
Q36390914 | Mxi1-0 regulates the growth of human umbilical vein endothelial cells through extracellular signal-regulated kinase 1/2 (ERK1/2) and interleukin-8 (IL-8)-dependent pathways |
Q51062791 | Myosin 16 levels fluctuate during the cell cycle and are downregulated in response to DNA replication stress. |
Q92000742 | NCAPG Is a Promising Therapeutic Target Across Different Tumor Types |
Q24313589 | NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint |
Q24298750 | NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling |
Q34240214 | NER initiation factors, DDB2 and XPC, regulate UV radiation response by recruiting ATR and ATM kinases to DNA damage sites |
Q28245966 | NFBD1/MDC1 is a protein of oncogenic potential in human cervical cancer |
Q35133431 | NG2 expression in glioblastoma identifies an actively proliferating population with an aggressive molecular signature. |
Q24338837 | NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor |
Q26851503 | NIRF/UHRF2 occupies a central position in the cell cycle network and allows coupling with the epigenetic landscape |
Q92255821 | NSCLC Mutated Isoforms of CCDC6 Affect the Intracellular Distribution of the Wild Type Protein Promoting Cisplatinum Resistance and PARP Inhibitors Sensitivity in Lung Cancer Cells |
Q50204965 | Naphthoquinone rich Onosma visianii Clem (Boraginaceae) root extracts induce apoptosis and cell cycle arrest in HCT-116 and MDA-MB-231 cancer cell lines |
Q39214217 | Natural Compounds as Modulators of Cell Cycle Arrest: Application for Anticancer Chemotherapies. |
Q92669975 | Nedaplatin reduces multidrug resistance of non-small cell lung cancer by downregulating the expression of long non-coding RNA MVIH |
Q46316014 | Neem Seed Oil Induces Apoptosis in MCF-7 and MDA MB-231 Human Breast Cancer Cells |
Q36329294 | Network-based analysis of transcriptional profiles from chemical perturbations experiments |
Q39181880 | Network-based identification of key proteins involved in apoptosis and cell cycle regulation. |
Q88730901 | Neuroblastoma |
Q34129155 | New insights into checkpoint kinase 1 in the DNA damage response signaling network |
Q36845724 | New technologies used in the study of human melanoma |
Q36724661 | New therapeutic strategies for the treatment of acute lymphoblastic leukaemia |
Q49962911 | New therapeutic strategies to treat human cancers expressing mutant p53 proteins |
Q36547381 | New tricks for old drugs: the anticarcinogenic potential of DNA repair inhibitors |
Q38753660 | Non-apoptotic functions of BCL-2 family proteins |
Q35237519 | Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells |
Q84921228 | Notch promotes radioresistance of glioma stem cells |
Q26851211 | Novel aspects of the liver microenvironment in hepatocellular carcinoma pathogenesis and development |
Q36939959 | Novel inhibitors of checkpoint kinase 1. |
Q37536599 | Novel piperazine-based compounds inhibit microtubule dynamics and sensitize colon cancer cells to tumor necrosis factor-induced apoptosis |
Q27932610 | Novel role for checkpoint Rad53 protein kinase in the initiation of chromosomal DNA replication in Saccharomyces cerevisiae |
Q38866642 | Novel targets for ATM-deficient malignancies |
Q64103522 | Nuciferine inhibits the progression of glioblastoma by suppressing the SOX2-AKT/STAT3-Slug signaling pathway |
Q39258788 | Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication |
Q28740849 | Nuclear accumulation of the papillomavirus E1 helicase blocks S-phase progression and triggers an ATM-dependent DNA damage response |
Q33675528 | Nucleoplasmic calcium is required for cell proliferation |
Q28511152 | Oct4 interaction with Hmgb2 regulates Akt signaling and pluripotency |
Q89880356 | Olaparib Combined with an ATR or Chk1 Inhibitor as a Treatment Strategy for Acquired Olaparib-Resistant BRCA1 Mutant Ovarian Cells |
Q37890974 | Oncogene-induced senescence and its role in tumor suppression. |
Q29617915 | Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication |
Q35015372 | Ophiobolin O isolated from Aspergillus ustus induces G1 arrest of MCF-7 cells through interaction with AKT/GSK3β/cyclin D1 signaling |
Q34484399 | Opiates, psychostimulants, and adult hippocampal neurogenesis: Insights for addiction and stem cell biology. |
Q36030219 | Opportunities and challenges for nutritional proteomics in cancer prevention |
Q55457072 | Orally bioavailable and blood-brain-barrier penetrating ATM inhibitor (AZ32) radiosensitizes intracranial gliomas in mice. |
Q30434208 | Origin licensing and p53 status regulate Cdk2 activity during G(1). |
Q30573133 | Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification |
Q92610926 | Outcompeting cancer |
Q33841579 | Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs) |
Q39685702 | Overexpression of cyclin Y in non-small cell lung cancer is associated with cancer cell proliferation |
Q36210995 | Overexpression of hepatocyte nuclear factor-4α initiates cell cycle entry, but is not sufficient to promote β-cell expansion in human islets |
Q38999451 | Oxidative DNA damage causes premature senescence in mouse embryonic fibroblasts deficient for Krüppel-like factor 4. |
