Cell-cycle checkpoints and cancer (scientific article)

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Q34296170	DNA damage signaling is activated during cancer progression in human colorectal carcinoma
Q33910490	DNA damage signaling regulates age-dependent proliferative capacity of quiescent inner ear supporting cells
Q38893748	DNA damage signalling barrier, oxidative stress and treatment-relevant DNA repair factor alterations during progression of human prostate cancer
Q37027188	DNA damage signalling guards against activated oncogenes and tumour progression
Q37785492	DNA damage stress response in germ cells: role of c-Abl and clinical implications
Q37187991	DNA damage tolerance: a double-edged sword guarding the genome
Q41989448	DNA damage-dependent cyclin D1 proteolysis: GSK3beta holds the smoking gun
Q39125363	DNA damage-induced cell cycle regulation and function of novel Chk2 phosphoresidues.
Q24652996	DNA damage-induced ubiquitylation of RFC2 subunit of replication factor C complex
Q42750184	DNA helicases Sgs1 and BLM promote DNA double-strand break resection
Q84632174	DNA hypermethylation biomarkers to predict response to cisplatin treatment, radiotherapy or chemoradiation: the present state of art
Q38893619	DNA intercalative 4-butylaminopyrimido[4',5':4,5]thieno(2,3-b)quinoline induces cell cycle arrest and apoptosis in leukemia cells
Q37962577	DNA methylation of tumor suppressor miRNA genes: a lesson from the miR-34 family
Q37146966	DNA protein kinase-dependent G2 checkpoint revealed following knockdown of ataxia-telangiectasia mutated in human mammary epithelial cells
Q36610563	DNA repair capacity as a possible biomarker of breast cancer risk in female BRCA1 mutation carriers
Q37368873	DNA repair deficiency and neurological disease
Q34183328	DNA repair deficiency in neurodegeneration.
Q38061847	DNA repair dysregulation from cancer driver to therapeutic target
Q29615572	DNA repair pathways as targets for cancer therapy
Q37154126	DNA strand breaks, neurodegeneration and aging in the brain
Q28116227	DNA-PKcs-PIDDosome: a nuclear caspase-2-activating complex with role in G2/M checkpoint maintenance
Q39881890	DNA-damage response, survival and differentiation in vitro of a human neural stem cell line in relation to ATM expression.
Q24312094	DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint
Q31055841	Data on cell cycle in breast cancer cell line, MDA-MB-231 with ferulic acid treatment
Q37135368	Death through a tragedy: mitotic catastrophe
Q38695071	Decision for cell fate: deubiquitinating enzymes in cell cycle checkpoint
Q37966330	Deconstructing p53 transcriptional networks in tumor suppression
Q33911206	Decreased DNA repair activity in bone marrow due to low expression of DNA damage repair proteins
Q41908765	Decreased translation of p21waf1 mRNA causes attenuated p53 signaling in some p53 wild-type tumors
Q60922825	Deduction of Novel Genes Potentially Involved in Upper Tract Urothelial Carcinoma Using Next-Generation Sequencing and Bioinformatics Approaches
Q40114129	Defective cell cycle checkpoint functions in melanoma are associated with altered patterns of gene expression
Q51057019	Deficient innate immunity, thymopoiesis, and gene expression response to radiation in survivors of childhood acute lymphoblastic leukemia.
Q33734684	Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation
Q33991135	Deinococcus radiodurans - the consummate survivor
Q36341493	Deoxycytidine kinase regulates the G2/M checkpoint through interaction with cyclin-dependent kinase 1 in response to DNA damage
Q48225463	Deoxyschizandrin, Isolated from Schisandra Berries, Induces Cell Cycle Arrest in Ovarian Cancer Cells and Inhibits the Protumoural Activation of Tumour-Associated Macrophages
Q40373985	Depletion of Chk1 leads to premature activation of Cdc2-cyclin B and mitotic catastrophe
Q38721629	Depletion of NFBD1/MDC1 Induces Apoptosis in Nasopharyngeal Carcinoma Cells Through the p53-ROS-Mitochondrial Pathway
Q38190332	Deregulation of cell signaling in cancer
Q33847620	Derivation and experimental comparison of cell-division probability densities
Q33951823	Design, synthesis, mechanisms of action, and toxicity of novel 20(s)-sulfonylamidine derivatives of camptothecin as potent antitumor agents
Q47310421	Developing an Agent-Based Drug Model to Investigate the Synergistic Effects of Drug Combinations
Q36039774	Development and Characterization of a Novel in vitro Progression Model for UVB-Induced Skin Carcinogenesis
Q34046125	Development of a regulatable oncolytic herpes simplex virus type 1 recombinant virus for tumor therapy
Q90380896	Development of hydroxamate-based histone deacetylase inhibitors of bis-substituted aromatic amides with antitumor activities
Q34253229	Development of serous ovarian cancer is associated with the expression of homologous recombination pathway proteins
Q49537557	Differences in MWCNT- and SWCNT-induced DNA methylation alterations in association with the nuclear deposition
Q37111110	Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS
Q38864150	Differential PAX5 levels promote malignant B-cell infiltration, progression and drug resistance, and predict a poor prognosis in MCL patients independent of CCND1.
Q38973197	Differential effects of lipid fractions from silver carp brain on human cervical carcinoma cells in vitro
Q42584836	Differential localization of ATM is correlated with activation of distinct downstream signaling pathways
Q36289902	Differential regulation of p21 (waf1) protein half-life by DNA damage and Nutlin-3 in p53 wild-type tumors and its therapeutic implications
Q39971219	Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation
Q39110541	Digalloylresveratrol, a novel resveratrol analog inhibits the growth of human pancreatic cancer cells.
Q99630195	Digitoxin inhibits proliferation of multidrug-resistant HepG2 cells through G2/M cell cycle arrest and apoptosis
Q90399896	Diplatin, a Novel and Low-Toxicity Anti-Lung Cancer Platinum Complex, Activation of Cell Death in Tumors via a ROS/JNK/p53-Dependent Pathway, and a Low Rate of Acquired Treatment Resistance
Q31054756	Discovering Biology in Periodic Data through Phase Set Enrichment Analysis (PSEA).
Q41761375	Discovery of 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as selective, orally bioavailable CHK1 inhibitors.
Q35808778	Discovery of dachshund 2 protein as a novel biomarker of poor prognosis in epithelial ovarian cancer
Q34049279	Disruption of G1-phase phospholipid turnover by inhibition of Ca2+-independent phospholipase A2 induces a p53-dependent cell-cycle arrest in G1 phase
Q33561346	Dissect the Dynamic Molecular Circuits of Cell Cycle Control through Network Evolution Model.
Q37579636	Dissecting the role of ubiquitylation in the DNA damage response checkpoint in G2.
Q30803682	Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans
Q59797742	Distinct prognostic value of dynactin subunit 4 (DCTN4) and diagnostic value of DCTN1, DCTN2, and DCTN4 in colon adenocarcinoma
Q37876491	Do bacterial genotoxins contribute to chronic inflammation, genomic instability and tumor progression?
Q54346146	Docking-based 3D-QSAR study of pyridyl aminothiazole derivatives as checkpoint kinase 1 inhibitors.
Q58572952	Downregulation of 5-hydroxytryptamine receptor 3A expression exerts an anticancer activity against cell growth in colorectal carcinoma cells
Q92015501	Dracorhodin perchlorate induces apoptosis and G2/M cell cycle arrest in human esophageal squamous cell carcinoma through inhibition of the JAK2/STAT3 and AKT/FOXO3a pathways
Q33800164	Drf1-dependent kinase interacts with Claspin through a conserved protein motif
Q33802649	Dual expression of Epstein-Barr virus, latent membrane protein-1 and human papillomavirus-16 E6 transform primary mouse embryonic fibroblasts through NF-κB signaling
Q33390327	Dual regulation of Cdc25A by Chk1 and p53-ATF3 in DNA replication checkpoint control
Q47154984	Dynamic Reorganization of the Cytoskeleton during Apoptosis: The Two Coffins Hypothesis
Q36320732	Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1
Q36720112	Dynamics of the DNA damage response: insights from live-cell imaging
Q33879479	E2F1 promotes the recruitment of DNA repair factors to sites of DNA double-strand breaks
Q36824489	E2F4 function in G2: maintaining G2-arrest to prevent mitotic entry with damaged DNA.
Q36996106	E2F4 regulates a stable G2 arrest response to genotoxic stress in prostate carcinoma
Q40330305	ECM overrides DNA damage-induced cell cycle arrest and apoptosis in small-cell lung cancer cells through beta1 integrin-dependent activation of PI3-kinase
Q28271191	EDD mediates DNA damage-induced activation of CHK2
Q34050547	EGFR-targeted plasmonic magnetic nanoparticles suppress lung tumor growth by abrogating G2/M cell-cycle arrest and inducing DNA damage
Q48240259	EMAP-II sensitize U87MG and glioma stem-like cells to temozolomide via induction of autophagy-mediated cell death and G2/M arrest.
Q33848050	EMSY overexpression disrupts the BRCA2/RAD51 pathway in the DNA-damage response: implications for chromosomal instability/recombination syndromes as checkpoint diseases
Q34210998	Early G2/M checkpoint failure as a molecular mechanism underlying etoposide-induced chromosomal aberrations.
Q43076205	Effect of Methanolic Leaf Extract of Ocimum basilicum L. on Benzene-Induced Hematotoxicity in Mice
Q47605330	Effect of cell cycle duration on somatic evolutionary dynamics
Q54309472	Effect of heparin-derived oligosaccharide on vascular smooth muscle cell proliferation.
Q36556389	Effective intra-S checkpoint responses to UVC in primary human melanocytes and melanoma cell lines
Q36350849	Effects of Low-Dose Bisphenol A on DNA Damage and Proliferation of Breast Cells: The Role of c-Myc
Q28551456	Efficient Activation of Apoptotic Signaling during Mitotic Arrest with AK301
Q92809614	Eimeria tenella ROP kinase EtROP1 induces G0/G1 cell cycle arrest and inhibits host cell apoptosis
Q34566631	Elevated DNA damage response in pancreatic cancer
Q33889555	Emergence of rationally designed therapeutic strategies for breast cancer targeting DNA repair mechanisms
Q36816885	Emerging links between the biological clock and the DNA damage response
Q35975127	Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapy
Q37359491	Enhanced levels of double-strand DNA break repair proteins protect ovarian cancer cells against genotoxic stress-induced apoptosis
Q35574213	Enhancement of cytotoxicity of artemisinin toward cancer cells by transferrin-mediated carbon nanotubes nanoparticles
Q36610767	Enhancement of radiation response by inhibition of Aurora-A kinase using siRNA or a selective Aurora kinase inhibitor PHA680632 in p53-deficient cancer cells
Q46847084	Enhancement of radiation response in p53-deficient cancer cells by the Aurora-B kinase inhibitor AZD1152.
