Promotion of DNA repair by nuclear IKKβ phosphorylation of ATM in response to genotoxic stimuli

scientific article

Promotion of DNA repair by nuclear IKKβ phosphorylation of ATM in response to genotoxic stimuli is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1044855855
P356DOI10.1038/ONC.2012.192
P698PubMed publication ID22614018

P2093author name stringR Takahashi
Y Hayakawa
S Maeda
Y Hirata
K Sakamoto
H Nakagawa
H Kinoshita
H Kamata
K Sakitani
M Akanuma
W Nakata
Y Hikiba
P2860cites workNEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signalingQ24298750
Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stressQ24300945
Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repairQ24310231
A single ataxia telangiectasia gene with a product similar to PI-3 kinaseQ24323579
The DNA-damage response in human biology and diseaseQ24606586
Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cellsQ24650179
The DNA damage response: putting checkpoints in perspectiveQ28131713
Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testingQ28140019
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociationQ28206029
Cell-cycle checkpoints and cancerQ28293996
Accumulation of DNA damage and reduced levels of nicotine adenine dinucleotide in the brains of Atm-deficient miceQ28593143
ATM and related protein kinases: safeguarding genome integrityQ29547735
Missing pieces in the NF-kappaB puzzleQ29547864
IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancerQ29614599
Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasionQ30434675
ATM is required for IkappaB kinase (IKKk) activation in response to DNA double strand breaksQ31677626
Multiple autophosphorylation sites are dispensable for murine ATM activation in vivoQ33388649
Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sitesQ33589782
ATM: a mediator of multiple responses to genotoxic stressQ33771767
How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complexQ33797139
IKKβ regulates the repair of DNA double-strand breaks induced by ionizing radiation in MCF-7 breast cancer cellsQ33872159
ATM Activation by Oxidative StressQ34145092
IKK and NF-kappaB-mediated regulation of Claspin impacts on ATR checkpoint functionQ34148484
ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.Q34298505
ATM- and NEMO-Dependent ELKS Ubiquitination Coordinates TAK1-Mediated IKK Activation in Response to Genotoxic StressQ34620780
Involvement of novel autophosphorylation sites in ATM activationQ34972885
Nuclear initiated NF-κB signaling: NEMO and ATM take center stageQ35347865
KinasePhos 2.0: a web server for identifying protein kinase-specific phosphorylation sites based on sequences and coupling patternsQ35914240
The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosisQ36368249
Inflammation and cancer: role of nuclear factor-kappaB activationQ37092305
Activation of ATM depends on chromatin interactions occurring before induction of DNA damageQ37280637
Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen speciesQ38335343
HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agentsQ39588354
Nuclear IKKβ Is an Adaptor Protein for IκBα Ubiquitination and Degradation in UV-Induced NF-κB ActivationQ39662942
Inhibitor of kappaB kinase beta regulates gastric carcinogenesis via interleukin-1alpha expression.Q39721819
3-Nitrobenzanthrone and 3-aminobenzanthrone induce DNA damage and cell signalling in Hepa1c1c7 cells.Q39770215
A nuclear poly(ADP-ribose)-dependent signalosome confers DNA damage-induced IkappaB kinase activationQ39773986
Ikappa B kinasebeta/nuclear factor-kappaB activation controls the development of liver metastasis by way of interleukin-6 expressionQ39788628
Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuliQ40312088
Helicobacter pylori induces IkappaB kinase alpha nuclear translocation and chemokine production in gastric epithelial cellsQ43164932
Loss of ATM sensitizes against O6-methylguanine triggered apoptosis, SCEs and chromosomal aberrationsQ44792776
Replication stress activates DNA polymerase alpha-associated Chk1.Q44803036
Effectiveness of IkappaB kinase inhibitors in murine colitis-associated tumorigenesis.Q45951895
Quantification of DNA strand breaks and abasic sites by oxime derivatization and accelerator mass spectrometry: application to gamma-radiation and peroxynitriteQ46554572
IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesisQ46576855
Determination of apurinic/apyrimidinic lesions in DNA with high-performance liquid chromatography and tandem mass spectrometryQ46950755
The response of Parp knockout mice against DNA damaging agents.Q52538829
A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation.Q52901092
Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivoQ59098643
The protective role of thiol reducing agents in the in vitro inhibition of rat liver DNA methylase by direct acting carcinogensQ71822513
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
genotoxicityQ1009245
P304page(s)1854-1862
P577publication date2012-05-21
P1433published inOncogeneQ1568657
P1476titlePromotion of DNA repair by nuclear IKKβ phosphorylation of ATM in response to genotoxic stimuli
P478volume32

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cites work (P2860)
Q41187419A novel pVHL-independent but NEMO-driven pathway in renal cancer promotes HIF stabilization
Q35745041A quasi-quantitative dual multiplexed immunoblot method to simultaneously analyze ATM and H2AX Phosphorylation in human peripheral blood mononuclear cells
Q38154199An unconventional role of BMP-Smad1 signaling in DNA damage response: a mechanism for tumor suppression
Q47159733Context-Dependent Role of IKKβ in Cancer
Q35799909Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma : ATM, ATR and FA in lung carcinoma
Q27005588New approaches to radiation protection
Q38224263Non-conventional functions for NF-κB members: the dark side of NF-κB.
Q92096585Paeonol attenuates inflammation by targeting HMGB1 through upregulating miR-339-5p
Q37536497Proteasome inhibition increases recruitment of IκB kinase β (IKKβ), S536P-p65, and transcription factor EGR1 to interleukin-8 (IL-8) promoter, resulting in increased IL-8 production in ovarian cancer cells
Q36951585Regulation of anoikis by deleted in breast cancer-1 (DBC1) through NF-κB.
Q37594798Sensitization of melanoma cells to alkylating agent-induced DNA damage and cell death via orchestrating oxidative stress and IKKβ inhibition

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