Q42017634 | Oxidative DNA damage in neurons: implication of ku in neuronal homeostasis and survival |
Q39108341 | Oxidative stress leads to increased mutation frequency in a murine model of myelodysplastic syndrome |
Q28576161 | Oxidative stress-induced DNA damage and cell cycle regulation in B65 dopaminergic cell line |
Q37004597 | Oxidative stress-induced DNA damage of mouse zygotes triggers G2/M checkpoint and phosphorylates Cdc25 and Cdc2. |
Q48127576 | P16 promotes the growth and mobility potential of breast cancer both in vitro and in vivo: the key role of the activation of IL-6/JAK2/STAT3 signaling. |
Q37271214 | PCNA promotes processive DNA end resection by Exo1. |
Q52646109 | PFKFB3 blockade inhibits hepatocellular carcinoma growth by impairing DNA repair through AKT. |
Q41881135 | PI3K/Akt/JNK/c-Jun signaling pathway is a mediator for arsenite-induced cyclin D1 expression and cell growth in human bronchial epithelial cells |
Q36544946 | PLK1 inhibitors synergistically potentiate HDAC inhibitor lethality in imatinib mesylate-sensitive or -resistant BCR/ABL+ leukemia cells in vitro and in vivo |
Q90610987 | PRR14 overexpression promotes cell growth, epithelial to mesenchymal transition and metastasis of colon cancer via the AKT pathway |
Q37437654 | Paf15 expression correlates with rectal cancer prognosis, cell proliferation and radiation response |
Q37114275 | Participation of DNA repair in the response to 5-fluorouracil |
Q33581774 | Pathway analysis using random forests with bivariate node-split for survival outcomes |
Q41135321 | Patterns of DNA damage response in intracranial germ cell tumors versus glioblastomas reflect cell of origin rather than brain environment: implications for the anti-tumor barrier concept and treatment |
Q36139867 | Perspective on mutagenesis and repair: the standard model and alternate modes of mutagenesis |
Q83520155 | Phenotypes associated with Saccharomyces cerevisiae Hug1 protein, a putative negative regulator of dNTP Levels, reveal similarities and differences with sequence-related Dif1 |
Q24336328 | Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage |
Q52375228 | Phosphorylation of CDC25C by AMP-activated protein kinase mediates a metabolic checkpoint during cell-cycle G2/M-phase transition. |
Q35131775 | Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit |
Q39659313 | Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint |
Q36562894 | Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin |
Q39460903 | Phosphorylation of SRSF1 is modulated by replicational stress |
Q33236676 | Phosphorylation of nucleotide excision repair factor xeroderma pigmentosum group A by ataxia telangiectasia mutated and Rad3-related-dependent checkpoint pathway promotes cell survival in response to UV irradiation |
Q34484346 | Phosphorylation of p62 by cdk1 controls the timely transit of cells through mitosis and tumor cell proliferation. |
Q27935850 | Phosphorylation of the budding yeast 9-1-1 complex is required for Dpb11 function in the full activation of the UV-induced DNA damage checkpoint |
Q36990776 | Phosphorylation-triggered CUEDC2 degradation promotes UV-induced G1 arrest through APC/C(Cdh1) regulation. |
Q33691551 | Phyllanthus spp. induces selective growth inhibition of PC-3 and MeWo human cancer cells through modulation of cell cycle and induction of apoptosis |
Q36927933 | Phytoestrogen Bakuchiol Exhibits In Vitro and In Vivo Anti-breast Cancer Effects by Inducing S Phase Arrest and Apoptosis |
Q49706343 | Pine needle oil induces G2/M arrest of HepG2 cells by activating the ATM pathway |
Q35164331 | Piperine causes G1 phase cell cycle arrest and apoptosis in melanoma cells through checkpoint kinase-1 activation |
Q36660250 | Plasma membrane estrogen receptors |
Q93083439 | Platinum(ii) complexes with rutaecarpine and tryptanthrin derivatives induce apoptosis by inhibiting telomerase activity and disrupting mitochondrial function |
Q33829178 | Polo-like kinase 1 enhances survival and mutagenesis after genotoxic stress in normal cells through cell cycle checkpoint bypass |
Q37321107 | Polo-like kinases mediate cell survival in mitochondrial dysfunction |
Q54252881 | Polymyxin B causes DNA damage in HK-2 cells and mice. |
Q40248130 | Polyploidization increases the sensitivity to DNA-damaging agents in mammalian cells |
Q39984989 | Possible involvement of caspase-7 in cell cycle progression at mitosis |
Q37719913 | Post-translational modifications of proliferating cell nuclear antigen: A key signal integrator for DNA damage response (Review). |
Q34221860 | Potentiation of tumor responses to DNA damaging therapy by the selective ATR inhibitor VX-970 |
Q33723727 | Pravastatin reduces radiation-induced damage in normal tissues |
Q37076763 | Preclinical evaluation of a novel ATM inhibitor, KU59403, in vitro and in vivo in p53 functional and dysfunctional models of human cancer |
Q54510509 | Preferential killing of p53-deficient cancer cells by reversine. |
Q38756843 | Prexasertib, a Chk1/Chk2 inhibitor, increases the effectiveness of conventional therapy in B-/T- cell progenitor acute lymphoblastic leukemia |