Q40048494	Enhancing proteotoxic stress as an anticancer strategy
Q41617336	Epidermal Growth Factor Receptor activation promotes ADA3 acetylation through the AKT-p300 pathway
Q99711836	Epigenetic based synthetic lethal strategies in human cancers
Q38871275	Epstein-Barr virus BZLF1 protein impairs accumulation of host DNA damage proteins at damage sites in response to DNA damage.
Q42166975	Eroded human telomeres are more prone to remain uncapped and to trigger a G2 checkpoint response.
Q39691899	Essential role of TRPC6 channels in G2/M phase transition and development of human glioma.
Q46875154	Essential roles of PI-3K/Akt/IKKbeta/NFkappaB pathway in cyclin D1 induction by arsenite in JB6 Cl41 cells
Q37262148	Estrogen inhibits ATR signaling to cell cycle checkpoints and DNA repair
Q33772035	Evaluating putative mechanisms of the mitotic spindle checkpoint
Q33925006	Evaluation of [18F]-ATRi as PET tracer for in vivo imaging of ATR in mouse models of brain cancer.
Q36392155	Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment
Q33754132	Evaluation of cytotoxic and chemotherapeutic properties of boldine in breast cancer using in vitro and in vivo models
Q37145413	Evidence for regulation of mitotic progression through temporal phosphorylation and dephosphorylation of CK2alpha
Q34387784	Evidence for the importance of personalized molecular profiling in pancreatic cancer
Q42199612	Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency
Q33979535	Expression of arf tumor suppressor in spermatogonia facilitates meiotic progression in male germ cells
Q44484798	Expression of cell cycle regulatory factors hus1, gadd45a, rb1, cdkn2a and mre11a correlates with expression of clock gene per2 in human colorectal carcinoma tissue
Q64386984	Expression of γ-H2AX in endometrial carcinomas: an immunohistochemical study with p53
Q41574502	FANCD2 and DNA Damage.
Q35828658	FBXW7 and USP7 regulate CCDC6 turnover during the cell cycle and affect cancer drugs susceptibility in NSCLC.
Q36659141	FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage
Q89156992	Facile construction of fused benzimidazole-isoquinolinones that induce cell-cycle arrest and apoptosis in colorectal cancer cells
Q37341109	Family cancer syndromes: inherited deficiencies in systems for the maintenance of genomic integrity
Q49340516	Fanconi Anemia Signaling and Cancer
Q39731350	Fangchinoline induced G1/S arrest by modulating expression of p27, PCNA, and cyclin D in human prostate carcinoma cancer PC3 cells and tumor xenograft
Q83796996	Finding disease-specific coordinated functions by multi-function genes: insight into the coordination mechanisms in diseases
Q36057574	Folate levels modulate oncogene-induced replication stress and tumorigenicity
Q45346807	Forced activation of Cdk1 via wee1 inhibition impairs homologous recombination
Q26822694	From scourge to cure: tumour-selective viral pathogenesis as a new strategy against cancer
Q89660218	Fucoidan Inhibition of Osteosarcoma Cells Is Species and Molecular Weight Dependent
Q33279576	Function of the ATR N-terminal domain revealed by an ATM/ATR chimera
Q38910507	Functional Genetic Screen Identifies Increased Sensitivity to WEE1 Inhibition in Cells with Defects in Fanconi Anemia and HR Pathways.
Q58195585	Functional characterization of TIP60 sumoylation in UV-irradiated DNA damage response
Q37171572	Functional interaction between FOXO3a and ATM regulates DNA damage response
Q38221703	Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress.
Q39126232	Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer
Q33235763	Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses
Q47133044	G2/M-Phase Checkpoint Adaptation and Micronuclei Formation as Mechanisms That Contribute to Genomic Instability in Human Cells
Q47949771	GBM radiosensitizers: dead in the water…or just the beginning?
Q35742357	Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression
Q37539997	Gartanin induces cell cycle arrest and autophagy and suppresses migration involving PI3K/Akt/mTOR and MAPK signalling pathway in human glioma cells
Q39115018	Gefitinib enhances the effects of combined radiotherapy and 5-fluorouracil in a colorectal cancer cell line.
Q40982895	Gene expression profiling via bioinformatics analysis reveals biomarkers in laryngeal squamous cell carcinoma
Q46344151	Generation of an indestructible cyclin B1 by caspase-6-dependent cleavage during mitotic catastrophe.
Q92563348	Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency
Q46605059	Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53.
Q36735336	Genetic studies of bone diseases: evidence for involvement of DNA damage response proteins in bone remodeling
Q37566958	Genetic variants in the cell cycle control pathways contribute to early onset colorectal cancer in Lynch syndrome
Q39012783	Genetics of primary ovarian insufficiency.
Q34564108	Genistein abrogates G2 arrest induced by curcumin in p53 deficient T47D cells
Q39038235	Genistein exhibits anti-cancer effects via down-regulating FoxM1 in H446 small-cell lung cancer cells
Q41831833	Genistein-induced G2/M cell cycle arrest of human intestinal colon cancer Caco-2 cells is associated with Cyclin B1 and Chk2 down-regulation
Q35676284	Genome maintenance defects in cultured cells and mice following partial inactivation of the essential cell cycle checkpoint gene Hus1.
Q34248736	Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations
Q30836392	Genome-scale RNAi profiling of cell division in human tissue culture cells
Q24815105	Genome-wide requirements for resistance to functionally distinct DNA-damaging agents
Q38776454	Genomic sequencing and precision medicine in head and neck cancers
Q26851196	Genotoxic anti-cancer agents and their relationship to DNA damage, mitosis, and checkpoint adaptation in proliferating cancer cells
Q36994736	Genotoxic stress-induced cyclin D1 phosphorylation and proteolysis are required for genomic stability
Q39052116	Geraniin induces apoptotic cell death in human lung adenocarcinoma A549 cells in vitro and in vivo
Q27860541	Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
Q54525472	Glycogen synthase kinase (GSK)-3 and mammalian target of rapamycin complex 1 (mTORC1) cooperate to regulate protein S6 kinase 1 (S6K1).
Q33510863	HARPing on about the DNA damage response during replication
Q47551132	HBV infection potentiates resistance to S-phase arrest-inducing chemotherapeutics by inhibiting CHK2 pathway in diffuse large B-cell lymphoma
Q39012457	HBXIP, a binding protein of HBx, regulates maintenance of the G2/M phase checkpoint induced by DNA damage and enhances sensitivity to doxorubicin-induced cytotoxicity
Q28294885	HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability
Q45214462	HCLK2 is required for activity of the DNA damage response kinase ATR.
Q34062580	HDAC inhibitor, valproic acid, induces p53-dependent radiosensitization of colon cancer cells
Q34579692	HERC2-USP20 axis regulates DNA damage checkpoint through Claspin
Q42952064	HP1 proteins are essential for a dynamic nuclear response that rescues the function of perturbed heterochromatin in primary human cells.
Q92129884	Hair Growth Promoting Effect of 4HGF Encapsulated with PGA Nanoparticles (PGA-4HGF) by β-Catenin Activation and Its Related Cell Cycle Molecules
Q35501750	Haplotypes of DNA repair and cell cycle control genes, X-ray exposure, and risk of childhood acute lymphoblastic leukemia
Q47883962	Haspin has Multiple Functions in the Plant Cell Division Regulatory Network.
Q35847836	Heat shock protein 90 inhibition sensitizes acute myelogenous leukemia cells to cytarabine
Q26764740	Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment
Q33711869	Hemizygosity for Atm and Brca1 influence the balance between cell transformation and apoptosis
Q46145732	Hepatocyte nuclear factor 1β induced by chemical stress accelerates cell proliferation and increases genomic instability in mouse liver
Q53319587	Herbal isoprenols induce apoptosis in human colon cancer cells through transcriptional activation of PPARgamma.
Q40056381	High Spicy Food Intake and Risk of Cancer: A Meta-analysis of Case-control Studies
Q33392443	Highly variable response to cytotoxic chemotherapy in carcinoma-associated fibroblasts (CAFs) from lung and breast
Q44307145	Histone deacetylase induces accelerated maturation in Xenopus laevis oocytes
Q33983255	Histone deacetylase inhibitor (HDACI) mechanisms of action: emerging insights
Q52674720	Histone deacetylase inhibitor chidamide induces growth inhibition and apoptosis in NK/T lymphoma cells through ATM-Chk2-p53-p21 signalling pathway.
Q36283075	Histone deacetylase inhibitor-mediated cell death is distinct from its global effect on chromatin
Q26991616	Histone displacement during nucleotide excision repair
Q41825478	Histone dosage regulates DNA damage sensitivity in a checkpoint-independent manner by the homologous recombination pathway
Q35227435	Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics the radiosensitivity syndrome of ataxia-telangiectasia
Q28478749	Honokiol arrests cell cycle, induces apoptosis, and potentiates the cytotoxic effect of gemcitabine in human pancreatic cancer cells
Q38296672	Hsk1 kinase and Cdc45 regulate replication stress-induced checkpoint responses in fission yeast
Q33995584	Human LINE-1 retrotransposon induces DNA damage and apoptosis in cancer cells
Q24529887	Human MMS21/NSE2 is a SUMO ligase required for DNA repair
Q36616893	Human Tim-Tipin complex affects the biochemical properties of the replicative DNA helicase and DNA polymerases.
Q33320538	Human VRK1 is an early response gene and its loss causes a block in cell cycle progression
Q40420099	Human aldehyde dehydrogenase 3A1 inhibits proliferation and promotes survival of human corneal epithelial cells
Q64388257	Human cancer cells require ATR for cell cycle progression following exposure to ionizing radiation
Q34479791	Human cytomegalovirus inhibits a DNA damage response by mislocalizing checkpoint proteins
Q37380692	Human cytomegalovirus protein UL38 inhibits host cell stress responses by antagonizing the tuberous sclerosis protein complex
Q42425307	Human papilloma virus type16 E6 deregulates CHK1 and sensitizes human fibroblasts to environmental carcinogens independently of its effect on p53.