Q50423643 | Prexasertib, a cell cycle checkpoint kinase 1 and 2 inhibitor, in BRCA wild-type recurrent high-grade serous ovarian cancer: a first-in-class proof-of-concept phase 2 study. |
Q48534871 | Prexasertib, a cell cycle checkpoint kinases 1 and 2 inhibitor, increases in vitro toxicity of PARP inhibition by preventing Rad51 foci formation in BRCA wild type high-grade serous ovarian cancer |
Q44025949 | ProEx C as an adjunct marker to improve cytological detection of urothelial carcinoma in urinary specimens. |
Q24620829 | Proapoptotic Bid mediates the Atr-directed DNA damage response to replicative stress |
Q37030594 | Processing of DNA damage clusters in human cells: current status of knowledge |
Q37065209 | Profiling DNA damage-induced phosphorylation in budding yeast reveals diverse signaling networks |
Q35550222 | Prognostic Value of Expression of Cyclin E in Gastrointestinal Cancer: A Systematic Review and Meta-Analysis |
Q64278894 | Prognostic implications of epidermal growth factor receptor variant III expression and nuclear translocation in Chinese human gliomas |
Q44270673 | Promotion of DNA repair by nuclear IKKβ phosphorylation of ATM in response to genotoxic stimuli |
Q38748694 | Prospect of rindopepimut in the treatment of glioblastoma. |
Q38974279 | Prospects for the Use of ATR Inhibitors to Treat Cancer. |
Q37375309 | Protective roles of Gadd45 and MDM2 in blueberry anthocyanins mediated DNA repair of fragmented and non-fragmented DNA damage in UV-irradiated HepG2 cells |
Q52724818 | Protein arginine methylation: an emerging regulator of the cell cycle. |
Q36908131 | Protein phosphatase 2A has an essential role in the activation of gamma-irradiation-induced G2/M checkpoint response |
Q33496409 | Protein phosphatase 2A-dependent dephosphorylation of replication protein A is required for the repair of DNA breaks induced by replication stress |
Q39600050 | Protein phosphatase-1 inhibitor-3 is an in vivo target of caspase-3 and participates in the apoptotic response |
Q24307983 | Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress |
Q36282835 | Putting cancer to sleep at night: the neuroendocrine/circadian melatonin signal |
Q47239224 | Pyruvate kinase M2 phosphorylates H2AX and promotes genomic instability in human tumor cells |
Q39328755 | Quiescence and attenuated DNA damage response promote survival of esophageal cancer stem cells |
Q36245598 | RAC1 GTPase plays an important role in γ-irradiation induced G2/M checkpoint activation |
Q24294922 | RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage |
Q37800769 | RAD51C: a novel cancer susceptibility gene is linked to Fanconi anemia and breast cancer |
Q40146451 | RAD51D protects against MLH1-dependent cytotoxic responses to O(6)-methylguanine |
Q29976886 | RAD6-RAD18-RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light. |
Q37472045 | RADIOSENSITIVITY TO HIGH ENERGY IRON IONS IS INFLUENCED BY HETEROZYGOSITY for ATM, RAD9 and BRCA1. |
Q37190148 | RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damage sites |
Q36352398 | RAP80 is critical in maintaining genomic stability and suppressing tumor development |
Q35116809 | RBM3-regulated genes promote DNA integrity and affect clinical outcome in epithelial ovarian cancer |
Q28245362 | RETRACTED: Small molecule-based reversible reprogramming of cellular lifespan |
Q35172957 | RFPL4A increases the G1 population and decreases sensitivity to chemotherapy in human colorectal cancer cells |
Q37385250 | RNA surveillance: molecular approaches in transcript quality control and their implications in clinical diseases |
Q97423911 | RNA-binding motif protein 43 (RBM43) suppresses hepatocellular carcinoma progression through modulation of cyclin B1 expression |
Q37421389 | RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks |
Q33260135 | RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint |
Q34181455 | Rad18-mediated Translesion Synthesis of Bulky DNA Adducts Is Coupled to Activation of the Fanconi Anemia DNA Repair Pathway |
Q46961821 | Rad3-dependent phosphorylation of the checkpoint clamp regulates repair-pathway choice |
Q34886275 | Rad4TopBP1, a scaffold protein, plays separate roles in DNA damage and replication checkpoints and DNA replication |
Q36477745 | Rad51 in regulating the radiosensitivity of non-small cell lung cancer with different epidermal growth factor receptor mutation status |
Q46936614 | Rad52 depletion in Candida albicans triggers both the DNA-damage checkpoint and filamentation accompanied by but independent of expression of hypha-specific genes. |
Q37387399 | Radiation carcinogenesis in context: how do irradiated tissues become tumors? |
Q28708956 | Radiation metabolomics and its potential in biodosimetry |
Q83275288 | Radiation-induced cell cycle arrests in Ehrlich ascites carcinoma cells in vivo |
Q38244964 | Radiation-induced signaling pathways that promote cancer cell survival (review). |
Q38823644 | Radioresistant human lung adenocarcinoma cells that survived multiple fractions of ionizing radiation are sensitive to HSP90 inhibition |
Q35005604 | Radiosensitization of colorectal carcinoma cell lines by histone deacetylase inhibition |