Q35758483	Human prostate epithelium lacks Wee1A-mediated DNA damage-induced checkpoint enforcement
Q35665702	Hypergrowth mTORC1 signals translationally activate the ARF tumor suppressor checkpoint
Q27331358	Hypersensitivity to DNA damage in antephase as a safeguard for genome stability.
Q53064517	Hypoxia enhances the radioresistance of mouse mesenchymal stromal cells.
Q35048958	Hypoxia-induced reactive oxygen species cause chromosomal abnormalities in endothelial cells in the tumor microenvironment
Q40335511	Hzf, a p53-responsive gene, regulates maintenance of the G2 phase checkpoint induced by DNA damage
Q42376094	ID3 regulates the MDC1-mediated DNA damage response in order to maintain genome stability
Q52320159	IDH2 deficiency accelerates skin pigmentation in mice via enhancing melanogenesis.
Q40331218	IKK alpha regulates estrogen-induced cell cycle progression by modulating E2F1 expression
Q34148484	IKK and NF-kappaB-mediated regulation of Claspin impacts on ATR checkpoint function
Q47213314	IMMUNEPOTENT CRP induces cell cycle arrest and caspase-independent regulated cell death in HeLa cells through reactive oxygen species production
Q53132557	ING3 promotes UV-induced apoptosis via Fas/caspase-8 pathway in melanoma cells.
Q35212640	Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines
Q37065125	Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.
Q51100217	Identification of a DNA Damage-Induced Alternative Splicing Pathway That Regulates p53 and Cellular Senescence Markers.
Q92640003	Identification of a small mutation panel of coding sequences to predict the efficacy of immunotherapy for lung adenocarcinoma
Q39276310	Identification of insulin-like growth factor 2 mRNA-binding protein 3 as a radioresistance factor in squamous esophageal cancer cells
Q92383038	Identification of key candidate tumor biomarkers in non-small-cell lung cancer by in silico analysis
Q52726915	Identification of key differentially expressed genes associated with non‑small cell lung cancer by bioinformatics analyses.
Q46146825	Identification of novel aminothiazole and aminothiadiazole conjugated cyanopyridines as selective CHK1 inhibitors
Q33234550	Identification of pathways regulating cell size and cell-cycle progression by RNAi
Q38633652	Identification of potential key genes associated with glioblastoma based on the gene expression profile
Q37619647	Identification of the lncRNA, AK156230, as a novel regulator of cellular senescence in mouse embryonic fibroblasts
Q89513477	Identifying Cell Cycle Modulators That Selectively Target ARID1A Deficiency Using High-Throughput Image-Based Screening
Q36179331	Imaging of protein movement induced by chromosomal breakage: tiny 'local' lesions pose great 'global' challenges
Q35770249	Immunohistochemical markers of prognosis in non-small cell lung cancer: a review and proposal for a multiphase approach to marker evaluation
Q40303796	Impairment of double-strand breaks repair and aberrant splicing of ATM and MRE11 in leukemia-lymphoma cell lines with microsatellite instability
Q30985752	Implementation of a 220,000-compound HCS campaign to identify disruptors of the interaction between p53 and hDM2 and characterization of the confirmed hits
Q37776824	Importance of DNA damage checkpoints in the pathogenesis of human cancers
Q59813798	In Vitro Evaluation of Sulforaphane and a Natural Analog as Potent Inducers of 5-Fluorouracil Anticancer Activity
Q39917387	In silico method for identification of promising anticancer drug targets.
Q39896689	Inappropriate activation of cyclin-dependent kinases by the phosphatase Cdc25b results in premature mitotic entry and triggers a p53-dependent checkpoint
Q66476157	Incineration of nanoclay composites leads to byproducts with reduced cellular reactivity
Q38801460	Increased activity of CHK enhances the radioresistance of MCF-7 breast cancer stem cells
Q47812607	Increased aldehyde reductase expression mediates acquired radioresistance of laryngeal cancer cells via modulating p53.
Q35120757	Increased expression of p21WAF1/CIP1 in kidney proximal tubules mediates fibrosis
Q37021730	Increased tumorigenicity and sensitivity to ionizing radiation upon loss of chromosomal protein HMGN1.
Q38492674	Induction of G1 arrest and apoptosis by schisandrin C isolated from Schizandra chinensis Baill in human leukemia U937 cells
Q24313318	Induction of SOX4 by DNA damage is critical for p53 stabilization and function
Q37508259	Induction of a Cellular DNA Damage Response by Porcine Circovirus Type 2 Facilitates Viral Replication and Mediates Apoptotic Responses
Q37376949	Induction of a reversible, non-cytotoxic S-phase delay by resveratrol: implications for a mechanism of lifespan prolongation and cancer protection
Q40063881	Induction of mitotic cell death in cancer cells by small interference RNA suppressing the expression of RecQL1 helicase
Q37667275	Inflammation, DNA Damage, Helicobacter pylori and Gastric Tumorigenesis
Q28390752	Influence of cell cycle on responses of MCF-7 cells to benzo[a]pyrene
Q23919671	Influence of light on aryl hydrocarbon receptor signaling and consequences in drug metabolism, physiology and disease
Q34786416	Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation
Q34230848	Inhibition of TFII-I-dependent cell cycle regulation by p53.
Q46603127	Inhibition of cell cycle progression by the hydroxytyrosol-cetuximab combination yields enhanced chemotherapeutic efficacy in colon cancer cells
Q39443786	Inhibition of checkpoint kinase 1 abrogates G2/M checkpoint activation and promotes apoptosis under heat stress
Q39289009	Inhibition of proliferation and induction of G1-phase cell-cycle arrest by dFMGEN, a novel genistein derivative, in lung carcinoma A549 cells
Q47128274	Inhibition of the IGF signaling pathway reverses cisplatin resistance in ovarian cancer cells
Q43270533	Inhibition of the c-Abl-TAp63 pathway protects mouse oocytes from chemotherapy-induced death
Q33645805	Inhibitory effect of PMC, a potent hydrophilic α-tocopherol derivative, on vascular smooth muscle cell proliferation: The pivotal role of PKC-α translocation
Q37361994	Inhibitory effect of quercetin on epithelial to mesenchymal transition in SK-MEL-28 human melanoma cells defined by in vitro analysis on 3D collagen gels
Q46858853	Inhibitory effects of 2,3,4',5-tetrahydroxystilbene-2-O-β-D-glucoside on angiotensin II-induced proliferation of vascular smooth muscle cells
Q36613829	Inhibitory effects of retinoic acid metabolism blocking agents (RAMBAs) on the growth of human prostate cancer cells and LNCaP prostate tumour xenografts in SCID mice.
Q47786231	Initial testing (stage 1) of M6620 (formerly VX-970), a novel ATR inhibitor, alone and combined with cisplatin and melphalan, by the Pediatric Preclinical Testing Program.
Q36891684	Integrating S-phase checkpoint signaling with trans-lesion synthesis of bulky DNA adducts
Q35694419	Integrating genetic and gene expression evidence into genome-wide association analysis of gene sets
Q64883630	Integrating the DNA damage and protein stress responses during cancer development and treatment.
Q90380099	Integrative Analysis of MicroRNA and Gene Interactions for Revealing Candidate Signatures in Prostate Cancer
Q92542684	Integrative Bioinformatics Approaches to Map Potential Novel Genes and Pathways Involved in Ovarian Cancer
Q24302320	Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cells
Q33812133	Interaction between human mismatch repair recognition proteins and checkpoint sensor Rad9-Rad1-Hus1
Q42953216	Interactions Between Ataxia Telangiectasia Mutated Kinase Inhibition, Poly(ADP-ribose) Polymerase-1 Inhibition and BRCA1 Status in Breast Cancer Cells
Q39574453	Interactions between Swi1-Swi3, Mrc1 and S phase kinase, Hsk1 may regulate cellular responses to stalled replication forks in fission yeast
Q28384376	Interactions of nucleolin and ribosomal protein L26 (RPL26) in translational control of human p53 mRNA
Q30850865	International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways
Q90117667	Interplay between DNA damage repair and apoptosis shapes cancer evolution through aneuploidy and microsatellite instability
Q36868759	Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor-induced DNA damage in vitro and in vivo in human multiple myeloma cells
Q96172104	Intrinsic and acquired resistance to CDK4/6 inhibitors and potential overcoming strategies
Q37856596	Ion channels and transporters in cancer. 1. Ion channels and cell proliferation in cancer
Q38895233	Ionizing radiation increases primary cilia incidence and induces multiciliation in C2C12 myoblasts
Q37530284	Is activation of the intra-S checkpoint in human fibroblasts an important factor in protection against UV-induced mutagenesis?
Q39120994	Isoalantolactone, a sesquiterpene lactone, induces apoptosis in SGC-7901 cells via mitochondrial and phosphatidylinositol 3-kinase/Akt signaling pathways.
Q35144843	Isorhamnetin flavonoid synergistically enhances the anticancer activity and apoptosis induction by cis-platin and carboplatin in non-small cell lung carcinoma (NSCLC).
Q37112305	Jungermannenone A and B induce ROS- and cell cycle-dependent apoptosis in prostate cancer cells in vitro
Q64098604	K1 gene transformation activities in AIDS-related and classic type Kaposi's sarcoma: Correlation with clinical presentation
Q36227159	Killing of Kras-mutant colon cancer cells via Rac-independent actin remodeling by the βGBP cytokine, a physiological PI3K inhibitor therapeutically effective in vivo
Q37235809	Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2.
Q36516789	Knock-down of hypoxia-induced carbonic anhydrases IX and XII radiosensitizes tumor cells by increasing intracellular acidosis
Q38762742	Knockdown of NFBD1/MDC1 enhances chemosensitivity to cisplatin or 5-fluorouracil in nasopharyngeal carcinoma CNE1 cells
Q92517055	Knockdown of SP1/Syncytin1 axis inhibits the proliferation and metastasis through the AKT and ERK1/2 signaling pathways in non-small cell lung cancer
Q39414227	Knockdown of eukaryotic translation initiation factors 3B (EIF3B) inhibits proliferation and promotes apoptosis in glioblastoma cells
Q39632383	Korean Scutellaria baicalensis water extract inhibits cell cycle G1/S transition by suppressing cyclin D1 expression and matrix-metalloproteinase-2 activity in human lung cancer cells
Q21245753	Krüppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts
Q37139954	L1 mobile element expression causes multiple types of toxicity.
Q41962409	L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1.
Q46527246	LDH, proliferation curves and cell cycle analysis are the most suitable assays to identify and characterize new phytotherapeutic compounds
Q38878616	LW-213 induces G2/M cell cycle arrest through AKT/GSK3β/β-catenin signaling pathway in human breast cancer cells
Q35636826	Label-Free Protein-RNA Interactome Analysis Identifies Khsrp Signaling Downstream of the p38/Mk2 Kinase Complex as a Critical Modulator of Cell Cycle Progression
Q34609906	Lack of Bcl11b tumor suppressor results in vulnerability to DNA replication stress and damages
Q64947321	Large-scale gene expression analysis reveals robust gene signatures for prognosis prediction in lung adenocarcinoma.
Q64268094	Leucine zipper and ICAT domain containing (LZIC) protein regulates cell cycle transitions in response to ionizing radiation
Q59010467	Ligand-Based Pharmacophore Modeling and Virtual Screening of RAD9 Inhibitors
Q37198572	Living on a break: cellular senescence as a DNA-damage response
Q91936408	LncRNA MAGI2-AS3 is involved in cervical squamous cell carcinoma development through CDK6 up-regulation
Q90705873	Long non-coding RNA small nucleolar RNA host gene 7 is upregulated and promotes cell proliferation in thyroid cancer
Q34241484	Long-distance inflammatory and genotoxic impact of cancer in vivo
Q35245608	Long-term prognostic value of the combination of EORTC risk group calculator and molecular markers in non-muscle-invasive bladder cancer patients treated with intravesical Bacille Calmette-Guérin
Q34288868	Loss of CCDC6, the first identified RET partner gene, affects pH2AX S139 levels and accelerates mitotic entry upon DNA damage.
Q47615958	Loss of DNA Damage Response in Neuroblastoma and Utility of a PARP Inhibitor.
Q61800245	Loss of NFBD1/MDC1 disrupts homologous recombination repair and sensitizes nasopharyngeal carcinoma cells to PARP inhibitors
Q37190502	MAPK15 upregulation promotes cell proliferation and prevents DNA damage in male germ cell tumors.
Q27336474	MASTL(Greatwall) regulates DNA damage responses by coordinating mitotic entry after checkpoint recovery and APC/C activation
Q49434689	MED28 increases the colony-forming ability of breast cancer cells by stabilizing the ZNF224 protein upon DNA damage
Q34972637	MET Inhibition Results in DNA Breaks and Synergistically Sensitizes Tumor Cells to DNA-Damaging Agents Potentially by Breaching a Damage-Induced Checkpoint Arrest
Q43201212	MG132 as a proteasome inhibitor induces cell growth inhibition and cell death in A549 lung cancer cells via influencing reactive oxygen species and GSH level
Q54940409	MIIP gene expression is associated with radiosensitivity in human nasopharyngeal carcinoma cells.
Q42317541	MK-8776, a novel chk1 kinase inhibitor, radiosensitizes p53-defective human tumor cells
Q37086224	MMP-13 is involved in oral cancer cell metastasis
Q26738970	Maintaining Genome Stability in Defiance of Mitotic DNA Damage
Q38023979	Maintenance of genomic integrity after DNA double strand breaks in the human prostate and seminal vesicle epithelium: the best and the worst
Q34369429	Maintenance of the DNA-damage checkpoint requires DNA-damage-induced mediator protein oligomerization
Q35712405	Massive interstitial copy-neutral loss-of-heterozygosity as evidence for cancer being a disease of the DNA-damage response
Q92661447	Maternal Obesity Alters Placental Cell Cycle Regulators in the First Trimester of Human Pregnancy: New Insights for BRCA1
Q36373215	Mcm10 is required for oogenesis and early embryogenesis in Drosophila
Q33788018	Mdm2 links genotoxic stress and metabolism to p53.
Q35652897	Mechanism of T-oligo-induced cell cycle arrest in Mia-PaCa pancreatic cancer cells
Q34181806	Mechanism-based screen establishes signalling framework for DNA damage-associated G1 checkpoint response
Q38134308	Mechanisms of action of non-steroidal anti-inflammatory drugs (NSAIDs) and mesalazine in the chemoprevention of colorectal cancer.
Q91814938	Mechanistic Understanding of Curcumin's Therapeutic Effects in Lung Cancer
Q38909263	Mediator subunit 23 overexpression as a novel target for suppressing proliferation and tumorigenesis in hepatocellular carcinoma
Q37581224	Membrane oestrogen receptor alpha signalling to cell functions
Q91297715	Mesenchymal stem cells in suppression or progression of hematologic malignancy: current status and challenges
Q38061051	Mesenchymal stromal cells: radio-resistant members of the bone marrow
Q36157320	Methylferulate from Tamarix aucheriana inhibits growth and enhances chemosensitivity of human colorectal cancer cells: possible mechanism of action
Q34079217	MiR-34a expression has an effect for lower risk of metastasis and associates with expression patterns predicting clinical outcome in breast cancer
Q53137197	MicroRNA and cancer.
Q41053612	MicroRNA inhibition fine-tunes and provides robustness to the restriction point switch of the cell cycle
Q37823782	MicroRNAs: new players in the DNA damage response
Q39005124	Microbeads mediated oral plasmid DNA delivery using polymethacrylate vectors: an effectual groundwork for colorectal cancer.
Q54445373	Millepachine, a novel chalcone, induces G2/M arrest by inhibiting CDK1 activity and causing apoptosis via ROS-mitochondrial apoptotic pathway in human hepatocarcinoma cells in vitro and in vivo.
Q37878159	Mind the gap: keeping UV lesions in check.
Q33292086	Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection
Q87035654	Missense mutations (p.H371Y, p.D438Y) in gene CHEK2 are associated with breast cancer risk in women of Balochistan origin
Q35549264	Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions
Q30581882	Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress
Q38053055	Mitosis-targeted anti-cancer therapies: where they stand.
Q37187176	Mode of action of the chloroethylating and carbamoylating moieties of the prodrug cloretazine
Q36286487	Modeling of autosomal-dominant retinitis pigmentosa in Caenorhabditis elegans uncovers a nexus between global impaired functioning of certain splicing factors and cell type-specific apoptosis
Q39355026	Molecular Basis for K63-Linked Ubiquitination Processes in Double-Strand DNA Break Repair: A Focus on Kinetics and Dynamics.
Q38999366	Molecular Network Dynamics of Cell Cycle Control: Periodicity of Start and Finish
Q38541699	Molecular Pathways: Overcoming Radiation Resistance by Targeting DNA Damage Response Pathways
Q33312958	Molecular characterization of spontaneous mesenchymal stem cell transformation
Q37826346	Molecular mechanisms of ultraviolet radiation-induced DNA damage and repair
Q37176648	Molecular signature of pancreatic adenocarcinoma: an insight from genotype to phenotype and challenges for targeted therapy
Q36792626	Molecular targets and mechanisms of radiosensitization using DNA damage response pathways
Q38204290	Molecularly targeting the PI3K-Akt-mTOR pathway can sensitize cancer cells to radiotherapy and chemotherapy.
Q50604424	Monitoring oxidative stress and DNA damage induced by heavy metals in yeast expressing a redox-sensitive green fluorescent protein.
Q36602578	Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects
Q37155146	Mouse models of DNA double-strand break repair and neurological disease
Q51409558	Moving forward with actionable therapeutic targets and opportunities in endometrial cancer: A NCI clinical trials planning meeting report.
Q39282629	Multiple facets of the DNA damage response contribute to the radioresistance of mouse mesenchymal stromal cell lines
Q36499765	Multiple functions of rad9 for preserving genomic integrity
Q36438934	Multiple isoforms of CDC25 oppose ATM activity to maintain cell proliferation during vertebrate development
Q24594847	Multiple roles of ATM in monitoring and maintaining DNA integrity
Q33248434	Murine Wee1 plays a critical role in cell cycle regulation and pre-implantation stages of embryonic development
Q37078650	Mus81, Rhp51(Rad51), and Rqh1 form an epistatic pathway required for the S-phase DNA damage checkpoint
Q35598807	Mutant BRAF induces DNA strand breaks, activates DNA damage response pathway, and up-regulates glucose transporter-1 in nontransformed epithelial cells
Q36390914	Mxi1-0 regulates the growth of human umbilical vein endothelial cells through extracellular signal-regulated kinase 1/2 (ERK1/2) and interleukin-8 (IL-8)-dependent pathways
Q51062791	Myosin 16 levels fluctuate during the cell cycle and are downregulated in response to DNA replication stress.
Q92000742	NCAPG Is a Promising Therapeutic Target Across Different Tumor Types
Q24313589	NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint
Q24298750	NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling
Q34240214	NER initiation factors, DDB2 and XPC, regulate UV radiation response by recruiting ATR and ATM kinases to DNA damage sites
Q28245966	NFBD1/MDC1 is a protein of oncogenic potential in human cervical cancer
Q35133431	NG2 expression in glioblastoma identifies an actively proliferating population with an aggressive molecular signature.
Q24338837	NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor
Q26851503	NIRF/UHRF2 occupies a central position in the cell cycle network and allows coupling with the epigenetic landscape
Q92255821	NSCLC Mutated Isoforms of CCDC6 Affect the Intracellular Distribution of the Wild Type Protein Promoting Cisplatinum Resistance and PARP Inhibitors Sensitivity in Lung Cancer Cells
Q50204965	Naphthoquinone rich Onosma visianii Clem (Boraginaceae) root extracts induce apoptosis and cell cycle arrest in HCT-116 and MDA-MB-231 cancer cell lines
Q39214217	Natural Compounds as Modulators of Cell Cycle Arrest: Application for Anticancer Chemotherapies.
Q92669975	Nedaplatin reduces multidrug resistance of non-small cell lung cancer by downregulating the expression of long non-coding RNA MVIH
Q46316014	Neem Seed Oil Induces Apoptosis in MCF-7 and MDA MB-231 Human Breast Cancer Cells
Q36329294	Network-based analysis of transcriptional profiles from chemical perturbations experiments
Q39181880	Network-based identification of key proteins involved in apoptosis and cell cycle regulation.