Q53599858 | Ras triggers ataxia-telangiectasia-mutated and Rad-3-related activation and apoptosis through sustained mitogenic signaling. |
Q35750491 | Rational Combinations of Targeted Agents in AML |
Q28115279 | Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1 |
Q39114322 | Reactive oxygen species mediate isoalantolactone-induced apoptosis in human prostate cancer cells. |
Q42801717 | Reconstitution of the cellular response to DNA damage in vitro using damage-activated extracts from mammalian cells |
Q33229469 | Recruitment of DNA damage checkpoint proteins to damage in transcribed and nontranscribed sequences |
Q33417335 | Recurrent CDC25C mutations drive malignant transformation in FPD/AML. |
Q34047115 | Reduced mRNA and protein expression of the genomic caretaker RAD9A in primary fibroblasts of individuals with childhood and independent second cancer |
Q49166715 | Reduced recruitment of 53BP1 during interstrand crosslink repair is associated with genetically inherited attenuation of mitomycin C sensitivity in a family with Fanconi anemia |
Q36228219 | Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase |
Q33685874 | Regulation of CHK1 by mTOR contributes to the evasion of DNA damage barrier of cancer cells |
Q28250925 | Regulation of Claspin degradation by the ubiquitin-proteosome pathway during the cell cycle and in response to ATR-dependent checkpoint activation |
Q35861281 | Regulation of DNA Damage Signaling and Cell Death Responses by Epstein-Barr Virus Latent Membrane Protein 1 (LMP1) and LMP2A in Nasopharyngeal Carcinoma Cells. |
Q34771336 | Regulation of DNA damage responses and cell cycle progression by hMOB2. |
Q64389865 | Regulation of DNA repair by non-coding miRNAs |
Q37540336 | Regulation of DNA replication by the S-phase DNA damage checkpoint |
Q47371096 | Regulation of G2/M Transition by Inhibition of WEE1 and PKMYT1 Kinases. |
Q36947768 | Regulation of Rad17 protein turnover unveils an impact of Rad17-APC cascade in breast carcinogenesis and treatment |
Q37995693 | Regulation of cell death and autophagy by IKK and NF-κB: critical mechanisms in immune function and cancer |
Q39680532 | Regulation of intra-S phase checkpoint by ionizing radiation (IR)-dependent and IR-independent phosphorylation of SMC3. |
Q51808299 | Regulation of mitotic function of Chk1 through phosphorylation at novel sites by cyclin-dependent kinase 1 (Cdk1). |
Q37410747 | Regulation of protein synthesis by ionizing radiation. |
Q36325888 | Regulation of rtt107 recruitment to stalled DNA replication forks by the cullin rtt101 and the rtt109 acetyltransferase |
Q31001642 | Regulation of the DNA damage response and gene expression by the Dot1L histone methyltransferase and the 53Bp1 tumour suppressor |
Q34722112 | Regulation of the cellular DNA double-strand break response |
Q37633137 | Regulation of the life cycle of HPVs by differentiation and the DNA damage response |
Q37801346 | Regulation of tissue- and stimulus-specific cell fate decisions by p53 in vivo. |
Q33535647 | Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase. |
Q38798535 | Regulatory roles of conserved phosphorylation sites in the activation T-loop of the MAP kinase ERK1 |
Q36611480 | Relationships between stem cell exhaustion, tumour suppression and ageing |
Q37365625 | Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining |
Q41789965 | Replication checkpoint: tuning and coordination of replication forks in s phase |
Q34547673 | Replication licensing and the DNA damage checkpoint. |
Q40262308 | Replication stress, DNA damage signalling, and cytomegalovirus infection in human medulloblastomas |
Q37156959 | Replicative stress, stem cells and aging |
Q35744967 | Requirement of ATR for maintenance of intestinal stem cells in aging Drosophila |
Q33924254 | Requirement of MTA1 in ATR-mediated DNA damage checkpoint function |
Q52868719 | Resistance to 3-HTMC-Induced Apoptosis Through Activation of PI3K/Akt, MEK/ERK, and p38/COX-2/PGE2 Pathways in Human HT-29 and HCT116 Colorectal Cancer Cells. |
Q91995103 | Response of the Green Alga Chlamydomonas reinhardtii to the DNA Damaging Agent Zeocin |
Q38829925 | Restoration of paclitaxel resistance by CDK1 intervention in drug-resistant ovarian cancer |
Q34261684 | Retracted: SPARC Overexpression Inhibits Cell Proliferation in Neuroblastoma and Is Partly Mediated by Tumor Suppressor Protein PTEN and AKT |
Q91880128 | Return to the Sea, Get Huge, Beat Cancer: An Analysis of Cetacean Genomes Including an Assembly for the Humpback Whale (Megaptera novaeangliae) |
Q35089524 | Review of Chromium (VI) Apoptosis, Cell-Cycle-Arrest, and Carcinogenesis |
Q33721213 | Ribonucleotide Reductase Inhibition Enhances Chemoradiosensitivity of Human Cervical Cancers |
Q28513144 | Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation |
Q40066661 | Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression |
Q36187434 | Role of Cdk1 in DNA damage-induced G1 checkpoint abrogation by the human papillomavirus E7 oncogene |
Q33977682 | Role of GLUT1 in regulation of reactive oxygen species |