Q88730901	Neuroblastoma
Q34129155	New insights into checkpoint kinase 1 in the DNA damage response signaling network
Q36845724	New technologies used in the study of human melanoma
Q36724661	New therapeutic strategies for the treatment of acute lymphoblastic leukaemia
Q49962911	New therapeutic strategies to treat human cancers expressing mutant p53 proteins
Q36547381	New tricks for old drugs: the anticarcinogenic potential of DNA repair inhibitors
Q38753660	Non-apoptotic functions of BCL-2 family proteins
Q35237519	Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells
Q84921228	Notch promotes radioresistance of glioma stem cells
Q26851211	Novel aspects of the liver microenvironment in hepatocellular carcinoma pathogenesis and development
Q36939959	Novel inhibitors of checkpoint kinase 1.
Q37536599	Novel piperazine-based compounds inhibit microtubule dynamics and sensitize colon cancer cells to tumor necrosis factor-induced apoptosis
Q27932610	Novel role for checkpoint Rad53 protein kinase in the initiation of chromosomal DNA replication in Saccharomyces cerevisiae
Q38866642	Novel targets for ATM-deficient malignancies
Q64103522	Nuciferine inhibits the progression of glioblastoma by suppressing the SOX2-AKT/STAT3-Slug signaling pathway
Q39258788	Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication
Q28740849	Nuclear accumulation of the papillomavirus E1 helicase blocks S-phase progression and triggers an ATM-dependent DNA damage response
Q33675528	Nucleoplasmic calcium is required for cell proliferation
Q28511152	Oct4 interaction with Hmgb2 regulates Akt signaling and pluripotency
Q89880356	Olaparib Combined with an ATR or Chk1 Inhibitor as a Treatment Strategy for Acquired Olaparib-Resistant BRCA1 Mutant Ovarian Cells
Q37890974	Oncogene-induced senescence and its role in tumor suppression.
Q29617915	Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
Q35015372	Ophiobolin O isolated from Aspergillus ustus induces G1 arrest of MCF-7 cells through interaction with AKT/GSK3β/cyclin D1 signaling
Q34484399	Opiates, psychostimulants, and adult hippocampal neurogenesis: Insights for addiction and stem cell biology.
Q36030219	Opportunities and challenges for nutritional proteomics in cancer prevention
Q55457072	Orally bioavailable and blood-brain-barrier penetrating ATM inhibitor (AZ32) radiosensitizes intracranial gliomas in mice.
Q30434208	Origin licensing and p53 status regulate Cdk2 activity during G(1).
Q30573133	Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification
Q92610926	Outcompeting cancer
Q33841579	Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)
Q39685702	Overexpression of cyclin Y in non-small cell lung cancer is associated with cancer cell proliferation
Q36210995	Overexpression of hepatocyte nuclear factor-4α initiates cell cycle entry, but is not sufficient to promote β-cell expansion in human islets
Q38999451	Oxidative DNA damage causes premature senescence in mouse embryonic fibroblasts deficient for Krüppel-like factor 4.
Q42017634	Oxidative DNA damage in neurons: implication of ku in neuronal homeostasis and survival
Q39108341	Oxidative stress leads to increased mutation frequency in a murine model of myelodysplastic syndrome
Q28576161	Oxidative stress-induced DNA damage and cell cycle regulation in B65 dopaminergic cell line
Q37004597	Oxidative stress-induced DNA damage of mouse zygotes triggers G2/M checkpoint and phosphorylates Cdc25 and Cdc2.
Q48127576	P16 promotes the growth and mobility potential of breast cancer both in vitro and in vivo: the key role of the activation of IL-6/JAK2/STAT3 signaling.
Q37271214	PCNA promotes processive DNA end resection by Exo1.
Q52646109	PFKFB3 blockade inhibits hepatocellular carcinoma growth by impairing DNA repair through AKT.
Q41881135	PI3K/Akt/JNK/c-Jun signaling pathway is a mediator for arsenite-induced cyclin D1 expression and cell growth in human bronchial epithelial cells
Q36544946	PLK1 inhibitors synergistically potentiate HDAC inhibitor lethality in imatinib mesylate-sensitive or -resistant BCR/ABL+ leukemia cells in vitro and in vivo
Q90610987	PRR14 overexpression promotes cell growth, epithelial to mesenchymal transition and metastasis of colon cancer via the AKT pathway
Q37437654	Paf15 expression correlates with rectal cancer prognosis, cell proliferation and radiation response
Q37114275	Participation of DNA repair in the response to 5-fluorouracil
Q33581774	Pathway analysis using random forests with bivariate node-split for survival outcomes
Q41135321	Patterns of DNA damage response in intracranial germ cell tumors versus glioblastomas reflect cell of origin rather than brain environment: implications for the anti-tumor barrier concept and treatment
Q36139867	Perspective on mutagenesis and repair: the standard model and alternate modes of mutagenesis
Q83520155	Phenotypes associated with Saccharomyces cerevisiae Hug1 protein, a putative negative regulator of dNTP Levels, reveal similarities and differences with sequence-related Dif1
Q24336328	Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage
Q52375228	Phosphorylation of CDC25C by AMP-activated protein kinase mediates a metabolic checkpoint during cell-cycle G2/M-phase transition.
Q35131775	Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit
Q39659313	Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint
Q36562894	Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin
Q39460903	Phosphorylation of SRSF1 is modulated by replicational stress
Q33236676	Phosphorylation of nucleotide excision repair factor xeroderma pigmentosum group A by ataxia telangiectasia mutated and Rad3-related-dependent checkpoint pathway promotes cell survival in response to UV irradiation
Q34484346	Phosphorylation of p62 by cdk1 controls the timely transit of cells through mitosis and tumor cell proliferation.
Q27935850	Phosphorylation of the budding yeast 9-1-1 complex is required for Dpb11 function in the full activation of the UV-induced DNA damage checkpoint
Q36990776	Phosphorylation-triggered CUEDC2 degradation promotes UV-induced G1 arrest through APC/C(Cdh1) regulation.
Q33691551	Phyllanthus spp. induces selective growth inhibition of PC-3 and MeWo human cancer cells through modulation of cell cycle and induction of apoptosis
Q36927933	Phytoestrogen Bakuchiol Exhibits In Vitro and In Vivo Anti-breast Cancer Effects by Inducing S Phase Arrest and Apoptosis
Q49706343	Pine needle oil induces G2/M arrest of HepG2 cells by activating the ATM pathway
Q35164331	Piperine causes G1 phase cell cycle arrest and apoptosis in melanoma cells through checkpoint kinase-1 activation
Q36660250	Plasma membrane estrogen receptors
Q93083439	Platinum(ii) complexes with rutaecarpine and tryptanthrin derivatives induce apoptosis by inhibiting telomerase activity and disrupting mitochondrial function
Q33829178	Polo-like kinase 1 enhances survival and mutagenesis after genotoxic stress in normal cells through cell cycle checkpoint bypass
Q37321107	Polo-like kinases mediate cell survival in mitochondrial dysfunction
Q54252881	Polymyxin B causes DNA damage in HK-2 cells and mice.
Q40248130	Polyploidization increases the sensitivity to DNA-damaging agents in mammalian cells
Q39984989	Possible involvement of caspase-7 in cell cycle progression at mitosis
Q37719913	Post-translational modifications of proliferating cell nuclear antigen: A key signal integrator for DNA damage response (Review).
Q34221860	Potentiation of tumor responses to DNA damaging therapy by the selective ATR inhibitor VX-970
Q33723727	Pravastatin reduces radiation-induced damage in normal tissues
Q37076763	Preclinical evaluation of a novel ATM inhibitor, KU59403, in vitro and in vivo in p53 functional and dysfunctional models of human cancer
Q54510509	Preferential killing of p53-deficient cancer cells by reversine.
Q38756843	Prexasertib, a Chk1/Chk2 inhibitor, increases the effectiveness of conventional therapy in B-/T- cell progenitor acute lymphoblastic leukemia
Q50423643	Prexasertib, a cell cycle checkpoint kinase 1 and 2 inhibitor, in BRCA wild-type recurrent high-grade serous ovarian cancer: a first-in-class proof-of-concept phase 2 study.
Q48534871	Prexasertib, a cell cycle checkpoint kinases 1 and 2 inhibitor, increases in vitro toxicity of PARP inhibition by preventing Rad51 foci formation in BRCA wild type high-grade serous ovarian cancer
Q44025949	ProEx C as an adjunct marker to improve cytological detection of urothelial carcinoma in urinary specimens.
Q24620829	Proapoptotic Bid mediates the Atr-directed DNA damage response to replicative stress
Q37030594	Processing of DNA damage clusters in human cells: current status of knowledge
Q37065209	Profiling DNA damage-induced phosphorylation in budding yeast reveals diverse signaling networks
Q35550222	Prognostic Value of Expression of Cyclin E in Gastrointestinal Cancer: A Systematic Review and Meta-Analysis
Q64278894	Prognostic implications of epidermal growth factor receptor variant III expression and nuclear translocation in Chinese human gliomas
Q44270673	Promotion of DNA repair by nuclear IKKβ phosphorylation of ATM in response to genotoxic stimuli
Q38748694	Prospect of rindopepimut in the treatment of glioblastoma.
Q38974279	Prospects for the Use of ATR Inhibitors to Treat Cancer.
Q37375309	Protective roles of Gadd45 and MDM2 in blueberry anthocyanins mediated DNA repair of fragmented and non-fragmented DNA damage in UV-irradiated HepG2 cells
Q52724818	Protein arginine methylation: an emerging regulator of the cell cycle.
Q36908131	Protein phosphatase 2A has an essential role in the activation of gamma-irradiation-induced G2/M checkpoint response
Q33496409	Protein phosphatase 2A-dependent dephosphorylation of replication protein A is required for the repair of DNA breaks induced by replication stress
Q39600050	Protein phosphatase-1 inhibitor-3 is an in vivo target of caspase-3 and participates in the apoptotic response
Q24307983	Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress
Q36282835	Putting cancer to sleep at night: the neuroendocrine/circadian melatonin signal
Q47239224	Pyruvate kinase M2 phosphorylates H2AX and promotes genomic instability in human tumor cells
Q39328755	Quiescence and attenuated DNA damage response promote survival of esophageal cancer stem cells
Q36245598	RAC1 GTPase plays an important role in γ-irradiation induced G2/M checkpoint activation
Q24294922	RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage
Q37800769	RAD51C: a novel cancer susceptibility gene is linked to Fanconi anemia and breast cancer
Q40146451	RAD51D protects against MLH1-dependent cytotoxic responses to O(6)-methylguanine
Q29976886	RAD6-RAD18-RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light.
Q37472045	RADIOSENSITIVITY TO HIGH ENERGY IRON IONS IS INFLUENCED BY HETEROZYGOSITY for ATM, RAD9 and BRCA1.
Q37190148	RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damage sites
Q36352398	RAP80 is critical in maintaining genomic stability and suppressing tumor development
Q35116809	RBM3-regulated genes promote DNA integrity and affect clinical outcome in epithelial ovarian cancer
Q28245362	RETRACTED: Small molecule-based reversible reprogramming of cellular lifespan
Q35172957	RFPL4A increases the G1 population and decreases sensitivity to chemotherapy in human colorectal cancer cells
Q37385250	RNA surveillance: molecular approaches in transcript quality control and their implications in clinical diseases
Q97423911	RNA-binding motif protein 43 (RBM43) suppresses hepatocellular carcinoma progression through modulation of cyclin B1 expression
Q37421389	RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks
Q33260135	RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint
Q34181455	Rad18-mediated Translesion Synthesis of Bulky DNA Adducts Is Coupled to Activation of the Fanconi Anemia DNA Repair Pathway
Q46961821	Rad3-dependent phosphorylation of the checkpoint clamp regulates repair-pathway choice
Q34886275	Rad4TopBP1, a scaffold protein, plays separate roles in DNA damage and replication checkpoints and DNA replication
Q36477745	Rad51 in regulating the radiosensitivity of non-small cell lung cancer with different epidermal growth factor receptor mutation status
Q46936614	Rad52 depletion in Candida albicans triggers both the DNA-damage checkpoint and filamentation accompanied by but independent of expression of hypha-specific genes.
Q37387399	Radiation carcinogenesis in context: how do irradiated tissues become tumors?
Q28708956	Radiation metabolomics and its potential in biodosimetry
Q83275288	Radiation-induced cell cycle arrests in Ehrlich ascites carcinoma cells in vivo
Q38244964	Radiation-induced signaling pathways that promote cancer cell survival (review).
Q38823644	Radioresistant human lung adenocarcinoma cells that survived multiple fractions of ionizing radiation are sensitive to HSP90 inhibition
Q35005604	Radiosensitization of colorectal carcinoma cell lines by histone deacetylase inhibition
Q53599858	Ras triggers ataxia-telangiectasia-mutated and Rad-3-related activation and apoptosis through sustained mitogenic signaling.
Q35750491	Rational Combinations of Targeted Agents in AML
Q28115279	Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1
Q39114322	Reactive oxygen species mediate isoalantolactone-induced apoptosis in human prostate cancer cells.
Q42801717	Reconstitution of the cellular response to DNA damage in vitro using damage-activated extracts from mammalian cells
Q33229469	Recruitment of DNA damage checkpoint proteins to damage in transcribed and nontranscribed sequences
Q33417335	Recurrent CDC25C mutations drive malignant transformation in FPD/AML.
Q34047115	Reduced mRNA and protein expression of the genomic caretaker RAD9A in primary fibroblasts of individuals with childhood and independent second cancer
Q49166715	Reduced recruitment of 53BP1 during interstrand crosslink repair is associated with genetically inherited attenuation of mitomycin C sensitivity in a family with Fanconi anemia
Q36228219	Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase
Q33685874	Regulation of CHK1 by mTOR contributes to the evasion of DNA damage barrier of cancer cells
Q28250925	Regulation of Claspin degradation by the ubiquitin-proteosome pathway during the cell cycle and in response to ATR-dependent checkpoint activation
Q35861281	Regulation of DNA Damage Signaling and Cell Death Responses by Epstein-Barr Virus Latent Membrane Protein 1 (LMP1) and LMP2A in Nasopharyngeal Carcinoma Cells.
Q34771336	Regulation of DNA damage responses and cell cycle progression by hMOB2.
Q64389865	Regulation of DNA repair by non-coding miRNAs
Q37540336	Regulation of DNA replication by the S-phase DNA damage checkpoint
Q47371096	Regulation of G2/M Transition by Inhibition of WEE1 and PKMYT1 Kinases.
Q36947768	Regulation of Rad17 protein turnover unveils an impact of Rad17-APC cascade in breast carcinogenesis and treatment
Q37995693	Regulation of cell death and autophagy by IKK and NF-κB: critical mechanisms in immune function and cancer
Q39680532	Regulation of intra-S phase checkpoint by ionizing radiation (IR)-dependent and IR-independent phosphorylation of SMC3.
Q51808299	Regulation of mitotic function of Chk1 through phosphorylation at novel sites by cyclin-dependent kinase 1 (Cdk1).
Q37410747	Regulation of protein synthesis by ionizing radiation.
Q36325888	Regulation of rtt107 recruitment to stalled DNA replication forks by the cullin rtt101 and the rtt109 acetyltransferase
Q31001642	Regulation of the DNA damage response and gene expression by the Dot1L histone methyltransferase and the 53Bp1 tumour suppressor
Q34722112	Regulation of the cellular DNA double-strand break response
Q37633137	Regulation of the life cycle of HPVs by differentiation and the DNA damage response
Q37801346	Regulation of tissue- and stimulus-specific cell fate decisions by p53 in vivo.
Q33535647	Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase.
Q38798535	Regulatory roles of conserved phosphorylation sites in the activation T-loop of the MAP kinase ERK1
Q36611480	Relationships between stem cell exhaustion, tumour suppression and ageing
Q37365625	Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
Q41789965	Replication checkpoint: tuning and coordination of replication forks in s phase
Q34547673	Replication licensing and the DNA damage checkpoint.
Q40262308	Replication stress, DNA damage signalling, and cytomegalovirus infection in human medulloblastomas
Q37156959	Replicative stress, stem cells and aging
Q35744967	Requirement of ATR for maintenance of intestinal stem cells in aging Drosophila
Q33924254	Requirement of MTA1 in ATR-mediated DNA damage checkpoint function
Q52868719	Resistance to 3-HTMC-Induced Apoptosis Through Activation of PI3K/Akt, MEK/ERK, and p38/COX-2/PGE2 Pathways in Human HT-29 and HCT116 Colorectal Cancer Cells.
Q91995103	Response of the Green Alga Chlamydomonas reinhardtii to the DNA Damaging Agent Zeocin
Q38829925	Restoration of paclitaxel resistance by CDK1 intervention in drug-resistant ovarian cancer
Q34261684	Retracted: SPARC Overexpression Inhibits Cell Proliferation in Neuroblastoma and Is Partly Mediated by Tumor Suppressor Protein PTEN and AKT
Q91880128	Return to the Sea, Get Huge, Beat Cancer: An Analysis of Cetacean Genomes Including an Assembly for the Humpback Whale (Megaptera novaeangliae)
Q35089524	Review of Chromium (VI) Apoptosis, Cell-Cycle-Arrest, and Carcinogenesis
Q33721213	Ribonucleotide Reductase Inhibition Enhances Chemoradiosensitivity of Human Cervical Cancers
Q28513144	Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation
Q40066661	Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression
Q36187434	Role of Cdk1 in DNA damage-induced G1 checkpoint abrogation by the human papillomavirus E7 oncogene
Q33977682	Role of GLUT1 in regulation of reactive oxygen species
Q37797479	Role of cell cycle perturbations in the combination therapy of chemotherapeutic agents and radiation
Q45080019	Role of cyclin polymorphisms in predicting outcome of 5-fluorouracil-based chemotherapy in colorectal cancer: one piece in a complex puzzle.
Q38291764	Role of the mammalian SWI/SNF chromatin remodeling complex in the cellular response to UV damage
Q37027389	Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling.
Q40135858	Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair
Q41475620	Roles of DNA Damage Response Proteins in Mitogen-Induced Thp-1 Differentiation into Macrophage
Q54117625	Roles of NUCKS1 in Diseases: Susceptibility, Potential Biomarker, and Regulatory Mechanisms.
Q36953179	Roles of cyclins A and E in induction of centrosome amplification in p53-compromised cells
Q38025085	Roles of p53 in various biological aspects of hematopoietic stem cells
Q35050799	Roles of protein arginine methylation in DNA damage signaling pathways is CARM1 a life-or-death decision point?
Q34352173	Rsf-1, a chromatin remodeling protein, induces DNA damage and promotes genomic instability.
Q37982323	Ruthenium(II) polypyridyl complexes and DNA--from structural probes to cellular imaging and therapeutics.
Q37857744	S-phase-coupled apoptosis in tumor suppression
Q64114357	SALMON: Survival Analysis Learning With Multi-Omics Neural Networks on Breast Cancer
Q36184268	SCAI promotes DNA double-strand break repair in distinct chromosomal contexts
Q89586306	SENEBLOC, a long non-coding RNA suppresses senescence via p53-dependent and independent mechanisms
Q33582882	SERPINA3 promotes endometrial cancer cells growth by regulating G2/M cell cycle checkpoint and apoptosis
Q38993472	SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint.
Q83600771	SKA3 Promotes tumor growth by regulating CDK2/P53 phosphorylation in hepatocellular carcinoma
Q33822328	SMARCAL1 and replication stress: an explanation for SIOD?
Q33559570	SNORD76, a box C/D snoRNA, acts as a tumor suppressor in glioblastoma
Q99572030	SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells
Q80455307	STAT1 activation in squamous cell cancer of the oral cavity: a potential predictive marker of response to adjuvant chemotherapy
Q42952151	Sap1 promotes the association of the replication fork protection complex with chromatin and is involved in the replication checkpoint in Schizosaccharomyces pombe
Q99608387	Sarcoma stratification by combined pH2AX and MAP17 (PDZK1IP1) levels for a better outcome on doxorubicin plus olaparib treatment
Q28472927	Saturated fatty acids modulate cell response to DNA damage: implication for their role in tumorigenesis
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Q46360304	Sinularin induces oxidative stress-mediated G2/M arrest and apoptosis in oral cancer cells.