Q37797479 | Role of cell cycle perturbations in the combination therapy of chemotherapeutic agents and radiation |
Q45080019 | Role of cyclin polymorphisms in predicting outcome of 5-fluorouracil-based chemotherapy in colorectal cancer: one piece in a complex puzzle. |
Q38291764 | Role of the mammalian SWI/SNF chromatin remodeling complex in the cellular response to UV damage |
Q37027389 | Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. |
Q40135858 | Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair |
Q41475620 | Roles of DNA Damage Response Proteins in Mitogen-Induced Thp-1 Differentiation into Macrophage |
Q54117625 | Roles of NUCKS1 in Diseases: Susceptibility, Potential Biomarker, and Regulatory Mechanisms. |
Q36953179 | Roles of cyclins A and E in induction of centrosome amplification in p53-compromised cells |
Q38025085 | Roles of p53 in various biological aspects of hematopoietic stem cells |
Q35050799 | Roles of protein arginine methylation in DNA damage signaling pathways is CARM1 a life-or-death decision point? |
Q34352173 | Rsf-1, a chromatin remodeling protein, induces DNA damage and promotes genomic instability. |
Q37982323 | Ruthenium(II) polypyridyl complexes and DNA--from structural probes to cellular imaging and therapeutics. |
Q37857744 | S-phase-coupled apoptosis in tumor suppression |
Q64114357 | SALMON: Survival Analysis Learning With Multi-Omics Neural Networks on Breast Cancer |
Q36184268 | SCAI promotes DNA double-strand break repair in distinct chromosomal contexts |
Q89586306 | SENEBLOC, a long non-coding RNA suppresses senescence via p53-dependent and independent mechanisms |
Q33582882 | SERPINA3 promotes endometrial cancer cells growth by regulating G2/M cell cycle checkpoint and apoptosis |
Q38993472 | SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint. |
Q83600771 | SKA3 Promotes tumor growth by regulating CDK2/P53 phosphorylation in hepatocellular carcinoma |
Q33822328 | SMARCAL1 and replication stress: an explanation for SIOD? |
Q33559570 | SNORD76, a box C/D snoRNA, acts as a tumor suppressor in glioblastoma |
Q99572030 | SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells |
Q80455307 | STAT1 activation in squamous cell cancer of the oral cavity: a potential predictive marker of response to adjuvant chemotherapy |
Q42952151 | Sap1 promotes the association of the replication fork protection complex with chromatin and is involved in the replication checkpoint in Schizosaccharomyces pombe |
Q99608387 | Sarcoma stratification by combined pH2AX and MAP17 (PDZK1IP1) levels for a better outcome on doxorubicin plus olaparib treatment |
Q28472927 | Saturated fatty acids modulate cell response to DNA damage: implication for their role in tumorigenesis |
Q93271476 | Screening of Long Noncoding RNAs Induced by Radiation Using Microarray |
Q46904587 | Screening of hub genes and pathways in colorectal cancer with microarray technology |
Q36525196 | Senescence-associated secretory phenotype favors the emergence of cancer stem-like cells. |
Q33824877 | Sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair |
Q89099939 | Sequence‑dependent effect of sorafenib in combination with natural phenolic compounds on hepatic cancer cells and the possible mechanism of action |
Q46303839 | Sequential molecular changes and dynamic oxidative stress in high-grade serous ovarian carcinogenesis |
Q37058602 | Sharpening the ends for repair: mechanisms and regulation of DNA resection |
Q39619172 | Shikonin inhibits the proliferation and induces the apoptosis of human HepG2 cells |
Q38048754 | Signaling pathways that regulate cell division |
Q54360188 | Significance of the melanocortin 1 receptor in the DNA damage response of human melanocytes to ultraviolet radiation. |
Q36022277 | Silencing NFBD1/MDC1 enhances the radiosensitivity of human nasopharyngeal cancer CNE1 cells and results in tumor growth inhibition. |
Q38895698 | Silver nanoparticles protect human keratinocytes against UVB radiation-induced DNA damage and apoptosis: potential for prevention of skin carcinogenesis |
Q38825141 | Simultaneous perturbation of the MAPK and the PI3K/mTOR pathways does not lead to increased radiosensitization |
Q33599844 | Single nucleotide polymorphism in ATM gene, cooking oil fumes and lung adenocarcinoma susceptibility in Chinese female non-smokers: a case-control study |
Q36318005 | Single-nucleotide polymorphisms of TGFβ1 and ATM associated with radiation-induced pneumonitis: a prospective cohort study of thoracic cancer patients in China |
Q46360304 | Sinularin induces oxidative stress-mediated G2/M arrest and apoptosis in oral cancer cells. |
Q35776514 | Size is an essential parameter in governing the UVB-protective efficacy of silver nanoparticles in human keratinocytes |
Q36781062 | Skp2 is required for Aurora B activation in cell mitosis and spindle checkpoint |
Q34298450 | Slx4 regulates DNA damage checkpoint-dependent phosphorylation of the BRCT domain protein Rtt107/Esc4 |
Q53031706 | Smad7 enhances ATM activity by facilitating the interaction between ATM and Mre11-Rad50-Nbs1 complex in DNA double-strand break repair. |