Q35776514	Size is an essential parameter in governing the UVB-protective efficacy of silver nanoparticles in human keratinocytes
Q36781062	Skp2 is required for Aurora B activation in cell mitosis and spindle checkpoint
Q34298450	Slx4 regulates DNA damage checkpoint-dependent phosphorylation of the BRCT domain protein Rtt107/Esc4
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Q64256282	Small Molecule Fluorescent Probes for G- Quadruplex Visualization as Potential Cancer Theranostic Agents
Q46862854	Small molecules thwart crash and burn
Q93128827	Solid state fermentation process with Aspergillus kawachii enhances the cancer-suppressive potential of silkworm larva in hepatocellular carcinoma cells
Q37020205	Soluble and insoluble nickel compounds exert a differential inhibitory effect on cell growth through IKKalpha-dependent cyclin D1 down-regulation
Q28235091	Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks
Q41967501	Speeding through cell cycle roadblocks: Nuclear cyclin D1-dependent kinase and neoplastic transformation
Q30431071	Spindle poisons and cell fate: a tale of two pathways.
Q34428974	Spontaneous abrogation of the G₂DNA damage checkpoint has clinical benefits but promotes leukemogenesis in Fanconi anemia patients
Q36405518	Stem Cell-Specific Mechanisms Ensure Genomic Fidelity within HSCs and upon Aging of HSCs
Q34738304	Sterigmatocystin-induced DNA damage triggers G2 arrest via an ATM/p53-related pathway in human gastric epithelium GES-1 cells in vitro
Q38791128	Sterigmatocystin-induced checkpoint adaptation depends on Chk1 in immortalized human gastric epithelial cells in vitro
Q43189813	Strand-specific analysis shows protein binding at replication forks and PCNA unloading from lagging strands when forks stall
Q37411955	Strategies for Molecularly Enhanced Chemotherapy to Achieve Synthetic Lethality in Endometrial Tumors with Mutant p53
Q42637891	Strategies for targeting the DNA damage response for cancer therapeutics
Q46259214	Strong expression of cyclin B2 mRNA correlates with a poor prognosis in patients with non-small cell lung cancer
Q39883693	StrucBreak: A Computational Framework for Structural Break Detection in DNA Sequences
Q38632321	Structural basis of Wee kinases functionality and inactivation by diverse small molecule inhibitors
Q54536177	Structural requirements of pyrimidine, thienopyridine and ureido thiophene carboxamide-based inhibitors of the checkpoint kinase 1: QSAR, docking, molecular dynamics analysis.
Q36541054	Structure meets function--centrosomes, genome maintenance and the DNA damage response
Q42128090	Structure-Based Drug Design of Novel Potent and Selective Tetrahydropyrazolo[1,5-a]pyrazines as ATR Inhibitors.
Q27675773	Structure-Guided Evolution of Potent and Selective CHK1 Inhibitors through Scaffold Morphing
Q91650623	Study of the Characterization of Side Population Cells in Endometrial Cancer Cell Lines: Chemoresistance, Progestin Resistance, and Radioresistance
Q42374939	Studying S-phase DNA damage checkpoints using the fission yeast Schizosaccharomyces pombe
Q34052481	Superaugmented eccentric distance sum connectivity indices: novel highly discriminating topological descriptors for QSAR/QSPR.
Q38912800	Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis
Q47928900	Suppression of the DNA damage response in acute myeloid leukemia versus myelodysplastic syndrome
Q37086576	Supreme EnLIGHTenment: damage recognition and signaling in the mammalian UV response
Q51075833	Synchronization and Desynchronization of Cells by Interventions on the Spindle Assembly Checkpoint.
Q40063670	Synergism between bosutinib (SKI-606) and the Chk1 inhibitor (PF-00477736) in highly imatinib-resistant BCR/ABL⁺ leukemia cells
Q33597926	Synergistic effects of a novel lipid-soluble extract from Pinellia pedatisecta Schott and cisplatin on human cervical carcinoma cell lines through the regulation of DNA damage response signaling pathway
Q34326278	Synergistic interaction of Rnf8 and p53 in the protection against genomic instability and tumorigenesis.
Q47370432	Synthetically lethal nanoparticles for treatment of endometrial cancer.
Q47193677	Systematic assessment of cervical cancer initiation and progression uncovers genetic panels for deep learning-based early diagnosis and proposes novel diagnostic and prognostic biomarkers
Q55339659	Systems and synthetic biology approaches in understanding biological oscillators.
Q90410019	TIM-3 Participates in the Invasion and Metastasis of Nasopharyngeal Carcinoma via SMAD7/SMAD2/SNAIL1 Axis-Mediated Epithelial-Mesenchymal Transition
Q92859986	TNAP inhibition attenuates cardiac fibrosis induced by myocardial infarction through deactivating TGF-β1/Smads and activating P53 signaling pathways
Q52726523	TRIP13 promotes tumor growth and is associated with poor prognosis in colorectal cancer.
Q39315433	Taiwanofungus camphoratus (Syn Antrodia camphorata) extract and amphotericin B exert adjuvant effects via mitochondrial apoptotic pathway
Q40046642	Take your PIKK: tumour viruses and DNA damage response pathways.
Q34865929	Tandem BRCT Domains: DNA's Praetorian Guard.
Q26822592	Targeting ATM-deficient CLL through interference with DNA repair pathways
Q28554501	Targeting CDKs with Roscovitine Increases Sensitivity to DNA Damaging Drugs of Human Osteosarcoma Cells
Q41993531	Targeting Chk1 in the replicative stress response
Q39220127	Targeting Chk2 improves gastric cancer chemotherapy by impairing DNA damage repair.
Q37960389	Targeting DNA repair and the cell cycle in glioblastoma
Q30480882	Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis
Q39328356	Targeting radiation-resistant hypoxic tumour cells through ATR inhibition
Q37667106	Targeting silibinin in the antiproliferative pathway
Q57115037	Targeting the cell cycle in breast cancer: towards the next phase
Q38191794	Targeting tumour-supportive cellular machineries in anticancer drug development
Q24304948	Tel2 regulates the stability of PI3K-related protein kinases
Q41191920	Telomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome
Q35597009	Telomere shortening alters the kinetics of the DNA damage response after ionizing radiation in human cells
Q37627017	Telomeres and telomerase in cancer
Q37071461	Teriflunomide, an immunomodulatory drug, exerts anticancer activity in triple negative breast cancer cells
Q36291440	Termination of Replication Stress Signaling via Concerted Action of the Slx4 Scaffold and the PP4 Phosphatase
Q51843085	Tetramethylpyrazine induces G0/G1 cell cycle arrest and stimulates mitochondrial-mediated and caspase-dependent apoptosis through modulating ERK/p53 signaling in hepatic stellate cells in vitro.
Q48604461	The Analysis of Cell Cycle, Proliferation, and Asymmetric Cell Division by Imaging Flow Cytometry
Q64249505	The Anti-Proliferation, Cycle Arrest and Apoptotic Inducing Activity of Peperomin E on Prostate Cancer PC-3 Cell Line
Q36010739	The CDK4/6 inhibitor PD0332991 reverses epithelial dysplasia associated with abnormal activation of the cyclin-CDK-Rb pathway
Q28265315	The CHEK2 gene and inherited breast cancer susceptibility
Q24305557	The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells
Q24317772	The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint
Q34557750	The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism
Q38178966	The DNA Damage Response: A Common Pathway in the Regulation of NKG2D and DNAM-1 Ligand Expression in Normal, Infected, and Cancer Cells.
Q38089570	The DNA damage checkpoint response to replication stress: A Game of Forks
Q26825363	The DNA damage response induced by infection with human cytomegalovirus and other viruses
Q46914764	The DNA damage signalling kinase ATM is aberrantly reduced or lost in BRCA1/BRCA2-deficient and ER/PR/ERBB2-triple-negative breast cancer
Q38884854	The DNA damage/repair cascade in glioblastoma cell lines after chemotherapeutic agent treatment
Q24606586	The DNA-damage response in human biology and disease
Q34009427	The DNA-damage response: new molecular insights and new approaches to cancer therapy
Q24310746	The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress
Q91658012	The Function of Lipin in the Wing Development of Drosophila melanogaster
Q24338440	The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress
Q94322163	The Possible Crosstalk of MOB2 With NDR1/2 Kinases in Cell Cycle and DNA Damage Signaling
Q48802370	The Role of Surgery in Cancer Prevention
Q26782011	The Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and Repair
Q33913826	The Spi1/PU.1 transcription factor accelerates replication fork progression by increasing PP1 phosphatase in leukemia
Q92619044	The TCP1 ring complex is associated with malignancy and poor prognosis in hepatocellular carcinoma
Q35873110	The UBC Domain Is Required for BRUCE to Promote BRIT1/MCPH1 Function in DSB Signaling and Repair Post Formation of BRUCE-USP8-BRIT1 Complex
Q33507753	The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks
Q42415006	The anti-apoptotic factor Che-1/AATF links transcriptional regulation, cell cycle control, and DNA damage response
Q58101390	The anticancer mechanism investigation of Tanshinone II by pharmacological clustering in protein network
Q92771330	The binding of lncRNA RP11-732M18.3 with 14-3-3 β/α accelerates p21 degradation and promotes glioma growth
Q37954328	The biology of the cytolethal distending toxins
Q95839849	The bromodomain containing protein BRD-9 orchestrates RAD51-RAD54 complex formation and regulates homologous recombination-mediated repair
Q24294320	The bromodomain protein Brd4 insulates chromatin from DNA damage signalling
Q36188646	The cell cycle regulator ecdysoneless cooperates with H-Ras to promote oncogenic transformation of human mammary epithelial cells
Q34110993	The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage
Q28390451	The circadian clock in cancer development and therapy
Q28395468	The effect of calcium phosphate nanoparticles on hormone production and apoptosis in human granulosa cells
Q64089103	The emerging roles and functions of circular RNAs and their generation
Q39084654	The epithelium specific cell cycle regulator 14-3-3sigma is required for preventing entry into mitosis following ultraviolet B.
Q33834976	The fission yeast Rad32(Mre11)-Rad50-Nbs1 complex acts both upstream and downstream of checkpoint signaling in the S-phase DNA damage checkpoint
Q28513565	The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1
Q24306086	The human DEK oncogene regulates DNA damage response signaling and repair
Q37606136	The human intra-S checkpoint response to UVC-induced DNA damage
Q55044969	The impact of a negligent G2/M checkpoint on genomic instability and cancer induction.
Q35950241	The intra-S-phase checkpoint affects both DNA replication initiation and elongation: single-cell and -DNA fiber analyses
Q37031690	The mTOR pathway negatively controls ATM by up-regulating miRNAs.
Q36182260	The metabolically-modulated stem cell niche: a dynamic scenario regulating cancer cell phenotype and resistance to therapy.
Q33375180	The molecular basis of genistein-induced mitotic arrest and exit of self-renewal in embryonal carcinoma and primary cancer cell lines
Q37821229	The molecular biology of head and neck cancer
Q33401051	The multi-replication protein A (RPA) system--a new perspective
Q39003096	The novel thymidylate synthase inhibitor trifluorothymidine (TFT) and TRAIL synergistically eradicate non-small cell lung cancer cells.
Q42827201	The nucleotide excision repair protein XPC is essential for bulky DNA adducts to promote interleukin-6 expression via the activation of p38-SAPK.
Q24339317	The overexpression of MCPH1 inhibits cell growth through regulating cell cycle-related proteins and activating cytochrome c-caspase 3 signaling in cervical cancer
Q39761186	The p53-inducible gene 3 (PIG3) contributes to early cellular response to DNA damage
Q36905454	The paracrine hormone hypothesis of colorectal cancer.
Q41292927	The plant-specific CDKB1-CYCB1 complex mediates homologous recombination repair in Arabidopsis
Q37983690	The potential of exploiting DNA-repair defects for optimizing lung cancer treatment
Q37390143	The potential role and application of PARP inhibitors in cancer treatment
Q36610597	The predictive value of molecular markers (p53, EGFR, ATM, CHK2) in multimodally treated squamous cell carcinoma of the oesophagus.
Q36417134	The role of ATM and 53BP1 as predictive markers in cervical cancer.
Q36689932	The role of BRCA1 in homologous recombination repair in response to replication stress: significance in tumorigenesis and cancer therapy
Q40378381	The role of ICP0-Null HSV-1 and interferon signaling defects in the effective treatment of breast adenocarcinoma.
Q35022520	The role of RAD9 in tumorigenesis
Q38967406	The role of hydrogen sulfide in aging and age-related pathologies
Q22306473	The role of poly(ADP-ribose) in the DNA damage signaling network
Q34341080	The role of the RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system
Q39171826	The stress response resolution assay. I. Quantitative assessment of environmental agent/condition effects on cellular stress resolution outcomes in epithelium
Q47203904	The therapeutic potential of cell cycle targeting in multiple myeloma
Q24305326	The tumor suppressor CYLD regulates entry into mitosis
Q37807639	The ubiquitous role of ubiquitin in the DNA damage response
Q46829817	The ultraviolet A-activated photosensitizer 2-(4-aminophenyl)-7-methoxybenzothiazole suppresses proliferation and induces apoptosis of keloid fibroblasts: a potential adjunctive therapy for keloids
Q34061440	The versatile functions of ATM kinase
Q30426400	The yin-yang of DNA damage response: roles in tumorigenesis and cellular senescence
Q37667246	Theabrownin Inhibits Cell Cycle Progression and Tumor Growth of Lung Carcinoma through c-myc-Related Mechanism
Q39705991	Three-dimensionally specific inhibition of DNA repair-related genes by activated KRAS in colon crypt model
Q99238896	TiO2 Nanoparticles Caused DNA Damage in Lung and Extra-Pulmonary Organs Through ROS-Activated FOXO3a Signaling Pathway After Intratracheal Administration in Rats
Q39632401	Tithonia diversifolia and its main active component tagitinin C induce survivin inhibition and G2/M arrest in human malignant glioblastoma cells
Q33894381	To fuse or not to fuse: how do checkpoint and DNA repair proteins maintain telomeres?
Q38580042	To senesce or not to senesce: how primary human fibroblasts decide their cell fate after DNA damage
Q36706894	TopBP1 activates ATR through ATRIP and a PIKK regulatory domain
Q34207633	TopBP1 and Claspin contribute to the radioresistance of lung cancer brain metastases
Q29614976	Topoisomerase I inhibitors: camptothecins and beyond
Q39211167	Transcriptional networks controlling the cell cycle.
Q33226984	Transcriptional profiling of mammary gland side population cells
Q41898095	Transcriptional regulation underlying recovery from a DNA damage-induced arrest.
Q37577423	Transcriptome analysis of glioma cells for the dynamic response to γ-irradiation and dual regulation of apoptosis genes: a new insight into radiotherapy for glioblastomas
Q91975036	Transcriptome analysis revealed key prognostic genes and microRNAs in hepatocellular carcinoma
Q38956034	Transfection of poly(I:C) can induce reactive oxygen species-triggered apoptosis and interferon-β-mediated growth arrest in human renal cell carcinoma cells via innate adjuvant receptors and the 2-5A system
Q33369693	Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation
Q38794109	Treating cancer with selective CDK4/6 inhibitors
Q52369537	TrkB-Target Galectin-1 Impairs Immune Activation and Radiation Responses in Neuroblastoma: Implications for Tumour Therapy.
Q28298710	Tumor Suppressor CHK2: Regulator of DNA Damage Response and Mediator of Chromosomal Stability
Q35922424	Tumor-suppressing function of caspase-2 requires catalytic site Cys-320 and site Ser-139 in mice
Q28485896	Two 4N cell-cycle arrests contribute to cisplatin-resistance
Q38568878	Two cell cycle blocks caused by iron chelation of neuroblastoma cells: separating cell cycle events associated with each block
Q53653118	Two-way traffic: centrosomes and the cell cycle.
Q64230199	Tyrosine kinase c-Abl couples RNA polymerase II transcription to DNA double-strand breaks
Q33770883	USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response
Q34592732	USP17- and SCFβTrCP--regulated degradation of DEC1 controls the DNA damage response
Q34699448	Ubiquitin proteasomal pathway mediated degradation of p53 in melanoma
Q36189465	Ubiquitin-H2AX fusions render 53BP1 recruitment to DNA damage sites independent of RNF8 or RNF168
Q38205099	Unravelling mechanisms of p53-mediated tumour suppression
Q34043118	Up-regulation of kin17 is essential for proliferation of breast cancer
Q55243690	Upregulated GAPLINC predicts a poor prognosis in bladder cancer patients and promotes tumor proliferation and invasion.
Q37206564	Uracil in DNA: consequences for carcinogenesis and chemotherapy
Q37010405	Vascular endothelial growth factor in astroglioma stem cell biology and response to therapy
Q37944142	Virus manipulation of cell cycle.
Q64095741	Visco-Node-Pore Sensing: A Microfluidic Rheology Platform to Characterize Viscoelastic Properties of Epithelial Cells
Q43105772	Vorinostat, a histone deacetylase inhibitor, combined with pelvic palliative radiotherapy for gastrointestinal carcinoma: the Pelvic Radiation and Vorinostat (PRAVO) phase 1 study
Q43243325	WD40-repeat protein WDR18 collaborates with TopBP1 to facilitate DNA damage checkpoint signaling.
Q41297946	WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis
Q35630642	WRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I-DNA covalent complexes
Q37154365	Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway
Q38351606	Widespread activation of the DNA damage response in human pancreatic intraepithelial neoplasia
Q89862470	Working on Genomic Stability: From the S-Phase to Mitosis
Q34103003	XPA-mediated regulation of global nucleotide excision repair by ATR Is p53-dependent and occurs primarily in S-phase
Q92376545	Zika Virus Infection Induces DNA Damage Response in Human Neural Progenitors That Enhances Viral Replication
Q39301654	Zika virus infection disrupts neurovascular development and results in postnatal microcephaly with brain damage.
Q34989600	Zygotic G2/M cell cycle arrest induced by ATM/Chk1 activation and DNA repair in mouse embryos fertilized with hydrogen peroxide-treated epididymal mouse sperm
Q43986168	[Human papillomavirus and cervical neoplasia].
Q99712187	eIF3a Regulation of NHEJ Repair Protein Synthesis and Cellular Response to Ionizing Radiation
Q52934924	miR-181a promotes G1/S transition and cell proliferation in pediatric acute myeloid leukemia by targeting ATM.
Q28594946	noxin, a novel stress-induced gene involved in cell cycle and apoptosis
Q38955021	p-21 activated kinase 4 promotes proliferation and survival of pancreatic cancer cells through AKT- and ERK-dependent activation of NF-κB pathway
Q50459138	p19(Ink4d) and p21(Cip1) collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis.
Q34659879	p38α MAPK Is a MTOC-associated protein regulating spindle assembly, spindle length and accurate chromosome segregation during mouse oocyte meiotic maturation
Q41157594	p38γ regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage
Q37123214	p53 prevents entry into mitosis with uncapped telomeres
Q35781572	p53-Dependent but ATM-independent inhibition of DNA synthesis and G2 arrest in cadmium-treated human fibroblasts
Q37342444	p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage
Q43006061	p53: Guardian of pancreatic epithelial identity
Q53556002	p53: a two-faced cancer gene.
Q37994350	p62: a versatile multitasker takes on cancer
Q64272523	translocated translation inhibitors are required for bacterial-induced host cell cycle arrest
Q34576805	βKlotho suppresses tumor growth in hepatocellular carcinoma by regulating Akt/GSK-3β/cyclin D1 signaling pathway

scholarly article	Q13442814
review article	Q7318358

P6179	Dimensions Publication ID	1012054610
P356	DOI	10.1038/NATURE03097
P3181	OpenCitations bibliographic resource ID	569790
P698	PubMed publication ID	15549093
P5875	ResearchGate publication ID	8178332

P50	author	Jiří Bártek	Q12025039
P2093	author name string	Michael B Kastan
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		The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways	Q40750310
		Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway	Q40916856
		Allosteric effects mediate CHK2 phosphorylation of the p53 transactivation domain.	Q41008574
		The retinoblastoma protein pathway in cell cycle control and cancer	Q41673697
		Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation	Q44817175
		Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint	Q46058691
		Loss of Rad52 partially rescues tumorigenesis and T-cell maturation in Atm-deficient mice	Q47662027
		Chromosome instability induced in vitro with mitomycin C in five Seckel syndrome patients.	Q51945941
		Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2.	Q52536019
		Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis.	Q53397555
		The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today	Q55872103
		The cellular response to DNA double-strand breaks: defining the sensors and mediators	Q63383934
		Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors	Q64387467
		53BP1, an activator of ATM in response to DNA damage	Q64388924
		Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice	Q75217030
P433	issue	7015
P407	language of work or name	English	Q1860
P921	main subject	cell cycle checkpoint signaling	Q1068809
P304	page(s)	316-23
P577	publication date	2004-11-18
P1433	published in	Nature	Q180445
P1476	title	Cell-cycle checkpoints and cancer
P478	volume	432

Cell-cycle checkpoints and cancer

scientific article

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