Q64256282 | Small Molecule Fluorescent Probes for G- Quadruplex Visualization as Potential Cancer Theranostic Agents |
Q46862854 | Small molecules thwart crash and burn |
Q93128827 | Solid state fermentation process with Aspergillus kawachii enhances the cancer-suppressive potential of silkworm larva in hepatocellular carcinoma cells |
Q37020205 | Soluble and insoluble nickel compounds exert a differential inhibitory effect on cell growth through IKKalpha-dependent cyclin D1 down-regulation |
Q28235091 | Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks |
Q41967501 | Speeding through cell cycle roadblocks: Nuclear cyclin D1-dependent kinase and neoplastic transformation |
Q30431071 | Spindle poisons and cell fate: a tale of two pathways. |
Q34428974 | Spontaneous abrogation of the G₂DNA damage checkpoint has clinical benefits but promotes leukemogenesis in Fanconi anemia patients |
Q36405518 | Stem Cell-Specific Mechanisms Ensure Genomic Fidelity within HSCs and upon Aging of HSCs |
Q34738304 | Sterigmatocystin-induced DNA damage triggers G2 arrest via an ATM/p53-related pathway in human gastric epithelium GES-1 cells in vitro |
Q38791128 | Sterigmatocystin-induced checkpoint adaptation depends on Chk1 in immortalized human gastric epithelial cells in vitro |
Q43189813 | Strand-specific analysis shows protein binding at replication forks and PCNA unloading from lagging strands when forks stall |
Q37411955 | Strategies for Molecularly Enhanced Chemotherapy to Achieve Synthetic Lethality in Endometrial Tumors with Mutant p53 |
Q42637891 | Strategies for targeting the DNA damage response for cancer therapeutics |
Q46259214 | Strong expression of cyclin B2 mRNA correlates with a poor prognosis in patients with non-small cell lung cancer |
Q39883693 | StrucBreak: A Computational Framework for Structural Break Detection in DNA Sequences |
Q38632321 | Structural basis of Wee kinases functionality and inactivation by diverse small molecule inhibitors |
Q54536177 | Structural requirements of pyrimidine, thienopyridine and ureido thiophene carboxamide-based inhibitors of the checkpoint kinase 1: QSAR, docking, molecular dynamics analysis. |
Q36541054 | Structure meets function--centrosomes, genome maintenance and the DNA damage response |
Q42128090 | Structure-Based Drug Design of Novel Potent and Selective Tetrahydropyrazolo[1,5-a]pyrazines as ATR Inhibitors. |
Q27675773 | Structure-Guided Evolution of Potent and Selective CHK1 Inhibitors through Scaffold Morphing |
Q91650623 | Study of the Characterization of Side Population Cells in Endometrial Cancer Cell Lines: Chemoresistance, Progestin Resistance, and Radioresistance |
Q42374939 | Studying S-phase DNA damage checkpoints using the fission yeast Schizosaccharomyces pombe |
Q34052481 | Superaugmented eccentric distance sum connectivity indices: novel highly discriminating topological descriptors for QSAR/QSPR. |
Q38912800 | Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis |
Q47928900 | Suppression of the DNA damage response in acute myeloid leukemia versus myelodysplastic syndrome |
Q37086576 | Supreme EnLIGHTenment: damage recognition and signaling in the mammalian UV response |
Q51075833 | Synchronization and Desynchronization of Cells by Interventions on the Spindle Assembly Checkpoint. |
Q40063670 | Synergism between bosutinib (SKI-606) and the Chk1 inhibitor (PF-00477736) in highly imatinib-resistant BCR/ABL⁺ leukemia cells |
Q33597926 | Synergistic effects of a novel lipid-soluble extract from Pinellia pedatisecta Schott and cisplatin on human cervical carcinoma cell lines through the regulation of DNA damage response signaling pathway |
Q34326278 | Synergistic interaction of Rnf8 and p53 in the protection against genomic instability and tumorigenesis. |
Q47370432 | Synthetically lethal nanoparticles for treatment of endometrial cancer. |
Q47193677 | Systematic assessment of cervical cancer initiation and progression uncovers genetic panels for deep learning-based early diagnosis and proposes novel diagnostic and prognostic biomarkers |
Q55339659 | Systems and synthetic biology approaches in understanding biological oscillators. |
Q90410019 | TIM-3 Participates in the Invasion and Metastasis of Nasopharyngeal Carcinoma via SMAD7/SMAD2/SNAIL1 Axis-Mediated Epithelial-Mesenchymal Transition |
Q92859986 | TNAP inhibition attenuates cardiac fibrosis induced by myocardial infarction through deactivating TGF-β1/Smads and activating P53 signaling pathways |
Q52726523 | TRIP13 promotes tumor growth and is associated with poor prognosis in colorectal cancer. |
Q39315433 | Taiwanofungus camphoratus (Syn Antrodia camphorata) extract and amphotericin B exert adjuvant effects via mitochondrial apoptotic pathway |
Q40046642 | Take your PIKK: tumour viruses and DNA damage response pathways. |
Q34865929 | Tandem BRCT Domains: DNA's Praetorian Guard. |
Q26822592 | Targeting ATM-deficient CLL through interference with DNA repair pathways |
Q28554501 | Targeting CDKs with Roscovitine Increases Sensitivity to DNA Damaging Drugs of Human Osteosarcoma Cells |
Q41993531 | Targeting Chk1 in the replicative stress response |
Q39220127 | Targeting Chk2 improves gastric cancer chemotherapy by impairing DNA damage repair. |
Q37960389 | Targeting DNA repair and the cell cycle in glioblastoma |
Q30480882 | Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis |
Q39328356 | Targeting radiation-resistant hypoxic tumour cells through ATR inhibition |
Q37667106 | Targeting silibinin in the antiproliferative pathway |
Q57115037 | Targeting the cell cycle in breast cancer: towards the next phase |
Q38191794 | Targeting tumour-supportive cellular machineries in anticancer drug development |
Q24304948 | Tel2 regulates the stability of PI3K-related protein kinases |
Q41191920 | Telomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome |
Q35597009 | Telomere shortening alters the kinetics of the DNA damage response after ionizing radiation in human cells |
Q37627017 | Telomeres and telomerase in cancer |
Q37071461 | Teriflunomide, an immunomodulatory drug, exerts anticancer activity in triple negative breast cancer cells |
Q36291440 | Termination of Replication Stress Signaling via Concerted Action of the Slx4 Scaffold and the PP4 Phosphatase |
Q51843085 | Tetramethylpyrazine induces G0/G1 cell cycle arrest and stimulates mitochondrial-mediated and caspase-dependent apoptosis through modulating ERK/p53 signaling in hepatic stellate cells in vitro. |
Q48604461 | The Analysis of Cell Cycle, Proliferation, and Asymmetric Cell Division by Imaging Flow Cytometry |
Q64249505 | The Anti-Proliferation, Cycle Arrest and Apoptotic Inducing Activity of Peperomin E on Prostate Cancer PC-3 Cell Line |
Q36010739 | The CDK4/6 inhibitor PD0332991 reverses epithelial dysplasia associated with abnormal activation of the cyclin-CDK-Rb pathway |
Q28265315 | The CHEK2 gene and inherited breast cancer susceptibility |
Q24305557 | The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells |
Q24317772 | The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint |
Q34557750 | The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism |
Q38178966 | The DNA Damage Response: A Common Pathway in the Regulation of NKG2D and DNAM-1 Ligand Expression in Normal, Infected, and Cancer Cells. |
Q38089570 | The DNA damage checkpoint response to replication stress: A Game of Forks |
Q26825363 | The DNA damage response induced by infection with human cytomegalovirus and other viruses |
Q46914764 | The DNA damage signalling kinase ATM is aberrantly reduced or lost in BRCA1/BRCA2-deficient and ER/PR/ERBB2-triple-negative breast cancer |
Q38884854 | The DNA damage/repair cascade in glioblastoma cell lines after chemotherapeutic agent treatment |
Q24606586 | The DNA-damage response in human biology and disease |
Q34009427 | The DNA-damage response: new molecular insights and new approaches to cancer therapy |
Q24310746 | The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress |
Q91658012 | The Function of Lipin in the Wing Development of Drosophila melanogaster |
Q24338440 | The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress |
Q94322163 | The Possible Crosstalk of MOB2 With NDR1/2 Kinases in Cell Cycle and DNA Damage Signaling |
Q48802370 | The Role of Surgery in Cancer Prevention |
Q26782011 | The Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and Repair |
Q33913826 | The Spi1/PU.1 transcription factor accelerates replication fork progression by increasing PP1 phosphatase in leukemia |
Q92619044 | The TCP1 ring complex is associated with malignancy and poor prognosis in hepatocellular carcinoma |
Q35873110 | The UBC Domain Is Required for BRUCE to Promote BRIT1/MCPH1 Function in DSB Signaling and Repair Post Formation of BRUCE-USP8-BRIT1 Complex |
Q33507753 | The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks |
Q42415006 | The anti-apoptotic factor Che-1/AATF links transcriptional regulation, cell cycle control, and DNA damage response |
Q58101390 | The anticancer mechanism investigation of Tanshinone II by pharmacological clustering in protein network |
Q92771330 | The binding of lncRNA RP11-732M18.3 with 14-3-3 β/α accelerates p21 degradation and promotes glioma growth |
Q37954328 | The biology of the cytolethal distending toxins |
Q95839849 | The bromodomain containing protein BRD-9 orchestrates RAD51-RAD54 complex formation and regulates homologous recombination-mediated repair |
Q24294320 | The bromodomain protein Brd4 insulates chromatin from DNA damage signalling |
Q36188646 | The cell cycle regulator ecdysoneless cooperates with H-Ras to promote oncogenic transformation of human mammary epithelial cells |
Q34110993 | The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage |
Q28390451 | The circadian clock in cancer development and therapy |
Q28395468 | The effect of calcium phosphate nanoparticles on hormone production and apoptosis in human granulosa cells |
Q64089103 | The emerging roles and functions of circular RNAs and their generation |
Q39084654 | The epithelium specific cell cycle regulator 14-3-3sigma is required for preventing entry into mitosis following ultraviolet B. |
Q33834976 | The fission yeast Rad32(Mre11)-Rad50-Nbs1 complex acts both upstream and downstream of checkpoint signaling in the S-phase DNA damage checkpoint |
Q28513565 | The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1 |
Q24306086 | The human DEK oncogene regulates DNA damage response signaling and repair |
Q37606136 | The human intra-S checkpoint response to UVC-induced DNA damage |
Q55044969 | The impact of a negligent G2/M checkpoint on genomic instability and cancer induction. |
Q35950241 | The intra-S-phase checkpoint affects both DNA replication initiation and elongation: single-cell and -DNA fiber analyses |
Q37031690 | The mTOR pathway negatively controls ATM by up-regulating miRNAs. |
Q36182260 | The metabolically-modulated stem cell niche: a dynamic scenario regulating cancer cell phenotype and resistance to therapy. |
Q33375180 | The molecular basis of genistein-induced mitotic arrest and exit of self-renewal in embryonal carcinoma and primary cancer cell lines |
Q37821229 | The molecular biology of head and neck cancer |
Q33401051 | The multi-replication protein A (RPA) system--a new perspective |
Q39003096 | The novel thymidylate synthase inhibitor trifluorothymidine (TFT) and TRAIL synergistically eradicate non-small cell lung cancer cells. |
Q42827201 | The nucleotide excision repair protein XPC is essential for bulky DNA adducts to promote interleukin-6 expression via the activation of p38-SAPK. |
Q24339317 | The overexpression of MCPH1 inhibits cell growth through regulating cell cycle-related proteins and activating cytochrome c-caspase 3 signaling in cervical cancer |
Q39761186 | The p53-inducible gene 3 (PIG3) contributes to early cellular response to DNA damage |
Q36905454 | The paracrine hormone hypothesis of colorectal cancer. |
Q41292927 | The plant-specific CDKB1-CYCB1 complex mediates homologous recombination repair in Arabidopsis |
Q37983690 | The potential of exploiting DNA-repair defects for optimizing lung cancer treatment |
Q37390143 | The potential role and application of PARP inhibitors in cancer treatment |
Q36610597 | The predictive value of molecular markers (p53, EGFR, ATM, CHK2) in multimodally treated squamous cell carcinoma of the oesophagus. |
Q36417134 | The role of ATM and 53BP1 as predictive markers in cervical cancer. |
Q36689932 | The role of BRCA1 in homologous recombination repair in response to replication stress: significance in tumorigenesis and cancer therapy |
Q40378381 | The role of ICP0-Null HSV-1 and interferon signaling defects in the effective treatment of breast adenocarcinoma. |
Q35022520 | The role of RAD9 in tumorigenesis |
Q38967406 | The role of hydrogen sulfide in aging and age-related pathologies |
Q22306473 | The role of poly(ADP-ribose) in the DNA damage signaling network |
Q34341080 | The role of the RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system |
Q39171826 | The stress response resolution assay. I. Quantitative assessment of environmental agent/condition effects on cellular stress resolution outcomes in epithelium |
Q47203904 | The therapeutic potential of cell cycle targeting in multiple myeloma |
Q24305326 | The tumor suppressor CYLD regulates entry into mitosis |
Q37807639 | The ubiquitous role of ubiquitin in the DNA damage response |
Q46829817 | The ultraviolet A-activated photosensitizer 2-(4-aminophenyl)-7-methoxybenzothiazole suppresses proliferation and induces apoptosis of keloid fibroblasts: a potential adjunctive therapy for keloids |
Q34061440 | The versatile functions of ATM kinase |
Q30426400 | The yin-yang of DNA damage response: roles in tumorigenesis and cellular senescence |
Q37667246 | Theabrownin Inhibits Cell Cycle Progression and Tumor Growth of Lung Carcinoma through c-myc-Related Mechanism |
Q39705991 | Three-dimensionally specific inhibition of DNA repair-related genes by activated KRAS in colon crypt model |
Q99238896 | TiO2 Nanoparticles Caused DNA Damage in Lung and Extra-Pulmonary Organs Through ROS-Activated FOXO3a Signaling Pathway After Intratracheal Administration in Rats |
Q39632401 | Tithonia diversifolia and its main active component tagitinin C induce survivin inhibition and G2/M arrest in human malignant glioblastoma cells |
Q33894381 | To fuse or not to fuse: how do checkpoint and DNA repair proteins maintain telomeres? |
Q38580042 | To senesce or not to senesce: how primary human fibroblasts decide their cell fate after DNA damage |
Q36706894 | TopBP1 activates ATR through ATRIP and a PIKK regulatory domain |
Q34207633 | TopBP1 and Claspin contribute to the radioresistance of lung cancer brain metastases |
Q29614976 | Topoisomerase I inhibitors: camptothecins and beyond |
Q39211167 | Transcriptional networks controlling the cell cycle. |
Q33226984 | Transcriptional profiling of mammary gland side population cells |
Q41898095 | Transcriptional regulation underlying recovery from a DNA damage-induced arrest. |
Q37577423 | Transcriptome analysis of glioma cells for the dynamic response to γ-irradiation and dual regulation of apoptosis genes: a new insight into radiotherapy for glioblastomas |
Q91975036 | Transcriptome analysis revealed key prognostic genes and microRNAs in hepatocellular carcinoma |
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